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Breakthrough Cancer Drug Reveals Hidden TumorsA smart drug that stops cancer cells "hiding" from treatment can shrink tumours by at least 30% in six of the world's most common forms of the disease, according to early trial results. While immunotherapy treatments have improved survival rates for many patients, their effectiveness can stall or fail when tumour cells hide and then spread.How the Smart Drug WorksResearchers in Oxford have developed a drug designed to stop cancer cells concealing themselves from the immune system, allowing immunotherapy treatments to identify and destroy them. In a trial spanning the UK, France, Spain and Australia, 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers were given the experimental drug, GRWD5769, alongside the immunotherapy treatment cemiplimab.The smart drug was able to remove "invisibility cloaks" from tumour cells, exposing them to the parts of the immune system that attack infections and diseases. This allowed the cemiplimab immunotherapy to pinpoint and destroy the cancer.Trial Results Across Cancer TypesResearchers, led by the Christie NHS foundation trust in Manchester, England, found that tumours shrank in 26 patients. Of those, 15 experienced tumour reductions of at least 30%. All participants had previously failed to respond to treatment, and most had no options left when they joined the study.GRWD5769 was shown to shrink tumours in all six cancer types included in the trial. The drug halted progression of the disease for at least six months in 18% of cervical cancer patients, 32% of liver cancer patients, 36% of bladder cancer patients, 38% of those with neck and head cancer, and more than half of bowel (51%) and lung (55%) cancer patients.Significance for Cancer TreatmentImmunotherapy enlists T-cells – immune system cells that attack infections and diseases – to hunt and destroy cancer. Although it has revolutionised cancer care, it fails in about two-thirds of patients. This is because immunotherapy struggles when tumours hide from the immune system.Tumours can evade the immune system by manipulating an enzyme called ERAP1 (endoplasmic reticulum aminopeptidase 1). By altering this enzyme, cancer cells can hide from a patient's T-cells. GRWD5769 solves this problem by inhibiting ERAP1, which removes cancer's invisibility cloak and makes tumour cells visible to T-cells that could not previously find them.Future Outlook for Cancer TreatmentThe findings were presented at the American Society of Clinical Oncology's annual meeting in Chicago, the world's largest cancer conference. Prof Fiona Thistlethwaite, the principal investigator, noted: "For a drug that is given as a tablet, this is very impressive. It's early days, and we need further studies, but this is a new drug with a new mechanism that clearly helps immunotherapy perform more effectively."The tablets, which were developed by Oxford-based Greywolf Therapeutics and were tolerated well by patients. The trial remains ongoing, with a larger study planned. Cancer Research UK's research information lead, Dr Samuel Godfrey, noted: "Immunotherapy has transformed treatment for some cancers but it doesn't yet work for everyone. This trial seems to show how this new drug could make immunotherapy more effective, including in some cases where immunotherapy had previously failed."

The Voice of a Generation: Kathy Sledge's Musical Journey Passion is the essential ingredient that made Kathy Sledge's musical journey possible, from her early days with Sister Sledge to becoming the voice of iconic songs like "We Are Family." For Sledge, these songs are more than just music—they're statements that brought the world together as a family through song. Lost in Music: The Sister Sledge Experience While "We Are Family" may be the group's most recognized song, Sledge considers "Lost in Music" to be the true theme of Sister Sledge. Having been in the industry since she was 11 years old, Sledge emphasizes the importance of balance to survive the demanding world of music, especially during the early years when the group toured extensively. The Chic Collaboration: Trust and Spontaneity Working with Chic's Nile Rodgers and Bernard Edwards was a defining experience for Sister Sledge. Sledge describes the process as leaning into a director as an actor, built on a foundation of trust. The producers believed in spontaneity, often having Sledge record songs without prior rehearsal to maintain freshness that continues to resonate with audiences today. Disco as Political Resistance Sledge views disco culture as inherently political, pointing to events like the 1979 Disco Demolition in Chicago as examples of industry resistance. She explains how disco challenged music segregation by knocking Neil Diamond and Barbra Streisand's "You Don't Send Me Flowers" from the top spot with Chic's "Le Freak," disrupting industry power dynamics and financial structures. The Myth of Leaving Sister Sledge Addressing one of the biggest untruths written about her, Sledge clarifies that she never left Sister Sledge voluntarily—she was voted out after being offered a solo project with Jimmy Jam and Terry Lewis. Despite wanting to maintain her connection to the group, she was given an ultimatum and prevented from acknowledging her Sister Sledge background, creating significant frustration. Breaking Barriers: Performance Style and Legacy Sister Sledge rarely wore skirts on stage, choosing trousers and jumpsuits for practical movement rather than making a statement. Sledge notes they were among the first girl groups to dance extensively on stage, opening pathways for future groups like Destiny's Child, the Spice Girls, and En Vogue. Their influence continues to shape the performance style of contemporary artists.

