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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

The mockumentary, a once-thriving film genre, seems to be losing its luster. Charli XCX's 'The Moment' and 'Spinal Tap II: The End Continues' are recent examples of films that have failed to recapture the magic of their predecessors.Historically, mockumentaries were a staple of comedy, with directors like Christopher Guest and Rob Reiner pushing the boundaries of the genre. Films like 'This Is Spinal Tap' and 'The Rutles: All You Need Is Cash' remain classics, celebrated for their improvisational style and satirical humor.However, the current crop of mockumentaries seems stale, relying on celebrity cameos rather than genuine comedic innovation. Even 'Spinal Tap II,' starring Guest, feels like a nostalgia exercise, struggling to recreate the original's charm.In contrast, smaller, independent projects like 'Rap World' and 'Nirvanna the Band the Show the Movie' are breathing new life into the genre. These films, made on shoestring budgets, use mockumentary techniques to create authentic, humorous stories that resonate with audiences.The decline of the mockumentary genre raises questions about its future. Can it be revitalized, or has it become a relic of the past? Only time will tell, but for now, it seems that the mockumentary needs a fresh perspective to regain its former glory.

In the spring of 2002, the modest Free Butt pub on Brighton’s seafront buzzed with a restless energy. Future stars such as Natasha Khan, then a university art student, danced atop the bar while the Yeah Yeah Yeahs thundered through their first UK dates. Behind the scenes, band frontmen like Guy McKnight of Eighties Matchbox B‑Line Disaster served pints, and budding engineers like Steve Ansell of Cat on Form fine‑tuned the sound. The atmosphere felt like a rite of passage, where any performer could slip from a cramped stage to national attention.Unlike the neatly branded scenes of New York’s garage‑rock revival or London’s Libertines‑driven hype, Brighton’s early‑2000s scene resisted a single aesthetic. Rock groups emerged from rehearsal rooms and tiny clubs with wildly different looks and sounds, creating a cultural mosaic rather than a monolithic movement.Electrelane’s guitarist recalls recording their debut Rock It to the Moon in a studio once owned by the Levellers, and crafting their sophomore effort inside a former public toilet. These unconventional spaces proved surprisingly fertile, underscoring the city’s DIY spirit.By the turn of the millennium, the big‑beat dominance of Fatboy Slim and Skint Records had faded, making way for a grassroots rock surge. Sea Power relocated from Reading to Brighton, drawn by the city’s “dilapidated charm and fresh sea air”. Their self‑organized Club Sea Power nights at the Lift offered a chaotic yet liberating platform that eventually caught Rough Trade’s attention.Women played a pivotal role in shaping the scene’s infrastructure. Promoters Lisa Lout and Anna Moulson, both still active, booked seminal shows—including the Strokes’ first UK gig at the Lift in 2001—and helped launch the Great Escape festival. Their efforts ensured that bands such as the Pipettes, Electrelane and Bat for Lashes could share stages and media coverage.Artists recall the city’s palpable sense of belonging. Rose Dougall of the Pipettes describes a landscape where “alternative culture was on every street, from vintage shops to the colour of the houses,” and where “small venues made it feel attainable to launch a project.” Similarly, Brakes frontman Eamon Hamilton contrasts Brighton’s walk‑able, collaborative vibe with London’s darker, more competitive energy.Music journalism mirrored the scene’s intensity. Everett True and photographer Steve Gullick launched Careless Talk Costs Lives in 2002, a deliberately short‑run magazine that championed female writers and bands at a time when the industry was still heavily male‑dominated.As rents surged through the 2010s, many of the cheap flats, rehearsal rooms and iconic venues that underpinned the scene vanished. The Free Butt closed, independent record stores shuttered, and the once‑abundant low‑cost infrastructure dwindled, prompting a migration of creative energy down the coast to places like Margate, Ramsgate, Folkestone and Shoreham.Nevertheless, the remnants of Brighton’s network continue to nurture new talent, from the Kooks to Dream Wife and Gazelle Twin. The city’s strength lies not in a singular sound but in its capacity to host a “constant collision of wildly dissimilar bands,” allowing artists to develop authentically and fearlessly.

Cornish film-maker Mark Jenkin has brought his latest film, Rose of Nevada, to his hometown of Newlyn in Cornwall. The film, a ghostly time travel tale, has received excellent early reviews and features Jenkin's signature authentic storytelling.Jenkin, who is from Newlyn, expressed his pride in Cornwall, stating, “This is the greatest town in the world. I see Cornwall as being at the centre of the world.” He emphasized the importance of showcasing Cornwall's culture and community in his films.The film was shot entirely in Cornwall, using a clockwork Bolex camera and featuring a working fishing boat. Jenkin's vision for his homeland is central to the film, rather than using it as a backdrop.Jenkin's success has put a spotlight on Cornwall, with other filmmakers, such as Brett Harvey and Dan Simpkins, highlighting the growing recognition of regional film-making. Laura Giles of Screen Cornwall noted that Jenkin is a “talisman for Cornish film-making” and that there are other emerging filmmakers in the region.The film's producer, Denzil Monk, emphasized the importance of sustainability and inclusivity in the production, stating, “We try to step very lightly” in terms of impact on the environment and community.

