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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

The LeadSéamas O'Reilly's debut novel "Prestige Drama" presents a brilliant wry comedy set in Derry, where a Hollywood actor disappears while filming a TV series about the Troubles. The novel transcends its intriguing premise to explore how places become defined by historical moments, and how stories about such places often fall into predictable formulas.Multiple Perspectives on Historical TraumaO'Reilly uses the TV series "Dead City" as a starting point to weave through different characters connected to the production. From a stressed scriptwriter to a local historian questioning how to talk about the past while still living it, the novel creates a patchwork portrait of the city. This approach echoes Tommy Orange's "There, There," which used multiple voices to explore Native American lives. Each character speaks directly to the reader, revealing their complex relationship with Derry's history and the Hollywood production that has descended upon the city.Commodification of MemoryThe novel masterfully examines how historical trauma becomes marketable. O'Reilly has a keen eye for absurdities: the artist who once painted Bogside murals now doing lecture tours with a "wee moustache and crucifix earring like a plastic Provo"; the ex-IRA hitman offering services as a "consultant." Those once bound by silence now demonstrate how to make a bottle bomb for the cameras. The locals, facing economic necessity, take work that perpetuates clichés—local painters recreate old murals for film sets, while aspiring actors see the production as their only chance to escape.The Haunting of HistoryThis recreation and commodification of the past creates a kind of haunting. The novel is permeated by different ways in which the dead remain inescapable. Ann-Marie, whose son was shot by a British soldier and whose image now appears on book covers and "bloody tea-towels," delivers one of the novel's most powerful voices: "My heart is small and hard, wind-bleached like seaside beach seats." Her reflection on those who came home safely after her son was killed—"It wasn't their fault and I'll never forgive them"—captures the unfixable contradictions of grief.A New Voice in Irish LiteratureBuilding on his previous memoir "Did Ye Hear Mammy Died?"—described as "heartbreakingly funny"—O'Reilly demonstrates a rare gift for moving between opposing tones. The humor in "Prestige Drama" is skillfully weaponized, allowing him to address subjects we often tiptoe around. His language is gloriously vivid, as when a hungover man wakes up "slowly, like a column of dog food muscling its way out of a tin." While some readers may wish the missing actor thread had more prominence, the novel's true focus is on the ordinary people behind the televised version of events, offering a polyphonic exploration of how history continues to shape the present.

The Graduation Contrast: Celebration vs. RealityFor decades, the ritual of graduation in New York City’s Washington Square Park symbolized a seamless transition from academia to the workforce. However, for the class of 2026, that transition has become a precarious journey. While the visual spectacle of caps and gowns remains, the underlying economic reality has shifted dramatically. The joy of the ceremony is increasingly dampened by a 'no-hire, no-fire' environment where the churn of the labor market has stalled, leaving millions of new graduates competing for a shrinking pool of entry-level opportunities.The 'No-Hire, No-Fire' Labor StagnationThe current economic climate is defined by a paradox: there are still millions of open jobs, but the barrier to entry for new graduates has never been higher. According to the United States Bureau of Labor Statistics, while there are 6.9 million open jobs in March, hirings only increased marginally by 655,000 to 5.6 million. This stagnation suggests that the labor market is effectively frozen for new entrants.Job Growth Slowdown: The US economy added an average of 68,000 jobs per month in 2026, a sharp decline from 186,000 in 2024 and 251,000 in 2023.Sectoral Shifts: While healthcare and retail saw growth, white-collar sectors like financial activities and information services shed jobs.The Churn Rate: The quits rate is down, indicating that workers are staying in their positions rather than switching, which leaves little room for new graduates to move up.The Federal Workforce ShrinkageA critical factor exacerbating the shortage of entry-level roles is the drastic contraction of the federal government workforce. Since October 2024, the federal workforce has declined by 348,000, with an additional 9,000 jobs lost in April alone. This exodus is largely driven by government funding cuts, including a $4bn reduction in research funds from the National Institutes of Health (NIH).These cuts have forced major universities, including Duke University and Harvard University, to implement hiring freezes. Consequently, recent graduates like Julie Patel and Molly Howard are not only competing with their peers but also with experienced professionals displaced by these funding cuts, creating a 'last-in, first-out' dynamic in the public health and research sectors.AI as the New GatekeeperPerhaps the most disruptive force reshaping the entry-level landscape is artificial intelligence. The analysis from the Stanford Digital Economy Lab reveals a 16 percent decline in relative employment for early-career workers, particularly in software engineering and customer service. This trend is expected to intensify, with Goldman Sachs forecasting an average of 16,000 jobs cut monthly due to AI advancements.The impact is twofold: entry-level roles are being eliminated and replaced by automation, while demand for experienced workers remains stable. Furthermore, the hiring process itself has become a minefield. Applicants are now facing AI recruiters and an influx of 'fake applicants,' leading to response rates as low as 10 to 12 percent for recent graduates applying to 60 roles.Navigating the Post-Pandemic CycleDespite the grim outlook, experts argue that this is not uncharted territory. The unemployment rate for recent college graduates is currently at 5.6 percent, higher than the general population's 4.2 percent, but historically manageable compared to the 13.4 percent peak during the COVID-19 pandemic. However, underemployment remains a persistent issue at 41 percent.The consensus among university leaders is that while the structural challenges of AI and political uncertainty are new, the resilience of graduates is not. As Christopher Davis of LeMoyne-Owen College notes, the degree may secure an interview, but it is the 'soft skills'—particularly in-person networking—that will ultimately determine success in this hyper-competitive market.

