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Sports Jun 06, 2026

Spain World Cup 2026 Team Guide: Squad, Coach, and Expectations

Spain is one of the favorites to win the 2026 World Cup, with a well-balanced and competitive squad…
The Road to Glory: Spain's 2026 World Cup Ambitions Spain is one of the big favorites in North America this summer, and the squad that Luis de la Fuente has picked has only reinforced that. He has a well-balanced and competitive group that believes in the sort of football that has already yielded great success. The European champions are dreaming of stitching a second star above their crest. The Key Players Much of the media focus has inevitably fallen on Barcelona's Lamine Yamal, whose imagination, creativity, and personality has transformed the Spain frontline into a real force. His partner in crime, Nico Williams, has hit form in the final weeks of the season at Athletic Bilbao. The two wingers were a revelation at Euro 2024, injecting freshness into a team that still dominates the ball. Group Stage Fixtures 15 June v Cape Verde, Atlanta (noon local, 5pm BST, 16 June 2am AEST) 21 June v Saudi Arabia, Atlanta (noon local, 5pm BST, 22 June 2am AEST) 26 June v Uruguay, Guadalajara (6pm local, 27 June 1am BST, 27 June 10am AEST) The Coach: Luis de la Fuente Luis de la Fuente has turned Spain into a fiercely competitive and united team. His style of play combines the traditional possession-based game of recent decades with a greater directness and tactical flexibility. The former under-21 coach is known for his communication and man-management skills, creating a healthy and competitive environment within the group. Star Player: Lamine Yamal Lamine Yamal will be the centre of attention at his first World Cup. The teenager will celebrate his 19th birthday on 13 July, the day before the semi-finals get under way, and yet his immense talent means he will carry the hopes of a nation on his shoulders. Cheeky and creative, the winger plays like he's just having a kickabout with his mates but has become a natural leader within the national team already. Unsung Hero: Eric García Eric García rarely makes the headlines. The former Manchester City player has quietly gone about his business at Barcelona, becoming a key figure for Hansi Flick thanks to his intelligence, positioning, and composure when bringing the ball out from the back. The 25-year-old has grown in maturity and is an organiser, often dictating play from centre-back or even midfield.
#Spain #World Cup 2026 #Luis de la Fuente
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Business Jun 06, 2026

The Billionaire’s Frontline: Rinat Akhmetov on Resilience, Business, and the Return to Donbas

