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The Lead A new study reveals that apitegromab, a drug promoting muscle growth, could significantly reduce the loss of lean body mass when using popular weight-loss medications like tirzepatide (found in Mounjaro). This breakthrough addresses a significant concern with current weight-loss treatments that cause patients to lose muscle along with fat. The Scientific Breakthrough GLP-1 based weight-loss jabs such as Wegovy and Mounjaro have proven highly effective for people who are overweight or obese, but studies show 25-40% of total weight loss comes from reduction in lean body mass – non-fat components including muscle. This matters because lean body mass is important for physical strength, burns more calories than fat tissue, and is linked to a lower risk of type 2 diabetes. Apitegromab works by blocking myostatin, a protein involved in inhibiting muscle growth. In a small trial, researchers in the US randomly divided 102 participants into two groups: 51 received apitegromab alongside tirzepatide, while the other 51 received a placebo with tirzepatide. The Clinical Trial Results After 24 weeks, the trial revealed that total weight loss was similar between the two groups. However, participants given apitegromab alongside tirzepatide lost on average 1.6kg (3.5lb) of lean mass (14.6% of total weight loss), while those given tirzepatide with a placebo lost an average of 3.5kg of lean mass. This means apitegromab was associated with a 55% greater retention of lean mass relative to placebo. The study had limitations, including that most participants were women and the trial was small and short in duration. However, the number of people experiencing side-effects was similar between the two groups, with most deemed to be mild. The Implications for Weight Loss Treatment Prof Alexander Miras, an obesity expert at Ulster University not involved in the work, described the findings as very important. While GLP-1s have been associated with improved "functionality" – making everyday activities easier – they've also been linked to loss in muscle mass and strength. This new medication may help reduce these effects and improve functionality even further. Prof Naveed Sattar, a cardiometabolic medicine expert at the University of Glasgow, emphasized that larger-scale and longer trials are needed to confirm safety and actual health benefits. In the meantime, he recommended that people prescribed weight-loss drugs should be supported to increase physical activity, which can help maintain muscle mass in a physiological way. The Future of Weight Loss Therapies The findings suggest a promising direction for weight-loss treatments that preserve muscle mass while reducing fat. As the popularity of GLP-1 based medications continues to grow, addressing muscle loss could become an important focus for pharmaceutical companies and healthcare providers. Future research will need to confirm the long-term safety and effectiveness of combining apitegromab with weight-loss medications. If successful, such combinations could become standard practice, potentially improving patient outcomes and quality of life during weight loss journeys.

The Voice of the Moment Marco da Silva Ferreira, a Portuguese choreographer, has emerged as a voice of the moment in the dance world. His work, 'F*cking Future', is a testament to his unique approach, blending protest and partying, activism and choreographic collectivism. The Event Details Last year, Ferreira was a finalist for the Rose international dance prize, competing for £40,000. Although he didn't win, his work left a lasting impression. 'F*cking Future' is a dance piece that features eight dancers in unison, performing a series of small, repeated movements that gradually shift and morph. The Performance The dancers, dressed in shiny trousers and chainmail vests with red makeup smeared under their eyes, create a mesmerizing spectacle. The piece builds slowly, with the dancers chanting a song of resistance: 'We are the ghosts you tried to kill!' The performance is a feat of intense concentration and aerobic fitness, leaving the dancers in a state of ecstatic exhaustion. The Impact Analysis Ferreira's dance is a departure from the typical 'show-us-everything-you-can-do' style of dance. Instead, it's an exercise in anti-instant gratification, slowly building energy and momentum. The piece raises questions about the politics of resistance and the role of the choreographer in shaping the energy in the room. The Prediction 'F*cking Future' is set to run at Sadler's Wells East, London, until June 6th. As Ferreira's star continues to rise, it's likely that his unique voice will be heard for years to come, inspiring a new generation of dancers and choreographers to experiment with protest and partying as a form of artistic expression.

