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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

At 19,000 miles above the lunar surface, the Artemis II astronauts heard the voice of Apollo‑13 commander Jim Lovell greeting them from beyond the grave, a message recorded shortly before his death at 97. Mission control transmitted the tribute on the morning of 6 April, when astronaut Reid Wiseman held a silk square bearing the original Apollo 8 patch—handed to him by Lovell’s son—before the crew’s launch. Launch director Charlie Blackwell‑Thompson secured a unanimous "go" from every console, a moment the author describes as a snapshot of humanity’s capacity to honor the past while reaching for the future. The ceremony stood in stark contrast to the Pentagon’s agenda. Two decades after a 2006 Iraqi kill‑board note reading “Let the bodies hit the floor,” the current defense chief pledged “death and destruction from the sky all day long” against Iran, a stance legal scholars warn could constitute a war crime. That rhetoric accompanies a proposed $1.5 trillion defense budget, including an additional $200 billion earmarked for operations against Iran—figures that dwarf NASA’s entire annual budget of $24.4 billion. Amid this fiscal disparity, crew members reflected on their place in history. Victor Glover, the first Black astronaut to travel deep space, described the view of Earth as an "oasis" in the void, while Christina Koch, the first woman to orbit the Moon, pressed her face to the window and formed a heart with her hands, calling the mission’s spirit "humility." Reid Wiseman watched the planet rotate beneath him, noting the sight of Africa, Europe, and the aurora‑lit north, saying it "paused all four of us in our tracks." Canadian astronaut Jeremy Hansen broke Jim Lovell’s 56‑year distance record and asked mission control to name a lunar feature after his late wife, Carroll. The crew agreed, designating a bright spot on the Moon as "Carroll," a tribute that will endure beyond any single lifetime. When Koch announced the spacecraft’s descent, she radioed, "We are now falling to the moon rather than rising away from Earth," a poetic reversal that underscored the mission’s symbolic return. The article recalls the author’s 2022 reflection on the James Webb Space Telescope, noting how humanity’s finest inventions now aim outward, seeking answers to our origins rather than turning inward toward conflict. Artemis II’s vessel, named Integrity, carried four breathing humans who, in a moment of collective grief, pressed their faces to the glass and imagined the faces of every loved one ever lived, captured in a single frame. Beyond the spacecraft, cultural threads wove through the mission: Hansen’s patch displayed the Seven Sacred Teachings of the Anishinaabe people, and the Chinese myth of Chang’e reminded viewers of the Moon’s timeless allure. As Carl Sagan famously wrote, "We are made of star‑stuff," the Artemis crew embodied that sentiment—not as passive observers, but as active participants in a fragile, hopeful narrative that rises above the relentless tally of bodies on Earth’s battlefields.

Goldman Sachs's chief executive, David Solomon, has expressed heightened awareness of the capabilities of Anthropic's Mythos AI model and is collaborating closely with the tech firm following warnings about the cybersecurity risk it poses.The US bank has been closely monitoring the rapid advancements in artificial intelligence, including large language models (LLMs), as part of broader efforts to protect itself from hackers.“Obviously the LLMs are making rapid progress and we’re hyper-aware of the enhanced capabilities of these new models with the help of the US government and the model publishers,” Solomon told analysts on an earnings call on Monday.Anthropic, the company behind the Claude family of AI tools, claimed last week that its latest model, Mythos, posed an unprecedented risk due to its ability to expose flaws in IT systems. The company warned that AI models have reached a level of coding capability where they can surpass all but the most skilled humans at finding and exploiting software vulnerabilities.Solomon emphasized that Goldman Sachs is working closely with Anthropic and all of its security vendors to harness frontier capabilities. “We are very focused on supplementing our cyber and infrastructure resilience. And this is part of our ongoing capabilities that we have been investing in, and are accelerating our investment in.”The news comes after the US Treasury secretary, Scott Bessent, summoned Solomon and other big American bankers to Washington to discuss the Mythos model last week. The meeting focused on heads of so-called systemically important banks, where regulators believe that a major disruption to their operations, or their potential collapse, would put financial stability at risk.On Monday, the UK government’s AI Security Institute (AISI) warned that Mythos was a “step up” over previous models in terms of the cyber threat it posed. AISI said Mythos could carry out attacks that required multiple actions and discover weaknesses in IT systems without human intervention.

