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The recent ceasefire talks between the United States and Iran have ended without a breakthrough, with Iran's chief negotiator, Mohammad Bagher Ghalibaf, blaming the US for the failure of the talks held in Islamabad, Pakistan. The talks, which were the first direct engagement between the two countries at this level since the 1979 Iranian Revolution, exposed deep divisions on core issues.The US framed the lack of a breakthrough primarily around Iran's alleged refusal to meet its core demand: a firm commitment not to develop nuclear weapons. US Vice President JD Vance said Washington had made its 'red lines' clear and presented what he described as a 'final and best offer'. However, Iran downplayed expectations and blamed the US for making unreasonable demands.The main sticking points between Tehran and Washington are:Iran's nuclear programme: The US wants a clear and enforceable commitment that Iran will not develop nuclear weapons – or even the capability to do so quickly. Iran has consistently rejected accusations that it seeks to build nuclear weapons but said it is willing to negotiate limits on its nuclear activities if sanctions are removed.Strait of Hormuz: Who gets to control this strategic waterway, through which almost all of the oil and natural gas exports from the Gulf nations pass, has become a major flashpoint. Iran has floated the idea of charging transit fees to allow ships to pass through the strait, while the US is adamant the strait is reopened free of any tolls.The near shutdown of shipping through the strait has sent global energy prices soaring with many countries, especially in Asia, forced to implement unprecedented austerity measures to soften the impact of fuel shortages. Experts said the near-closure of the strait has caused the worst economic shock since the 1973 oil embargo.

The light‑heavyweight division entered a new chapter on Saturday night in Miami when Carlos Ulberg secured the vacant UFC title by delivering a decisive left hook to former champion Jiri Prochazka. President Donald Trump watched from the cageside as Ulberg’s strike landed at the 3:45 mark of the opening round, ending the bout with a knockout and awarding him the undisputed belt. Ulberg entered the fight with a professional record of 14‑1 in MMA (10‑1 in the UFC), while Prochazka held a 32‑6‑1 MMA record (6‑3 in the UFC). Early in the first round Ulberg felt a knee give way, yet he persisted, capitalising on Prochazka’s hesitation to land the winning blow. “I blew out my knee, but I never counted myself out,” Ulberg said afterward. “I knew I needed one clean shot, and when I saw Jiri pulling back, I threw my left hand and it landed.” Prochazka, who has gone 1‑3 in UFC title fights since June 2022, reflected on the loss: “I felt sorry for him, and this is one of the biggest lessons in my life. The fight was in my hands, I saw his injury, and I’ll be back.” The championship was vacant after former champion Alex Pereira vacated the belt to pursue an interim heavyweight title at UFC Freedom 250, a bout scheduled for the White House on Donald Trump’s 80th birthday. Trump promoted the event on his Truth Social account and arrived at the Kaseya Center accompanied by UFC president Dana White, Secretary of State Marco Rubio, and U.S. ambassador to India Sergio Gor. A Kid Rock track blared as Trump took his seat beside the officials. In the co‑main event, Azamat Murzakanov knocked out Paulo Costa with a right round‑house at 1:23 of the third round, extending his perfect UFC record to 17‑0‑0. After his victory, Murzakanov shook hands with Trump, who praised the fighter. Murzakanov acknowledged the president during his post‑fight interview with Joe Rogan. The heavyweight showdown between Josh Hokit and Curtis Blaydes turned into a gritty slugfest, with Hokit prevailing by unanimous decision (29‑28 on all three cards). Trump cheered loudly as the fighters exchanged blows. Following Hokit’s win, UFC chief Dana White announced on social media that a bout between Hokit and Derrick Lewis would be added to the UFC Freedom 250 card, noting that President Trump helped bring the matchup together.