The Digital Dilemma I recently learned through Apple's Screen Time app that I was spending about eight hours a week on my phone browsing Reddit and Instagram. That's 17.3 days a year spent consuming entertaining but ultimately pointless fluff. The warning signs are if your phone is the first thing you look at in the morning and the last thing you look at in bed, says Prof Marcantonio Spada, emeritus professor of addictive behaviours and mental health at London South Bank University. The Psychology of Phone Addiction Too many of us have "outsourced our brain to California," Spada says, but that's not completely our fault: "There are behavioural scientists and neuroscientists who are working daily to ensure that it's outsourced. I know some of them really well." Phones also suck our time. "We all complain: 'I don't have time to exercise, cook healthy food or read novels,'" says Hilda Burke, psychotherapist and author of The Phone Addiction Workbook. "But then we look at how much time we spend on YouTube, TikTok, Instagram – we find there is time to do those things." The Turning Point Changing habits can be daunting, she says, but, like Spada, she insists that the rewards are worth any early discomfort. "Initially there's that twitchiness, but I guess what happened [for me] was a kind of a positive reinforcement where I was like: 'Actually, this is quite nice.'" The point of using any of the techniques outlined in the piece is to see what we're missing, he says, not just to act on a puritanical urge to purge technology from our lives for the sake of it. "I'm generation X, so I had the benefit of access to the real world, real emotions, the heart racing in anticipation of meeting somebody, which has been numbed by virtual existence," he says. "Stay there [in the real world] long enough, and you can get massive rewards." The Solution That Worked The trick that worked best for me was Brick, a small, grey, magnetic square you stick to a metal surface – in my case, the front door, because it's reinforced with metal. It'll set you back £54, which is undoubtedly a big ask for something so simple, but if time is indeed money, you can make a case that it will quickly justify the outlay. Touch your phone to it, and apps that rely on you opening them without thinking can't be tapped. To regain access, you have to physically get up and unlock your problem apps with another touch – which is just enough of a pain to make you reassess your priorities. Implementing Change You can choose what to lock down, and I've been quite conservative. WhatsApp is a social lifeline for those of us who work from home, for example, and Gmail is essential for work. Podcasts expand the mind, and even Netflix is something I only use in the gym, so it's a wellbeing positive overall. But Reddit, Instagram, Bluesky and Facebook? I have them locked all day except when I leave the house (what else am I going to do on the tube?). I'm especially vigilant at bedtime, so there's no temptation to doomscroll in bed or delay getting up in the morning. The Results The friction that Brick adds has made all the difference, and I'm already feeling the benefit. I feel more focused, and my brain feels calmer. I still check in on social sites on my desktop work PC, but these are easily closeable tabs rather than full-screen, infinitely scrolling apps. It's genuinely a quick break – after all, who wants to sit at their desk any longer than they have to? By my earlier back-of-an-envelope sums, I've already lost about three days of 2026 to mindless scrolling. But I'm excited about what I'm going to do with the recovered 15.

The Rise of Meth Production in South Africa In the quiet mining town of Swartruggens, a small courthouse is preparing to decide whether five Mexicans accused of a major illegal drug operation will be granted bail or remain in custody. Their arrests followed a raid on a remote farm in North West province, where police said they uncovered a large methamphetamine laboratory worth about one billion rand ($60m). The Scope of the Problem The case is one of several pointing to a pattern taking shape in South Africa’s rural interior. The Swartruggens laboratory was not an isolated discovery. It was one of four major meth sites linked to Mexican criminals uncovered in South Africa in just two years. In 2024, police dismantled a large meth facility worth about $105–110 million on a farm near Groblersdal in Limpopo. Later that year, another laboratory worth roughly $5–6 million was discovered near Tshwane. Arrests were made last year in Mpumalanga. The New Cartel Footprint Mexicans are increasingly being found working alongside local collaborators in rural production sites, suggesting a shift from trafficking meth into Africa to producing it there. Organised crime researcher Julian Rademeyer told Al Jazeera the model reflects a deliberate strategy. “It’s quite a unique development where you have members of Mexican drug cartels franchising, moving chemists into remote rural areas and farms,” he said. How it Spread Mexican-linked networks in Africa did not begin in South Africa. Researchers trace early activity back to Nigeria, where local groups were producing meth with Mexican involvement by around 2016. From there, the networks spread through East Africa, then south through Mozambique and Botswana, before reaching South Africa more recently. Who Looks the Other Way Methamphetamine dominates parts of South Africa’s illicit drug market because cheaper drugs such as cocaine and heroin remain out of reach for many users, creating steady demand for a cheaper, highly addictive stimulant. Crime expert Willem Els says demand is only part of the story. “The main reason why manufacturing locally is lucrative to cartels is the local conditions that exist, where there is protection from corrupt police and politicians,” he told Al Jazeera. A Frontier that Keeps Moving US Africa Command officials have warned that Mexican cartels are now not only moving drugs through Africa, but also producing them on the continent. For South Africa, the challenge is no longer just border control, it is institutional capacity, intelligence and corruption within the system meant to contain it. Without deeper reform, analysts warn, the pattern is likely to continue: new farms, new labs, new chemists arriving quietly in rural provinces.

