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The Current Standings There are seven players tied for the lead, and another 42 within three shots of them. The day before Moving Day is going to feature a lot of jostling for position. Here's what the top of the leaderboard looked like at the end of the first day: -3: Potgieter, Jaeger, Lee, Hisatsune, Kaymer, Scheffler, Smalley -2: Brown, Theegala, Greyserman, Schauffele, Conners, Reed, Lowry Weather Conditions at Aronimink It shouldn't be too different to the first day. A little bit warmer, but with the wind expected to occasionally pick up again. It's blowing pretty briskly right now. There's not much chance of rain, and the course didn't get a soaking tonight, so it'll be a little bit firmer and the ball should scuttle further. Which, given so many of the fairways at Aronimink tilt towards penal rough, may not necessarily be a good thing. But it's a great day for golf! Michael Block's Remarkable Run Block party. It's happening again. He's happening again. Michael Block, the club pro who lit up the 2023 tournament with three rounds of 70 and a 71 that included an ace with Rory McIlroy in attendance, is doing it again. A round of 70 yesterday, and now a 20-foot putt for birdie at the par-three 5th. He's -1 overall and already beginning to dream of making the cut. It'd be an early birthday present: he's 50 next month. Good luck finding a single punter at Aronimink who won't be cheering him on. Today's Tee Times Starting on the 1st: 1145 Michael Block, Rasmus Højgaard, Dustin Johnson 1156 Mark Geddes, Steven Fisk, David Lipsky 1207 Sungjae Im, Austin Hurt, Casey Jarvis 1218 Andrew Putnam, Michael Kartrude, Matt Wallace 1229 Martin Kaymer, Elvis Smylie, Davis Riley 1240 Jason Dufner, Haotong Li, Jimmy Walker 1251 Nick Taylor, Rasmus Neergaard-Petersen, Jordan Smith 1302 Emiliano Grillo, Patrick Reed, Pierceson Coody 1313 Brian Campbell, Adam Schenk, Christiaan Bezuidenhout 1324 Marco Penge, Sepp Straka, Patrick Rodgers 1335 Aaron Rai, Travis Smyth, Sami Valimaki 1346 Sam Stevens, Jayden Schaper, Garrett Sapp 1357 Timothy Wiseman, Matti Schmid, Austin Smotherman 1715 Aldrich Potgieter, David Puig, Denny McCarthy 1726 William Mouw, Chris Gabriele, Taylor Pendrith 1737 Tom Hoge, Bryce Fisher, Joaquin Niemann 1748 Keith Mitchell, Billy Horschel, Ian Holt 1759 Gary Woodland, Jason Day, Sam Burns 1810 Wyndham Clark, Cameron Smith, Brian Harman 1821 Patrick Cantlay, Min Woo Lee, Sahith Theegala 1832 Si Woo Kim, Derek Berg, Joe Highsmith 1843 Bryson DeChambeau, Ludvig Aberg, Rickie Fowler 1854 Xander Schauffele, Brooks Koepka, Tyrrell Hatton 1905 Rory McIlroy, Jordan Spieth, Jon Rahm 1916 Daniel Hillier, Ryan Vermeer, Max McGreevy 1927 Paul McClure, Mikael Lindberg, Angel Ayora Starting on the 10th: 1150 Andrew Novak, John Parry, Jordan Gumberg 1201 Ben Polland, Kurt Kitayama, Nico