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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

King Charles's upcoming visit to the White House to meet with Donald Trump is poised to be a delicate diplomatic situation. The king will have to navigate a complex web of potential insults and controversies, including Trump's past comments about the UK's military assets, his criticism of British politicians, and his unconventional social media posts.Historically, Charles has had his share of awkward encounters with US presidents. During his visit to President Nixon in 1970, officials awkwardly presented Nixon's daughter Tricia as a potential match for the then-young prince. Later, during a visit to Ronald Reagan, Charles was handed a cup of tea with the bag still in it, leaving him unsure of how to proceed.In contrast, Charles's meetings with the Clintons and Bushes were uneventful, and his 2015 meeting with Obama was notable for his frank discussion on climate change, which, although not necessarily polite, was a significant moment.However, the current situation with Trump is particularly challenging. Trump has publicly criticized the UK's military assets, including the HMS Queen Elizabeth and HMS Prince of Wales, bearing the names of members of the royal family. Additionally, Trump has made derogatory comments about Pope Francis, which could complicate relations between the US and the Vatican.The king will also have to address Trump's recent social media post featuring an AI-generated image of himself as Jesus, which could be seen as blasphemous or insensitive. Given Trump's unpredictable nature, it's uncertain what he might say or do during the visit.While it would be unprecedented for the king to cancel the visit, the situation is already out of the ordinary. It remains to be seen how Charles will navigate this complex diplomatic situation and maintain the dignity of his office.

A comprehensive study from Denmark has concluded that taking acetaminophen, commonly known as Tylenol, during pregnancy has no effect on later autism diagnoses in children. The research, which utilized Denmark's robust national healthcare system to track more than 1.5 million children born between 1997 and 2022, including 31,098 children who were exposed to Tylenol in utero, found no significant link between Tylenol use and autism. The study's findings contradict claims made by the Trump administration, which had suggested that Tylenol use during pregnancy was a major cause of autism in children. This led to a notable 16% drop in Tylenol orders for pregnant women in emergency rooms following the announcement. However, the new study provides reassurance that Tylenol is safe to use during pregnancy for pain relief and fever reduction. According to the study, autism was diagnosed in 1.8% of children who were exposed to Tylenol and 3% of those who weren’t. A similar 2024 study in Sweden found a marginal link that disappeared after considering siblings, suggesting that autism is strongly genetic. Health officials had previously announced a label change for acetaminophen, warning of a potential link to autism, which has now been called into question. Experts, such as Jeremy Faust, an emergency physician at Mass General Brigham and a health services researcher at Harvard Medical School, have noted that the words of health officials can significantly affect behavior, as evidenced by the drop in Tylenol orders. However, Faust also emphasized that Tylenol remains one of the safest options for pain control and fever reduction during pregnancy.

England and Spain meet again on Tuesday night in front of more than 70,000 at Wembley in the Women's World Cup 2027 qualifiers. This match comes eight-and-a-half months after they faced off in the Euro 2025 final, which England won.Spain has undergone significant changes since then, with a new head coach, Sonia Bermúdez, and a crop of emerging young players. Despite these changes, they remain unbeaten since the Euros with five wins and a draw in six matches. Bermúdez has already led them to the Nations League title.The visitors have a number of talented young players, including Fiamma Benítez, the 21-year-old Atlético Madrid midfielder, who has made a strong impact with seven goal contributions in the Champions League this season. Another player to watch is Vicky López, the Barcelona winger, who has become a regular starter.England head coach Sarina Wiegman believes that despite the changes, Spain's DNA remains the same: they want to have the ball and play dynamically. Wiegman noted that there might be some tweaks but the principle will be very similar.For England, Leah Williamson is an injury doubt due to a hamstring injury, but she has started training with her international teammates. Keira Walsh is set to win her 100th cap and Wiegman praised her vision and game understanding.England will have to make at least one change from the starting XI that beat Spain in Switzerland, with Ella Toone out injured. Jess Park is likely to start in her place.

Plans to alter the size of HS2 trains, aimed at maximizing capacity, may result in increased costs and fewer seats, potentially leading to slower services north of Birmingham. A senior government and rail industry figure, Chris Gibb, has warned against changing the train order.The original £2bn order for 54 high-speed trains, to be built by a joint venture of Alstom and Hitachi, was placed in 2021. However, the project has been under review since the cancellation of the northern leg of HS2 by Rishi Sunak in 2023. The initial plan was for the 200-metre, eight-carriage units to double into 16-carriage trains, similar in size to a Eurostar. But this will only be feasible on the new line between London and Birmingham, as existing stations like Manchester Piccadilly cannot accommodate a 400-metre train.Gibb, a non-executive director of DfT Operator, expressed concerns that if HS2 opens with eight-coach trains, they would be full, leaving people behind. He suggested that instead of varying the train order, which could incur extra costs and delays, the government should retain the original order and plan to replace the current Pendolino fleet with longer, faster, modern versions around 2040.This approach, Gibb argued, would provide a significant increase in capacity, revenue, and a reduction in journey times on all routes without the need for further railway construction. Lord McLoughlin, former transport secretary, and Lord Berkeley, a long-term HS2 sceptic, have backed Gibb's idea, emphasizing the importance of consistent rolling stock for future use.A spokesperson for HS2 Ltd stated that no changes have been made to the original order, and they are still working closely with the manufacturer and the DfT to finalize train designs. The trains will be built in Derby and Newton Aycliffe.

