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The Road to Wembley Hull City owner Acun Ilicali is set to take his team to Wembley for a chance to secure a Premier League spot. The Turkish media mogul has been at the helm of Hull since January 2022 and has overseen a tumultuous period, including multiple coaching changes and playoff battles. The Coaching Carousel Ilicali has changed coaches several times, which some attributed to his ego. However, he claims it was due to his 'lack of ego,' as he aims to correct mistakes and find success. The current coach, Sergej Jakirovic, was appointed after a series of changes, and Ilicali is optimistic about the team's chances. Overcoming Adversity The team has faced challenges, including the 'spygate' scandal involving Southampton. Despite this, Hull secured sixth place on the final day and defeated Millwall to reach the playoffs. Ilicali is proud of his team's achievement and believes they have a good chance of promotion. Financial Commitment and Future Plans Ilicali has invested significantly in the team, spending over £100m and owning every player who started the recent win against Millwall. He is committed to long-term recruitment and is optimistic about the team's future prospects. Premier League Ambitions If Hull City secures promotion, Ilicali is aware of the challenges they will face in the Premier League. He cites Sunderland as an example of a team that can survive their first season and progress. Ilicali is not afraid of failure but is focused on helping the team learn and grow.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Sudden Loss of a Racing Legend Longtime teammates, former rivals and others around the sports world have joined the wave of condolences over the sudden death of Nascar driver Kyle Busch on Thursday. Busch, a two-time Cup Series champion who was the winningest driver across the sport's three series in history, died at 41 after being hospitalized earlier Thursday with a severe illness. No cause of death has been announced. Tributes from the Racing Community "Absolutely cannot comprehend this news," Denny Hamlin, a 22-year Nascar veteran and Busch's former teammate, said on social media. "We just need to think of his family during this time. We love you KB." "There aren't really words for today. I've raced against Kyle for a long time, and anyone who's lined up next to him knows exactly what made him special, he gave you everything he had, every single lap, and he made all of us better for it," driver Ricky Stenhouse Jr said in a post. "But more than the wins and the records, I keep thinking about Samantha, Brexton, and Lennix, and the entire Busch family right now. That's where my heart is. Rest easy, Rowdy. The sport won't be the same without you." A Legendary Career Busch was in his fourth season at Richard Childress Racing. He ranked 24th in the Cup Series standings, with two top-10 finishes in 12 races this season, and had been the Cup Series champion in 2015 and 2019 with Joe Gibbs Racing. He won a Nascar Truck Series race at Dover International Speedway last week and was slated to compete in this weekend's Coca-Cola 600 in Charlotte, North Carolina, before his family announced on Thursday he had been hospitalized. The Impact on the Racing World Dale Earnhardt Jr, an on-track rival after he took over Busch's car after he departed Hendrick Motorsports in 2007 who later became a friend, called Busch one of the "greatest drivers in Nascar history". "Kyle and I had a really challenging existence for many years. But we luckily took the time to figure out our differences and that was something he instigated with a conversation in his bus around how we each managed our racing teams. I was super eager for us to get on better terms. But it was he who made the effort for that to be possible," Earnhardt said. "I will never be able to make sense of this loss but I am thankful that we had found a way to become friends."

The Disco Legend Returns to the SpotlightLost in Music, He's the Greatest Dancer, Thinking of You and We Are Family – many artists would long for just one of these songs at any time in their career, but for Sister Sledge they all appeared on a single side of one of their albums. As she brings these and the rest of the disco group's still-sensational catalogue to the Electric Paradise festival this summer, Kathy Sledge will be joining us to answer your questions.The Rise of Sister SledgeKathy is one of four Sledge sisters along with Debbie, Joni and Kim, who formed the group as children in the mid-1960s, picking up gigs at churches and local events in their home city of Philadelphia as the Sledge Sisters. After flipping the name around, they got a record deal and their first chart success came in the UK in 1973, with the Top 20 hit Mama Never Told Me.The Chic Collaboration That Defined an EraFurther commercial success eluded them for a few years – though that's no reflection on the quality of early disco material such as Pain Reliever – until their label paired them with Chic's Nile Rodgers and Bernard Edwards. Sister Sledge's poise and charisma shone from the aforementioned hits the pair wrote for them, collected on the album We Are Family. The title track reached No 2 in the US and it, along with the others, endure as pinnacles of the disco era.Chart Success Through the DecadesRemixed versions of those songs came back around in 1984 and 1993, each to great success particularly in the UK, though the group's only UK No 1 single was in a very different style in 1985, with the swaying neo-60s pop of Frankie.A Solo Career and Continued PerformancesKathy took the lead vocal on some of their biggest hits, and after Sister Sledge went on hiatus in 1987, she had a solo career interspersed with occasional Sister Sledge reunions, and later – amid some legal wrangles with her sisters – solo tours of Sister Sledge material. Next up she'll perform at Electric Paradise in Milton Keynes, on 8 August, alongside other legends of the era such as Grace Jones, Candi Staton, Kool and the Gang and more.Your Questions for the Disco IconNow 67, Kathy has been in countless nightclubs and recording studios around the world across her multi-decade career, so there's plenty to ask her. Post your questions in the comments below before 6pm GMT on Wednesday, and we'll publish her answers later in the week.