World champion boxer Terence Crawford was found guilty of careless driving on Monday and ordered to pay a $75 fine stemming from a traffic stop last year that led to a gunpoint incident. The incident occurred on September 28, hours after Crawford's hometown of Omaha held a parade to celebrate his unanimous-decision victory over Canelo Álvarez in a super middleweight championship fight.Crawford was stopped by police after officers observed his vehicle driving recklessly. During the stop, Crawford's head of security informed an officer that he was carrying a legal firearm, and seconds later, another officer spotted a gun on the floorboard. With guns drawn, officers ordered everyone out of the vehicle. Crawford claimed he had leaned over to tell the officer that he also had a legal firearm, but the officer didn't hear him. Police confirmed that all occupants of the vehicle were legally permitted to carry firearms.The traffic stop led to an internal investigation by the Omaha police chief into the officers' actions, which was found to have been lawful. In addition to the $75 fine, Crawford was ordered to pay $49 in court costs. This incident comes after Crawford announced his retirement in December with a 42-0 record and 31 knockouts, making him the first male boxer to capture three unified division titles.

The ongoing global finance talks between the International Monetary Fund (IMF) and the World Bank Group (WBG) have taken a contentious turn. Governments are being urged not to mention climate change, despite its growing impacts and the pressing need for climate finance.The climate crisis has significant implications for developing countries, which are already paying billions to repair damage from droughts, floods, and storms. The World Bank Group aims to devote 35% of its funding to climate-related activities, but US pressure may hinder these efforts.US Treasury Secretary Scott Bessent has demanded the removal of some climate finance targets from the World Bank's aims, insisting on an 'all-of-the-above approach to energy' that includes financing for gas, oil, and coal. This move has sparked alarm among other countries, including large developed economies.Experts warn that sidelining climate change discussions would be disastrous for the developing world. Mohamed Adow, director of the Power Shift Africa thinktank, described the situation as 'beyond absurd', emphasizing that fossil fuels and the climate emergency are inextricably linked.The World Bank is the biggest single source of climate funding, and many donor countries channel their climate finance largely through the multilateral development banks. At the Cop29 UN climate summit in Azerbaijan in 2024, countries agreed that at least $1.3tn a year should flow to the developing world by 2035 to help countries cut greenhouse gas emissions and cope with the impacts of extreme weather.Lord Stern, a former World Bank chief economist, suggested that much could still be achieved without formally labelling projects as climate-related, emphasizing that investing in low-carbon infrastructure and energy systems is crucial for sustainable development.

Rising energy costs stemming from the Iran war are set to deliver a sharp blow to British living standards, with the Resolution Foundation estimating that the average working‑age household could lose about £480 in income this year. Before the conflict began, the think‑tank projected a modest 0.9% rise in household earnings. Market‑driven energy price spikes have now pushed that forecast into a -0.6% decline, effectively turning a gain into a loss. Oil and gas markets have reacted dramatically: Brent crude has surged back above $100 per barrel (£74), while analysts such as JPMorgan Chase expect prices to stay elevated through the current quarter, with Goldman Sachs revising its Brent outlook to an average of $90 per barrel in Q2. For the poorest fifth of households, the outlook is equally grim. Expected income growth has been trimmed from 2.8% to 1.2%, despite a long‑overdue real‑terms increase in benefits for some low‑income families. Families with three or more children stand out as a relative bright spot. The abolition of the two‑child limit is projected to generate a 7.7% income boost for this group, contrasting with zero growth for poorer families with fewer children. Energy bills are also poised to climb this summer, erasing the £117 average savings households enjoyed after the regulator lowered the energy price cap in April, according to Jonathan Marshall, the foundation’s principal economist. In response, the Resolution Foundation is urging the UK government to fast‑track a social tariff before winter, aiming to shield the most vulnerable households from the worst of the price shock. James Smith, chief economist at the foundation, warned that “while hopes for sustained peace persist, the path of this conflict remains uncertain and energy prices stay well above pre‑war levels, meaning many households face a decline in purchasing power this year.” He added that “de‑escalation is welcome, but the damage to household finances is already largely done; the government should act now to prepare a social tariff that reaches households falling through the cracks this winter.”

