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The Guardian’s latest science podcast examines the worldwide campaign to wipe out Guinea worm disease, a parasitic infection that could become the second human disease ever eradicated after smallpox. Hosted in 2026, the episode highlights why the disease remains a focal point for public‑health leaders and what its elimination would mean for global health security.Guinea worm, transmitted through contaminated water, has been the target of an intensive eradication effort led by the World Health Organization and partners in endemic regions. The podcast underscores the progress made: cases have plummeted from millions in the 1980s to just a handful today, illustrating the power of coordinated surveillance, safe‑water interventions, and community education.Despite the gains, experts caution that complete eradication is not guaranteed. Residual hotspots in remote villages, logistical challenges in delivering clean water, and the need for sustained funding pose ongoing risks. The discussion stresses that a lapse in commitment could allow the parasite to rebound, undoing decades of progress.Historically, smallpox remains the only disease humanity has fully eradicated, a milestone achieved in 1980 after a global vaccination campaign. The potential success of the Guinea worm program would mark a watershed moment, demonstrating that eradication is feasible beyond vaccine‑preventable illnesses and could inspire similar initiatives for other neglected tropical diseases.Listeners are encouraged to support the effort through the Guardian’s science podcast platform, where additional resources and ways to contribute are provided. As the episode concludes, the hosts reiterate that the fight against Guinea worm is both a test of global solidarity and a template for future disease‑elimination campaigns.

Background and Early Years Bob Mould – former frontman of Hüsker Dü, solo artist after 1988. 1991: Mould writes songs that become Copper Blue while grunge explodes via Nirvana. 1992: Formation of Sugar with bassist David Barbe and drummer Malcolm Travis. Rise of Sugar and *Copper Blue* The debut album Copper Blue blended metallic guitar walls with melodic pop, earning critical plaudits and commercial success unprecedented for an underground act. It reached the UK Top 10 and won NME’s 1992 Album of the Year – a win Mould likens to “winning an Oscar.” This chart position represented a shift from niche indie sales (typically under 50,000 units) to mainstream exposure, roughly a 5‑fold increase in album‑move volume. Impact of Kurt Cobain’s Death In April 1994, while recording their second album at Triclops Studio, Mould learned of Kurt Cobain’s suicide. The shock prompted him to “pull the plug” on the recordings, erasing the tapes and stating there was “nothing worth saving.” This abrupt halt illustrates how the post‑Nirvana cultural landscape forced alternative bands into a new celebrity‑driven paradigm, pressuring them to navigate fame and personal trauma simultaneously. Second Album and Disbandment 1994: Release of the EP Beaster, reaching No 3 in the UK charts despite its dark religious themes. 1995: After a rushed three‑month writing session for File Under: Easy Listening, internal pressures and Barbe’s family commitments lead to Sugar’s dissolution. Reunion and Legacy After three decades of solo work, Mould, Barbe, and Travis reconvened in 2026. The band announced a European and US tour from May to October, adding two new tracks to commemorate the reunion. While Mould remains non‑committal about future recordings, he emphasizes enjoying the live experience—a contrast to the “no‑time‑for‑reflection” era of the early 90s. Key Takeaways Copper Blue transformed Sugar from an underground act to a mainstream chart‑breaker. The death of Kurt Cobain acted as a cultural inflection point, prompting Mould to abandon a nearly finished second album. Three‑decade‑long hiatus underscores the lasting influence of 90s alternative rock on today’s touring circuits. Fans are advised to bring earplugs—the band’s signature “colossal, metallic, thunderous” sound remains as punishingly loud as ever.