Echavarria 1212 Akshay Bhatia, Ricky Castillo, Michael Thorbjornsen 1223 Luke Donald, Jesse Droemer, Stewart Cink 1234 Hideki Matsuyama, J.J. Spaun, Max Homa 1245 Ben Kern, J.T. Poston, Russell Henley 1256 Adam Scott, Corey Conners, Daniel Berger 1307 Viktor Hovland, Collin Morikawa, Shane Lowry 1318 Chris Gotterup, Robert MacIntyre, Tommy Fleetwood 1329 Cameron Young, Keegan Bradley, Justin Thomas 1340 Scottie Scheffler, Matt Fitzpatrick, Justin Rose 1351 Zach Haynes, Alex Smalley, Chandler Blanchet 1402 Bernd Wiesberger, Sudarshan Yellamaraju, Andy Sullivan 1710 Braden Shattuck, Alex Fitzpatrick, Ben Griffin 1721 Francisco Bide, Harry Hall, Ryan Gerard 1732 Johnny Keefer, Rico Hoey, Nicolai Højgaard 1743 Shaun Micheel, Michael Brennan, Garrick Higgo 1754 YE Yang, Jhonattan Vegas, Matt McCarty 1805 Lucas Glover, Tom McKibbin, Stephan Jaeger 1816 Daniel Brown, Adrien Saddier, Harris English 1827 Jacob Bridgeman, Bud Cauley, Alex Noren 1838 Chris Kirk, Max Greyserman, Kristoffer Reitan 1849 Maverick McNealy, Thomas Detry, Padraig Harrington 1900 Ryan Lenahan, Ryan Fox, Kazuki Higa 1911 Jared Jones, Michael Kim, Ryo Hisatsune 1922 Tyler Collet, Kota Kaneko, Brandt Snedeker

Debut Poet Sasha Debevec‑McKenney Secures Dylan Thomas PrizeSasha Debevec‑McKenney, an American poet based in Georgia, was announced as the winner of the £20,000 Swansea University Dylan Thomas Prize for her debut collection Joy Is My Middle Name. The award, presented in Swansea, honors writers 39 or under and recognized the collection’s “exuberant, blistering” style.Joy Is My Middle Name: A Bold Exploration of Race, Addiction, and WomanhoodThe collection delves into twenty‑ and thirties‑life themes—race, sex, womanhood, addiction, and consumerism—through a voice described as “fast and furious” by critics. Judges, led by Irenosen Okojie, praised its humor, intimacy, and relevance to “tricky times.”£20,000 Prize Highlights Growing Investment in Young PoetsPrize amount: £20,000Eligibility: writers aged 39 or underShortlisted titles: To Rest Our Minds and Bodies, We Pretty Pieces of Flesh, Under the Blue, Open, Heaven, Borderline FictionIndie press Fitzcarraldo’s first poetry title to achieve major awardImplications for Indie Presses and Contemporary Poetry LandscapeThe win underscores the rising credibility of small presses like Fitzcarraldo in launching award‑winning poetry, potentially encouraging more funding and distribution channels for experimental voices. It also raises the profile of American poets in the UK literary scene.What This Win Signals for Emerging Voices in PoetryIndustry observers expect increased attention to debut collections that blend personal narrative with social critique. Emerging poets may find greater opportunities for fellowships—such as Debevec‑McKenney’s role at Emory University—and for cross‑Atlantic publication deals.

