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Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

The economic consequences of an Iran war could have devastating effects on global poverty, with 32 million people at risk of being pushed into poverty worldwide. The United Nations Development Programme (UNDP) warns that developing countries will bear the brunt of this impact. In a report released amid concerns over a fragile ceasefire, the UNDP highlights a 'triple shock' affecting energy, food, and economic growth. This conflict is reversing international development gains, with uneven regional impacts expected. Alexander De Croo, UNDP administrator and former Belgian prime minister, emphasizes that even if the war ends, its impact will persist, especially in poorer countries where people may be pushed back into poverty. He notes that those who had previously escaped poverty are now at risk of falling back into it. The report outlines three scenarios for the war's impact. In the worst-case scenario, involving six weeks of major disruption to oil and gas production and eight months of higher costs, 32.5 million people globally could fall into poverty. The UNDP uses the upper-middle-income poverty line, an international standard defined as income below $8.30 per person per day, calculated by the World Bank. To mitigate these effects, the UNDP suggests targeted and temporary cash transfers to protect vulnerable households in developing nations, estimating a cost of about $6 billion to neutralize the shocks for those falling below the poverty line. The agency also recommends interventions like temporary subsidies or vouchers for essential services. The news comes as Western governments face criticism for cutting aid spending amid economic pressures and increased defense spending. The UNDP and other international agencies stress the importance of maintaining or increasing development aid to support countries hardest hit by the economic fallout.

The US has announced plans to blockade the Strait of Hormuz, a vital waterway through which about 20% of global oil passes. This move comes after ceasefire talks with Iran ended without an agreement over the weekend. The blockade, threatened by President Donald Trump, aims to pressure Iran into reopening the strait, which has been effectively closed since February 28. Trump's announcement on social media stated that the US Navy will begin the process of blockading any and all ships trying to enter or leave the Strait of Hormuz. He accused Iran of 'WORLD EXTORTION' and threatened that any person who attacked US vessels would be 'BLOWN TO HELL!' However, the blockade's scope appears to have been scaled down, with US Central Command (Centcom) stating it would be confined to vessels transiting through Iranian ports, permitting passage of ships headed to ports belonging to America's Gulf allies. The blockade is set to come into effect at 10am ET (2pm GMT). The UK will not be involved in any blockade of the strait, and Australian Prime Minister Anthony Albanese has stated that his country was not asked to participate. Oil prices have surged following Trump's announcement, with US crude increasing 8% to $104.24 a barrel and Brent crude oil rising 7% to $102.29. Experts warn that the blockade could lead to higher oil prices, but much depends on its 'scope and implementation.' The managing director of research at ClearView Energy Partners, Kevin Book, noted that leaner volumes generally mean tighter markets and higher prices. Iranian and/or Houthi reprisals against Gulf producers' alternative routes could drive prices still higher. The blockade could cut off one of the Iranian regime's major sources of funding but might also have a short-term negative effect on global prices. About 100 tankers have transited the strait since the US and Israel started bombing Iran, most carrying Iranian oil products bound for China and India. Iran's Revolutionary Guards have stated that any warships approaching the strait to enforce a blockade would be considered in breach of the current ceasefire and would be dealt with strongly. Trump floated the possibility of a resumption of US strikes inside Iran, citing missile factories as one possible target.

How shaky is the Iran‑US ceasefire? The question underscores growing concerns among analysts about the durability of the truce that has held between Tehran and Washington since the latest diplomatic outreach.While the ceasefire has prevented direct military clashes, underlying mistrust and competing strategic interests continue to cast doubt on its long‑term viability. Observers point to recent diplomatic exchanges, economic sanctions, and regional proxy activities as potential flashpoints that could reignite hostilities.Experts caution that any misstep—whether a perceived violation of the agreement or an escalation in proxy conflicts—could quickly erode the fragile peace, prompting a renewed cycle of confrontation that would affect not only the two nations but also the broader stability of the Middle East.