The world’s largest randomised trial of a multi‑cancer early detection (MCED) blood test, involving 142,942 NHS participants, did not achieve its main aim of cutting late‑stage cancer diagnoses, according to data presented at the ASCO annual meeting in Chicago.Trial Overview and Primary ObjectiveThe study enrolled adults aged 50‑77 with no cancer symptoms, assigning half to annual Galleri testing alongside standard screening and the other half to standard screening alone. Positive Galleri results triggered diagnostic follow‑up, mirroring the protocol for symptomatic participants in both arms.Key Findings and Statistical OutcomesParticipants: 142,942 screened over three years.Primary endpoint: Combined stage III and IV diagnoses across 12 pre‑specified cancers.Result: No statistically significant reduction in advanced‑stage cancers in the Galleri arm versus control.Secondary signal: Stage IV cancers fell by 14% in the Galleri group, a finding the company Grail highlighted as encouraging.Dr Julie Gralow, ASCO’s chief medical officer, noted the trial showed “some encouraging trends toward tumour downstaging” but emphasized the primary endpoint was not met.Implications for NHS Cancer Screening StrategyExperts such as Prof Richard Houlston (Institute of Cancer Research) warned that the lack of a primary‑endpoint hit undermines any justification for nationwide adoption of Galleri. Prof Peter Johnson, NHS England’s national clinical director for cancer, said the NHS will scrutinise the full data before deciding on future implementation.The trial’s outcome raises questions about the cost‑effectiveness of MCED tests at population scale and may temper enthusiasm for rapid integration into existing screening programmes.Future Directions and Remaining QuestionsMortality outcomes, expected in the next few years, will be critical to assess whether earlier detection translates into survival benefits. Researchers and policymakers will likely await these results before committing to broader rollout, while Grail may refine its assay based on the secondary findings.

The Road to World Cup 2026 Canada's national football team has made significant progress in recent years, with a record of 4W-2L-3D against the United States in their last nine matches. They have also qualified for consecutive World Cups, winning the regional qualifying tournament ahead of Mexico and the USA. Key Player: Alphonso Davies Alphonso Davies, a 25-year-old left back, is Canada's most accomplished player. Born in the Buduburam refugee camp in Ghana, Davies moved to Canada at the age of five and grew up in Edmonton. He captains the Canadian team and has played for Bayern Munich. Accomplished Coach: Jesse Marsch American coach Jesse Marsch, 52, has been hired to lead the team. Marsch has a strong coaching background, having worked in five countries, including Austria, Canada, England, Germany, and the US. He has won titles in two countries and has guided top players like Erling Haaland. Cautionary Tales from Qatar Canada's previous World Cup campaigns in 1986 and 2022 ended with losses in all their games. This time, they face a challenging Group B with Bosnia, Qatar, and Switzerland. To reach the knockout stages, they will need to improve their defense and free up striker Jonathan David to lead the attack. Canada's Group Stage Matches ⚽ June 12: Canada vs Bosnia and Herzegovina (Toronto, Canada), 3pm ET (19:00 GMT) ⚽ June 18: Canada vs Qatar (Vancouver, Canada), 6pm ET (22:00 GMT) ⚽ June 24: Switzerland vs Canada (Vancouver, Canada), 3pm ET (19:00 GMT) Canada's World Cup Squad Goalkeepers: Dayne St Clair (Inter Miami), Maxime Crepeau (Orlando City), Owen Goodman (Crystal Palace) Defenders: Alistair Johnston (Celtic), Derek Cornelius (Marseille), Richie Laryea (Toronto FC), Niko Sigur (Hajduk Split), Joel Waterman (Chicago Fire), Luc de Fougerolles (Fulham), Moise Bombito (Nice), Alphonso Davies (Bayern Munich), Alfie Jones (Middlesbrough) Midfielders: Stephen Eustaquio (Porto), Ismael Kone (Sassuolo), Tajon Buchanan (Villarreal), Mathieu Choiniere (Los Angeles FC), Ali Ahmed (Norwich City), Nathan Saliba (Anderlecht), Liam Millar (Hull City), Marcelo Flores (Tigres UANL), Jacob Shaffelburg (Toronto FC), Jonathan Osorio (Toronto FC) Forwards: Jonathan David (Juventus), Cyle Larin (Southampton), Tani Oluwaseyi (Villarreal), Promise David (Union SG)