The Lead: Beth Orton's Artistic Philosophy in the Age of AI Beth Orton, the acclaimed British singer-songwriter, has shared her thoughts on the intersection of technology and creativity in a recent interview. While discussing her illustrious career spanning decades, Orton made a striking statement about artificial intelligence's impact on music, expressing skepticism that AI "isn't going to have any beneficial influence on humans." This perspective comes from an artist who has navigated the evolving music industry while maintaining her unique voice and creative integrity. The Creative Journey: From Fear to Finding Her Voice Orton discovered her singing ability in 1989 while experimenting with theater, initially driven by a desire to confront her fear of performing publicly. "My biggest fear was singing in public and I wanted to do something I was afraid of," she recalled. This led her to transform a Rimbaud poem into what she imagined was a blues song, marking the beginning of her musical journey. Her talent was quickly recognized by producer William Orbit, who connected her with a singing teacher and helped launch her career, though Orton still struggles with identifying herself primarily as a musician. The Creative Process: Inspiration meets Craft When asked about her songwriting approach, Orton described a process where inspiration often strikes during everyday moments. "I get inspired and that's why I write. I could be walking in nature or having a conversation and it'll spark something in my head and I'll make notes," she explained. The elements of melody, words, and chords frequently emerge together, followed by the challenging work of refining these initial ideas. "The easy part is the la la la, here's the idea, here's the shape, here's the form, and then it's like: this all came unconsciously, how do I write to that standard consciously?" she noted, highlighting the difficulty of translating inspiration into finished songs. Musical Influences: Bowie's Wake-Up Call One of Orton's earliest musical memories involves hearing David Bowie's "Oh! You Pretty Things" as a child. "Anything he played was fucking loud. Mostly it was raging punk rock, but this one morning that track woke me up – he must have been up all night – and I heard something that made me feel excited for life. I was like: 'Wow, what the hell is that? I wanna find that.'" This experience exemplifies the profound impact that authentic human creativity can have, a theme that resonates with her later skepticism about AI-generated art. Industry Reflections: Authenticity in Commercial Pressures Orton reflected on her career in the music industry, particularly her experience with the album "Central Reservation" in 1999. She expressed discomfort with the pressure to conform to commercial expectations, noting that "it was like: 'Oh, she likes to be remixed. Let's get her remixed up the wazoo and that'll make this work and make it successful.'" This experience highlights the tension between artistic authenticity and commercial pressures that many musicians face, a challenge that AI might further complicate by potentially devaluing human creativity even more. The Economic Reality: Making Music Outside the Mainstream When asked about the financial challenges of being a musician outside the mainstream, Orton acknowledged the difficulties. "It is not easy. I think the lucky break is if you can make music for TV or films. That didn't happen for me and I have had to support a family," she shared. Despite these challenges, she found motivation in her dedication to her craft: "at a certain point it was like, well, there's no going back because I'm not good at anything. I'm useless at everything, but I can make music so I'll just keep doing that and hope for the best." The AI Question: Human Creativity vs. Machine Generation Orton's most controversial statement came when addressing the impact of AI on music: "Yes. It's pretty depressing. I still live in the hope that the real deal is the real deal and that only humans can make art the way humans can. And I think that's really important, spiritually and emotionally and energetically. I sound really hippy, I don't care. If you make music you feel maybe it can have an energetic influence in a powerful, positive way and I just can't see that AI is going to have any beneficial influence on humans." The Future Outlook: Preserving Human Artistry As AI continues to advance in creative fields, Orton's perspective represents a significant viewpoint from an established artist. Her stance emphasizes the irreplaceable human element in creative expression—something that cannot be replicated by algorithms, no matter how sophisticated. This viewpoint raises important questions about the value we place on human creativity in an increasingly automated world and challenges the notion that technology can fully replace the authentic, emotionally resonant qualities of human-made art.

