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The Lead: Unprecedented Cancer Treatment SuccessDoctors have hailed "unprecedented" trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.The Breakthrough: Amivantamab's Triple-Action ApproachThe jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.The smart jab targets cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumours grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumour.The Clinical Trial Data: Impressive Response RatesIn the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumours shrank or disappeared completely in 43 patients, including 28 whose tumours shrank significantly and 15 who saw them eradicated entirely.Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.The Impact Analysis: New Hope for Treatment-Resistant CancersKevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR), said: "These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy. This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. That is particularly significant, they said, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.The Patient Experience: Transforming Quality of LifeOne of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025. "I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I'm now on my 17th cycle of treatment and I'm very pleased with the progress so far."Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.The Future Outlook: Expanding Treatment ApplicationsThe results will be presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.Prof Kristian Helin, the chief executive of the ICR, said: "This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options. Achieving this level of tumour response and encouraging survival outcomes in such a challenging-to-treat group represents a significant step forward."

The Partial Internet Restoration Reveals Public AngerThe partial lifting of internet restrictions in Iran has revealed a rising tide of anger about food price inflation as ordinary Iranians decry annual price increases of 308% for vegetable oil, 190% for chicken, and 170% for rice. Iranian authorities began restoring the connection to the global internet that was severed on the first day of the US-Israeli war against the Islamic Republic on 28 February, as it had been during mass protests in January.Connectivity Remains Limited Despite Partial RestorationConnectivity remained patchy on Wednesday, with mobile internet still largely disconnected and many sites remaining restricted. But even the partial restoration was enough to reveal an outpouring of anger over price inflation and food shortages. "Everything is so expensive. It has become a disaster," wrote one user on social media. "You leave the market with a broken heart after spending all your savings. It is unbearable. We have no patience left to lead a normal life."Government Response and Blame-ShiftingPresident Masoud Pezeshkian, who has been given some credit for lifting the internet restrictions, blamed the US for Iran's economic woes, saying Washington "had moved to economic warfare after failing to bring the government down." In a lengthy statement, the ministry of intelligence revealed its concerns that internet freedom could be used for "cognitive warfare", warning that Iran's adversaries aimed to "incite protesters and drag them on to the streets."Hyperinflation Data Reveals Economic CrisisThe government announced the launch of a "resistance economy committee" to crack down on price gouging and address surging shortages, but hyperinflation is now endemic in Iran owing to trade sanctions, exchange rate pressure, and moves taken to reduce subsidies given to traders in January. Data from the International Monetary Fund showed food inflation had risen to between 140% and 200%, pushing overall inflation to 70%. Support for continuing internet restrictions was put at just 9% in a survey published on Wednesday.Government Propaganda and Public ResponseIn an attempt to forestall support for Reza Pahlavi, the son of the late shah, government backers tried to flood the internet with claims directed at "youngsters returning to the internet" that Pahlavi had openly applauded the attacks mounted by Israel and the US. Others expressed simple relief that they could now talk to the wider world. The human rights activist Emadeddin Baghi wrote: "Three bloody months have passed, but not for those who lost a loved one or had their home destroyed. In this period our voices found no echo except on some internal platforms and to the best of our ability we spoke and wrote in defence of the rights of the voiceless."Future Outlook: Digital Rights and Economic InstabilityThe prominent rapper Toomaj Salehi, who was sentenced to death in 2024 for supporting protests in 2022 but was later released, said being connected to the internet was "not a favour to us – it is our right. And without filters as well. Like free elections, freedom of expression, freedom of assembly, freedom of parties, and many other freedoms, these are our rights and not favours," he wrote on X. With public sentiment increasingly turning against the government and economic conditions worsening, Iran faces a precarious future balancing between maintaining control and addressing growing public discontent.