The Lead: Arsenal's Mixed Season of Triumph and HeartbreakArsenal's 2025-2026 season encapsulated both remarkable achievement and painful disappointment. While the club secured its first Premier League title since 2004 under Mikel Arteta's leadership, they also endured the agony of losing two finals, most recently the Champions League final against PSG on penalties. This duality defined a season that stretched players to their physical and mental limits.The Season Marathon: Physical and Mental Toll on PlayersDeclan Rice emphasized the extraordinary demands of the season, noting that Arsenal's journey began in July with a pre-season match in Singapore and concluded with their 63rd game across all competitions. The midfielder highlighted the particularly grueling stretch from October onward, when the team faced three matches per week. Rice himself played in 55 of Arsenal's matches while battling through a persistent injury that left him operating at '70%' fitness for 'quite a while,' according to Thomas Tuchel.The Final Performance: Tactical Execution and Individual FlawsIn the Champions League final, Arsenal demonstrated their tactical discipline under Arteta's guidance. After Kai Havertz's early goal, the team effectively neutralized PSG's formidable attack until Cristhian Mosquera conceded a penalty that led to Ousmane Dembélé's equalizer. However, the match exposed several persistent issues: Arsenal's pass completion rate was a concerning 69% compared to PSG's 91%, and they made only 196 successful passes to PSG's 806. Individual attacking statistics were equally troubling, with Bukayo Saka completing just four passes and Martin Ødegaard touching the ball only 12 times.The Penalty Shootout: Misses and Mental FortitudeThe final's conclusion on penalties highlighted both Arsenal's resilience and their remaining vulnerabilities. Gabriel Magalhães missed the decisive fifth penalty, continuing a pattern that saw him miss in a pre-season shootout against Villarreal. Eberechi Eze's penalty technique, which had previously failed him in Crystal Palace's Community Shield victory, resurfaced with identical results against Arsenal. Despite these setbacks, Declan Rice's successful conversion in round three symbolized the team's character and determination throughout the match.Arteta's Evolution: From 'Mikelito' to Respected ManagerThe final showcased Mikel Arteta's growth as a manager, particularly in how his players executed the gameplan against PSG. Luis Enrique's affectionate yet potentially patronizing use of Arteta's old nickname 'Mikelito'—a reference to his time as a young hopeful at Barcelona—underscored the respect Arteta has earned. The Arsenal manager's ability to nullify Europe's most feared attack demonstrated his tactical acumen, even as the team's lack of precision in final passes revealed areas for continued development.The Road Ahead: Building on ProgressArsenal's season, while ending in Champions League final heartbreak, represents significant progress under Arteta. The combination of Premier League triumph and European final appearance establishes a foundation for future success. The physical and mental resilience demonstrated throughout the season, particularly in the face of such a demanding fixture schedule, suggests that the team is building the necessary characteristics to compete at the highest level consistently. As Rice noted, the experience gained from this grueling campaign will fuel their ambitions in seasons to come.