The American Dream Mauricio Pochettino's journey to becoming the head coach of the USMNT began in small-town Murphy, Santa Fe, Argentina. Growing up, he was inspired by the 1978 World Cup and Argentine football legends like Ossie Ardiles and Daniel Passarella. Pochettino's Vision for US Soccer Pochettino sees the 2026 World Cup as an opportunity for the US to make a statement in the soccer world. He believes that being hosts can create synergy with the people and give the team the freedom to succeed. Despite being seen as underdogs, Pochettino is optimistic about the team's chances. The Challenges Ahead Pochettino acknowledges that changing the cultural perception of soccer in the US will take time. He emphasizes the importance of patience and building an emotional relationship with the sport, rather than just investing in it. The Impact of Messi and MLS Pochettino notes that the growth of MLS and the impact of Lionel Messi have brought belief and excitement to the US soccer scene. He believes that the country's vast resources and passionate fans can help drive the team's success. The Road to Success Pochettino's approach to coaching the USMNT focuses on collaboration, cultural understanding, and building a team that represents the country's diverse population. He is determined to make a lasting impact on US soccer and prove that the team can be a contender in the 2026 World Cup.

The Clash Over Knicks Finals CelebrationsJames Dolan’s MSG Sports has launched a fierce rebuttal against Mayor Zohran Mamdani and Police Commissioner Jessica Tisch, characterizing their security strategy for Game 4 as an attempt to suppress public celebration. The statement, titled “Mayor Mamdani and Police Commissioner Tisch are New York City’s Biggest Party Poopers,” argues that the restrictions are unnecessary and detrimental to the city's spirit.Security Measures and Permit DisputesThe conflict centers on the implementation of a large restricted zone around Madison Square Garden for Game 4. MSG Sports claims that while similar restrictions earlier in the week were attributed to Donald Trump’s presence, the decision to maintain the perimeter for game four is evidence that the president’s appearance was “a convenient excuse to restrict how and when Knicks fans celebrate.”Permit Request: MSG Sports proposed a crowd limit of between 500 and 1,000 attendees for the watch party.Approval: City officials approved attendance up to the maximum of 1,000 people.Access Control: Entry is limited to ticket holders, train riders, residents, or specific business visitors, with screening at 6th Avenue and 33rd Street.Post-Game Chaos and Public SafetyThe heightened security measures are a direct response to the disorder that erupted during Monday’s Game 3 watch party at Bryant Park. The NYPD has cited the need to prevent a repeat of the violent incidents that occurred as fans moved from the park onto the streets.Arrests: 21 individuals were arrested following the Game 3 gathering.Injuries: 5 police officers were reportedly injured during the unrest.Incidents: Footage showed fans wearing Spurs apparel being chased and attacked, with one video showing a Victor Wembanyama jersey being ripped off and destroyed.Business Interests vs. GovernanceThe dispute highlights a growing tension between city governance and business interests. MSG Sports argues that shutting down the surrounding area hurts the atmosphere of the celebration and negatively impacts nearby small businesses that rely on game-day foot traffic. The company contends that the joy of the fans is palpable and that the administration is prioritizing control over community engagement.Future Outlook for NYC Watch PartiesAs the Knicks push for a victory, the city faces a difficult balancing act between public safety and the right to assemble. Mayor Mamdani has called for responsible celebration, but the strict enforcement of the restricted zone for Game 4 suggests that the NYPD and the Mayor’s office are prepared to take a hardline stance to maintain order, potentially setting a precedent for future high-profile sporting events in New York City.