The United States men’s national team has confirmed a 26‑man roster and will face Senegal (Charlotte) and Germany (Chicago) as its last tune‑ups before the 2026 World Cup. With a mid‑cycle coaching change and a star striker in a prolonged scoring slump, the friendlies are a decisive laboratory for Mauricio Pochettino to lock in his starting XI and bench options. USMNT’s Final Warm‑up Schedule and Tactical Uncertainties Pochettino admitted he has a provisional XI in mind but remains open to adjustments after training sessions. The coach is unlikely to field a full‑strength side in both matches, preferring to experiment with formations that could shift between a 3‑2‑5 in possession and a 4‑4‑2 or 5‑3‑2 out of possession. Pulisic’s Goal Drought: Numbers That Matter Since 1 January, Christian Pulisic has taken 38 shots for Milan without scoring. In March friendlies he added 6 more attempts with no goal. He has logged 1,164 consecutive minutes for club and country – roughly 13 full matches – without finding the net. The striker’s dry spell is a focal point; a goal before the tournament could restore confidence and influence his role, potentially moving him from a half‑time substitute back to a starter. Defensive Options: Freeman’s Role and the Wing‑Back Conundrum The squad lists ten defenders, suggesting flexibility between a back‑four and a back‑three with wing‑backs. Alex Freeman emerges as a versatile option, having featured in all eight post‑Gold Cup friendlies and capable of operating as a traditional right‑back or a wide centre‑back in a three‑man defence. Freeman played all but three minutes of the US’s six‑match Gold Cup run. He started three of Villarreal’s final La Liga games at right‑back. His performance will determine whether he backs up Sergiño Dest or competes with Joe Scally for minutes. Bench Firepower: Reyna, Balogun and the Emerging Super‑Sub The expanded roster creates room for impact substitutes. Gio Reyna is the most obvious candidate, despite limited club minutes (520 Bundesliga minutes across 19 games for Borussia Mönchengladbach). His last season with over 625 league minutes was 2020‑21. Striker depth includes Folarin Balogun, who offers quick‑turn‑and‑shoot ability, and the contrasting styles of Ricardo Pepi (13 goals in 35 caps) and Haji Wright (7 goals in 20 caps). Both could earn bench minutes as tactical switches in the latter stages of matches. What the Friendlies Reveal About USMNT’s World Cup Prospects If Pulisic breaks his drought against Senegal, he may retain a starting spot, allowing Pochettino to rotate other attackers. Conversely, a strong showing from Reyna or Balogun could cement a super‑sub role that changes the team’s late‑game dynamics. Defensive clarity—whether the US adopts a three‑centre‑back system with wing‑backs or sticks to a traditional back‑four—will hinge on Freeman’s performances and Dest’s fitness. The outcomes of these two matches will shape the tactical blueprint for the group‑stage opener against Paraguay on 12 June.

The LeadThe week's art scene is abuzz with exciting exhibitions and showcases. From British landscapes to gothic paintings, there's something for every art enthusiast. Exhibition HighlightsBritish Landscapes: A Sense of Place at Pallant House Gallery, Chichester, explores the romance and mystery of Britain's green and pleasant land through works by artists from Gainsborough to Hepworth. Lisa Ivory: Creepy gothic paintings at Gramercy Park Studios, London, featuring skeletons and nudes in shadowy landscapes. Jack White: An exhibition at Newport Street Gallery, London, showcasing his artistic skills. Delaine Le Bas: Mystical new artworks at Maureen Paley Gallery, London, including pieces made in glass at Venice's Murano workshops. Wendy McMurdo: A 30-year survey of her work at Portrait, Edinburgh, exploring the border between reality and digital fantasy. The Featured ArtistSteven Shearer's work, including Tokerman, is highlighted, with the artist discussing how his paintings conjure art history through adolescent ennui and coming-of-age alienation. Masterpiece of the WeekPortrait of a Poet by Palma Vecchio, circa 1516, is showcased at the National Gallery, London, featuring a poet with a laurel tree growing out of his head, symbolizing poetic associations in Renaissance Italy.