Rolls-Royce has secured a significant investment of up to £599m from the UK's national wealth fund to develop the country's first small modular nuclear reactors (SMRs). The funding will support Rolls-Royce's design of SMRs at Wylfa on the island of Anglesey, Wales. The investment is expected to create around 1,000 jobs at Rolls-Royce and contribute to the UK's goal of generating electricity without carbon dioxide emissions. The project also offers the potential for a large new export industry in SMRs. The UK government has embraced nuclear energy as a key component of its clean energy strategy, and this investment marks a significant milestone in the development of SMR technology. SMRs aim to produce nuclear power stations in factories, driving down costs and speeding up installation. The Wylfa site has a history of nuclear power generation, having operated from 1971 until 2015. Hitachi had previously attempted to build a new nuclear power station at the site but abandoned its plans in 2020 due to funding issues. The site was later acquired by the state-owned Great British Energy – Nuclear (GBE-N) in 2024. The chancellor, Rachel Reeves, highlighted the importance of the investment, stating that it will strengthen energy security, create skilled jobs, and help build a new generation of homegrown nuclear technology that will power the UK's economy for decades to come. Tufan Erginbilgiç, chief executive of Rolls-Royce, described the investment as a critical milestone for the business and for the UK, marking the beginning of a golden age of new nuclear. The company owns the majority of Rolls-Royce SMR, alongside Qatar's sovereign wealth fund, France's BNF Resources, and the Czech utility CEZ.

A devastating air strike by the Nigerian military on a village market in northeastern Nigeria has killed dozens and injured hundreds, sparking widespread outrage and condemnation. The strike, which occurred on Sunday, was aimed at members of the rebel group Boko Haram.According to Amnesty International, over 100 people were killed and 35 others wounded in the attack on the Jilli village market in Yobe state. A local chief, Lawan Zanna Nur Geidam, reported that the total casualties, including dead and injured, were around 200.The Nigerian Air Force claimed to have killed Boko Haram fighters in an air strike on the Jilli axis in Borno state, but did not mention hitting a market. The government of Yobe state later confirmed that an air strike near a market had been conducted, affecting people attending the weekly market.Amnesty International condemned the strike, stating that launching air raids is not a legitimate law enforcement method and that the Nigerian military's actions demonstrate a shocking disregard for human life. The organization called on Nigerian authorities to immediately investigate the incident and hold suspected perpetrators accountable.The Yobe State Emergency Management Agency (SEMA) activated the emergency response, and many of the injured were taken to hospitals in nearby Geidam and Maiduguri. A worker at the Geidam General Hospital reported that at least 23 people injured in the incident were receiving treatment.

Tehran – Iranian officials warned that the United States must increase pressure for any peace agreement while urging their supporters to keep the streets under control.Parliament speaker Mohammad Bagher Ghalibaf said the US delegation in Islamabad “failed to gain the trust of the Iranian delegation” during the marathon talks.US President Donald Trump announced an immediate naval blockade of the Strait of Hormuz and declared that US forces are “locked and loaded” to finish Iran at the “appropriate moment.”Iran hailed the delegation’s refusal to accept Washington’s core demands – ending nuclear enrichment and relinquishing control of the Strait – as a sign of defiant resolve.Judiciary chief Gholam‑Hossein Mohseni‑Ejei thanked the Islamabad team for “guarding the rights” of government supporters, including paramilitary forces that have been gathering in Tehran’s main squares for more than six weeks.State television aired an IRGC aerospace officer urging flag‑waving crowds not to worry, stating, “If the enemy does not understand, we will make them understand,” which was met with cheers demanding more missile and drone attacks.Iranian officials blamed Trump’s “excessive demands” for the talks’ failure, noting the Ministry of Foreign Affairs did not expect an agreement after a single day of negotiations.Hard‑line parliamentarians expressed satisfaction with the stalemate, viewing Iran as holding the upper hand. Deputy speaker Hamidreza Haji‑Babaei said only a UN Security Council resolution signalling US surrender would lift sanctions on Iran.Lawmaker Amir Hossein Sabeti of the Paydari faction thanked the negotiating team for standing by red lines and called for “resistance in the field against these evildoers.”The sudden announcement of a two‑week cease‑fire left pro‑state voices disappointed; local media reported the Iranian delegation numbered over 85 members, including state‑affiliated journalists and factional analysts.The talks confirmed that a diplomatic breakthrough was not imminent and hinted at further escalation, though not necessarily a return to full‑scale fighting.National security commission head Ebrahim Azizi dismissed Trump’s blockade threats as “excessive talk.”The IRGC warned it would meet any vessel passing the Strait of Hormuz with “full force” and rejected US claims that two warships had already transited the waterway.Russian President Vladimir Putin told Iranian President Masoud Pezeshkian he remains ready to facilitate a Middle‑East peace settlement.Pezeshkian, focused on domestic affairs, reaffirmed support for Supreme Leader Ayatollah Ali Khamenei and announced that schools and universities will continue online via a limited intranet.Iran’s economy continues to suffer from chronic inflation, rising unemployment and a near‑total internet shutdown, deepening public hardship.