The Latest Escalation in Lebanon Israeli attacks have killed at least 11 people in southern Lebanon, including several healthcare workers. The attacks occurred on Friday in the Tyre district and are the latest in a long line, questioning the durability of the shaky United States-mediated ceasefire between Israel and Lebanon. Details of the Attacks At least 11 people killed in Israeli attacks in southern Lebanon Several healthcare workers among the dead, including paramedics and a child Attacks occurred in the Tyre district, including in the municipality of Deir Qanoun en-Nahr and the town of Hannaouiyah The Humanitarian Impact More than 400 people have been killed by Israeli fire since the ceasefire came into force in mid-April. Israel insists it will continue to target the Hezbollah armed group, which opposed the Lebanese government’s agreement on the ceasefire. At least 2,896 people killed in Lebanon since Israeli attacks began More than 8,824 injured and over 1.6 million displaced – about one-fifth of the country’s population The Systematic Destruction of Health Facilities The Israeli military has repeatedly attacked health facilities and medical teams in Lebanon, accusing Hezbollah of using them to conceal weapons and fighters. The Lebanese government rejects that claim. 116 healthcare workers killed since the latest escalation in early March 16 hospitals damaged and 147 ambulances attacked The Future Outlook A ceasefire brokered by the United States came into effect in mid-April, but the violence has continued, and Hezbollah has continued to trade attacks with Israel. The US has imposed sanctions on individuals with links to Hezbollah, including Iran’s ambassador to Lebanon.

The Lead: Russia's Escalation and Ukraine's Counteroffensive Russia's attempts at escalation via Belarus, where it has delivered more nuclear weapons and held highly publicized joint war games, come as its ground war falters in Ukraine. Ukrainian commander-in-chief Oleksandr Syrskii reports that Ukraine has seized the tactical initiative, with Ukrainian offensive assaults now outnumbering Russian assaults on Ukrainian positions. Russia's Soldier Shortage and Recruitment Crisis Ukraine's forces have gained the upper hand because Russian forces are running out of soldiers to conduct offensive operations. According to Syrskii, "Since the beginning of 2026, the total losses of the enemy have already exceeded 141,500 people, of which more than 83,000 are irreversible." Ukraine's Foreign Intelligence Service believes Russia is unable to replenish these losses of more than 1,000 people a day, and this year is recruiting at a rate of 800-930 a day, suffering a net decrease of battlefield strength. In response, 40 Russian regions have increased sign-up bonuses by between 30 and 100 percent. Putin has also simplified citizenship procedures for Russian speakers in the Transnistrian region of Moldova, which Ukrainian President Volodymyr Zelenskyy described as "Russia looking for new soldiers." Economic Impact: Ukraine's War on Russian Oil Infrastructure Russia's economy is fraying, having run up a $78.4bn deficit in the first four months of 2026 after budgeting for a $50.5bn deficit for the entire year. "Oil dealt the main blow. Revenues from hydrocarbons fell by 38.3 percent," according to Ukraine's Foreign Intelligence Service. Ukraine has scaled up its long-range campaign against Russian refineries and oil export terminals, depriving Moscow of windfall profits from high oil prices. International Energy Agency (IEA) data shows Russia has curtailed production by 460,000 barrels per day (bpd) in April 2026 compared with April 2025. Reuters estimates that Ukrainian drone attacks knocked out about 700,000 bpd of refining capacity between January and May across 16 refineries, accounting for a quarter of Russia's refining capacity. Shift to Asymmetric Warfare: Ukraine's Strategy Evolution "Given our limited resources, to effectively resist a much larger enemy, we are trying to shift from a 'war of attrition' to an asymmetric strategy," Syrskii told the European Union Military Committee. "Our main tasks are to stop the enemy's advance and effectively counterattack, strike at the Russians' rear, including deep within their territory." Ukraine has attacked military-industrial targets in a 100km radius around Moscow, including the Angstrem semiconductor plant, the Solnechnogorsk oil pumping station, and the Moscow Refinery. Ukraine has also targeted refineries in Ryazan, Yaroslavl, Kstovo, and Sizran, as well as military hardware including helicopter gunships, amphibious craft, and anti-aircraft missile systems. Belarus Front: Russia's Nuclear Escalation and Ukraine's Warning Russia has put pressure on Belarus President Alexander Lukashenko to open a new front in the war against Ukraine. Zelenskyy stated that Russia would launch a simultaneous attack from its neighboring region of Bryansk against Chernihiv. "We know that there have been additional contacts between the Russians and Alexander Lukashenko aimed at persuading him to join new Russian aggressive operations," Zelenskyy said. Russia involved Belarus in a joint nuclear exercise with 64,000 personnel, more than 200 missile launchers, 140 aircraft, 73 surface ships and 13 submarines. Russian President Vladimir Putin confirmed that the two countries would launch ballistic and cruise missiles as part of the exercise. Russia has parked its new Oreshnik tactical nuclear missile in Belarus since last year and has threatened to attack European arms manufacturing and military sites with it.