Lead: Sleep Deprivation Emerges as a Possible Driver of Early-Onset CancerResearch presented at the American Society of Clinical Oncology’s annual meeting in Chicago suggests that irregular sleeping patterns could be a significant, yet modifiable, risk factor for cancers diagnosed before age 50.The Study Linking Sleep Disruption to Early-Onset CancerTwo investigations led by MD Anderson Cancer Center analysed health records of over 18 million U.S. adults aged 18‑50. Participants with chronic insomnia showed a markedly higher incidence of bowel, breast, uterine, and ovarian cancers compared with well‑rested peers.Key Numbers Highlight the Scale of the IssueGlobal early‑onset cancer cases rose from 1.82 million (1990) to 3.26 million (2019), an 80% increase in three decades.Cancer deaths among people in their 30s, 40s, or younger climbed 27% over the same period.In the MD Anderson cohorts, insomnia was associated with up to three‑fold higher cancer risk within five years.Why This Matters for Public Health and Clinical PracticeThe data position sleep quality alongside genetics and lifestyle as a potential lever for curbing the surge in early‑onset cancers. Experts caution that the studies show association, not causation, but note that sleep deprivation can impair immune function and promote behaviours (smoking, poor diet, reduced exercise) that are already linked to cancer.Looking Ahead: Research, Screening, and Prevention StrategiesStakeholders anticipate a wave of longitudinal studies to test whether improving sleep can lower cancer incidence. In the meantime, clinicians are likely to incorporate sleep assessments into risk‑stratification tools, while public‑health campaigns may emphasise sleep hygiene alongside anti‑smoking and sun‑safety messages.

The Lead: A Midlife Comedy Triumph Middle age is a brutal time of life, perfectly suited for mining laughs that are bound up with tears, crisis, and death. Tina Fey's The Four Seasons returns for a second season that is even more perspicacious, poignant and hilarious than the first, proving once again why Fey remains one of comedy's most insightful voices. The Event Details: Season Two's Narrative Structure The second season continues with four fancy holidays split across the seasons, each given two gag-packed episodes. This rigid but neat structural device allows big moments to happen off-screen while we experience the aftermath soundtracked by an avalanche of Vivaldi and bracing jokes about sad lonely donkeys, secret vapes mistaken for thumb drives, and the tragicomedy of being an angry, unravelling fiftysomething man. The three couples have been reconfigured after the death of Nick (Steve Carell) at the end of season one. We follow Kate (played by Fey) and Jack as they workshop their marriage, Danny and Claude as gay, unbearably chic, forever bickering couple, and Nick's ex-wife Anne and the much younger woman for whom he left her, Ginny – now heavily pregnant with his baby. By summer, Anne and Ginny have moved in together with the baby, creating an unconventional but loving family unit. The Critical Analysis: Why This Season Excels The Four Seasons season two delivers moments so hilarious they rival Fey's previous masterpiece, 30 Rock. The show's strength lies in its ability to balance absurd humor with genuine emotional depth. The conversations between Danny and Claude are particularly funny, moving, and sensitively wrought, while Kate and Jack's "freeballing" – their decision to "grow apart on purpose" – evolves into a beautiful meditation on the endurance test of long-term relationships. This season belongs to Anne, who makes a joyous transition from lonely, fearful ex-wife to contented (enough) single woman willing to dress up as a folkloric old witch at an Italian Christmas pageant. She delivers many of the best lines and sports the most fabulous wardrobe, proving that middle-aged women can be both hilarious and fashionable. The Impact Analysis: Redefining Midlife Comedy The Four Seasons stands out in today's television landscape by tackling middle age with honesty and humor. Unlike the aspirational settings of Nancy Meyers movies that the show lovingly mocks, The Four Seasons presents a more realistic – though still beautiful – vision of midlife. The lush lakeside lawns and lobster rolls serve as a lure to reel viewers into the murky depths of actual midlife experience, where good men smash up vintage snack shacks, regrets must be lived with, and people who love each other want completely different things. Fey's special power lies in creating jokes so specific they feel personally tailored to the middle-aged experience. The show's ability to make viewers laugh while simultaneously acknowledging the existential dread that comes with this life stage represents a significant contribution to the comedy genre. The Prediction: The Future of The Four Seasons Given the critical acclaim and the rich narrative possibilities still available, The Four Seasons seems poised for additional seasons. The show has established itself as a worthy successor to Fey's 30 Rock, with the potential to become a modern classic of television comedy. Its unique blend of high-concept settings and low-stakes domestic problems, combined with Fey's signature wit and emotional intelligence, suggests the series will continue to resonate with audiences navigating the complexities of middle age. As streaming platforms increasingly compete for quality content, The Four Seasons represents the kind of smart, character-driven comedy that awards seasons and cultural conversations are built around. If the show maintains this level of quality, it may not only extend its own run but also inspire more television creators to tackle middle age with the same honesty, humor, and heart.