The Architecture of an African GiantIn less than two decades, Morocco has redefined African football, evolving from a team frequently eliminated in group stages to a global powerhouse ranked in the top 10 of the FIFA men’s rankings. This meteoric rise is not accidental but the result of a long-term national project initiated by King Mohammed VI in 2008.The success is built on three distinct pillars: good governance, financial investment, and competent human resources. The first step involved creating a national department for financial control to professionalise the federation's structure. This was followed by a massive infrastructure overhaul, including the construction of thousands of 'proximity fields' for mass participation and the Mohammed VI Complex in Maamoura, a technical center often compared to France's elite Clairefontaine academy.A Trophy Cabinet OverflowingThe impact of this strategy is evident in the sheer volume of recent accolades. The Atlas Lions have dominated across every age group, securing titles that span senior, youth, and women's football:2025 AFCON Champions (after Senegal were stripped of the title)2025 WAFCON Finalists2025 FIFA Arab Cup Champions2025 African Nations Championship (CHAN) Champions2025 U-20 FIFA World Cup Champions2025 U-17 AFCON Champions2024 Olympic Men’s Bronze Medallist2024 Futsal AFCON ChampionsThe Diaspora Strategy and Infrastructure BoomA critical factor in Morocco's ascent is the reform of national eligibility rules, which opened the door to players from the European diaspora. This strategy has attracted stars like Hakim Ziyech, Nordin Amrabat, and Brahim Diaz.The latest addition to this lineage is Ayyoub Bouaddi, an 18-year-old Lille midfielder. Despite interest from Zinedine Zidane and the French national team, Bouaddi chose to represent Morocco, highlighting the magnetic pull of the national project. The Mohammed VI Complex has already produced top talent, including Nayef Aguerd, Azzedine Ounahi, and Youssef En-Nesyri.Navigating the 2026 World Cup and the 2030 DreamWith high expectations for the 2026 World Cup in the USA, Canada, and Mexico, Morocco faces a transitional period following the resignation of coach Walid Regragui after the controversial 2025 AFCON final. The federation has appointed Mohamed Ouahbi, who led the youth team to the U-20 World Cup title.While Ouahbi’s more adventurous style differs from Regragui’s pragmatic resilience, the foundation is solid. The world views Morocco as a credible contender, but the team understands that the 2026 tournament is merely a milestone. With Morocco set to co-host the 2030 World Cup alongside Spain and Portugal, the current success is viewed as the acceleration of a broader national development agenda.

The Lead: Liverpool at a CrossroadsAs Liverpool prepares for life after Arne Slot, the club faces significant challenges that will define their immediate future. The Dutchman's tenure ended without the dominance expected, leaving a squad in need of strategic overhaul both on and off the pitch. The new manager inherits a team that must rediscover its identity while addressing key personnel departures and tactical shortcomings.Style Evolution: From Heavy Metal to Soft RockPerhaps Mohamed Salah's style of communication wasn't the slickest, but he was correct that Liverpool need to redefine the style of football they play. Everything on the pitch last season under Arne Slot felt very placid as Liverpool failed to dominate opponents and were often found overrun. The new head coach will want to demonstrate his plans and implement an attacking style to best use what is available to him. Anfield does not want to witness back-foot football, fans want to see a swagger to those in red. Supporters and Slot suffered from a disconnect in the final months. The Dutchman was hindered by not possessing the vivacious personality of Jürgen Klopp nor the results in the end, and the aforementioned tedious style. The successor will want to put fans at the forefront and build a strong bond between stands and dugout, built on a platform of attractive play.Investment Analysis: Underperforming Key SigningsAfter spending heavily last summer trying to build a squad capable of dominating the Premier League for years to come, it was difficult to pick out someone who thrived. Hugo Ekitiké was the best of the new arrivals but record signings Florian Wirtz and Alexander Isak barely made the season's footnotes. Isak could at least attribute his struggles to fitness and injury problems, including a leg fracture, but the German's first taste of English football was a sour one. He never looked comfortable as a No 10, physically finding it tough going as speed on the ball and strength in battle were lacking. Getting the best out of a clearly talented player must be a priority, because Wirtz has the capabilities to open defences and help Liverpool control games but needs a confidence boost and an arm around the shoulder.Structural Impact: Midfield Deficiencies and Leadership VacuumWirtz is part of a wider midfield issue that lacks physicality and an obvious No 6. Ryan Gravenberch was elected as the man for the role by Slot, which worked well when the possession stats were in Liverpool's favour but finding someone who can break things up effectively is advisable. Every other team have someone who can break up play but Liverpool lack someone in that role. Not since Georginio Wijnaldum or Fabinho have the club possessed someone capable of overwhelming opponents with their physical attributes and in an evolving sport, this oversight must end. Dominik Szoboszlai being moved around the pitch was unhelpful because he can be one of the best central midfielders