The vastness of space has always been a profound source of inspiration and terror for humanity. The recent launch of the Artemis II space mission brought this into sharp focus, as the tiny Orion craft and its four-person crew drifted silently through the void, further and further from home. This sense of cosmic isolation is a feeling that video games have long sought to capture.In his autobiography, Apollo astronaut Michael Collins described the experience of being left alone in the command module while Neil Armstrong and Buzz Aldrin walked on the moon: 'I am alone now, truly alone, and absolutely isolated from any known life. I am it. If a count were taken, the score would be three billion plus two over on the other side of the moon, and one plus God knows what on this side.'Games like Elite, No Man's Sky, and Outer Wilds have attempted to evoke this sense of solitude and vulnerability. Outer Wilds thrusts players into a time loop on a doomed planetary system, while Xenonauts 2 challenges players to manage Earth's defenses against alien invaders. These games, and others like them, concentrate not on generational starships or laser wars, but on small crews in tiny pods, the weight of the universe stacked against them in the dark.Other notable mentions include Alien: Isolation, Freelancer, Homeworld, and Out There, which all capture the minimalist elements of space travel – often just isolated noises and details. As Tracey McGarrigan noted, even classic games like Solaris on the Atari 2600 managed to evoke a sense of loneliness and awe.For those interested in exploring these themes further, the article recommends checking out Xenonauts 2, available on PC, with an estimated playtime of over 30 hours.

Donald Trump's decision to accept a two-week ceasefire in Iran has created a stir within his Make America Great Again (MAGA) movement, with some supporters expressing mixed reactions to the development. While some have defended the president's decision, others have accused him of betrayal and capitulation.The ceasefire, which was agreed upon after more than a month of war, has been hailed as a victory by both the US and Iran. However, critics argue that the agreement has failed to achieve its objectives, with Iran's regime still intact and its nuclear facilities persisting. The strait of Hormuz remains closed, and fighting continues in Lebanon.Dinesh D'Souza, a right-wing commentator, defended Trump on social media, stating that the president had outsmarted his critics and proved himself to be the adult in the room. Similarly, Matt Schlapp, chairman of the American Conservative Union, expressed confidence in Trump's decision-making, citing his real, actionable intelligence.However, not all supporters are convinced. Matthew Feinberg, a self-described 'MAGA Jew', expressed disappointment, stating that the ceasefire allows the IRGC to regroup and rearm. Laura Loomer, an activist and Islamophobe, also criticized the outcome, saying that the negotiation didn't yield any significant benefits for the US.The Pew Research survey found that, among Republicans, there had been an 18-point decline in confidence in Trump's policymaking about Iran since 2024. Despite this, Republicans aged 65 and older remain overwhelmingly confident in Trump's ability to make good decisions on Iran.

Footage captured on the streets of Tehran shows small groups of citizens gathering around Enghelab Square – a historic rally point for pro‑regime supporters – some waving Iranian flags, others draped over their backs. The atmosphere is far from uniform; debates and arguments erupted shortly after the ceasefire announcement, reflecting a spectrum of emotions from shock to tentative hope.The video, posted by Majid Nouri – son of former prison official Hamid Nouri – includes his running commentary. He notes that the discussions began around 3 a.m. and continued into the morning, with participants expressing both anger and disbelief. "In no way do we trust America," Nouri declared, echoing a sentiment he says is shared by virtually every Iranian.Pro‑government demonstrators were heard chanting "Death to America, death to Israel, death to compromisers!" and burning U.S. and Israeli flags, according to the Associated Press. The chants persisted despite attempts by organizers to calm the crowd, underscoring the depth of anti‑Western feeling among hardliners.While the ceasefire halted active hostilities, the war has already claimed at least 1,900 lives in Iran. With internet services largely blacked out, gauging the broader public mood is challenging, but pockets of Tehran reported subdued celebrations in the early hours of Wednesday.Local resident Ali, a 31‑year‑old, summed up the prevailing uncertainty: "Most people here don’t trust the US and still don’t know exactly what is going to happen, so they are unsure whether they should be happy or worried." He warned that the ceasefire’s two‑week duration offers no guarantee of lasting peace.Business owners are beginning to test the waters. Hamid, a 43‑year‑old shopkeeper whose grocery and cleaning‑supplies store closed after the February bombings, said, "Today feels like there is no war," and he has reopened his shop, hoping to recover lost income for his family.Iranian officials are framing the pause as a diplomatic victory. Former foreign minister Ali Akbar Velayati posted on X that the conflict has reshaped the global power balance, positioning Iran within a new multipolar order. President Masoud Pezeshkian praised the ceasefire as the fruit of the blood of Iran’s “great martyred leader” and the collective will of the people.Strategically, the ceasefire highlights Tehran’s ability to disrupt the vital Strait of Hormuz, a chokepoint for global oil shipments. Analysts note that this leverage could bolster Iran’s negotiating stance, even as former U.S. President Donald Trump previously warned that a full‑scale clash would threaten "a whole civilisation." As sunrise illuminated the capital, daily life resumed with shops reopening and traffic returning to the streets, yet the prevailing mood remains a blend of exhaustion, cautious optimism, and lingering mistrust of the United States.