Interviewing Mouse on Mars: A Conversation Like No Other Interviewing Mouse on Mars is no easy feat. Not because the duo are hard to find, even though their current studio is hidden in a courtyard deep in Berlin’s Kreuzberg district. Nor because they continue to be notoriously busy, particularly since one half of the band, Jan St Werner (born Jan Stephan Werner), is now a professor in pop music, at the Folkwang University of the Arts in the western German city of Essen. The Collaboration with Lee 'Scratch' Perry After a five-year silence, they are about to release Spatial, No Problem, a collaboration with Lee “Scratch” Perry recorded during the late dub and reggae legend’s whirlwind visit to their former Berlin studio in 2019, two years before his death aged 85. The meeting had been set up by mutual friends, though it was not clear whether it would really happen until Perry arrived at Berlin’s airport – the former Bob Marley producer had a reputation for unpredictability, and dates kept shifting. The Making of Spatial, No Problem The result is a collage-esque fever dream of a record, marrying Perry’s signature free-flowing vocals with a strange, yet warm mix of countless instruments played by friends, all held together by glitchy electronics. They had the idea to record the session as spatial audio, a technology used to mimic a more “natural” hearing experience in 3D. Asking about his familiarity with the technique, Perry answered with a wide grin, and the sentence “Spatial? No problem”. The title to the album was born, which includes recordings that are said to be some of Perry’s last. The Impact of the Collaboration Their reverence for Perry is obvious, every attempt to steer the conversation towards other topics brings the trio back to their time with him. They paint a picture of a creative frenzy: technicians installing microphones whichever corner Perry ended up standing and performing in, friends popping in and out of the sessions, NKishi being proclaimed “God” by Perry in a graffito on the studio’s walls, a general sense of a meeting of minds between artists with a similarly anarchic approach to life and craft. The Future of Mouse on Mars At a moment when the music industry is becoming ever more algorithmic, more optimised, more relentlessly targeting fickle attention-spans on social media, Mouse on Mars remain a genuinely anomalous proposition: a band whose greatest asset is their refusal to be legible. And they have been doing this for 30 years, ending up somewhere entirely different than originally planned – and making it sound, against all odds, exactly where they meant to be.

