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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

At 19,000 miles above the lunar surface, the Artemis II astronauts heard the voice of Apollo‑13 commander Jim Lovell greeting them from beyond the grave, a message recorded shortly before his death at 97. Mission control transmitted the tribute on the morning of 6 April, when astronaut Reid Wiseman held a silk square bearing the original Apollo 8 patch—handed to him by Lovell’s son—before the crew’s launch. Launch director Charlie Blackwell‑Thompson secured a unanimous "go" from every console, a moment the author describes as a snapshot of humanity’s capacity to honor the past while reaching for the future. The ceremony stood in stark contrast to the Pentagon’s agenda. Two decades after a 2006 Iraqi kill‑board note reading “Let the bodies hit the floor,” the current defense chief pledged “death and destruction from the sky all day long” against Iran, a stance legal scholars warn could constitute a war crime. That rhetoric accompanies a proposed $1.5 trillion defense budget, including an additional $200 billion earmarked for operations against Iran—figures that dwarf NASA’s entire annual budget of $24.4 billion. Amid this fiscal disparity, crew members reflected on their place in history. Victor Glover, the first Black astronaut to travel deep space, described the view of Earth as an "oasis" in the void, while Christina Koch, the first woman to orbit the Moon, pressed her face to the window and formed a heart with her hands, calling the mission’s spirit "humility." Reid Wiseman watched the planet rotate beneath him, noting the sight of Africa, Europe, and the aurora‑lit north, saying it "paused all four of us in our tracks." Canadian astronaut Jeremy Hansen broke Jim Lovell’s 56‑year distance record and asked mission control to name a lunar feature after his late wife, Carroll. The crew agreed, designating a bright spot on the Moon as "Carroll," a tribute that will endure beyond any single lifetime. When Koch announced the spacecraft’s descent, she radioed, "We are now falling to the moon rather than rising away from Earth," a poetic reversal that underscored the mission’s symbolic return. The article recalls the author’s 2022 reflection on the James Webb Space Telescope, noting how humanity’s finest inventions now aim outward, seeking answers to our origins rather than turning inward toward conflict. Artemis II’s vessel, named Integrity, carried four breathing humans who, in a moment of collective grief, pressed their faces to the glass and imagined the faces of every loved one ever lived, captured in a single frame. Beyond the spacecraft, cultural threads wove through the mission: Hansen’s patch displayed the Seven Sacred Teachings of the Anishinaabe people, and the Chinese myth of Chang’e reminded viewers of the Moon’s timeless allure. As Carl Sagan famously wrote, "We are made of star‑stuff," the Artemis crew embodied that sentiment—not as passive observers, but as active participants in a fragile, hopeful narrative that rises above the relentless tally of bodies on Earth’s battlefields.

Elizabeth Allen, a visionary artist known for her vibrant textile works, lived a reclusive life in a dilapidated hut in Biggin Hill, Kent. Her journey to fame began unexpectedly in 1965 when artist Patrick Heron visited her, leading to a series of exhibitions across Britain and internationally.Allen's work, characterized by its naive style and use of recycled materials, often depicted scenes from her life, including her orthopaedic footwear and a notable piece titled The Great Swan Song, which reflects her surprise at sudden fame. Her textiles also addressed social issues like the independence of African nations.Despite her brief moment in the spotlight, Allen's work was largely forgotten after her death in 1967. However, her art has been rediscovered and is now featured in the exhibition Troublemakers and Prophets at Compton Verney in Warwickshire. The exhibition includes pieces that have been stored away for decades, offering a fresh perspective on Allen's life and work.Curator Ila Colley highlights Allen's critical view of the church and her use of the Bible as inspiration for many of her pieces. The exhibition also features Autobiraggraphy, a textile work that includes scenes from Allen's life, such as her eviction by police in 1934.The exhibition aims to rediscover marginalized artists like Allen and provide a more inclusive view of art history. Colley hopes that this exhibition will lead to the discovery of more works by Allen and a deeper understanding of her life.

On a recent weekday evening, a special bus tour whisked art lovers through over twelve galleries and museums that stayed open until midnight, offering a late‑night glimpse of the Abidjan Art Week programme.The after‑hours event, dubbed the Night of the Galleries, was first trialled in January 2024 alongside the Africa Cup of Nations – a tournament that Côte d’Ivoire both hosted and won – and has become a staple of the festival’s third edition, which ran from Tuesday to Sunday.Since its inception, the week has broadened its footprint, moving beyond the city centre to include venues such as the La Rotonde des Arts contemporary‑arts hub in the Plateau district and the Adama Toungara Museum of Contemporary Cultures (MuCAT) in the working‑class neighbourhood of Abobo.Local collectors are emerging in force. MuCAT has hosted the Africa Foto Fair each year since 2022, and the Marché des Arts du Spectacle d’Abidjan – the city’s answer to the Dakar Biennale – is set to launch its 14th edition later this month.A graffiti festival launched two years ago has transformed the perception of street art, with vibrant murals now adorning the façade of the La Pyramide building and several upscale hotels in Plateau.Organisers stress that the festival’s growth should be independent of external validation. This year’s roster featured artists from Cameroon, the Democratic Republic of the Congo and Mali, and the number of participating galleries more than doubled compared with previous editions.Founder Yacouba Konaté, who also directs La Rotonde des Arts, highlighted the festival’s commitment to accessibility, arguing that art should not be seen as an elite pastime.The opening tribute honoured Simone Guirandou‑N’Diaye, a pioneering Ivorian art historian whose legacy lives on through Galerie LouiSimone Guirandou, now run with her daughter Gazelle.Among the week’s highlights, MuCAT presented Murmures d’Archives, a quieter, archival‑focused exhibition that concluded with an artists’ workshop and a DJ set.In the upscale Cocody district, New York‑based artist Ouattara Watts staged a solo show at Galerie Cécile Fakhoury, drawing the Ivorian diaspora into dialogue with the local scene. Watts explained that his work aims to transcend borders, describing it as “a vision that goes beyond any map – it is the cosmos that I paint.”