Amidst the heaviest aerial raids on Kyiv, Ukraine's richest man Rinat Akhmetov reflects on his 30-y…
The War Economy: A Billionaire’s Perspective from the FrontlineUkraine is reeling from its heaviest aerial raid in months, with at least 25 people killed in the night sky. In the aftermath, Rinat Akhmetov, the country's wealthiest oligarch and owner of Shakhtar Donetsk, gives a rare interview from a location outside Kyiv. This conversation marks the 90th anniversary of the club and the 30th year of Akhmetov's leadership, offering a unique insight into how the war has reshaped his personal and professional life.From Coal Traders to Champions: The Akhmetov StrategyAkhmetov’s rise from a child in 1970s Donbas to the owner of one of eastern Europe’s most influential football clubs is a story of calculated risk and strategic foresight. His journey began not in football, but in the volatile economy of the 1990s.The Proximity of Danger: Akhmetov was five seconds away from death when his business partner and predecessor, Akhat Bragin, was killed in a stadium explosion in 1995. This tragedy left the club abandoned, with players earning as little as $200 or $300 a month.Industrial Expansion: Leveraging the collapse of the Soviet Union, Akhmetov moved from trading coke and coal to acquiring cheap stakes in metallurgy plants. He revitalized the Yenakiieve plant, where workers previously earned $45 a month, transforming it into a globally competitive enterprise.Breaking the Mold: To break Dynamo Kyiv's dominance, Akhmetov hired foreign managers like Nevio Scala and Mircea Lucescu. He argued that a patriot is someone who works for Ukraine's benefit, regardless of origin, a philosophy that yielded 22 trophies over 12 years.The Financial Toll of Occupation and the Iron and Steelworks of AzovstalThe conflict in Donbas has been devastating for Akhmetov’s industrial empire. Since the occupation began in 2014, his businesses have suffered severe losses. The Azovstal iron and steelworks became a global symbol of Ukraine's resilience during the 2022 siege, though it came at a massive cost to the local economy.Shakhtar was forced to flee their home, losing the Donbas Arena—a stadium that once held 40,000 to 50,000 fans—to the occupying forces. The club's relocation to Lviv and Poland turned them into a powerful ambassador for the Ukrainian state, using the Conference League semi-finals to keep the world's attention on the war.Shakhtar as a Symbol of Ukrainian ResilienceAkhmetov reveals that Shakhtar has always been pro-Ukrainian, evidenced by their 2007 decision to use the Ukrainian spelling of their name over the Russian one. However, the full-scale invasion has crystallized this identity. The club is now viewed globally as a symbol of the fight for independence, sovereignty, and freedom.The Road to Donbas: A Promise Kept and BrokenFor years, Akhmetov maintained a moral imperative: he vowed not to attend another game until Shakhtar returned to their beloved Donbas Arena. This promise was broken last month when he returned for the Conference League quarter-final following the death of his long-time manager, Mircea Lucescu. The spontaneous decision was driven by emotion, as the players' applause during the warm-up moved him to tears. It marks a significant moment in the club's history, signaling a potential return to the region that birthed them, even as the war continues.
#Rinat Akhmetov #Shakhtar Donetsk #Ukraine
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Entertainment Jun 06, 2026

A Tragic Farewell: John Huston’s The Misfits and the End of an Era

The Guardian reviews the rerelease of John Huston's 1961 western 'The Misfits' on the 100th anniver…
The Final Curtain Call for Hollywood IconsThe 100th anniversary of Marilyn Monroe’s birth has prompted a rerelease of her most serious work, John Huston’s 1961 western The Misfits. This retrospective offers a sombre look at a film that marked the final chapter for its three iconic leads: Monroe, Clark Gable, and Montgomery Clift.The Irony of a 'Misfit' in the American WestAdapted by Arthur Miller, the film tells the story of Roslyn, a woman seeking a quickie divorce in Reno who becomes entangled with three men: an ageing cowboy, a submissive friend, and a reckless bronco rider. The Guardian review notes that despite the title, the characters fit perfectly into their desolate landscape, trapped in a cycle of loneliness and yearning. The film serves as a poignant 'American pastoral' that reflects the disillusionment of the era.The Tragic Destiny of the Wild HorsesThe film's climax, where the characters attempt to capture wild mustangs only to realize they are being sold as pet food, serves as a powerful metaphor. The Guardian describes this as a 'horrible, inglorious and symbolic destiny,' mirroring the characters' own struggles. Monroe’s performance is noted as 'fascinatingly sad,' moving away from her signature breathiness to reveal a raw, authentic vulnerability.Enduring Legacy of a Tragic RomanceAs the film returns to cinemas for the BFI Southbank retrospective, it serves as a reminder of the tragic personal toll on its creators. The Guardian suggests that the film's sombre tone feels more relevant than ever, cementing its status as a masterpiece of American cinema that explores the cost of freedom and the inevitability of loss.
#Marilyn Monroe #John Huston #Clark Gable
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Tech Jun 06, 2026