The Earliest Known Dental TreatmentNeanderthals used stone drills to treat cavities almost 60,000 years ago in what is the earliest known evidence of dental treatment. This groundbreaking discovery challenges previous assumptions about Neanderthal capabilities and reveals their sophisticated approach to medical care.The Discovery in SiberiaThe single molar, unearthed in a cave in southern Siberia's Chagyrskaya site, features a deep hole that appears to have been created using a sharp, thin stone tool during the lifetime of the tooth's owner. The tooth, dated to be 59,000 years old, was found alongside the remains of Neanderthals and thousands of stone tools that have been excavated at the site.Scientific Evidence of Ancient DentistryThe lower molar features a deep hole in the centre of the tooth extending into the pulp cavity. Microscopic X-ray imaging revealed changes in mineralization that indicated severe tooth decay. Researchers conducted experiments on three modern human teeth to demonstrate that a hole of the same shape and patterns of microscopic grooves could be created by manually rotating a narrow, elongated tool made from local jasper between two fingers. Penetrating the dentin using this approach took between 35 and 50 minutes of continuous work.Expert Analysis of the ProcedureDr. Kseniya Kolobova, an archaeologist at the Siberian branch of the Russian Academy of Sciences, noted that this discovery "powerfully reinforces the now well-supported view that Neanderthals were not the brutish, inferior cousins of outdated stereotypes but a sophisticated human population with complex cognitive and cultural capacities."A dental professor who reviewed images of the tooth rated the Neanderthal's work as "a decent job." Justin Durham, a professor of orofacial pain at Newcastle University and the British Dental Association's chief scientific adviser, stated: "If I was marking this for a dental student, I wouldn't give it an A, but given the circumstances it's pretty impressive."Implications for Understanding Neanderthal CapabilitiesThis discovery represents the first time dental drilling has been demonstrated outside of Homo sapiens, and it is the oldest example of such behavior by more than 40,000 years. The smoothed edges of the drilled cavity and wear patterns inside it suggest the individual survived and continued to chew with the tooth for some time after the procedure.Dr. Lydia Zotkina, an archaeologist at the Russian Academy of Sciences and co-author, emphasized the remarkable strength of will required: "What struck me, and continues to strike me, is what an incredibly strong-willed person this Neanderthal must have been. They must have surely understood that although the pain of the procedure was greater than the pain of the inflammation, it was only temporary and had to be endured."This finding adds to previous evidence of Neanderthals caring for the sick and vulnerable group members, including an adult man with a withered arm and deformities in both legs, and a child with Down's syndrome who survived until at least the age of six. The latest discovery reveals not only compassion, but an impressive level of self-control by the patient and advanced technical skills by the practitioner.

The Risks of Sharing Secrets with AI Chatbots The ongoing legal battle between Elon Musk and OpenAI has taken a dramatic turn with the revelation that OpenAI's president, Greg Brockman, kept a diary during the company's founding years. This diary has become central to the case, with one heavily cited extract reading: "Financially what will take me to $1B?" Another scrutinized passage states: "It'd be wrong to steal the non-profit from [Musk]. to convert to a b-corp without him. that'd be pretty morally bankrupt. and he's really not an idiot." The Implications of Chatbot Conversations in Court As millions of people use tools like ChatGPT as a digital confession box or therapist, experts warn that these conversations can be admissible in court. In fact, a lawyer told Axios that "within the next decade," the diary equivalent will be standard discovery in every major executive litigation in the country. This means that you shouldn't trust a chatbot with your secrets, as conversations with AI are not always private and may be retained indefinitely and shared with other humans. The Privacy Concerns of Chatbot Conversations Most chatbot conversations are not private, and users should be wary about sharing sensitive information. A recent case involving a former NFL player who allegedly asked ChatGPT for help after killing his girlfriend demonstrates the potential risks. As David Friedberg, a co-host of the All-In podcast, said: "You're just sitting here at home, like, let me write about the crime I'm committing … and by the way, let me never delete it." The Future of AI and Confidentiality As AI technology continues to evolve, it's essential to consider the implications of sharing sensitive information with chatbots. While chatbots like ChatGPT may seem like a safe space to share your thoughts, they are not a substitute for human therapists or lawyers. In fact, they can be a liability in court. As the use of AI chatbots becomes more widespread, it's crucial to prioritize confidentiality and consider the potential risks of sharing secrets with AI.