Executive Summary: Masturbation Recognized as Natural Avian BehaviorA collaborative survey of 120 bird species shows that self‑pleasuring is widespread, more frequent in the wild than in captivity, and poses no health risk. The findings challenge long‑standing advice to discourage or punish the behavior and call for a shift in veterinary guidance.Comprehensive Survey Highlights Widespread Onanism Across Diverse SpeciesThe research, led by Dr Chloe Heys (University of Lancashire) and co‑author Dr Matilda Brindle (Oxford University), combined expert interviews, online keeper communities, and published literature. Species documented include parrots, ducks, turkeys, chickens and numerous others, with both males and females engaging in the activity.Quantitative Findings Underscore Higher Incidence in Wild Populations120 bird species examined, spanning captive and wild individuals.Incidence reported as higher in wild birds than in captivity.Male birds were slightly more frequently mentioned, but female participation was notable.Repercussions for Veterinary Practice and Bird WelfareVeterinarians are urged to reassure owners that the behavior is normal and not a sign of distress. Interventions such as perch removal, hormonal treatments, or even surgical de‑sexing are deemed unnecessary except in rare pathological cases. Dr Ana Basto (University of Lancashire) emphasizes that the study will help vets provide evidence‑based advice.Projected Shift Toward Non‑Interventionist Care in Avian HusbandryAs the scientific community accepts masturbation as a natural component of avian sexual repertoires, bird‑keeping guidelines are expected to evolve. Future husbandry practices will likely focus on monitoring for genuine health issues rather than attempting to suppress a harmless behavior, fostering better welfare outcomes for both captive and wild birds.

A Day of Artful ParentingThere's a special magic in introducing young children to the world of art, especially when it happens in the comfort of home. This narrative follows a parent and toddler as they navigate a day filled with creative expression, from building animal houses with colorful magnet tiles to exploring the welcoming spaces of a local gallery.Creating an Artistic Home EnvironmentThe journey begins in the child's bedroom, where walls are adorned with playful prints by artist Moira Frith and a William Nicholson piece of the Velveteen Rabbit. The ceiling features elephant and bee mobiles alongside Japanese paper animal balloons, creating an immersive artistic space that welcomes the child into a world of creativity from the moment they wake up.Morning Art AdventuresThe day commences with art-themed board books featuring Miffy, the little white rabbit, and an interactive color-mixing book. Despite the artistic focus, the toddler's attention naturally shifts to his plastic tractor, demonstrating how children naturally balance different interests. The morning continues with building a house for farm animals using colorful magnet tiles, stacking wooden blocks, and experimenting with stickers on paper.The Gallery ExperienceAfter a brief outdoor chalk-drawing interlude, the parent and child visit the William Morris Gallery, which the child affectionately calls "the gallery." This familiar space offers crayons, blank paper, building blocks, and soft toys—all set against an artistic backdrop. The gallery has become a regular Wednesday destination with the child's grandmother, representing how cultural institutions can be woven into family routines.Art Education for the Very YoungChildren naturally lack hierarchical distinctions about what constitutes art, embracing everything from professional paintings to their own scribbles. This democratic approach to creativity allows for boundless exploration and expression. The article suggests that both home-based art activities and gallery visits play complementary roles in nurturing young artistic sensibilities.Cultivating Future Art EnthusiastsAs the child grows, the parent envisions future art adventures, possibly even a trip to the Miffy Museum in Utrecht for the child's second birthday. This forward-looking perspective suggests that early artistic experiences can blossom into lifelong appreciation of creativity and culture.Resources for Young ArtistsFor parents looking to bring art into their homes, the article recommends several books:Miffy the Artist by Dick Bruna (also Miffy at the Gallery, and Miffy and the Artists)Famous Art to Colour by Susan MeredithThis Book Will Make You an Artist by Ruth Millington

The Early Season Surge: Rookies Reshaping the WNBA LandscapeLess than three weeks into the WNBA season, the league has already delivered high-stakes drama, with thirteen games decided by five points or fewer. Amidst this competitive intensity, the spotlight has shifted to the rookie class, who are not only adapting but thriving in the professional spotlight. From elite point guard play to record-breaking shooting performances, the new wave of talent is proving they belong at the highest level.Elite Company: Olivia Miles and the Point Guard BlueprintOlivia Miles has quickly established herself as the premier rookie point guard in the league. Through her first six games, Miles has averaged 15 points and 5 assists, a feat that places her in