The United States is exploring multiple avenues to broker a ceasefire and bring an end to the conflict. According to John Feehery, there are seven key approaches that America can take to achieve this goal. Diplomatic engagement is crucial, involving direct talks with conflicting parties to negotiate a peaceful resolution. The US can leverage its global influence to facilitate dialogue and foster an environment conducive to compromise. Another strategy involves economic incentives, where the US offers financial benefits to parties that agree to a ceasefire. This approach can motivate warring factions to consider peace as a viable option. International cooperation is also vital, as the US can work with other nations and international organizations to apply collective pressure on conflicting parties. This collaborative effort can enhance the credibility and effectiveness of ceasefire negotiations. The US can also employ military de-escalation tactics, aimed at reducing tensions and creating a conducive environment for peace talks. By demonstrating a commitment to de-escalation, the US can build trust with conflicting parties. Furthermore, humanitarian assistance can play a critical role in supporting affected populations and demonstrating the US's commitment to alleviating human suffering. This approach can help create a positive atmosphere for ceasefire discussions. Strategic communication is another essential strategy, involving clear and consistent messaging to conflicting parties, regional stakeholders, and the international community. Effective communication can help manage expectations and promote a unified approach to peace. Lastly, the US can focus on post-conflict reconstruction, offering support for rebuilding and development once a ceasefire is in place. This long-term perspective can encourage parties to commit to a lasting peace.

Saudi Arabia has returned its East‑West oil pipeline to full operational capacity, enabling the transport of approximately 7 million barrels of crude per day after a series of attacks disrupted flow earlier this week. In a statement released on Sunday, the Ministry of Energy praised the swift repair work, noting that the turnaround demonstrates the high operational resilience and crisis‑management efficiency of Saudi Aramco and the broader national energy system. The ministry also confirmed that production at the Manifa oilfield—situated off Saudi Arabia’s eastern coast—has been restored to its full capacity of about 300,000 barrels per day (bpd). Efforts continue at the inland Khurais oilfield, which is still recovering from a loss of roughly 300,000 bpd. Earlier reports from the Saudi Press Agency indicated that attacks on a pumping station along the East‑West pipeline had cut daily output by 700,000 bpd. Simultaneous assaults on the Manifa and Khurais fields were said to have reduced combined capacity by 600,000 bpd. No party was identified as responsible for the attacks. The East‑West pipeline, linking the prolific Abqaiq field in the east to the Red Sea port of Yanbu, has become a vital conduit for international oil supplies, especially as Iran’s effective closure of the Strait of Hormuz has choked off about 20% of global oil shipments, driving up energy prices worldwide. Despite a fragile cease‑fire announced on Tuesday between the United States and Iran, maritime traffic through the strait remains severely limited. Data from S&P; Global show that only 22 vessels with active AIS transponders passed through the strait between Wednesday and Friday, a stark drop from the pre‑conflict average of 135 daily transits. Restoring the pipeline’s full capacity is expected to reinforce supply continuity for both domestic and international markets, providing a modest but meaningful cushion to the global economy as geopolitical tensions persist.

Day 44 of the US‑Iran war ended without a peace deal as a marathon 21‑hour session in Islamabad collapsed, jeopardising the fragile cease‑fire that has held since the conflict began over six weeks ago.Vice President JD Vance, leading the US delegation, told reporters that the lack of an agreement was "bad news for Iran much more than it’s bad news for the United States of America," before departing Pakistan.Pakistan’s Foreign Minister Ishaq Dar pledged that Islamabad would continue to facilitate dialogue between the two longtime adversaries.In Iran, officials downplayed expectations, noting that no one anticipated a settlement in a single session. State‑run IRIB quoted ministry spokesperson Esmaeil Baghaei saying the talks were never expected to conclude quickly. Meanwhile, Tehran residents expressed a mix of scepticism and hope after weeks of air attacks that have left a nation of 93 million people reeling; more than 2,000 Iranians have been killed in the US‑Israel‑Iran conflict.In the United States, Vance reiterated that the delegation left with a "final and best offer" for Iran, emphasizing that Washington had communicated its position repeatedly during the talks. He cited multiple conversations with President Donald Trump, Secretary of State Marco Rubio, Treasury Secretary Scott Bessent, and Central Command head Brad Cooper. Trump, however, maintained that the US had already "won" on the battlefield by eliminating Iranian leaders and key infrastructure, stating that a deal would not alter the outcome.The US military reported that two destroyers transited the Strait of Hormuz ahead of planned mine‑clearing operations – a first since hostilities began – though Iran’s state media claimed the joint command denied the movement.Academic David Des Roches of the Thayer Marshall Institute told Al Jazeera that while Washington clarified its stance, it did not shift its core demand: preventing Iran from acquiring a nuclear weapon.In Lebanon, Israel continued strikes, claiming to have hit a "loaded and ready‑to‑launch rocket launcher" in Jouaiya, southern Lebanon. Protests have erupted in Beirut against any direct Israel‑Lebanon negotiations. The Lebanese Ministry of Public Health reported at least 2,020 deaths and 6,436 injuries from Israeli attacks since March 2.In Israel, Channel 12 reported that a drone launched from Lebanon triggered sirens in the Upper Galilee before being intercepted.The stalemate has kept global oil and gas prices soaring, underscoring the broader economic ripple effects of a war that shows no sign of abating.