Iran’s attempt to impose tolls on vessels passing through the Strait of Hormuz has been labeled illegal by Arsenio Domínguez, the head of the United Nations’ International Maritime Organization (IMO). In an interview with Al Jazeera, Domínguez stressed that such charges would set a dangerous precedent for global shipping. Tehran has asserted its right to levy fees even after the conflict ends, while U.S. President Donald Trump floated the idea of a joint U.S.-Iran venture to collect the payments. Both proposals clash with established maritime conventions. "Countries do not have the right to introduce tools or payments or charges on these straits," Domínguez said, adding that any toll system would be contrary to international law and could cripple the free flow of trade. The remarks came as marathon cease‑fire negotiations between U.S. and Iranian officials in Pakistan concluded without an agreement. U.S. Vice President JD Vance noted that Tehran rejected Washington’s terms, which included a commitment to forgo nuclear weapons development, prompting the American delegation to depart Islamabad after presenting its "final and best offer." Iran’s state‑run Press TV blamed the stalemate on what it called the United States' "excessive demands," citing the toll issue and the nuclear programme as major points of contention. Despite a two‑week cease‑fire announced earlier in the week, maritime traffic remains severely limited. Only 22 vessels with active AIS signals exited the strait between the truce’s start and Friday, a stark drop from the pre‑conflict average of about 135 daily transits, according to S&P Global. The bottleneck is throttling oil and natural‑gas exports from the Gulf. The U.S. military reported that two warships had navigated the waterway to clear Iranian mines, a move Iran denied. President Trump later insisted the strait would reopen "fairly soon," with or without Tehran’s cooperation. Domínguez emphasized that ending the hostilities is the fundamental solution to restoring safe passage. He warned that any resumption of traffic must be accompanied by thorough de‑mining and safety checks to protect both vessels and crews. He also dismissed calls for new legal frameworks, noting that the 1968 traffic‑separation agreement between Iran and Oman—which splits the strait into north‑ and south‑bound lanes—had functioned effectively before the war and does not require revision. Humanitarian concerns feature prominently in Domínguez’s statements. He highlighted that roughly 20,000 seafarers are stranded in the Gulf due to the blockade, warning that prolonged isolation would not only harm these workers but also have a negative ripple effect on the global economy.

“The world is grown so bad that wrens make prey where eagles dare not perch,” wrote Shakespeare in *Richard III*. The line now echoes a hopeful development: the iconic golden eagle could once again soar over England after more than a century and a half of absence. The golden eagle, a bird with a wingspan of roughly 2 metres, was a common sight in Shakespeare’s England, yet it has been effectively extinct in the country since the death of the last native individual in 2015. Centuries of persecution by gamekeepers and farmers, who feared predation on lambs and game birds, drove the species to the brink. A feasibility study commissioned by Forestry England and released on Sunday pinpoints eight potential “recovery zones”—predominantly in northern England—where the habitat could sustain a viable eagle population. The report cautions that establishing breeding pairs may take **more than a decade**. In response, Environment Secretary Emma Reynolds announced an additional £1 million in species‑recovery funding. The money will underwrite a programme that could see juvenile eagles, aged six to eight weeks, released into the wild as early as next year. Reynolds said, “This government is committed to protecting and restoring our most threatened native wildlife – and that includes bringing back iconic species like the golden eagle. Backed by £1 million of government funding, we will work alongside partners and communities to make the golden eagle a feature of English landscapes once again.” Across the border, golden eagle numbers in southern Scotland have surged to record levels thanks to a major restoration project. Satellite tracking shows that some translocated Scottish birds are already venturing into northern England, offering a natural source of future colonisers. The new funding will support these cross‑border movements and enable targeted reintroductions. While experts anticipate that golden eagles could be regularly observed across northern England within 10 years, establishing a self‑sustaining breeding population will require a longer horizon. Mike Seddon, chief executive of Forestry England, explained, “The detailed findings of our feasibility study will guide us, with our partners at Restoring Upland Nature, to take the next steps toward recovering golden eagles in northern England. This DEFRA funding means we can build on the good work we have begun, engaging local communities, landowners and conservation organisations.” The £1 million allocation forms part of a broader £60 million species‑recovery fund announced by DEFRA. It aligns with the UK’s legally binding commitment to halt the decline in species abundance by 2030 and to reduce extinction risk by 2042 relative to 2022 levels.