The ongoing global finance talks between the International Monetary Fund (IMF) and the World Bank Group (WBG) have taken a contentious turn. Governments are being urged not to mention climate change, despite its growing impacts and the pressing need for climate finance.The climate crisis has significant implications for developing countries, which are already paying billions to repair damage from droughts, floods, and storms. The World Bank Group aims to devote 35% of its funding to climate-related activities, but US pressure may hinder these efforts.US Treasury Secretary Scott Bessent has demanded the removal of some climate finance targets from the World Bank's aims, insisting on an 'all-of-the-above approach to energy' that includes financing for gas, oil, and coal. This move has sparked alarm among other countries, including large developed economies.Experts warn that sidelining climate change discussions would be disastrous for the developing world. Mohamed Adow, director of the Power Shift Africa thinktank, described the situation as 'beyond absurd', emphasizing that fossil fuels and the climate emergency are inextricably linked.The World Bank is the biggest single source of climate funding, and many donor countries channel their climate finance largely through the multilateral development banks. At the Cop29 UN climate summit in Azerbaijan in 2024, countries agreed that at least $1.3tn a year should flow to the developing world by 2035 to help countries cut greenhouse gas emissions and cope with the impacts of extreme weather.Lord Stern, a former World Bank chief economist, suggested that much could still be achieved without formally labelling projects as climate-related, emphasizing that investing in low-carbon infrastructure and energy systems is crucial for sustainable development.

While the two‑week pause in the US‑Israel campaign against Iran remains uncertain, one constant is clear: Donald Trump lacks a concrete plan, but Benjamin Netanyahu does. The war’s stated aim – to cripple Iran’s state capacity – is only a stepping stone toward a larger vision of a Greater Israel. For Israel’s right‑wing, the phrase often evokes a purely territorial ambition: enlarging the land Israel claims. History shows this expansionist drive has repeatedly displaced Palestinians, a process that has accelerated dramatically in recent years. Since the war began, Israel has flattened Gaza, killing tens of thousands and reducing the civilian‑inhabitable area to roughly 12 % of its pre‑war size. In the West Bank, a wave of settlement expansion and property destruction rivals the scale of the 1967 conflict. Beyond the occupied territories, Israel has seized parts of Syria and is forging a de‑facto occupation zone in southern Lebanon, with ministers from Religious Zionism, Jewish Power and Likud openly demanding Israeli sovereignty there. Finance minister Bezalel Smotrich even called for an expansion “to Damascus,” and Netanyahu has publicly expressed a deep personal connection to this territorial vision. However, Greater Israel is as much a geopolitical and strategic construct as a land‑grab. Netanyahu’s ambition extends beyond occupying borders; he seeks a regional dominion built on new alliances and hard‑power dependencies. After the October 7 attacks and the ensuing Gaza devastation, Israel’s prospects for Arab‑state normalization stalled. Faced with a choice between a conciliatory approach and a zero‑sum rejection of a Palestinian future, Netanyahu chose the latter, aiming to eliminate Iran as a regional counterweight – a move that inevitably required massive US military involvement. Former Israeli security analysts note that, from the perspective of Sunni Gulf states, a weakened Iran would elevate Israel to the role of “dominant regional power.” Achieving this, according to the article, also means softening the Gulf Cooperation Council (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, UAE) and making them dependent on Israel for security and energy routes. The spill‑over of Iranian drone and missile attacks on GCC infrastructure is portrayed not as an accident but as a calculated element of Israel’s strategy. When the US‑Israel coalition struck Iranian energy sites, Iran retaliated against the Gulf, disrupting global oil flows through the Strait of Hormuz. Netanyahu seized the moment to propose “alternative routes” – oil and gas pipelines that would bypass Hormuz and Bab‑al‑Mandab, ending at Israeli Mediterranean ports. In a meeting with Indian Prime Minister Narendra Modi, Netanyahu outlined a “hexagon of alliances” linking India, Arab nations, African states, Greece, Cyprus and other Asian partners, positioning Israel as the central hub. Recent IDF strategy papers echo this, suggesting Israel could achieve “operational control” far beyond its borders without permanent occupation, likening the Middle East to a “jungle” where Israel would become the “queen.” Netanyahu now describes Israel not merely as a “regional superpower” but, in some contexts, as a “global superpower.” He promises the hexagonal alliance will confront a “radical Shia axis” and an “emerging radical Sunni axis,” with Turkey singled out as the next strategic threat. Dismissal of the Greater Israel rhetoric as wartime hyperbole would be misleading. The article warns that a permanent war‑oriented mindset permeates Israel’s political elite, security establishment and media, posing a risk of overreach and regional blowback. Containing this expansive vision may become one of the most pressing post‑war challenges for the Middle East.

