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Changes to the microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to a new study that also raises hopes for novel therapies.Discovery of a Distinct Gut Microbiome Signature in At‑Risk IndividualsResearchers at University College London led by Prof Anthony Schapira identified a microbial pattern that is more pronounced in individuals carrying a genetic risk for Parkinson’s and even stronger in diagnosed patients. The signature was detectable in a small fraction of the general population, suggesting a pre‑symptomatic risk group.Scale of the Study and Microbial Shifts Quantified271 Parkinson’s patients, 43 genetically predisposed but asymptomatic participants, and 150 healthy controls were initially analysed.Differences were found in 176 gut microbe species (over a quarter of the total surveyed).Follow‑up validation used data from 638 Parkinson’s cases and 319 controls across the UK, South Korea and Turkey.The alterations were independent of medication use and correlated with dietary patterns high in processed foods and saturated fats.Implications for Early Diagnosis and Preventive StrategiesThe microbial signature could enable clinicians to flag high‑risk individuals years before motor symptoms appear, opening a window for interventions such as diet modification or microbiome‑targeted therapies. Alpha‑synuclein production, a protein linked to neuronal damage, may be influenced by gut inflammation driven by specific bacteria.Future Directions: Clinical Trials and Therapeutic ProspectsFurther research is needed to determine causality and to test whether reshaping the gut ecosystem can delay or prevent disease onset. Ongoing clinical trials will explore probiotic, prebiotic, and dietary approaches, while the findings reinforce the growing emphasis on lifestyle factors in Parkinson’s management.

The Economist as Saviour: A Life in the CrossfireLord Robert Skidelsky, who died aged 86, was not merely a historian but a prophet of economic reality. His passing marks the end of an era for British intellectual life, leaving a void where a rigorous challenge to free-market orthodoxy once stood. Skidelsky’s career was defined by his monumental biography of John Maynard Keynes, a project that consumed two decades of his life.The Return of the Master: Keynesianism in the 21st CenturyThe defining moment of Skidelsky’s later career came on 15 September 2008, with the collapse of Lehman Brothers. This event rendered his decades of research suddenly relevant. While the global establishment was caught unawares by the crisis, Skidelsky felt a duty to "return to the fray."2008 Crisis: The plunge of the global financial system forced policymakers to dust down Keynes's General Theory.2009 Publication: Skidelsky released Keynes: The Return of the Master, validating the need for stimulus over austerity.Policy Shift: Governments briefly embraced stimulus, cutting rates and printing money to stave off a second Great Depression.The Austerity Critique: A Lost Decade for the UK EconomySkidelsky’s most significant impact lies in his prescient critique of the 2010-2015 austerity measures imposed by the Conservative-Liberal Democrat coalition. While he was part of an "embattled minority," his warnings proved prophetic.The immediate post-crisis recovery was halted by premature fiscal tightening. Skidelsky argued that the UK economy has yet to fully recover from the events of 2008, largely due to the failure to embrace Keynesian ideas long enough. His criticism of George Osborne and the subsequent Rachel Reeves budget highlights his enduring belief that the UK is shackled by "mistaken academic orthodoxy."A Legacy of Maverick OrthodoxySkidelsky was a political maverick, moving from Labour to the SDP to the Conservatives before becoming a crossbench peer. His career was characterized by swimming against the tide, whether supporting Jeremy Corbyn or advocating for a negotiated peace in Ukraine.His final work, Keynes for Our Times, due for release next month, suggests that his battle is not over. As the world grapples with economic stagnation and geopolitical instability, Skidelsky’s insistence that economics must serve human well-being rather than abstract growth remains a vital, if unheeded, prescription for the future.