Conversations about mundane topics are often dreaded, but research suggests that people enjoy them more than they anticipate. A study involving 1,800 volunteers found that participants enjoyed chatting about dull subjects, such as the stock market or vegan diets, more than they expected. The findings indicate that by avoiding potentially dull exchanges, individuals may miss out on the mood boost and health benefits that come with connecting with others. Elizabeth Trinh, a PhD candidate in management and organisations at the University of Michigan, noted that people tend to underestimate how interesting and enjoyable conversations about boring topics can be. Trinh and her colleagues conducted a series of experiments to gauge how people responded to conversations on dull topics. Participants were asked to predict how much they would enjoy discussing topics they considered boring, and then engage in brief conversations about those topics. The results, published in the Journal of Personality and Social Psychology, showed that people consistently found the conversations more enjoyable than they expected. The surprise enjoyment arises because individuals base their expectations on static components, such as the topic and the other person, rather than dynamic components, like the conversation itself. Trinh suggests that people may benefit from lowering the bar for what makes a conversation worth having and reframing conversational goals. Instead of focusing on enjoyment, individuals could think about what they might learn from the conversation. Nicholas Epley, a professor of behavioural science at the University of Chicago, added that the fear of a boring conversation shouldn’t prevent people from starting one. “If a conversation is boring once you’re in it, you also have a surprising amount of power to make it better!”

Elon Musk's X has taken a firm stance against clickbait and low-quality content by reducing payments to users who engage in such practices. The platform has cut payouts by 60% for 'aggregators' who repost news stories without adding significant value, with further reductions of 20% planned. This move is part of X's effort to promote high-quality, original content and prevent the platform's timeline from being flooded with low-quality posts.According to Nikita Bier, X's head of product, the platform will impose permanent deductions on users who excessively use 'BREAKING' in their posts, a tactic often employed to attract clicks without adding substance. The goal is to incentivize creators to produce original material that adds value to the platform.Under X's creator revenue sharing program, users with at least 500 verified followers and 5 million views over a three-month period can earn a share of advertising revenue. However, the platform has begun to scrutinize the type of content that qualifies for monetization, with some users reporting that their payments have been stopped or significantly reduced.The crackdown on low-quality content comes as X prepares to float on US markets as part of Musk's SpaceX empire. The platform is seeking to maintain a high-quality user experience and attract advertisers by promoting valuable and original content.In response to the changes, some users have expressed support for the policy, with Candace Owens, a right-wing US commentator, commenting that 'this is a good policy'. Others, however, have expressed concern about the impact on their earnings and the lack of transparency in X's moderation process.

The ongoing global finance talks between the International Monetary Fund (IMF) and the World Bank Group (WBG) have taken a contentious turn. Governments are being urged not to mention climate change, despite its growing impacts and the pressing need for climate finance.The climate crisis has significant implications for developing countries, which are already paying billions to repair damage from droughts, floods, and storms. The World Bank Group aims to devote 35% of its funding to climate-related activities, but US pressure may hinder these efforts.US Treasury Secretary Scott Bessent has demanded the removal of some climate finance targets from the World Bank's aims, insisting on an 'all-of-the-above approach to energy' that includes financing for gas, oil, and coal. This move has sparked alarm among other countries, including large developed economies.Experts warn that sidelining climate change discussions would be disastrous for the developing world. Mohamed Adow, director of the Power Shift Africa thinktank, described the situation as 'beyond absurd', emphasizing that fossil fuels and the climate emergency are inextricably linked.The World Bank is the biggest single source of climate funding, and many donor countries channel their climate finance largely through the multilateral development banks. At the Cop29 UN climate summit in Azerbaijan in 2024, countries agreed that at least $1.3tn a year should flow to the developing world by 2035 to help countries cut greenhouse gas emissions and cope with the impacts of extreme weather.Lord Stern, a former World Bank chief economist, suggested that much could still be achieved without formally labelling projects as climate-related, emphasizing that investing in low-carbon infrastructure and energy systems is crucial for sustainable development.

Britney Spears, one of the most iconic pop artists in US history, has taken a significant step towards recovery by voluntarily entering a rehabilitation centre after her arrest in March for driving under the influence (DUI). The arrest occurred in Ventura County, California, where Spears was stopped by police for driving erratically. The tests revealed the presence of drugs and alcohol in her system, leading to her brief detention. Her manager at the time described her actions as 'completely inexcusable' and emphasized that Spears would take the necessary steps to comply with the law and make overdue changes in her life. This recent development marks another chapter in Spears' journey, which has seen her step back from her music career in recent years. Her last album was released in 2016, and her most recent chart success was in 2022 with 'Hold Me Closer,' a collaboration with Elton John that reached the US and UK Top 10. In 2024, Spears expressed her intention to never return to the music industry, stating a preference for ghostwriting for other artists. Additionally, in January, she mentioned that she would never perform again in the US, though she hoped to perform in the UK and Australia. Spears has also made headlines with her memoir, 'The Woman in Me,' published in 2023, which is currently being adapted for the big screen. Her career has not been without challenges, including a conservatorship arrangement in 2008 that lasted until 2021, which significantly impacted her personal and financial independence. Spears' decision to seek rehab is seen as a proactive step towards addressing her challenges and regaining control over her life. The journey ahead will likely be closely followed by her fans and the media, given her status as a cultural icon.