The LeadMajor US social media companies including Meta's Facebook and Instagram platforms have blocked the accounts of Saudi Arabian dissidents so they are no longer visible inside the kingdom, following orders by Saudi authorities. Those affected include Abdullah Alaoudh, a US-based activist and vocal critic of Saudi human rights violations, and Omar Abdulaziz, a Canada and UK-based activist who worked closely with Jamal Khashoggi before the journalist's murder by Saudi agents in 2018.The Platform Response to Government DemandsAt least seven accounts had been blocked by Meta at the end of April, including those of two American citizens and two individuals based in Europe, according to the advocacy group American Committee for Middle East Rights (ACMER). Meta did not respond to the "dirty work" claim, but provided a statement to the Guardian saying that when "something happens" on one of its platforms that is reported as violating local law but not the companies' own community standards, the company may restrict the content's availability in the country where it is alleged to be unlawful.Meta operates a public "transparency center," where it acknowledges that Saudi authorities contacted the company and sought restrictions on a total of 144 Instagram accounts, Facebook pages, and Facebook profiles during April. The site also shows that Meta restricted access to 108 "items".Inconsistent Approaches to Government RequestsInterviews with some of the dissidents targeted suggest the companies approached by Saudi authorities did not all respond in the same way. While Meta did alert users that their content was being blocked due to a "local legal requirement, or a request from a government," Snapchat appears to have slowed or removed accounts in Saudi Arabia – including one used by Abdulaziz – without alerting the account owners of the change. It is not clear how many Snapchat accounts were affected, and its owner, Snap Inc, declined to comment.At least two users of X, which is owned by Elon Musk, received letters informing them that the platform had received a request from the Saudi communications, space and technology commission claiming their accounts violated Saudi laws. X told users including Abdulaziz that it had not taken any action on the reported content yet, writing that the company "strongly believes in defending and respecting the voice of our users". It then urged addressees to seek legal advice if they wished, or to delete the relevant content voluntarily.Human Rights Concerns and ImplicationsAbdulaziz told the Guardian: "I think this is just the introduction to a massive crackdown by the Saudi government to mute opposition. It could go as far as committing atrocities, just like they did with the murder of Jamal Khashoggi." The Saudi government did not respond to a request for comment, sent through the Saudi embassy in Washington.Other accounts targeted include those of individuals linked to the London-based human rights organisation ALQST, including its founder, Yahya Assiri. Dr Maryam Aldossari, an ALQST board member, stated: "These [account holders] are not dangerous actors; they are people documenting abuses, challenging state propaganda and giving voice to Saudis inside the country who cannot speak freely. Blocking these accounts would not protect public safety, it would project authoritarian power from scrutiny."The Future of Digital DissentDr Aldossari further commented: "This is how authoritarian censorship travels: through legal notices, platform pressure and the attempted outsourcing of repression to global technology companies." As social media platforms continue to navigate the complex landscape of international laws and human rights standards, the case of Saudi dissidents highlights the growing challenge of maintaining free expression in an increasingly interconnected digital world where governments increasingly seek to control online discourse beyond their borders.