President Donald Trump signed an executive order on Saturday in the Oval Office, joined by podcaster Joe Rogan, to fast‑track the federal review of psychedelic drugs such as ibogaine, aiming to broaden treatment options for serious mental illness.The ceremony highlighted Rogan’s long‑standing advocacy for ibogaine, a plant‑derived compound used by some veteran groups to address post‑traumatic stress. Rogan recounted texting Trump about the drug, to which the president replied, “Sounds great. Do you want FDA approval? Let’s do it.”Trump framed the order as a lifeline for patients: “Today’s order will ensure that people suffering from debilitating symptoms might finally have a chance to reclaim their lives and lead a happier life.” He added that successful outcomes could have “a tremendous impact.”In a brief moment of levity, Trump joked, “Can I have some, please? I’ll take some.” He quickly refocused, noting he has no time for depression and stays busy instead.The move enjoys rare bipartisan backing, despite ibogaine and other psychedelics remaining classified under the federal government’s most restrictive drug schedule.Health Secretary Robert F. Kennedy Jr. had previously pledged to ease medical access to psychedelics, a stance echoed in the new order, which directs the Department of Health and Human Services to allocate at least $50 million to states developing programs for serious mental‑health conditions.Simultaneously, the FDA is set to issue “national priority” vouchers for three psychedelic candidates. Commissioner Marty Makary said the vouchers will enable rapid approval “if they align with our national priorities.”The agency also plans the first human trials of ibogaine in the United States, overcoming earlier concerns about potential fatal heart effects.Ibogaine’s origins trace back to the Bwiti religious ceremonies in West‑Central Africa, where the plant has been used for centuries in spiritual contexts.Former Navy SEAL Marcus Luttrell, also present at the event, praised ibogaine, stating, “It absolutely changed my life for the better.”Rogan’s endorsement and the executive order have added a new dimension to Trump’s 2024 campaign narrative, even as he has publicly questioned the administration’s stance on the war with Iran.

The United Nations refugee agency has revealed that nearly 900 Rohingya refugees were reported dead or missing in the Bay of Bengal and the Andaman Sea in 2025. This was the deadliest year on record for maritime movements in South and South East Asia.Thousands of people continue to make the dangerous journeys in 2026, with the UNHCR describing the area as an “unmarked graveyard for thousands of desperate Rohingya refugees”. Over the last decade, some 5,000 Rohingya are thought to have drowned at sea.Hundreds of thousands of Rohingya refugees began fleeing Myanmar in 2017 amid an ethnic cleansing campaign. They largely settled in refugee camps in Bangladesh, which continues to give refuge to those fleeing today. However, humanitarian aid in the country has been reduced due to funding shortfalls, and there is limited access to education and opportunities in the camps, prompting people to attempt the dangerous sea crossings.More than 2,800 Rohingya have made the sea journeys this year, with the majority leaving from Cox’s Bazar in Bangladesh or Rakhine State in Myanmar in the hope of reaching Malaysia or Indonesia. The UNHCR hopes that highlighting the record death toll will make people aware of “what the Rohingyas are going through inside Myanmar and in the refugee camps and in the wider region” and prompt solutions to avoid another record toll in 2026.

On 17 April 2026 the Guardian released its weekly sports quiz, testing readers on recent European football semi‑finalists, Tottenham’s relegation history, the first female head coach in Europe’s top five leagues, and a range of other sporting milestones. The quiz, published on the Guardian’s website, aims to engage fans by linking current events with historic trivia. European Cup tally: The quiz asks how many times Bayern Munich, Arsenal, Paris Saint‑Germain and Atlético Madrid have collectively won the competition. The correct answer is seven – Bayern’s six titles, PSG’s inaugural win last season, while Arsenal and Atlético have yet to lift the trophy. Tottenham’s relegation: After a 14‑match winless streak, Spurs fell into the relegation zone. The quiz asks when they were last demoted; the answer is 1977, a year also marked by Elvis Presley’s death, Pelé’s final professional match, the debut of Star Wars and Manchester United’s sacking of Tommy Docherty. Breaking the glass ceiling: Marie‑Louise Eta became the first woman to manage a club in Europe’s top five leagues when she was appointed interim boss of Union Berlin. Her tenure is expected to be brief as she will move to the women’s side next season. Golf history: Rory McIlroy’s sixth major win prompts the question of which European golfer has more majors. The answer is Harry Vardon, who captured seven majors (six Opens and one U.S. Open) and is celebrated as golf’s first international star. Masters oddities: Shane Lowry made Masters history by becoming the first player to record two holes‑in‑one at Augusta, the 35th hole‑in‑one overall at the tournament. Women’s Six Nations: Wales suffered a 24‑19 defeat to Scotland in the opening round, continuing a recent run of wooden‑spoon finishes. World Cup coaching: Carlos Queiroz was appointed Ghana’s manager, giving him the chance to coach at a sixth World Cup after previous stints with