The Incident and Its Aftermath Jake Paul has admitted that the broken jaw he suffered during his loss to Anthony Joshua in December may have ended his boxing career. The YouTuber turned boxer was stopped during December's fight after a brutal shot from former world champion Joshua. Paul said the injury is still being monitored five months later. The Extent of the Injury “We'll see what my doctors say,” Paul told Uncrowned on Monday. “I'll be able to get a more accurate timeframe, or can I even fight again? That is definitely in the realm and possibilities of things [that I can't]. [The jaw] does feel a lot better as weeks and time goes by, but I definitely need to get cleared first to be able to spar. Possible Career Implications “Most definitely [my boxing career could be over],” he added. “It just depends on how the bone heals. Then, also, there's a tooth missing. I'm pretty sure I'm going to have to get an implanted tooth of some sort. I'm not sure how much time that's going to add to things, but we just have to see and figure out what the smartest thing is for me.” Paul's Boxing Career and Business Ventures Paul's defeat to Joshua was the second of his 14-fight professional career, during which he proved a competent but limited boxer. The Joshua bout was his first against a world-class boxer, with his other fights coming against fighters past their prime – such as a 58-year-old Mike Tyson – or crossover stars from other sports: his second contest was against former NBA player Nate Robinson. Paul's Reflection on the Fight While the 29-year-old never established himself as a force in the ring, he is a savvy businessman and made tens of millions of dollars from his fights. He said he had no regrets about fighting Joshua, despite his injuries. “I think it was such a win on so many different levels, and I had a really good experience,” Paul said. “Just overall, such a net positive for me, my companies, my fighting experience, my content, and yeah, I just really will fight anybody, to be honest. I've been saying that, and I think people now believe me, but I'm here for entertainment purposes.”

The Collapse of a European GiantThere were more than seven minutes left to play in a crucial end-of-season match, yet San Siro was already half empty. Milan's Ultras had deserted the Curva Sud to prepare a post-game protest, but even the more forgiving parts of the club's fanbase could not be bothered to stay until the end of another humiliating defeat. Their team was losing 3-0, at home, to Atalanta, and it hardly even felt a surprise.With this loss, inevitable as it now appeared, the Rossoneri had collected just seven points from their last eight games. Only three teams in Serie A had done worse over the same stretch. Two of those – Verona, and Pisa – have been relegated. The third, Lecce, are perilously close to joining them.The Maldini Factor and Management DecisionsWatching their beleaguered team struggle to get the ball out from the back against Atalanta's persistent press, fans started to sing for Paolo Maldini. One of the all-time great defenders, he won seven Serie A titles and five Champions Leagues as a player, extending the legacy of success begun by his father, Cesare.Appointed as a director for sporting strategy and development by Milan's then owners, Elliott Management, in 2018, Maldini was promoted to technical director a year later. He played a central role in player recruitment, helping build the team that won Serie A in 2021-22 – the club's first Scudetto for 11 years.Maldini's position was initially confirmed after RedBird Capital bought Milan in 2022. But he was fired one year later, despite having just overseen a fourth-place finish. The Rossoneri had just finished fourth, and Maldini spoke about a need for further squad investment to stay competitive at the highest level. But Milan's most expensive signing of the previous summer, Charles De Ketelaere, had been a flop, and their new CEO Giorgio Furlani said the objective given to him by RedBird was to get the club "living within our means."The Summer Investment and Early PromiseThe appointment of Massimiliano Allegri this summer was supposed to get things back on track. Here was a man defined by Italy's sporting press as a "guarantee" of Champions League football. An aggressive summer transfer window followed, headlined by the arrival of Luka Modric, and featuring significant outlays on the likes of Christopher Nkunku, Ardon Jashari, Samuele Ricci, Koni De Winter, Adrien Rabiot and Pervis Estupiñán.With no European distractions, Milan looked well equipped for a strong domestic campaign. Up until March, they delivered. The performance to beat Inter was classic Allegri, controlling the game while surrendering possession. Estupiñán scored before half-time, and Milan barely gave their opponents a sniff after that. This had