an exclusive club alongside legends like Candace Parker, Sue Bird, Caitlin Clark, and Sabrina Ionescu. Her ability to see the floor and elevate her teammates is evident, as veteran players like Courtney Williams and Natasha Howard have thrived in their natural roles alongside her. With the Minnesota Lynx sitting in fourth place without their star Napheesa Collier, Miles’ leadership and scoring are crucial to the team's early success.Azzi Fudd's Breakout: Setting the Standard for ShootingAzzi Fudd, the No 1 overall pick, delivered a statement performance against the New York Liberty. In a game that saw intense back-and-forth action, Fudd broke the rookie franchise record for threes with six, finishing with 24 points in 32 minutes off the bench. Her most impressive stat came in the third quarter, where she scored 17 points, the second-most single-quarter points by a rookie in league history. This performance has seemingly cured her early-season shooting struggles, providing a massive confidence boost for the Dallas Wings.Awa Fam and the Seattle Storm's Youth MovementAwa Fam officially joined the Seattle Storm after a successful overseas campaign, including a Spanish league championship. In her debut against the Washington Mystics, Fam scored 10 points, making her the 14th teenager to play in the WNBA and only the second to score double figures in her first game. Her arrival completes a formidable young core for the Storm, alongside Flau'jae Johnson and Dominique Malonga. This depth suggests a bright future for the franchise and the league as a whole.Future Outlook: A Competitive League and Rookie DominanceThe early season data indicates a highly competitive landscape, with the Atlanta Dream currently leading the league at 4-1. The return of Rhyne Howard has bolstered their title hopes, even without All-Star forward Brionna Jones. As the season progresses, the performances of these rookies will likely continue to drive viewership and engagement. With teams like the Indiana Fever and Chicago Sky facing critical matchups, the combination of veteran experience and rookie energy promises to make the remainder of the season one of the most exciting in recent memory.

The Guardian’s latest review of Beetlejuice: The Musical notes that the production has turned Tim Burton’s cult‑film into a Halloween‑like, shock‑jock musical extravaganza now playing at the Prince Edward Theatre until 17 April. The show mixes grotesque humor, topical references and high‑octane staging, delivering a wild but uneven theatrical experience.Beetlejuice Musical Reanimates Tim Burton’s Cult Classic on the West EndOriginally staged on Broadway in 2019, the London version abandons the film’s “less‑is‑more” restraint. The titular character, played by David Fynn, bursts onto the stage with a self‑aware ballad, immediately setting a tone of anarchic satire. The production leans heavily into contemporary jokes—hip‑ster vaping, six‑seven slang, and even a jab at Andrew Lloyd Webber—while preserving the film’s macabre spirit.Creative Team’s Off‑kilter Vision Drives the Show’s AestheticDirector Alex Timbers orchestrates a chaotic visual palette: Kenneth Posner’s lighting creates an uncanny glow, Peter Nigrini supplies trippy projections, and set designer David Korins transforms the theatre into a haunted house complete with a sandworm that slithers through the auditorium. Costume designer William Ivey Long delivers “toxic yet sparkly” outfits, from Miss Argentina’s glittering ensemble to Lydia Deetz’s spidery black lace. The special‑effects team—Jeremy Chernick, Michael Weber and puppeteer Michael Curry—adds a layer of tactile wonder, most memorably a roast pig that stands upright during a possession scene set to “Day‑O.”Critical Reception Highlights Strengths and WeaknessesThe review praises standout performances: Hannah Nordberg brings “drop‑dead energy” to Lydia, while David Hunter and Chelsea Halfpenny convincingly portray the newly deceased Maitlands. However, the script’s rapid swing between the Netherworld and the living world can feel “tiresome,” and the musical numbers, though varied, are described as “oddly unmemorable.” The show’s relentless gag‑fest is likened to a “Netflix megastar stand‑up desperate to cause outrage,” suggesting that the novelty may wear thin over a full run.What Lies Ahead for Beetlejuice on the London StageDespite its unevenness, the production’s bold visual identity and strong cast give it a solid footing in the competitive West End market. If the show can harness its cult‑film fanbase and attract audiences seeking a high‑energy, Halloween‑style experience, it may enjoy a sustained run beyond the current booking. Conversely, word‑of‑mouth about the “scattershot dialogue” could limit its appeal to repeat‑viewers, making the next few weeks critical for box‑office momentum.