The Moral Code Paradox: Former Spy Chief Advocates for AI-Driven Drone Ethics

Former GCHQ chief David Omand has reversed his stance on autonomous weapons, arguing that AI drones…
The Shift in Defense EthicsFormer GCHQ head David Omand has called for the integration of moral guidelines into future AI-powered weapon systems, arguing that autonomous drones are the only way to manage the speed of modern warfare. Omand, who previously chaired a 2014 commission on armed drones expressing doubts about AI's ability to distinguish civilians, now believes technology can "formalize moral authority" to ensure compliance with international humanitarian law.From Skepticism to "Adaptive Moral Control"Omand's intervention marks a significant pivot in the debate over autonomous weapons. He proposes an "adaptive moral control layer" where humans set the parameters of a mission—such as the expected proximity of civilians—before deployment. The AI then operates within these constraints, making split-second targeting decisions that reflect "sound moral reasoning." This approach aims to move away from the "in the loop" model, where a human authorizes every action, to an "on the loop" model where humans supervise the system's parameters.The $54bn AI Arms RaceThe push for ethical AI in warfare is fueled by massive investment and the reality of modern combat. The US is aggressively pursuing this technology, allocating $54bn for autonomous systems in its 2027 budget. This spending is driven by the need to shorten the "kill chain" in conflicts like the Iran war, where AI tools from companies like Palantir and Anthropic are already being deployed to process data faster than human operators can react.Redefining Human Oversight in CombatThe debate is fundamentally changing how military leaders view human involvement. Omand argues that relying on humans to make every decision in the "heat of combat" is operationally impossible and likely to lead to worse collateral damage. Instead, he envisions a future where machines execute attacks under strict human-defined ethical boundaries. However, critics like Chris Cole of Drone Wars UK argue that AI is merely a data processor incapable of the cognitive judgment required to distinguish combatants from civilians or judge proportionality.The Future of Automated WarfareThe consensus among defense analysts is that the shift to "on the loop" systems is inevitable. As warfare accelerates, the ability to program ethical constraints into autonomous systems may become a standard requirement for military capability. The challenge moving forward will be ensuring that these "moral codes" are robust enough to prevent civilian casualties while maintaining the speed advantage that AI provides.
#David Omand #GCHQ #AI Warfare
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Business Jun 05, 2026

Asda Chair Allan Leighton Defies Critics with Turnaround Strategy Against Aldi Threat

Veteran retail boss Allan Leighton is leading Asda's second turnaround in his career, implementing …
The Asda Turnaround Challenge"It's not bloody inevitable," that Asda will be overtaken by Aldi as the UK's third biggest supermarket, roars Allan Leighton, the veteran retail boss who returned to lead the business after 20 years in November 2024. Leighton is attempting to defy the critics and revive Asda for the second time in his career, despite grocery sales and market share continuing to fall according to industry data.The Market Position and Aldi ThreatWith 580 supermarkets, 517 convenience stores and four stand-alone George outlets, Asda faces significant challenges. In terms of market share, its rival Aldi is now less than one percentage point away from overtaking Asda, where sales and profits have dived since a debt-fuelled £6.8bn takeover in early 2021 by Blackburn's billionaire Issa brothers and the private equity company TDR Capital.The Technology TransformationLeighton admits that "Project Future" – the transfer of Asda's technology from former owner Walmart's systems to its own at an estimated cost of close to £1bn – left gaps on shelves and put plans six months behind schedule. The IT is now "stable," he says, with only smaller jobs to do, availability has improved dramatically and a new deal with Ocado will help modernize Asda's online business from next year.The Competitive Differentiation Strategy"We are more than a supermarket. Everybody thinks we are a supermarket, we are not. Almost 50% of our business does not come from food," Leighton emphasizes. He argues that where Asda can win is through its scale in clothing and general merchandise, which competitors cannot match. "Nobody else can do things the way we do it. We are trying to accentuate that," he says.The Four Pillars of Asda's FutureAsda has four cornerstones according to Leighton – superstores, the George brand, fuel and convenience stores, with online being the future. "We can be the online discounter," he states. Rejecting speculation about selling Asda's Express convenience store chain or merging with Sainsbury's or Morrisons, Leighton focuses on "just be better today than we were yesterday." He claims prices are now between 4% and 7% cheaper than other traditional supermarkets – Tesco, Sainsbury's and Morrisons.The Consumer and Economic ChallengesLeighton acknowledges that "the consumer's confidence is shot" and inflation on food is building again. "We've seen bits of it beginning to come through now," he says. All retailers are under pressure from rising labour, energy and regulatory costs as well as a squeeze on household spare cash. However, Leighton remains optimistic: "If we get it right, then we've got more ammo than anybody else."
#Asda #Allan Leighton #Aldi
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Entertainment Jun 05, 2026