Health‑service workers have voiced strong unease after it emerged that engineers from the controversial US tech firm Palantir were issued NHS.net email accounts. Those accounts unlock a directory containing contact details for as many as 1.5 million NHS staff members, as well as access to SharePoint file‑sharing and Microsoft Teams groups used by the service. Palantir’s engineers are supporting the rollout of the Federated Data Platform (FDP), a £300 million contract awarded in 2023 to link patient records across disparate NHS systems. The government touts FDP as a cornerstone of its plan to "reinvent the NHS" by moving from analogue to digital, promising faster diagnoses, better appointment allocation and more personalised treatment. While the use of NHS email accounts by external suppliers is not unprecedented, Palantir’s reputation for AI‑driven surveillance and military‑grade technology has amplified staff, patient and human‑rights concerns. Rory Gibson, a resident doctor, warned that his personal contact details should not be accessible to a company that also works on drone‑strike systems. The Guardian has identified at least six Palantir engineers who have been given NHS.net credentials. In response, a Palantir spokesperson argued that such access is "normal practice for government suppliers" and cited official guidance that government systems are more secure than external alternatives. Palantir claims its software has already yielded measurable benefits: 110,000 additional operations, a 15.3% reduction in discharge delays and a 6.8% rise in cancer diagnoses within 28 days of referral. The company stresses that it merely provides software, with data usage remaining under NHS control and subject to strict contractual confidentiality. David Rowland, director of the Centre for Health and the Public Interest, acknowledged that granting NHS email addresses may not breach rules but highlighted the "deep ethical concerns" that Palantir’s profit‑driven model clashes with NHS values. He called for a comprehensive review of which private firms receive public‑sector funding. Some NHS staff reported being placed in virtual Teams meetings with Palantir personnel who joined using NHS credentials, without any disclosure of their employer – a practice that further eroded trust. Under the NHSmail access policy, "independent sector organisations" delivering health and social‑care services nationally may use NHSmail. An unrestricted NHS.net account can reveal staff roles, locations, workplace details and even grant access to commercial "Blue Light" discounts. Palantir’s technology is already deployed by UK police forces and the Ministry of Defence, prompting critics to warn that its "drag‑and‑drop" interoperability could facilitate state overreach, including a potential British analogue of the US Immigration and Customs Enforcement agency. The firm’s founders include US businessman and former Trump supporter Peter Thiel and CEO Alex Karp, both known for advocating aggressive surveillance tools. Its UK arm is led by Louis Mosley, grandson of historic British fascist leader Oswald Mosley. An NHS spokesperson reiterated that all suppliers, including Palantir, operate strictly under NHS instruction, with data access governed by robust contractual confidentiality obligations.

The recent conflict between the US and Iran has resulted in a devastating war with no winners. Despite Donald Trump's claims of victory, the two-week ceasefire announced is not a triumph, and the war may not be over. The Iranian regime has not undergone regime change, and less experienced but more hardline figures are now in charge.The conflict has killed thousands in the region, including children, and left many more exhausted, terrified, and traumatized. The war has also spooked markets, raised prices at home, and shown signs of fracturing Trump's Maga base. The US has squandered tens of billions of dollars, burned through its interceptors, and torched relations with allies.Israel has achieved none of its stated aims and is left with a weaker but less predictable adversary. The Iranian regime can count survival as a kind of success, but senior leaders are dead, its economy is on its knees, and essential infrastructure has been smashed. The people are likely to face yet greater repression.The war has destabilized the region and normalized talk of war crimes, further trashing the idea of a rules-based order. Restrictions on transit will continue to damage humanitarian aid operations and raise prices worldwide, hitting the poorest hardest.The only real winners are arms manufacturers, Russia, and arguably China, at least for now. This is a strategic defeat for the US that will resound for decades, and a clear sign of its systemic failures.