South Africa, Portugal and Iran. Grand National legacy: I Am Maximus joins the post‑war elite of multiple Grand National winners, following Tiger Roll, who claimed back‑to‑back victories in 2018 and 2019. Managerial debut: Former England midfielder Jack Wilshere secured his first trophy as a manager, guiding Luton Town to an EFL Trophy win at Wembley. County Championship rule change: The quiz highlights that Tom Westley, Jonny Bairstow and others have all been substituted this season under new regulations allowing injury or personal‑circumstance replacements. NBA consistency: The Boston Celtics have reached the playoffs for a 12th consecutive season, though they have captured only one championship in that span (2024). Combat sports crossover: Oleksandr Usyk will face kick‑boxing legend Rico Verhoeven, who held the heavyweight kick‑boxing world title for 12 years, in a bout billed as “Glory in Giza” at the Egyptian pyramids. Snooker prodigy: Fourteen‑year‑old Stan Moody qualified for the World Snooker Championship after playing a decisive match while recovering from tonsillitis, underscoring his remarkable determination. Overall, the quiz blends current headlines with historic facts, offering readers a chance to test their knowledge while reflecting on the broader narratives shaping sport today.

Disney introduced InfinityVision at this year’s CinemaCon, positioning it as a certification for premium large‑format (PLF) auditoriums that meet or exceed undisclosed standards for screen size, brightness and sound quality. While the name sounds like a Marvel spin‑off, the label applies to any film, not just superhero titles. Disney claims roughly 300 screens worldwide already carry the badge, though a public directory has yet to appear. The timing is strategic: Disney’s Avengers: Doomsday is slated for a December debut that coincides with the release of the third Dune film, which has secured a limited run on coveted Imax screens. By promoting InfinityVision, Disney hopes to reassure audiences that alternative PLF venues—such as Dolby, RPX and other branded auditoriums—can deliver an equally spectacular experience, a tactic the author dubs screenmaxxing. Screenmaxxing has become a lifeline for a theatrical sector under pressure from streaming and rising ticket prices. Even the smallest multiplex PLF screens dwarf the televisions owned by the majority of consumers, yet theatres cannot simply charge a $5 premium for a larger screen; they need to sell a demonstrably superior visual and auditory package. Today’s market offers a bewildering array of PLF options, especially in cities where multiple chains compete. Directors like Ryan Coogler (Sinners) and the team behind Project Hail Mary use the variety of formats as a marketing hook, explaining aspect‑ratio differences and visual nuances to fans. Even legacy formats have resurfaced: Paul Thomas Anderson’s One Battle After Another revived the rarely used VistaVision, an analog high‑definition process dormant for half a century, alongside traditional 70mm and Imax prints. Adding to the mix, a new digital projector brand—HDR by Barco—is being rolled out to compete with Dolby‑branded auditoriums. The technology promises deeper blacks, heightened contrast and unprecedented brightness, and has already been adopted by the Alamo Drafthouse chain for its dine‑in locations. Many of these Barco‑equipped rooms also feature Dolby Atmos sound, though the author cautions against conflating sound systems with projection technologies. To gauge HDR by Barco’s performance, the writer visited the Brooklyn Alamo Drafthouse, one of three New York venues using the system (the others are Regal locations equipped with RPX screens). While the recent Super Mario Galaxy movie showcased the projector’s vivid palette, the reviewer chose a more demanding test: Lee Cronin’s horror‑reimagining The Mummy. Compared with a prior Dolby projection of the same film, the Barco version delivered a noticeable boost in clarity—especially in shadow‑heavy scenes—without the oversharpening or motion‑smoothing artifacts sometimes seen on consumer TVs. The experience was “brighter” yet retained natural colour balance, offering a subtle but real upgrade over standard cinema projection. Despite the technical gains, the piece questions whether another premium brand can truly shift audience habits. The author argues that healthy competition among laser‑projection systems may prevent theatres from settling for “dim” images, encouraging cinephiles to seek out PLF venues. However, blockbuster spectacles like the climactic battle in Avengers: Endgame remain visually underwhelming even on an InfinityVision‑certified screen, suggesting that format alone cannot rescue a film’s visual impact. Ultimately, the most compelling case for premium formats may be the construction of genuine Imax theatres, not retrofits. True Imax auditoriums prioritize height over width, delivering an immersive field of view that even high‑end digital projectors struggle to match. Yet only a few dozen such venues exist worldwide; most “Imax” screens are simply Dolby, Barco or RPX rooms equipped with the brand’s hardware. Screenmaxxing, therefore, is likely to remain a niche pursuit rather than a universal solution for the exhibition industry. While hunting for the loudest, sharpest presentation can be entertaining, an overabundance of competing formats may reinforce the perception that a standard movie‑going experience is insufficient—potentially undermining the very audience the industry hopes to attract.