The Arrest That Sparked International ConcernThe operation began at 9am Moscow time, but took place across all of Russia's 11 time zones. Almost simultaneously, agents of the federal security service (FSB) raided the homes and workplaces of 17 Indigenous rights activists. Officers carried out searches, confiscated laptops and phones, and arrested and interrogated activists about participation in international forums. Most were let go; many have since left the country. Others remain in Russia, but will no longer speak up.Six months later, one remains in jail. Daria Egereva, one of Russia's foremost Indigenous rights activists, is accused of membership of a terror group. No trial date has been set. Her supporters say the charges are fabricated and she has been targeted for speaking out.Egereva was not just any activist. A member of the Selkup indigenous group, from western Siberia, she was a "bright star" of Russia's indigenous rights movement. As a member of the UN's Indigenous Peoples' Coordinating Body, she had international status. Weeks before her arrest, she had played a key role at Cop30 in Brazil as co-chair of the Indigenous People's Forum on Climate Change.Her jailing has shone a spotlight on the plight of Russia's Indigenous people, threatened by authoritarianism, extractivism and climate breakdown.The Climate Crisis in Russia's Arctic"They are really seeing the worst effects of climate change," said Alicia Moncada, director of global advocacy at Cultural Survival, which campaigns for Indigenous rights. "They are on the frontline of the frontline – that's why [Egereva's] advocacy was super important."The polar north is heating faster than any other part of the planet. In recent decades, temperatures in Arctic regions have risen three to four times faster than the global average. Communities based on permafrost are seeing their world collapse around them."The elders are saying that nature has stopped trusting us," said one exiled Indigenous leader, who requested that his name be withheld. "The traditional ways of predicting nature are not working any more."Many settlements sit next to the banks of rivers and lakes. Due to the melting permafrost, those banks are beginning to crumble. "There is a real threat of destruction for a lot of those villages," said the leader, who spoke through an interpreter. And the melting ice has brought a new source of tension: newly accessible critical mineral resources.Resource Extraction and Indigenous Displacement"All these resources of the Russian Federation, a majority of them are located under the lands of Indigenous people: gold, diamonds, oil, gas, coal," the leader said. "For some people it is a treasure, but for us it is a curse."Because the companies are coming to our land for those resources and they are pushing us out. Even if they don't push us out, the environmental situation in those places will become so bad that we are unable to hunt or fish."One of the elders said that we can adapt to anything, but we will not be able to survive without our land."The Government Crackdown on Indigenous ActivismAlthough Indigenous groups maintained their identities, by the end of the Soviet era they lacked independent organisation and relied on the state. Egereva had been part of a new generation of leaders who had encouraged community self-empowerment.But this assertiveness brought them into conflict with the authorities. Even before the war in Ukraine, the Russian state claimed that its enemies were exploiting environmental and indigenous issues. Now, with the war a pretext for a crackdown on civil society, Indigenous people are among those at the sharp end.To date, 830 organisations and 20,813 individuals have been put on the "list of terrorists and extremists", according to the UN. Among them was Aborigen Forum, a network of Indigenous defenders designated an "extremist organisation" in July 2024.Russian authorities have based their charges against Egereva and her co-defendant, Natalia Leongardt, a civil rights activist, on their involvement with Aborigen. Authorities claim it is part of an anti-state "post-Russia free nations forum".International Response and Russian DefenseIn a bail hearing on 29 April, Egereva and Leongardt denied being part of any anti-state conspiracy. "I am not familiar with and do not know this organisation," Egereva told the court. "What we are being accused of is completely untrue ... I ask to be allowed to return home and embrace my children."The court refused to grant them bail, remanding them in custody until at least mid-June. The following day, Russia celebrated a new federal holiday: the "Day of Indigenous Small-Numbered Peoples".The Russian embassy told the Guardian: "The investigation concerning Daria Egereva is an internal Russian legal matter, conducted in full accordance with Russian law. As proceedings are ongoing, we are not in a position to comment on the specifics of the case."Russia firmly rejects any allegations of violations of Indigenous people's rights. Unlike a number of western states – including Britain in its former colonies – Russia has no history of forced assimilation of Indigenous communities. Russian law affords Indigenous peoples special legal protections, guaranteeing their collective and individual rights, cultural identity, and linguistic heritage under the constitution and in line with international norms."Russia is actively engaged in the international climate agenda, taking account of both the challenges and the economic opportunities emerging in its northern regions – including expanded access to the northern sea route and mineral resources in permafrost zones. All such projects are carried out with the aim of supporting regional development, creating jobs and attracting investment, including for the benefit of Indigenous communities in these areas."

The Legacy of Mohamed Salah at Liverpool Mohamed Salah's departure from Liverpool marks the end of an era for the Egyptian forward, who has been a key player for the club since his arrival in 2017. With 257 goals and 441 appearances, Salah has cemented his place in Liverpool's history books. A Career of Achievements Third-highest goalscorer in Liverpool's history Won the Premier League title, Champions League, and numerous other honors Four-time Premier League Golden Boot winner Hat-trick of clean sweeps of the Professional Footballers' Association and Football Writers' Association footballer of the year awards The Impact of Salah's Departure Salah's departure has been marked by controversy, with the player publicly criticizing manager Arne Slot and the team's style of play. However, it is seen as a necessary move for both parties, with Salah seeking a new challenge and Liverpool looking to refresh their squad. The Future for Salah and Liverpool As Salah moves on to a new chapter in his career, Liverpool will look to build on the foundations he has helped establish. With a legacy that will be remembered for generations to come, Salah's impact on the club will not be forgotten.