Experts are closely monitoring climate patterns in the Pacific Ocean, which indicate a high chance of El Niño developing this summer. A strong El Niño event could lead to severe weather conditions, including super-charged rainstorms and droughts, depending on the region. A 'super El Niño' could push 2027 to break global heat records, according to climate scientists. This phenomenon occurs when ocean surface temperatures in the central and eastern tropical Pacific Ocean warm up, leading to significant impacts on global weather patterns. El Niño is characterized by warming of the ocean surface in the central and eastern tropical Pacific Ocean. It's one of three states scientists observe: La Niña, conversely, happens when sea surface temperatures are below average, and neutral conditions are defined when neither El Niño or La Niña are present and surface temperatures are about average. The 'El Niño-southern oscillation' (Enso) tends to develop during spring in the northern hemisphere and shifts every three to seven years. Warming and cooling at sea surface during El Niño and La Niña can range from 1C to 3C, and have enormous effects on precipitation, drought, heat, and climate disasters in different regions. Conditions are currently shifting from La Niña to a neutral pattern, according to the latest outlook from the US Climate Prediction Center. Models show a 62% chance El Niño will emerge this summer and linger until at least the end of the year. A super El Niño that occurred in 2015 brought severe drought in Ethiopia, water supply shortages in Puerto Rico, and smashed records after unleashing a vicious hurricane season in the central North Pacific. A 'super' El Niño means one that is stronger, typically defined by sea surface temperatures spiking up to at least 2C. Noaa scientists have given a 1 in 4 chance that this could happen by fall or winter, with the caveat that spring forecasts are sometimes muddled. Transitions in conditions that happen in the spring can make outcomes a bit harder to predict. Experts warn that a strong or super El Niño could lead to drought and heat across Australia, southern and central Africa, India, and parts of South America. Heavy precipitation, meanwhile, could hit the southern tier of the US, parts of the Middle East, and south-central Asia.

In the quiet town of Iseyin, about 200 km north‑west of Lagos, shaded courtyards and narrow lanes have become the beating heart of Nigeria’s iconic aso‑oke textile industry. Under makeshift sheds, weavers operate wooden looms that have remained largely unchanged for generations. Recent years have seen a surge in demand for the thick, multicoloured fabric, driven by the Nigerian diaspora and an expanding international appetite for African fashion. Yet the craftsmen and women of Iseyin staunchly oppose the introduction of machines, arguing that the hand‑woven process is essential to the cloth’s distinctive texture and cultural value. The craft now serves as an economic lifeline. Young Nigerians—including university graduates—are flocking to Iseyin to learn the trade, attracted by the promise of a steady income. One such convert, Waliu Fransisco, abandoned a career as a Lagos nightclub singer a decade ago to master the loom. At 34, he says, “I now earn a decent living from weaving aso‑oke and I’m satisfied.” Aso‑oke, literally meaning “cloth from the up‑country,” has become a staple in Nigeria’s fashion scene, appearing in ceremonial attire, contemporary streetwear, and even high‑profile outfits such as the wrapper and shawl worn by Meghan Markle during her 2024 visit to Nigeria with Prince Harry. Traditionally, the fabric was produced from locally sourced cotton or silk, with threads hand‑spun, dyed, and woven in limited colour palettes. Today, most weavers use loom‑ready yarns imported primarily from China, allowing for a broader spectrum of hues while preserving the labor‑intensive hand‑weaving technique. Each loom requires meticulous arrangement of narrow, tightly patterned strips that are later sewn together to form the wider cloth used for garments and accessories. “This is what Iseyin is known for,” says 35‑year‑old weaver Kareem Adeola, echoing the sentiment of a community that views the craft as a direct inheritance from its forebears. As global fashion houses and consumers continue to seek authentic African textiles, the artisans of Iseyin stand at the crossroads of tradition and market opportunity, proving that cultural heritage can thrive alongside modern demand.

Benin's presidential election is a significant event in the country's democratic journey. The election process is crucial in determining the nation's leadership and future direction.The country's democratic institutions and electoral processes are under scrutiny as the nation heads to the polls. Transparency and fairness are key concerns for both local and international observers.Benin's experience with democracy is influential in the region, serving as a model or a cautionary tale for other West African nations. Electoral reforms and political stability are critical factors in the country's development trajectory.