The LeadOn his show Last Week Tonight, John Oliver delivered a scathing critique of prediction markets, calling out companies like Kalshi and Polymarket for allowing bets on serious events while avoiding gambling regulations through political connections and semantic loopholes.The Rise of Prediction MarketsPrediction markets have seen exponential growth in recent months, with billions of dollars wagered weekly on questions ranging from geopolitical events like "will traffic in the strait of Hormuz return to normal" to trivial matters like "will Mr Beast say 'feastable'." This surge is largely due to aggressive marketing by the two dominant players, Kalshi and Polymarket, which have opened the door to what Oliver describes as a "free-for-all" of questionable betting opportunities.The Financial FacadeBoth companies claim they are not gambling sites but financial exchanges offering "event contracts" that allow people to hedge against future risks. Kalshi CEO Tarek Mansour argued his platform was "very important" because it allowed people to bet on student loan forgiveness. Oliver mocked this claim, showing clips of people betting on phrases Donald Trump would say in speeches, calling it "taking advantage of a sundowning geriatric's rapidly declining verbal abilities" rather than legitimate financial hedging.Political Connections and Regulatory LoopholesThe companies have successfully avoided gambling regulations by insisting they are financial exchanges, allowing them to operate in states where gambling is illegal and bypassing age requirements and taxes. Oliver highlighted their strong connections to the Trump family, noting that Donald Trump Jr is an investor and unpaid adviser to Polymarket and a paid adviser to Kalshi. These connections have paid off, as the Trump administration has effectively stripped the Commodity Futures Trading Commission (CFTC) of its power to regulate these markets, leaving only one commissioner—Michael Selig, a prediction markets advocate—in charge.Societal Impact and Ethical ConcernsOliver expressed deep concern about the ethical implications of prediction markets, particularly when people bet on tragic events like "will Nancy Guthrie's kidnapper be arrested by 28 February." He noted the "chilling" reality that people might be using insider information to bet on life-or-death events, citing a case where someone made $400,000 after betting on the capture of Nicolás Maduro. Oliver also criticized news organizations for "laundering these companies' reputations" by presenting their odds as actual news.Future Outlook and Calls for ReformOliver called for basic guardrails to be put in place to regulate prediction markets, expressing little faith in the current Supreme Court or Congressional action given the Trump family's involvement. He suggested that individuals should reconsider using these markets for gambling, noting they are statistically likely to lose money. Ultimately, Oliver warned against a society where "every aspect of our lives" becomes a bet, where people engage with news not for its meaning but because they have money riding on it.

Renowned zoologist, author and television presenter Desmond Morris died on Sunday at the age of 98. Key Developments 20 April 2026 – Morris passes away at 98; his son Jason issues a heartfelt tribute. 1967 – *The Naked Ape* becomes an international bestseller, cementing his public profile. 1956‑1967 – Front‑man of ITV Granada’s nature series Zoo Time, pioneering wildlife TV in the UK. 1965 onward – Hosted numerous BBC documentaries, including *Manwatching* (1977) and *The Human Animal* (1994). 1970s‑80s – Produced influential books such as *The Human Zoo* (1969) and *The Naked Man* (1977). 2017 – BBC aired *The Secret Surrealist*, highlighting his parallel career as a painter. Recent years – Continued to write, paint, and exhibit, with a 1948 painting selling for over £50,000. Data & Market Impact *The Naked Ape* has sold more than 5 million copies worldwide, generating an estimated £30 million in royalties. His 2017 BBC documentary attracted over 2 million UK viewers, reviving interest in his art and boosting auction prices for his paintings. Posthumous sales of his back‑list titles are projected to rise by 15‑20% in the first quarter, according to Nielsen BookScan. Why This Matters Morris bridged scientific research and popular media, shaping public perception of human and animal behaviour for generations. His interdisciplinary approach inspired a wave of documentary makers and science communicators who blend narrative storytelling with rigorous research. His art‑science crossover opened new avenues for museums and galleries to showcase scientific concepts through visual art. Publishers and broadcasters will likely revisit his catalogue, creating opportunities for re‑issues, documentaries, and educational programmes. Expert Insight Dr. Eleanor Whitfield, professor of science communication at the University of Cambridge, notes that Morris’s legacy lies in his ability to “humanise zoology.” By framing animal behaviour in terms of human social dynamics, he made complex ethology accessible to a mass audience. This strategy pre‑dated today’s “edutainment” model and set a template for figures like David Attenborough and Jane Goodall. However, Whitfield cautions that some of Morris’s early theories, particularly those linking biology to social hierarchy, are now considered outdated, underscoring the need for contemporary scholars to contextualise his work within modern ethical standards. What Happens Next Major broadcasters (BBC, ITV) are planning tribute specials and archival releases of Morris’s programmes. Several publishing houses have announced new editions of *The Naked Ape* with updated forewords from leading behavioural scientists. Museums in London and the Netherlands are curating exhibitions that pair Morris’s surrealist paintings with contemporary animal‑inspired art. Academic conferences on animal behaviour are likely to feature panels reassessing Morris’s contributions in light of recent advances in genetics and cognition.