Chris Evans’ attempt to resurrect the 1990s chatshow juggernaut TFI Friday began quietly on Virgin Radio’s YouTube channel earlier this year. The lo‑fi series, titled TFI: Unplugged, featured a handful of high‑profile guests – Danny Dyer, Chris Hemsworth, Bono and Noah Wyle – and quickly attracted enough viewers for Channel 4 to commission six late‑night episodes. While the media spotlight has been on Claudia Winkleman’s foray into celebrity interviewing, Evans’ revival arrives with far less fanfare and pressure. The new format is deliberately stripped back: a cramped studio, casually dressed staff, and a budget that Evans himself jokes is “only 1% of the original”. Channel 4 commissioning editor Cimran Shah pitched the show as “personality‑led, stripped‑back chat”, positioning it as a precursor to today’s visual podcasts. In practice, the production feels more like a video‑recorded audio interview than a full‑blown TV spectacle. The episode lineup mixes legacy and fresh talent. Vintage performances from Sleeper, The Cure and Garbage provide a nostalgic soundtrack, while contemporary guests such as Jack Savoretti – who Evans repeatedly hails for a recent chart‑topping album – and Indian star Shreya Ghoshal, who covers Coldplay’s “Fix You”, aim to broaden appeal. A promised appearance by Gemma Arterton and Peter Capaldi never materialised; instead, singer‑songwriter Sam Ryder appeared despite having lost his voice. One of the few moments that truly harkens back to the original is a splice of Evans’ 1999 interview with David Bowie, in which the legendary musician bizarrely claims to have contracted gastroenteritis from eating monkey meat. The clip underscores Evans’ desire to remind viewers of the show’s storied past, even if the anecdote feels more odd than iconic. Critics note that the new Unplugged version lacks the “laddish, often cruel humour” that defined the 1990s TFI Friday, including infamous segments like the “Fat Lookalikes”. The original’s chaotic energy and Britpop‑fuelled vibe have been replaced by a more restrained, if still frenetic, studio atmosphere. In terms of relevance, the series appears out of step with current trends. Unlike interview podcasts that create an intimate, off‑camera feel, Evans’ format retains the sweaty, over‑the‑top live‑TV aesthetic without delivering the depth or novelty that modern audiences expect. Overall, TFI Friday Unplugged may not reshape the UK chatshow landscape or outshine Winkleman’s high‑profile debut, but it does carve out a modest niche for nostalgia‑driven viewers. Its inexpensive production model proves sustainable, even if the show remains a modest footnote in the broader revival of British talk‑show culture.