The Sorcerer's Apprentice: A Mindboggling Theatrical Magic Show That Makes You Believe

The Sorcerer's Apprentice at Buxton Opera House is a captivating theatrical production that combine…
The Enchantment of The Sorcerer's ApprenticeIf you catch a young audience member at just the right moment, when they are old enough to be fully engaged but not so old that the sharp edges of teenage cynicism have begun to slink into view, you can make them truly believe in the magic of theatre. The Sorcerer's Apprentice is the kind of show that will make them – and possibly some adults – believe in magic.A Master Magician's Theatrical VisionTo begin by praising the lighting design may seem odd, but this is one of the most effectively lit pieces of theatre you might see. Lighting designer Simon Bond's barn doors, gels and gobos are integral to creating the many illusions on the stage. Director Paul Bosco McEneaney was a magician before turning his hand to theatre directing and he empties out a bag of tricks on to the stage of the jewel-like Buxton Opera House.Gunda (Philippa O'Hara), our narrator, begins by conjuring a village of 100 wooden houses out of thin air, the village stretching up into the darkness, the first of many impressively created stage images from designer Diana Ennis. Much of the story is simply told by Gunda; when it is occasionally sung, Fiona O'Kane and Neve Hutchinson's score adds to the mystical quality of the storytelling.The Technical Wizardry Behind the MagicThe production showcases an impressive array of technical achievements that bring the story to life. The sorcerer appears in the form of an owl – you will believe he flies on to and around the stage with actual wind in his wings before taking on human form. For fans of the Disney version of this story, there is a moment in which an army of brooms fly around the stage.But there is so much more to this stage adaptation, a co-production between the Northern Irish company Cahoots and Buxton Opera House. The tricks include levitation, shape shifting, things – and people – appearing out of nowhere. Entrances and exits provide little challenge for this director. Holding it all is a simply told, effective narrative.The Revival of Traditional Theatre MagicIn an era dominated by digital effects and high-tech spectacles, The Sorcerer's Apprentice represents a return to traditional theatrical magic. The production demonstrates that with clever design, skilled performers, and imaginative direction, live theatre can create illusions that captivate audiences in ways that digital media often cannot.This collaboration between Cahoots and Buxton Opera House highlights the growing trend of regional theatres partnering with specialized companies to create unique productions that might not otherwise be possible. Such partnerships are breathing new life into the regional theatre scene across the UK.The Future of Theatrical IllusionAs The Sorcerer's Apprentice continues its run at Buxton Opera House until June 6, it sets a high bar for future productions seeking to blend storytelling with technical wizardry. The success of this production suggests that there is a significant appetite for theatre that celebrates the art of illusion and magic.We can expect to see more productions that blur the line between magic and theatre, as directors with backgrounds in magic bring their unique skills to the stage. This fusion of disciplines represents an exciting frontier in theatrical innovation that could redefine what audiences expect from live performance.
#The Sorcerer's Apprentice #Buxton Opera House #Paul Bosco McEneaney
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Entertainment Jun 05, 2026