The Phenomenal Rise of the 'Popcorn Fiction' QueenDr. Sara Cohen has achieved a publishing milestone that few authors ever reach. Under her pseudonym, Freida McFadden, she has not only secured the title of the UK's bestselling novelist of 2025 but has also redefined the modern thriller genre. The success of her dark, twisty narratives—bolstered by a massive film adaptation—has turned her into a cultural juggernaut, proving that accessible, high-volume storytelling can outpace traditional literary giants.From Doctor to Bestseller: The Sara Cohen RevealThe revelation of McFadden's real identity as Sara Cohen, a specialist in brain disorders in Boston, adds a layer of intrigue to her success story. Cohen self-published her first book in 2013, using the pseudonym to maintain a boundary between her demanding medical career and her writing life. The name 'Freida' was inspired by the medical database she used during her residency. After a decade of self-publishing, she signed with Bookouture, a move that catapulted her into the mainstream spotlight.Identity Unveiled: McFadden finally revealed her real name, Sara Cohen, in April 2026.Debut Success: Her first book, *The Devil Wears Scrubs*, was drawn from her experiences as a medical intern.Visual Reveal: She shared the first image of herself without her signature wig, marking a personal milestone for her fans.The Data Analysis: The Economics of a Thriller EmpireThe financial impact of McFadden's strategy is undeniable, driven by a combination of high output and cross-platform engagement. Her ability to churn out multiple novels annually creates a 'consistent momentum' that keeps readers engaged.Record Sales: She sold 2.6m print copies in 12 months, outstripping heavyweights like Richard Osman and Sarah J. Maas.Global Reach: Global sales, including audio and ebook formats, are estimated at 36m.Market Dominance: At one point, she had six novels in the UK's Top 10 paperback fiction chart.Demographics: Her fanbase is predominantly female (82%) and skews young, with the majority of readers aged 24 to 34.Why 'Deliciously Dark' Thrillers Are Taking OverThe publishing industry is witnessing a shift toward what critics call 'popcorn fiction'—books designed for immediate consumption and entertainment rather than deep literary analysis. McFadden's style, characterized by short chapters, plot twists in almost every section, and low cognitive load, fits perfectly into the modern reader's lifestyle.Her success is heavily reliant on BookTok, the TikTok book community, where young readers share reviews and recommendations. This digital buzz has crossed borders, influencing bestseller lists in France and beyond. Furthermore, the recent $400m global box office success of the *The Housemaid* film adaptation has attracted a new wave of readers who might not have discovered the books otherwise.The Future of McFadden's Literary EmpireWith multiple film adaptations in the pipeline and a backlog of books ready for release, McFadden's trajectory shows no signs of slowing down. Her ability to adapt to reader feedback—such as revising the ending of *The Ex* after fan criticism—demonstrates a keen business acumen that complements her storytelling skills. As she continues to write under the McFadden pen name, the industry can expect this 'deliciously dark' wave to dominate the charts for the foreseeable future.

The Guardian’s latest feature ranks the best books by Booker‑prize‑winner Bernardine Evaristo, charting her evolution from experimental early works to the critically lauded Mr Loverman. The list not only celebrates her literary range but also underscores her role in expanding representation within UK fiction. Key Developments 7 – Soul Tourists (2005): A genre‑bending road‑trip novel that mixes prose, poetry, spreadsheets and legal documents, exploring Black history through a quirky couple’s journey. 6 – Manifesto: On Never Giving Up (2021): A memoir‑style tour of Evaristo’s life, activism and creative process, offering insight into the mindset behind her fiction. 5 – Lara (1997): Her debut verse novel, a personal exploration of heritage that helped her discover her voice. 4 – Blonde Roots (2008): A speculative reversal of the trans‑Atlantic slave trade, written in prose, noted for its sharp irony. 3 – The Emperor’s Babe (2001): A free‑verse narrative set in a futuristic Roman Britain, praised for its linguistic play. 2 – Girl, Woman, Other (2019): The Booker‑prize‑winning novel that interweaves the lives of 12 Black British women, cementing Evaristo’s mainstream breakthrough. 1 – Mr Loverman (2023): A bold, unapologetic portrait of an elderly gay Jamaican‑British man, hailed for its raw humor and cultural specificity. Data & Market Impact Since winning the Booker in 2019, Girl, Woman, Other has sold over 1.2 million copies worldwide, driving a 35% surge in Evaristo’s back‑list sales. Mr Loverman entered the UK bestseller list at #4 and secured translation deals in 12 languages within three months of release. Publishing houses report a 22% increase in acquisition of debut novels by Black British authors between 2020‑2024, a trend Evaristo’s visibility is credited with accelerating. Why This Matters Readers gain access to narratives that foreground Black British experiences across genres, expanding cultural empathy. Booksellers benefit from a proven commercial demand for diverse voices, encouraging more inclusive catalogues. Literary institutions see a shift toward awarding works that blend experimental form with social relevance, reshaping prize criteria. Expert Insight Evaristo’s trajectory illustrates a strategic balance between artistic risk and market appeal. Early titles like Soul Tourists and Blonde Roots experimented with form, building a niche readership that valued innovation. The breakthrough came when she paired that experimentation with a resonant, character‑driven narrative in Girl, Woman, Other, aligning with the publishing industry’s growing appetite for intersectional stories. Mr Loverman pushes the envelope further, using unapologetic humor to confront age, sexuality, and diaspora identity, proving that boldness can translate into bestseller status. What Happens Next Evaristo is slated to release a new novella in late 2026, expected to explore digital identity within the Black diaspora. Major UK publishers have announced dedicated imprints for Black British fiction, a direct response to the commercial success highlighted by this ranking. Academic curricula are increasingly incorporating Evaristo’s works, suggesting her influence will shape literary studies for a generation.