Two planes of Iranian negotiators, many from the Islamic Revolutionary Guard Corps, arrived in Pakistan to confront a 21‑hour deadline for talks that span two decades of nuclear tension and new strategic concerns such as control of the Strait of Hormuz and U.S. compensation for past attacks.The United States responded with a delegation that included Vice‑President JD Vance and roughly 300 officials, signaling a recognition that Iran’s seasoned team—featuring figures like Ali Bagheri Kani and former chief negotiator Abbas Araghchi—was well‑prepared.During the marathon, Vance held multiple conversations with former President Donald Trump and, notably, with Israeli Prime Minister Benjamin Netanyahu. Iranian officials claimed the Netanyahu call hardened the U.S. stance, underscoring the delicate diplomatic balance.Veteran negotiators Robert Malley and Aaron David Miller warned that the time frame was either too long for a mere reiteration of rejected demands or far too short for genuine negotiation, highlighting a strategic misreading of Tehran’s position.Vance concluded the session by presenting what he described as a “best and final offer,” leaving the door open for further dialogue pending Iranian acceptance.Meanwhile, President Donald Trump signaled an intention to impose a blockade of the Strait of Hormuz—a move that could inflate global oil prices and further destabilize the region.Iran’s objectives included drafting a memorandum of understanding to extend a tentative ceasefire and address three core issues: an end to Israel’s offensive in Lebanon, a governance framework for Hormuz shipping, and the disposition of its highly enriched uranium stockpile, whether through UN‑supervised down‑blending or export to a third party.Vance emphasized the need for an affirmative Iranian commitment not to pursue a nuclear weapon or the rapid pathways to one, a demand that intersects with ongoing debates about Iran’s sovereign right to enrich uranium—a capability currently null after recent U.S. strikes.In practice, Iran is already exercising selective control over Hormuz traffic, allowing 2 million barrels of Iraqi oil and 4 million barrels of Saudi oil to pass, a tactic described by an Iranian parliamentarian as a “continuous atomic bomb” that provides strategic depth.Beyond the diplomatic impasse, Iran confronts severe domestic challenges: hyperinflation approaching triple‑digit levels, an internet blackout threatening economic activity, and a political climate marked by assassination threats. These pressures compound the difficulty of achieving a sustainable peace settlement.

GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

Former President Donald Trump and Secretary of State Marco Rubio arrived at Miami’s Kaseya Center shortly after 9 p.m. on Saturday to watch a UFC card, joining UFC president Dana White and several members of the Trump family. Seated nearby were U.S. ambassador to India Sergio Gor, rapper Vanilla Ice and former FBI deputy director Dan Bongino. The crowd greeted Trump enthusiastically as a Kid Rock track blared, and he exchanged handshakes and smiles with fans and the broadcast crew, which included podcaster Joe Rogan. While the fights unfolded, Vice‑President JD Vance told reporters that the diplomatic mission in Pakistan aimed at ending the conflict with Iran had broken down. He noted that Iran’s refusal to renounce its nuclear ambitions remained the chief obstacle, stating, "We need an affirmative commitment that Iran will not seek a nuclear weapon or the tools to achieve one quickly." Despite the diplomatic setback, Trump appeared focused on the cage action, occasionally leaning toward Rubio to discuss matters on his phone. After the co‑main event victory of Paulo Costa over Azamat Murzakanov, the champion approached the former president for a handshake. Trump’s family members at the venue included his children Ivanka, Tiffany and Donald Jr.; Ivanka’s husband Jared Kushner was in Pakistan with Vance for the failed talks. UFC has long been a platform that bolsters Trump’s appeal among young, male audiences. The promotion recently announced a special event at the White House slated for 14 June—coinciding with Trump’s 80th birthday—to commemorate the United States’ 250th anniversary. According to White, a bout featuring Josh Hokit was added to the June card at Trump’s request, with both White and Rogan confirming the arrangement. Vance emphasized that the United States remains committed to securing a binding Iranian pledge against nuclear weapon development, framing it as the core objective of the administration’s foreign policy agenda.