in the world but needs a defined position to make his own.The players departing Anfield are weighed down with individual and team trinkets, thanks to the success they have enjoyed with Liverpool. Arguably, the influence of Salah and Andy Robertson on the pitch waned in their final season with the club but their experience and winning mentality will be a huge loss to the dressing room and training ground. Ibrahima Konaté is another exiting, providing a recruitment headache the club were not fully anticipating. It does beg the question if it is the right time to allow Alisson Becker, who has suffered from injury problems in recent times, to be sold and allow a new generation to start afresh, with Virgil van Dijk leading the transition. There are plenty of potential internal candidates who can take on greater responsibility but it may require a change in transfer strategy to acquire players in their late-20s with Champions League experience to help give the right balance.Defensive Rebuild: Addressing Key DeparturesKonaté's contract expiration will be softened by Jérémy Jacquet's impending arrival but further investment is required. Van Dijk's longevity is unknown so finding a partnership for the long term will be critical; a more rugged centre-back like Nottingham Forest's Murillo could be an ideal choice to offer balance and greater aggression. Competition for Milos Kerkez will be important, but if Andoni Iraola does take the job the reunion could get the best out of the Hungarian and get him to flourish after a mixed first year on Merseyside. On the opposite side, continuity would help everyone because Slot was forced to trying numerous people in the role, many out of position. Ideally, Conor Bradley or Jeremie Frimpong can make it their own, having struggled to replace Trent Alexander-Arnold, although both have suffered with injury problems. If they can stay fit, they both possess the quality to be a solution, especially if clever coaching can embrace their attacking prowess and incorporate more defensive discipline.Future Outlook: Rebuilding the AttackSlot insisted that new wingers would change the dynamic next season but he will not be the one to benefit. Salah is off, Federico Chiesa cannot carry on as a bit-part, so will almost certainly leave too, freeing up some space on the flanks. Rio Ngumoha offered brief teenage glimpses of excitement as someone with the pace and trickery to get past full-backs. Frimpong, brought in as a right-back, was more often found on the wing because he possessed the speed Slot desired in those areas, while also offering a further indication that the transfer dealings left a lot to be desired. They did not replace the maverick tendencies of Luis Díaz and Cody Gakpo has never looked a natural winger. Targeting new wide men will be imperative. RB Leipzig's Yan Diomande, Brighton's Yankuba Minteh or Athletic Club's Neco Williams would be ideal candidates to bring thrust to a side lacking dynamism and get supporters off their seats.

Donald Trump told Fox News he is in no hurry to finalize a nuclear deal with Iran as Israeli forces deepened their ground incursion in southern Lebanon, marking day 93 of the regional war. The statements came alongside reports of a captured strategic castle, new Iranian naval capabilities, and a draft memorandum that would release $12 billion in frozen Iranian assets.Intensifying Ground Operations: Israel Captures Beaufort CastleIsraeli troops seized the historic Beaufort Castle (Qalaat al‑Shaqif) near Nabatieh, the deepest Israeli advance in 26 years.The Israeli military warned residents south of the Zahrani River to evacuate and launched large‑scale operations across the Beaufort Ridge and Wadi al‑Salouqi.Air raids hit Arnoun, Kfar Tebnit, Kfar Remman, Kfarjouz and Dbeibine, while a 21‑year‑old Israeli soldier was killed and four wounded.Lebanon’s Prime Minister Nawaf Salam condemned what he called a “scorched‑earth policy” as forces push toward Nabatieh.Financial Stakes: $12 Billion Frozen Iranian Assets in Draft DealIranian state media cited an “unofficial” memorandum that would free $12 billion of Iranian assets frozen by the United States.U.S. officials reported that President Trump requested several amendments to the preliminary agreement during a White House Situation Room meeting.Congress advanced a U.S.–Israeli military integration plan, potentially deepening joint weapons research and production.Regional Ramifications: Heightened Tensions Across the Middle EastIran’s IRGC claimed to have shot down a U.S. drone and unveiled a new naval attack craft capable of 100 knots, signaling a rapid military modernization.The United States disabled a Gambia‑flagged vessel attempting to reach an Iranian port, prompting Tehran to accuse Washington of “betraying diplomacy.”Rear Admiral Habibollah Sayyari warned that any further aggression would meet an even stronger response.Israel’s expanded forward‑defense line now crosses the Litani River, tightening the front against Hezbollah.What Lies Ahead: Prospects for U.S.–Iran Negotiations and Regional StabilityTrump’s “no rush” stance suggests the nuclear framework will be refined before any release of assets, potentially extending negotiations into late 2026.Continued Israeli advances risk drawing Hezbollah into a broader ground conflict, which could pressure the U.S. to reassess its diplomatic leverage.The new U.S.–Israeli integration plan may lock Washington into a tighter security partnership, influencing future policy toward Iran.Analysts warn that without a clear de‑escalation path, the war’s 93‑day trajectory could expand beyond Lebanon, affecting regional energy markets and global diplomatic efforts.