Lizzo's 'Bitch': A Star Searching for Her Musical Identity Amidst Controversy

Lizzo's fifth album 'Bitch' arrives at a career crossroads, following lawsuits and failed musical e…
The Comeback That Never MaterializedJust over a year ago, Lizzo appeared on Saturday Night Live, announcing a new album called Love in Real Life in grandstanding style. Wielding an electric guitar, clad in a Trump-baiting T-shirt that read Tariffied, she performed its title track and two other new songs, Still Bad and Don't Make Me Love U. As with her appearance earlier the same week on a late night talkshow – during which she ran into the audience to high-five fans who were yelling "we love you Lizzo!" – it looked very much like a defiant comeback, fit to drag her out of the controversy that erupted at the end of her hugely successful 2023 world tour. Three former backing dancers and a costume designer filed lawsuits against the singer alleging harassment and discrimination: damaging claims given how Lizzo's songs have preached a message of inclusivity, body positivity and self-confidence. Some of the allegations were dismissed by a judge but others are ongoing; Lizzo has refused to settle out of court, saying: "I'm fighting the case because I know that it's not true."The Album That Never WasBut the Love in Real Life single, a pivot towards rock that owed a little to Tom Petty's American Girls – or the Strokes' American Girls-indebted Last Nite if you prefer – failed to make the charts, a far cry from the period between 2018 and 2022 when Lizzo's singles seemed to go multi-platinum as a matter of course. The same fate befell Still Bad, a track much more in the vein of her big hits, prompting a rethink. The album was pulled, Lizzo apparently taking control of her own destiny – "I need to do shit my way". A mixtape that returned her more-or-less to where she started, before pop stardom came calling – punchy hip-hop, albeit tricked out with guest appearances from Doja Cat and SZA – appeared in its place: My Face Hurts from Smiling received mixed reviews and underwhelming streaming figures.A Career at a CrossroadsAll of which means that Bitch, her fifth album proper, lands at a deeply peculiar juncture in Lizzo's career. Given that the public apparently don't want her going rock, nor rapping in the style of her 2013 debut Lizzobangers, nor indeed making the kind of music they were buying in their millions three years ago, the question of what they actually do want has presumably hung heavy over its making.Musical Identity CrisisLizzo hasn't come up with a definitive answer. Bitch tries a bit of everything, from pastiching Tame Impala on Happy 2 Be to making clipped new-wave rock decorated with Cure-like guitars on She Stole My Man; Sexy Ladies is a girls-night-out-soundtracking reiteration of the old body positivity message. This scatter-gun approach makes Bitch a disjointed listen.The Subdued ToneMoreover, there's something oddly subdued about its tone, whether it's dabbling in 80s retro – Don't Make Me Love U brings to mind the arena-rousing keyboard hook from Tina Turner's The Best, but renders it into a distant, affectless backing vocal – or delving into jazzy R&B; on Too Nice. The vibraphone-heavy beat on the latter is fantastic, rich in small-hours atmosphere, but the actual song feels nondescript: it only really comes to life in its dying moments, when Lizzo stops singing and starts playing a flute solo. The title track interpolates the chorus from Meredith Brooks' 1997 pop-grunge hit of the same name, but somehow flattens it in the process. Crooned over smooth, G-funky R&B;, it feels stripped of its fiery power, less of a snarl and more of a shrug.Equivocal LyricsThe lyrics often seem similarly equivocal. You don't want for apparent references to Lizzo's recent woes – "I hope it makes you happy to hurt somebody else", "the thing about depression, you think your life is over", "you'd still be working at the mall if it wasn't for me" – but they ultimately feel neither pugilistic nor racked, just confused and sore: "I have feelings too," she sings on piano ballad A Toast.Highlights Amidst the StruggleNot everything here is underwhelming: Whose Hair Is This is a great southern soul pastiche, home to an impressively raw vocal and a snappy plot twist at the end of the lyrics; That Grrrl employs an old-school Chicago house bassline to energising effect. But what's definitely lacking is an unequivocal pop smash, the kind of thing that Lizzo once seemed to be able to write to order.A Changing Cultural LandscapePerhaps that's inevitable. One of the reasons Lizzo hit so big in the first place was that she made pop music that perfectly captured a zeitgeist, and that zeitgeist has moved on: the era of body positivity has been displaced by the era of Ozempic and Mounjaro; the kind of post-pandemic, post-Trump optimism embodied on 2022's About Damn Time now sounds like a transmission from a distant lost age. We're living in a different world now, and Bitch suggests Lizzo has yet to work out how to respond to it: "I'm doing my best," she sings on A Toast, which feels like the most telling lyric of all.
#Lizzo #Bitch album #Music Review
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Tech Jun 05, 2026