been the mode all season: just win, it does not need to be pretty.The Tactical Breakdown and Player IssuesBut the problem with focusing always on the outcome is that you have nothing to fall back on once that part goes wrong. Milan's form early this season was built on the performances of talented individuals – Modric, certainly, but also Rabiot and especially Christian Pulisic, who had eight goals and two assists in the league, despite missing five games, by the end of December.Allegri's innovation was to move the American inside to operate as a centre-forward. He pulled the same trick with Rafael Leão after the Portuguese returned from a calf injury. Both thrived at first, but as their goals tailed off, Milan have struggled to replace them. Too many square pegs forced into round holes? Or is the picture a little more nuanced? Both Pulisic and Leão have been affected by physical issues as the season progressed.Atalanta were excellent, pressing selectively and executing ruthlessly. Giacomo Raspadori, signed from Atlético Madrid in January, brought a typically high-energy bustle behind the attack and it was his blocked shot that rebounded to Éderson inside the box for the opener. Nikola Krstovic, in the No 9 role, pinned his man expertly before laying the ball off to Davide Zappacosta to make it 2-0 before half-time.Fan Protests and Management ResponseWhat stood out in these moments was the clarity of purpose: each player performing the role they are best suited to and understanding what was required. The contrast with Milan's disjointed assembly of talents was stark. Absent the injured Modric, there was no glue to bind them together.Ultras had already made their feelings known before kick-off with a protest outside the ground then a choreography in the Curva Sud, using their bodies and mobile phone flashlights to spell out the letters "G.F. OUT" – Furlani's initials. Reporters saw a pair of fans attempt a protest, holding up shirts with Maldini's name on the back in front of the section where executives sit, but stewards ushered them away.By leaving early, they almost missed an improbable turnaround. Milan pulled a goal back in the 88th minute, Strahinja Pavlovic heading home from a Ricci free-kick. Nkunku, on as a second-half substitute, then won and converted a penalty. Suddenly the deficit was down to one goal. In the seventh minute of injury time, Matteo Gabbia almost equalised, flashing a header wide from another set-piece.Uncertain Future for Italian Football's PowerhouseMilan exist in a different orbit, still fourth in the table, even if their grip on a Champions League spot looks very loose indeed. It feels absurd to say it now, but before this miserable run they were the team keeping the Serie A title race alive. They were the last team to beat Inter, since crowned as champions, on 8 March. The gap between them, with mocking symmetry, was seven points.The layers to these decisions are complex, each party with their own version of how working relationships grew strained. But Maldini's assessment resonated with fans who want to see their team fight for trophies. Milan finished second in 2023-24 but fell all the way to eighth last season, and now find themselves once again struggling to maintain their position among Europe's elite.With the season approaching its conclusion, the question remains whether this is merely a temporary setback or a sign of deeper structural issues at the club. The contrast between the clear, purposeful football of Atalanta and Milan's disjointed performance suggests that tactical clarity may be as much a problem as player quality or management decisions.

The Lead The Netflix adaptation of Shelby Van Pelt's novel Remarkably Bright Creatures stars Sally Field as Tova, a cleaner at an aquarium who forms a bond with an octopus voiced by Alfred Molina. The film is a gentle, heart-first drama about broken people trying to heal. Sally Field Shines in a Gentle Drama Every now and then, a strange forgotten chapter of life during Covid will interrupt my thoughts. Remember when we used to fake happy hour merriment on the Houseparty app? Or when Anne Hathaway and Chiwetel Ejiofor made an unwatchably awful film about stealing diamonds from Harrods during lockdown? The unavoidability of My Octopus Teacher led to everything from a creepy spike in people googling “did octopus teacher sex with octopus” (time-saver: he didn’t) to an unforgivably undeserved Oscar win for best documentary (Collective, you were robbed) and then, while not a direct on-record inspiration, it at least paved the way for the success of Shelby Van Pelt’s best-selling novel Remarkably Bright Creatures in 2022. The Film's Emotional Resonance It’s a film that can also sit in the streamer’s row of originals aimed at an older audience, alongside gentle afternoon watches like Nonnas, Our Souls