The LeadAs temperatures soar to unprecedented levels in May, a concerning pattern emerges among swallow populations across the UK. Young chicks, unable to withstand the extreme heat, are prematurely abandoning their nests, resulting in high mortality rates and threatening the survival of this year's broods.The Event DetailsUnder the scorching tin roofs where swallow nests are typically built, temperatures have become unbearable for the young chicks. With no sweat glands to regulate body temperature, the chicks are forced to the edge of their nests, eventually making the fatal decision to leap—often before they've developed the ability to fly. The author describes finding chicks huddled on the ground, vulnerable to predators and environmental hazards, while parent birds continue to bring insects that provide both nutrition and moisture in a desperate attempt to sustain their young.The Data AnalysisThis phenomenon occurs during a record-breaking week of May heat in the UK, with temperatures reaching unprecedented levels for this time of year. The heatwave represents a significant deviation from the normal climate patterns that migratory birds like swallows have evolved to rely on. These birds typically leave South Africa for the UK's plentiful insect supply and temperate spring and summer, only to encounter conditions far exceeding their evolutionary adaptations.The Impact AnalysisThe premature nest abandonment represents a broader environmental crisis as extreme weather events disrupt natural ecosystems. The heatwave is dehydrating animals, drying up soil and ponds, disrupting food chains, stressing trees, and scorching plants. For migratory species like swallows, these changes create a mismatch between their biological rhythms and environmental conditions, potentially leading to population declines and ecosystem imbalances. The situation highlights how climate change is affecting wildlife at the most vulnerable life stages.The PredictionAs climate patterns continue to shift, such extreme weather events may become more frequent, posing increasing challenges for wildlife populations. Conservation efforts may need to adapt to provide additional support for vulnerable species during extreme weather conditions. For swallows and other migratory birds, the changing climate could alter migration patterns, breeding seasons, and survival rates, potentially leading to long-term ecological consequences if adaptation doesn't occur quickly enough.

The LeadNature groups have pleaded with swimmers to give wildlife a wide berth after dozens of people swam in a nature pond on Hampstead Heath among nests of baby birds during record-breaking temperatures in London.The Wildlife Disturbance IncidentSwans and their 12-day-old cygnets were disturbed by hordes of splashing revellers in the north London park on Monday as London reached record 35C temperatures. In one video, a swan was seen poking an unhatched egg with its beak after it fell into the water during the chaos.Conservationists responded with dismay after a video was shared on social media of the scenes, which the City of London called "utterly appalling". Coots, moorhens and swans were seen guarding their eggs and young as people obliviously splashed around them.There are large signs around the pond urging people not to swim as it is a wildlife conservation area. The unseasonably hot weather has meant that people have been going into water sources en masse to cool off, coinciding with the nesting season for water birds.Conservation ConcernsThe RSPB said it was "a crucial time of year for breeding birds which just want to nest and care for their young in peace". The bird charity urged people to swim in authorised, lifeguarded spaces rather than nature reserves."Along with the dangers of swimming in unauthorised places, there is a significant risk of disturbing wildlife. Many species are already under huge pressure and disturbance can make a parent abandon their nest, putting eggs and chicks at risk. Everyone has a part to play in protecting nature so we'd urge people to be responsible and give birds and other wildlife plenty of space when outdoors this summer," it said.Swans of Hampstead Heath, the Instagram account that raised the alarm about the birds, posted: "We are currently in peak nesting season. There are still eggs waiting to hatch, ducklings and chicks only days/weeks old, and for the first time in years, swans have successfully nested on this pond, with cygnets now just 13 days old. Restricting these birds to a small section at the back of the pond makes it incredibly difficult for them to access the natural food they need to survive."When nests are disturbed, the adult birds often flee, leaving their young to be eaten by predators or die of starvation.Official Response and EnforcementThe chair of the City of London Corporation's Hampstead Heath, Highgate Wood and Queen's Park committee, alderman Gregory Jones KC, said: "The recent conduct of some visitors swimming in non-lifeguarded ponds is utterly appalling. Entering other non-lifeguarded water bodies is extremely dangerous, against our bylaws, and causes significant harm to wildlife habitats.""We always seek to engage with visitors first, but the constabulary will take enforcement action where necessary, including issuing fines or making arrests."Broader Environmental ContextThe nature campaigner and barrister Paul Powesland said: "I am not defending the people in the video, but scenes like this are an almost inevitable consequence of the destruction of outdoor lidos and the poisoning of rivers across London. It's madness for a city the size of London to have only one set of wild swimming ponds; conveniently located in one of the wealthiest areas."There have, however, been warnings of cold water shock and drownings as lakes, rivers and the sea are much colder than the air temperatures at present.