The Unexpected Leftward Walking Bias UncoveredScientists observed that, when asked to start walking in an empty or everyday space, most people drift counter‑clockwise. The phenomenon was first noticed during pandemic‑era crowd‑density experiments and has since been confirmed in controlled laboratory settings.Laboratory and Real‑World Experiments Reveal Counter‑Clockwise TendencyDr Iñaki Echeverría Huarte at the University of Navarra led a series of tests where individual pedestrians and small groups moved around enclosed areas. The same left‑turn bias emerged when the team collaborated with Dr Claudio Feliciani at the University of Tokyo, replicating the effect in Japan.Observed in museums, supermarkets, and empty rooms.Consistent across right‑handed, right‑footed, and right‑eye‑dominant participants.More pronounced in children than adults.Quantifying the Bias Across Age and CultureWhile the study did not publish exact percentages, the researchers noted that the bias appeared in the majority of trials across both Spanish and Japanese cohorts. The effect persisted regardless of gender and remained after accounting for dominant side preferences.Implications for Crowd Management, Architecture, and SportsThe discovery suggests that current crowd‑evacuation simulations may underestimate natural rotation patterns, potentially affecting the design of public spaces such as museums, supermarkets, train stations, and stadiums. In athletics, the historic shift to anticlockwise running tracks may reflect the same underlying human asymmetry.Future Research Directions and Potential ApplicationsFurther work will explore virtual‑reality scenarios, simulated injuries (e.g., pretending a leg is broken), and possible biomechanical or neurological origins. Understanding the bias could improve safety protocols, inform architectural layout, and inspire new studies on lateral preferences in other species, such as the left‑turn bias observed in rock ants.

The US Remake of Doc Martin: A Fresh Take on Smalltown Life The US remake of Doc Martin, titled Best Medicine, has arrived on Sky One and Now, bringing with it a quirky charm that is reminiscent of its British counterpart. The show, created by Dominic Minghella and starring Josh Charles as Dr. Martin Best, has been tweaked for a new market, relabelled Best Medicine, and transplanted to Maine. Character Backstories and Smalltown Charm Charles shines as the tetchy doctor with a heart of gold, a departure from his usual smooth sophistication seen in The Good Wife and Unbreakable Kimmy Schmidt. The character's name is Dr. Martin Best instead of Ellingham, and he attended Harvard medical school instead of Imperial College London. The show maintains the original's cast of eccentric characters, including a saintly local schoolteacher Louisa (Abigail Spencer) and a pharmacist-in-a-neck-brace Sally Tishall, now Mark's mother, Sally Mylow (Clea Lewis). Comparing Best Medicine to Doc Martin Best Medicine is softer than Doc Martin, with a backstory that explains away Dr. Best's abrasiveness. The show features more hugging and learning, making it a celebration of smalltown values and the secret goodness hidden behind even the prickliest of men. The series promises to soothe viewers' souls with its wholesome content, making it 'perfect rubbish' that viewers need. The Future of Best Medicine As the show progresses, it will be interesting to see how Dr. Best navigates his new life in Maine, including his relationship with Louisa and his interactions with the town's eccentric residents. With its lighthearted tone and quirky charm, Best Medicine is sure to delight audiences looking for a feel-good television experience.

The Rise of Alternative Venture Capital Last year, Justin Ernest noticed a significant gap in the venture capital landscape: family offices and smaller institutional investors were eager to invest in fast-growing AI companies but lacked access to their cap tables. With over five years of experience at Playground Global, Ernest was well-positioned to bridge this gap. Securing Allocations Without a Traditional Fund Instead of launching a formal VC fund—a process that can take 12 to 18 months—Ernest leveraged his network to secure stock allocations in high-profile, later-stage companies. He then offered these individual deals to about 30 smaller institutional investors using SPVs, single-asset funds, and nominee structures. The Data Behind Sabertooth Capital Nearly $500 million invested in 10 companies over the last 12 months. Companies include Anthropic, Base Power, Databricks, PsiQuantum, and SpaceX. Check sizes range from $10 million to $275 million. Why This Model Matters Sabertooth Capital's approach provides smaller investors with access to high-profile startups while offering these companies a vetted and respected investor. This model has earned Ernest a solid reputation, particularly in an industry where legitimacy is crucial. The Future Outlook While Sabertooth Capital currently focuses on raising funds for specific companies, Ernest's ultimate goal is to raise a traditional venture fund. With significant returns already realized, such as the $20 billion acquisition of Groq by Nvidia, and anticipated IPOs like SpaceX and Anthropic, Ernest is well on his way to achieving this goal.