Mira Murati Returns to Spotlight with New AI Vision at Thinking Machines Lab

Mira Murati, former OpenAI CTO and current CEO of Thinking Machines Lab, makes her first major medi…
The Return of Mira Murati to the Public StageMira Murati, former CTO of OpenAI and current CEO of Thinking Machines Lab, has made her first major media appearance in approximately 18 months, sitting down with Bloomberg in San Francisco. This rare public appearance comes as Murati's company, which has been operating largely in the background, seeks to establish its presence in an increasingly competitive AI landscape.Thinking Machines' New Approach: Interaction ModelsDuring the interview, Murati previewed what Thinking Machines is calling "interaction models," described as a fundamentally different kind of AI interface. Unlike the traditional turn-based, prompt-and-response dynamic common in most AI products today, the company's models are designed to process continuous streams of audio, text, and video in 200-millisecond intervals. This approach aims to capture the nuances of human communication—including interruptions, mid-thought corrections, and pauses—in something closer to real time.Murati emphasized that this approach aligns with her lab's core thesis that the path to powerful AI runs through closer human collaboration, not around it. She was careful to frame it as a first step rather than a finished product, declining to specify a release date.The Competitive AI LandscapeThe timing of Murati's public return is strategic. While Thinking Machines has spent the past year and a half operating in the background—raising capital, hiring researchers, and shipping one product, Tinker (an API for fine-tuning open-source AI models)—its competitors have grown more omnipresent. OpenAI, where Murati spent six years as CTO, remains constantly in the news cycle. Anthropic has gained significant momentum, and Elon Musk's xAI has been folded into SpaceX ahead of what is expected to be a massive public offering.In this environment, Murati acknowledged that staying heads down has diminishing returns, and at some point, a company must make noise to remind the market it exists.Reflections on OpenAI's Leadership CrisisMurati also addressed the chaotic week in November 2023 when OpenAI's board fired Sam Altman, and she became interim CEO—an event referred to internally as "the blip." She expressed clarity about her decisions during that period, stating that protecting the mission and team guided her choices even as the situation appeared to be unraveling externally. Murati claimed the company would have "imploded" without her involvement during those five days and their immediate aftermath.In retrospect, she acknowledged she would have pushed harder for more information, a better transition plan, and more transparency. When asked if she still trusts her former boss, she sidestepped the question, instead focusing on her broader concern about the concentration of consequential decisions in too few hands across the industry.Talent Challenges and Compensation CultureChang pressed Murati on the departures of several high-profile researchers from Thinking Machines in recent months, a subject Murati has largely avoided in public. She explained that building a frontier AI lab from scratch compresses years of normal organizational volatility into months. Regarding compensation—the nine-figure packages that have become standard in the AI talent war—Murati suggested it isn't usually the whole story behind talent decisions."When I wake up in the morning, I am not thinking about how to kill the competitor," Murati quipped, drawing audience laughter and highlighting her competitive approach to building rather than destroying.The Future of AI and Human AgencyWhen asked about the future of AI and its impact on humanity, Murati pushed back on both inevitable dystopia and inevitable utopia scenarios. She argued that neither outcome is predetermined and that the current period will determine which direction things go. However, she warned that if humans "take their hands off the wheel too soon," the future will look very different, and not better.Born in Albania and speaking with a slight Eastern European accent, Murati emphasized the importance of maintaining human agency in AI development, reflecting on concerns about mass job displacement and potential misuse of AI for harmful purposes like creating chemical weapons.
#Mira Murati #OpenAI #Thinking Machines Lab
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Science Jun 05, 2026