At a damp morning meeting in Sandy Park, Exeter Chiefs chairman Tony Rowe outlined the club’s next chapter: a potential sale to an American investment group that will be decided by the club’s 700‑plus members at an extraordinary general meeting on 7 May.Rowe, now 77, has steered the Chiefs for more than three decades, guiding the team from a modest county‑ground side to Premiership champions in 2010. Yet he admits that “romance doesn’t pay the bills” in today’s professional rugby, and a well‑funded owner could finally provide the financial muscle the club needs.The proposed buyer is described as a “mega‑wealthy multi‑sport investor” already active in British football. If the vote passes, the investor would inject fresh capital, allowing Exeter to compete for top talent such as marquee player Immanuel Feyi‑Waboso and to pursue broader ambitions.Rowe argues that English club rugby must look beyond nostalgia. “We’ve got to wake up and smell the coffee,” he said, emphasizing the need for an owner with deep pockets. He warned that the club’s current shareholder structure, which “has no money,” limits growth.The takeover is part of a wider trend of foreign money entering English rugby, following recent investments in Newcastle Red Bulls and Bath. Rowe believes a cash‑rich owner will position Exeter to help expand the Premiership from its current ten clubs to twelve, and eventually fourteen, with a view to incorporating Welsh sides.He suggested that adding “two Welsh clubs” could revitalise Welsh rugby, which he described as “on its arse,” and noted that travel logistics would not be a barrier for English clubs making weekend trips to Wales.Financial pressures remain acute. Rowe cited a £25 million loss from Covid and the post‑pandemic mini‑recession, compounded by a government grant that was later converted into a loan and a Rugby Football Union (RFU) contribution that covered only half of the promised support.He also criticised a £200 million 2018 deal that gave private‑equity firm CVC Capital Partners a 27 % share of the club’s commercial rights. “We should never have sold those shares,” Rowe lamented, adding that CVC has done little to boost sponsorship or “razzmatazz” for the sport.Looking ahead, Rowe stresses the importance of attracting a younger, millennial fan base, noting that “our future supporters are millennials” and that they will be the financial lifeline of the club.Despite the uncertainties, Rowe remains optimistic. He confirmed he will stay on under the new ownership, describing the investors as “long‑term” and “understanding of the sport.” He warned the new owners must respect Exeter’s Devonian heritage, likening the club’s future to a bus that needs a fresh fuel supply to reach “even greater success.”

Britain is bracing for its most severe economic contraction in decades, a side‑effect of the United States’ escalating conflict with Iran and the resulting shutdown of the Strait of Hormuz. The British Treasury and the IMF warn that the nation’s growth could be crushed, public confidence in the government is eroding, and the prime minister’s position may become untenable. The original aim of sanctions was to punish hostile states and force leaders like Vladimir Putin to change course. Yet, data shows that in the years following the sanctions, Russia’s growth outpaced that of the United Kingdom. Similarly, the 2010s sanctions on Iran, intended to halt its nuclear programme, appear to have accelerated it, and current measures aimed at toppling the ayatollahs show little prospect of success. The United States now enforces economic restrictions on around 30 countries, including North Korea, Myanmar, Belarus and Afghanistan. Despite the breadth of these measures, the targeted regimes have largely remained in power, indicating a systemic failure of sanctions to destabilise entrenched governments. Beyond their limited impact on regime change, sanctions have unintentionally bolstered the Sino‑Russian trade bloc and driven many nations toward the BRICS alliance, positioning it as a counterweight to the G7. This realignment underscores the counter‑productive nature of the policy. Academic research, such as Nicholas Mulder’s The Economic Weapon, reinforces the historical pattern: except for very small states, trade restrictions are easily circumvented, and authoritarian regimes insulated from democratic pressures are largely immune. Mulder concludes that “the history of sanctions is a history of disappointment,” a sentiment echoed by critics who warn that each new round of sanctions repeats the same mistakes. One of the most damaging side‑effects is the exodus of skilled professionals. Iran, for example, has seen a diaspora of over four million people as of 2021, many of whom belong to the educated middle class that could have fueled internal reform. The brain drain weakens any potential opposition and inadvertently benefits Western economies that absorb this talent. Russia experienced a similar talent flight after the 1990s, when a vibrant civil society briefly flourished. Today, the remaining dissenters face both Kremlin repression and Western ostracism, creating an atmosphere reminiscent of McCarthy‑era loyalty tests. Given these outcomes, the article argues that the West must abandon blunt economic coercion in favour of nuanced, soft‑power strategies. Supporting opposition groups through academic, cultural, and diplomatic channels could nurture the very alternatives that sanctions have helped to erode. In sum, sanctions have proven illiberal and counter‑productive, reinforcing authoritarian borders while draining the human capital needed for genuine change. Restoring constructive relationships with societies like Iran and Russia, rather than relying on punitive trade measures, may offer a more viable path to long‑term stability.