Pakistan dispatched a mixed fleet of fighter and support aircraft to King Abdulaziz Air Base in Saudi Arabia’s Eastern Province on Saturday, marking the first visible military action under the mutual defence agreement signed in September 2025. The Saudi Ministry of Defence confirmed the landing, noting the deployment aligns with the collective defence clause that obliges each signatory to treat an attack on the other as an attack on itself. At the same time, Islamabad is hosting direct US‑Iran negotiations aimed at halting weeks of regional fighting triggered by Iran’s missile and drone strikes on Gulf targets after the US‑Israeli killing of Supreme Leader Ali Khamenei on 28 February. Foreign Minister Ishaq Dar told reporters he personally warned Iranian leaders in early March that Pakistan must honour its obligations to Riyadh. Tehran, seeking assurances that Saudi soil would not be used for attacks against it, received such guarantees, Dar added. Despite these diplomatic overtures, Iranian attacks on Saudi facilities – including key bases and a US embassy building – have persisted. In early March, Pakistan’s army chief, Field Marshal Asim Munir, flew to Riyadh to discuss measures to curb Iranian strikes within the framework of the defence pact. Four days before the jet deployment, Prime Minister Shehbaz Sharif phoned Crown Prince Mohammed bin Salman, pledging that Pakistan would stand “shoulder to shoulder” with Saudi Arabia. The two leaders also agreed to accelerate a $5 billion Saudi investment package earmarked for Pakistan. Saudi Finance Minister Mohammed al‑Jadaan met Sharif, Dar and Munir in Islamabad on Saturday, underscoring the economic dimension of the partnership. Saudi Arabia hosts roughly 2.5 million Pakistani workers, whose remittances are vital to Pakistan’s fragile economy, and has repeatedly provided financial assistance. Security analyst Imtiaz Gul told Al Jazeera the deployment was not intended as a military escalation but as a “messaging tool” to remind Tehran of Pakistan’s treaty obligations. “Three jets won’t make much of a difference militarily,” he said, noting Saudi Arabia’s own sizable air force. Michael Kugelman, senior fellow for South Asia at the Atlantic Council, described the move as “a risky gambit.” He warned that if Iran refuses concessions, Pakistan could be drawn closer to Saudi Arabia, potentially invoking the defence pact in a renewed conflict.

Ali Majed Hamadneh, 23, was killed after Israeli settlers opened fire during a raid on the West Bank village of Deir Jarir, north‑east of Ramallah, the Palestinian Ministry of Health reported on Saturday. He was transported to the Palestine Medical Complex in critical condition and later succumbed to his gunshot wounds.The Palestinian news agency Wafa described the attack as carried out by "armed colonists, under the protection of Israeli forces," who entered the village from its western entrance and fired on residents. The Israeli military has not issued an immediate comment.This raid occurs just two days after Israel approved 34 new settlements in the occupied West Bank, a move denounced by the Palestinian Presidency, the Organisation of Islamic Cooperation and the European Union as a breach of international law.Since assuming office in 2022, Prime Minister Benjamin Netanyahu's right‑wing government has sanctioned at least 102 settlements, a marked increase compared with previous administrations. All Israeli settlements in the occupied West Bank are considered illegal under international law.Violence in the West Bank has escalated sharply since Israel's war in Gaza began in October 2023, and a further spike in deadly settler attacks has been reported since the United States‑Israel conflict with Iran started at the end of February, according to Palestinian authorities and the United Nations.While settler assaults have persisted for years, the recent surge has drawn criticism from influential rabbis, settler leaders, and Israel’s military chief Eyal Zamir, who labeled the attacks "morally and ethically unacceptable."