Biotech Barbie Cathy Tie Pursues Open Gene Editing of Babies Despite Global Bans

Canadian entrepreneur Cathy Tie, known as 'Biotech Barbie,' is pursuing genetic modification of emb…
The Lead: Biotech Barbie's Mission to Edit Human DNA Cathy Tie, a Canadian entrepreneur known as "Biotech Barbie," is pursuing a controversial mission to genetically modify embryos to prevent hereditary diseases, following in the footsteps of her ex-husband He Jiankui, who served prison time for creating the world's first gene-edited babies. Despite global bans on germline gene editing for reproductive purposes, Tie aims to conduct this work openly with regulatory approval and venture capital funding. The Technical Breakthrough: Gene Editing Made Accessible Since the invention of the Crispr-Cas9 gene editing tool in 2012, the technical process of altering DNA has become relatively straightforward. "The hardest thing about genetically engineering a baby is getting permission to do it; the technical part is not particularly complicated," the article explains. The process is compared to using "find, copy, cut and paste functions on a computer" and doesn't require extensive expertise in molecular biology. Germline gene editing—altering eggs, sperm, or early embryos—is particularly significant because changes are passed down to future generations, potentially altering human evolution permanently. This is why such procedures are banned in the UK, US, and China, with international agreement against research that could result in gene-edited babies. The Financial Landscape: Billionaires Investing in Genetic Engineering Money is flowing into human genetic engineering, with some of the world's richest men investing in companies pursuing similar goals. Preventive, a gene editing startup launched in October 2025 with the aim of "preventing disease before birth," has attracted investment from OpenAI's Sam Altman, his husband Oliver Mulherin, and Coinbase CEO Brian Armstrong. Armstrong has coined the term "the Gattaca stack"—referencing the dystopian film about a genetically engineered society—which includes technologies for "disease prevention, or enhancement" of babies. This suggests a growing interest not just in preventing diseases but in enhancing human traits. Preimplantation genetic testing (PGT), already common in the US fertility treatments, allows parents to "choose the embryo that best matches what you want," with companies like Nucleus Genomics advertising on subways with the tagline "Have your best baby." The Global Impact: A New Biological Arms Race? "There's a big geopolitical component to this," Tie states, referring to the growing interest in genetic engineering. China, where Tie was banned from entering, has already demonstrated what gene editing can do—Chinese researchers made the first edits to human embryos in 2015, and Tie's ex-husband He Jiankui created the first gene-edited babies, twin girls known as Lulu and Nana. Since his release from prison in 2022, He has become an unlikely social media star with close to 150,000 followers on X, making unrepentant posts about "designer babies" being "inevitable." Meanwhile, China's biotechnology ambitions have expanded, with Premier Li Qiang announcing new regulations emphasizing "the need to promote innovative development" and "accelerate R&D; and commercialization." In response to China's announcement, Tie posted: "Welcome to the dawn of the biological arms race." The Future Outlook: Inevitable Genetic Modification "Biology is a double-edged sword – it can be used for good, to heal people, or it can be used for bad," Tie explains. "Stopping this research will only drive bad actors to do it secretively. There is no way to stop this. This is inevitable. The only way to proceed is to do it openly and transparently." Tie named her first human gene-editing company the Manhattan Project, drawing a parallel between the nucleus of the atom and the nucleus of the cell. "In the 20th century, we understood the nucleus of the atom very well, and we learned some very difficult lessons via weapons and wars," she says. "I don't want to see the same happen with the second nucleus." Despite her declared commitment to openness, much of Tie's work remains shrouded in secrecy. Her first company, the Manhattan Project, has since shut down due to what she calls a "fundamental mistake" in choosing a co-founder. She has since launched Origin Genomics, continuing her pursuit of genetic modification of embryos.
#Cathy Tie #He Jiankui #gene editing
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