Translated Fiction Review Roundup A collection of recent translated fiction has been reviewed, showcasing the diversity and complexity of global literature. The reviews include: 'Sisters in Yellow' by Mieko Kawakami Sisters in Yellow by Mieko Kawakami, translated by Laurel Taylor and Hitomi Yoshio (Picador, £16.99) Kawakami’s latest opens with a bang, as narrator Hana learns that her old friend Kimiko has been charged with abduction. This MacGuffin takes us to their friendship in late-1990s Tokyo, when teen Hana and the older woman open a bar called Lemon: “Yellow attracts money.” But it’s a turbulent ride and soon Hana is in a world of organised crime. “The world is crazy. I feel like I’m living in a manga.” She’s not the only one, and you need an appetite for Kawakami’s style, which prefers to explore rather than explain – people come and go, buildings burn down, cancer is diagnosed, almost at random – but the relentless rush means there’s no time to get bored. At its best – as in a scene where Hana’s unreliable mother wants to borrow 2m yen for investment in lingerie that helps “your spine and organs move back to where they’re supposed to be” – this is a story both absurd and horrifying. 'All Flesh' by Ananda Devi All Flesh by Ananda Devi, translated by Jeffrey Zuckerman (Pushkin, £12.99) “Forgive me for starting this story with bodily, unpalatable origins.” You may as well – it’s all like that. In an unnamed European country, a schoolgirl “born with no urge but to consume” is getting bigger and bigger. “My gut, my ass, my thighs – they were all set on reaching the farthest corners of the world.” She blames her gluttony on the need to silence the voice of her dead twin sister, who was “absorbed into my tissues” in the womb. She hates school, where other kids mock her, as though her own self-disgust weren’t enough. After a blackly comic scene where she gets stuck in her bedroom doorframe like “an uncooperative cork”, she falls in love with the lonely carpenter who arrives to widen the door – but there are more twists to come. This powerful story is deeply physical, but driven by a compelling voice describing the torment of a girl who is “the psychical mirror of our time … immoderation made manifest”. 'The White Desert' by Luis López Carrasco The White Desert by Luis López Carrasco, translated by Rosalind Harvey (Granta, £14.99) This unpredictable book, comprising five linked stories about a Spanish couple, opens with the end of the world and gets weirder from there. A balloon debate about a post-apocalyptic scenario turns nasty when one participant pulls a knife, or thinks he does. A plane crash-lands on an island. “Can [we] go and get our luggage … Lots of people have, you know, soiled themselves.” What links the scenes is a sense of disconnection in our connected world, but the book subverts expectations: when a group of people celebrating New Year’s Eve go missing, it turns out to be a game of hide and seek. Footnotes peppered throughout suggest we’re viewing all this from the future (“Emirates was a well-known passenger airline …”), and discovering what the white desert is turns everything on its head. For readers who like to do their own joining up, and who want a playful, original take on our precarious lives, this is a thought-provoking treat. 'The Home of the Drowned' by Elin Anna Labba The Home of the Drowned by Elin Anna Labba, translated by Elizabeth Clark Wessel (Harvill, £16.99) “You could have waited, you bastards.” In 1942 Lapland, a village occupied by the semi-nomadic Sámi people is flooded by a new hydroelectric plant’s dam. One family watch as their goahti (peat-covered hut) disappears under the water. “It wasn’t the nicest goahti,” says Ánne. “No, but it was mine,” says her sister Rávdná. When Rávdná wants to build a house to replace it, the authorities refuse permission: the Sámi way of life has been rejected but alternatives are not permitted. A local newspaper half-heartedly offers to publicise their case, but “we receive a lot of angry letters if we use any foreign words”. When the government tells local people the new dam “will lift us out of poverty and injustice”, the words reek with irony. This intimate story of infuriating discrimination is, Labba says, based on real events in Sweden.