Veteran Stars Flood the 2026 World Cup Squad Lists The expanded 48‑team format has opened the door for a record number of seasoned internationals. Cristiano Ronaldo (41), Lionel Messi (39), Luka Modrić, Edin Džeko, and goalkeepers such as Manuel Neuer and Guillermo Ochoa are all set to feature, creating a roster that could rival the combined total of the previous 22 tournaments. Age Statistics Reveal Record‑Breaking Participation Seven outfield players and goalkeepers are aged 40 or older – the highest ever. The oldest World Cup player on record remains Essam El Hadary (45 years, 161 days in 2018). Goalkeepers dominate the senior cohort: Faryd Mondragón (43) in 2014, Pat Jennings (1986), Peter Shilton (1990), and Ali Boumnijel (2006). Only two outfield players have previously broken the 40‑year barrier: Roger Milla (42 in 1994) and Essam El Hadary. The surge is partly a by‑product of the tournament’s expansion, which allows lower‑ranked nations – such as Cape Verde (ranked 69th) – to qualify, bringing along veteran keepers who might not have made the cut in a 32‑team format. Implications for Team Dynamics and Tournament Competitiveness While experience offers tactical nous and leadership, the physical toll of age is evident. Ronaldo, for instance, still scores and wins aerial duels but lacks the explosive pace that defined his prime. Messi’s occasional brilliance in MLS does not guarantee the same impact against elite European defenses. Teams relying heavily on these stars risk over‑dependence on a dwindling athletic base, potentially hampering overall squad balance. Conversely, the presence of veterans can elevate younger teammates, as seen with Argentina’s Julian Álvarez and Rodrigo De Paul covering Messi’s reduced work‑rate. The trade‑off between mentorship and on‑field effectiveness will shape each nation’s tactical approach. Future of Age and Performance in International Football Advances in sports science – nutrition, recovery protocols, and injury prevention – have extended careers, but the “500‑game rule” still looms for many. Players like James Milner and Robert Lewandowski are already showing signs of wear despite modern conditioning. As leagues worldwide improve medical standards, we can expect more 40‑plus athletes, yet the ceiling for peak performance may remain unchanged. Potential developments include: Greater emphasis on squad rotation and specialized roles for older players. Possible regulatory discussions about age‑related squad limits to preserve competition quality. Increased marketability of veteran icons, driving commercial interest despite on‑field limitations. Outlook: Balancing Experience with Athletic Prime in Upcoming Tournaments For the 2026 World Cup, the gamble is clear: nations must decide whether the tactical acumen of legends outweighs the risk of reduced mobility and stamina. If veteran reliance proves costly, future editions may see a swing back toward younger, high‑tempo squads. However, should seasoned players deliver pivotal moments, the era of the “old‑guard” could solidify, reshaping scouting, contract negotiations, and the very narrative of international football.

The LeadCorridors have long been more than just passageways in cinema—they are narrative spaces that build tension, create atmosphere, and advance storytelling. The Guardian has compiled a definitive ranking of the 20 most memorable corridors in film history, showcasing how these seemingly simple spaces have become iconic elements of cinematic language.The Art of Cinematic CorridorsFrom the claustrophobic hallways of horror films to the dystopian passageways of science fiction, corridors have served as powerful storytelling devices across genres. The ranking includes entries from 1979 to 2011, with films like "The Thing" (1982), "Brazil" (1985), and "The Raid: Redemption" (2011) demonstrating how directors use these spaces to create memorable sequences.Ranking Criteria and Notable MentionsThe selection process appears to prioritize corridors that have become iconic through their visual impact, narrative significance, and ability to evoke emotion. Notable mentions include:The marble corridor in "Phantasm" (1979), which became a source of nightmares for viewersThe endless grey passageway in "Brazil" (1985), created using forced perspective in a disused flour millThe baroque corridors of "Last Year at Marienbad" (1961), which create a uniquely spooky ambienceThe modern corridor chase in "The Red Queen Kills Seven Times" (1972), featuring a figure in a red cloakThe Impact of Corridors on FilmmakingThese cinematic corridors have influenced generations of filmmakers and continue to be referenced in contemporary cinema. The ranking reveals how directors have mastered the use of confined spaces to build suspense, create visual symbolism, and advance character development. Horror filmmakers, in particular, have long recognized the corridor's potential for terror, using its linear nature to create anticipation and dread.The Future of Corridor Scenes in CinemaAs filmmaking techniques evolve, the corridor continues to be a vital space for cinematic storytelling. With advances in virtual production and immersive technologies, future corridor scenes may push the boundaries of visual storytelling even further. The enduring appeal of these spaces suggests that corridors will remain essential tools for filmmakers seeking to create memorable, tension-filled sequences that resonate with audiences.