at Night, Juanita and Otherhood. Like those films it welcomes in an actor we haven’t seen as much lately as we once did – Sally Field in this instance – and grants her more screen time than she has been given in over a decade – her last lead role was 2015’s Hello, My Name Is Doris. I’m not sure how much of the film would really work without her anchoring it – she adds volume to what’s otherwise a pretty low-level hum – but with Field smoothly moving between comedy and drama in a film that can’t always move quite so gracefully, it all just about stays afloat. The Impact of Molina's Voiceover Field is Tova, a cleaner at an aquarium in a picturesque coastal town who struggles to connect with those around her, still tending to the wound she endured after the death of her son years earlier. She now prefers being alone, something she has in common with Marcellus, an elderly octopus voiced by Dr Octopus himself, Alfred Molina. He hates humans, an understandable response to being trapped in a tank by them, but he appreciates the relative calm of Tova who talks to him in detail about her life. The Future of Gentle Dramas Assistance in that department also comes from Molina’s octopus, who isn’t always made to feel like a natural element of the story (there’s a stretch when it seems like Newman has forgotten about him entirely), but when he’s brought back to the forefront in the final act, there’s a neatly contrived yet sweetly effective and emotionally earned ending, If Newman doesn’t quite get the tears she’s clearly craving, she manages to leave us charmed enough for it not to matter all that much. Remarkable might be a stretch, but decent will do.

The Power of Negative ExpectationIn her latest book, Helen Pilcher investigates the profound connection between the mind and the body, specifically focusing on the phenomenon where negative beliefs can cause physical illness. Drawing on Roald Dahl’s The Twits, Pilcher illustrates the age-old intuition that ugly attitudes deform the face. However, her work moves beyond fiction to explore the scientific reality of the nocebo effect—a Latin term meaning "I will harm"—which occurs when a person's negative expectations lead to symptoms.Deconstructing the Nocebo EffectThe nocebo effect operates on a simple yet powerful psychological principle: the more you are warned to expect a symptom, the more likely you are to experience it. This is often described as the psychological equivalent of the "pink elephant" paradox; if you are told not to think of a pink elephant, you inevitably do. Pilcher analyzes 231 placebo-controlled clinical trials, finding that 76% of people in experimental groups reported side-effects, compared to 73% of those on a placebo. This suggests that most of us experience bodily sensations, but the nocebo effect causes us to misattribute these harmless feelings to medication.Measurable Biological ShiftsPilcher argues that the impact of the nocebo effect is not merely subjective but measurable. She highlights a striking study from Stanford where participants were told they possessed a gene associated with either high or low obesity risk, regardless of their actual genetics. The results showed that those told they had the "skinny" gene experienced a significant increase in GLP-1 (a hormone that induces satiety) after a meal, while those told they had the "fat" gene showed no change. Furthermore, Pilcher discusses research where stimulating a specific area of a mouse's brain associated with positive emotion was found to curb cancer growth, while dampening it accelerated it. This challenges the boundary between mental processes and physical disease.From Mass Panic to Medical PracticeThe book delves into the history of mass psychogenic illness (MPI), where collective anxiety spreads symptoms through a population. Historically limited by geography, MPI today can go viral due to global communication and social media. A prime example cited is the 2014 outbreak in Colombia, where social media was thought to transmit symptoms among schoolgirls who had received the HPV vaccine. Despite health officials finding no link, public confidence collapsed, dropping immunization rates from over 90% to 5%. This case underscores the vulnerability of public health to the nocebo effect at scale.The Future of Mind-Body MedicinePilcher’s work raises central philosophical questions about the nature of mind and matter. While she cautions against drawing direct parallels between mouse brain stimulation and human thought, the evidence suggests that our internal narratives can significantly alter our biology. Ultimately, understanding the nocebo effect offers a path to mitigate its negative impacts, potentially allowing individuals to avoid self-fulfilling prophecies of illness. As Pilcher notes, avoiding the nocebo effect is a "pretty good one" side-effect to have.