Three Very Large Crude Carriers (VLCCs) successfully navigated the Strait of Hormuz on Saturday, marking a rare movement of oil cargoes amid the fragile truce between the United States and Iran.The vessels – the Liberia‑flagged Serifos, and the China‑flagged Cospearl Lake and He Rong Hai – each can transport about 2 million barrels of crude, collectively representing a significant volume for a waterway that channels roughly 20% of the world’s oil and LNG shipments.According to data from the London Stock Exchange Group (LSEG) and analytics firm Kpler, the Serifos is chartered by Thailand’s state‑owned energy firm PTT. Loaded with Saudi and UAE crude in early March, it is slated to dock at Malaysia’s Malacca Port on April 21.The other two carriers, Cospearl Lake and He Rong Hai, are chartered by Unipec, the trading arm of Chinese energy giant Sinopec. Cospearl Lake, carrying Iraqi oil, is expected to reach China’s Zhoushan port on May 1, while the destination for He Rong Hai remains undisclosed.Earlier, a tanker named Ocean Thunder, chartered by a Petronas subsidiary, also transited the strait, underscoring a gradual, albeit limited, resumption of traffic.Despite these movements, hundreds of tankers remain stranded in the Gulf, awaiting clearance during the two‑week ceasefire. Their prolonged idling continues to pressure global energy prices, which have surged since Iran’s blockade began in late February.In addition to the loaded vessels, three empty tankers – Mombasa B, Agios Fanourios I, and Shalamar – were observed heading into the strait on Sunday to load fresh cargoes. Notably, Agios Fanourios I signaled a route to Iraq’s Basrah fields to pick up crude destined for Vietnam.Management firms such as Eastern Mediterranean Maritime, Cmb.Tech NV, and Pakistan National Shipping have not provided comments on the recent transits.While the passage of these three supertankers offers a modest relief to the global oil supply chain, the overall situation remains precarious. The continuation of the ceasefire and the resolution of Iran’s blockade will be critical determinants of oil market stability in the weeks ahead.

“The world is grown so bad that wrens make prey where eagles dare not perch,” wrote Shakespeare in *Richard III*. The line now echoes a hopeful development: the iconic golden eagle could once again soar over England after more than a century and a half of absence. The golden eagle, a bird with a wingspan of roughly 2 metres, was a common sight in Shakespeare’s England, yet it has been effectively extinct in the country since the death of the last native individual in 2015. Centuries of persecution by gamekeepers and farmers, who feared predation on lambs and game birds, drove the species to the brink. A feasibility study commissioned by Forestry England and released on Sunday pinpoints eight potential “recovery zones”—predominantly in northern England—where the habitat could sustain a viable eagle population. The report cautions that establishing breeding pairs may take **more than a decade**. In response, Environment Secretary Emma Reynolds announced an additional £1 million in species‑recovery funding. The money will underwrite a programme that could see juvenile eagles, aged six to eight weeks, released into the wild as early as next year. Reynolds said, “This government is committed to protecting and restoring our most threatened native wildlife – and that includes bringing back iconic species like the golden eagle. Backed by £1 million of government funding, we will work alongside partners and communities to make the golden eagle a feature of English landscapes once again.” Across the border, golden eagle numbers in southern Scotland have surged to record levels thanks to a major restoration project. Satellite tracking shows that some translocated Scottish birds are already venturing into northern England, offering a natural source of future colonisers. The new funding will support these cross‑border movements and enable targeted reintroductions. While experts anticipate that golden eagles could be regularly observed across northern England within 10 years, establishing a self‑sustaining breeding population will require a longer horizon. Mike Seddon, chief executive of Forestry England, explained, “The detailed findings of our feasibility study will guide us, with our partners at Restoring Upland Nature, to take the next steps toward recovering golden eagles in northern England. This DEFRA funding means we can build on the good work we have begun, engaging local communities, landowners and conservation organisations.” The £1 million allocation forms part of a broader £60 million species‑recovery fund announced by DEFRA. It aligns with the UK’s legally binding commitment to halt the decline in species abundance by 2030 and to reduce extinction risk by 2042 relative to 2022 levels.