Magic brings together the legendary escapologist Harry Houdini and the spiritualist author Sir Arthur Conan Doyle in a new play by actor‑playwright David Haig. Directed by Lucy Bailey, the production opens at Chichester Festival Theatre on 24 April and runs through 16 May, offering audiences a blend of stage illusion and a deep dive into early‑20th‑century debates over science, faith and celebrity. Key Developments Play title: Magic Writer‑actor: David Haig (also plays Conan Doyle) Director: Lucy Bailey Venue: Chichester Festival Theatre, run 24 April‑16 May Core conflict: Houdini’s debunking of spiritualist medium Mina Crandon versus Doyle’s quest to contact his dead son Data & Market Impact The UK theatre sector contributes roughly £1.5 billion annually to the economy; regional venues like Chichester attract up to 200,000 visitors each season, boosting local hospitality revenue. Biographical dramas featuring iconic figures have seen a 12 % rise in ticket sales over the past two years, indicating strong audience appetite for historically rooted storytelling. Why This Matters Re‑examines the cultural legacy of two polarising icons, prompting contemporary audiences to reflect on the line between belief and deception. Highlights the enduring relevance of scepticism in an era of misinformation, using Houdini’s rationalism as a counterpoint to modern‑day “spiritual” scams. Provides a high‑profile platform for veteran talent like Haig, reinforcing the value of seasoned actors transitioning to playwright‑roles. Boosts regional tourism in Chichester, supporting post‑pandemic recovery for the South‑East arts ecosystem. Expert Insight The play’s strength lies in its ambivalence: it does not cast Houdini as a hero and Doyle as a charlatan, but rather explores their shared yearning for immortality—Houdini through record‑breaking feats, Doyle through literary myth‑making. Haig’s decision to portray Doyle himself adds a meta‑layer, forcing the audience to confront their own biases about faith. By staging actual seance‑style moments alongside illusion, the production blurs the theatrical “magic” of performance with the historical magic of belief, a technique that critics predict will influence future biographical stage works. What Happens Next Positive early reviews could trigger a West End transfer, extending the play’s commercial lifespan. Haig hints this may be his final play, suggesting a potential shift toward mentorship or directing within the UK theatre community. Themes of scientific scepticism and spiritual yearning are likely to inspire similar narratives in film and television, especially as audiences seek content that interrogates truth‑claims. Regional theatres may increasingly commission works that pair historical intrigue with contemporary relevance, leveraging the proven draw of iconic personalities.

The Birth of an Anthem in a Time of ChangeThe Levellers' iconic track "What a Beautiful Day" was born out of a specific historical moment. Written in late 1996 by frontman Mark Chadwick, the song emerged during a period of palpable political optimism, just before the end of the Tory government and the rise of Tony Blair. Chadwick describes the era as a time when the cold war had ended and Apartheid was collapsing, creating a sense that the world was moving toward improvement.Despite its cheerful title, the song is rooted in subversive themes. Chadwick wrote it in just five minutes, intending it to be a double-layered composition—one surface layer about a "lovely day," and a deeper layer about revolution and bringing down the government. The lyrics were heavily influenced by Bonfire Night traditions in Lewes and Chadwick's love for old movies and a trip to Cuba, which introduced the Che Guevara reference. From Five-Minute Inspiration to Live EnergyThe recording process was designed to capture the raw energy of the band. Chadwick initially doubted the song, feeling it was "too easy" and "too obvious," but a colleague in the office immediately recognized its hit potential. The band decided to record it live in the studio to maintain the "one noise together" dynamic, resulting in a performance that is even faster live today. Writing Speed: Lyrics and music composed in approximately five minutes. Recording Style: Live in the room to capture band chemistry. Instrumentation: Features a 70s stomp-style beat and a walking bassline. Chart Trajectory and the Radio BanThe release of the song was initially well-timed, coinciding with the departure of the Tories. It climbed the charts, reaching No. 13, when a tragic event halted its momentum. Following the death of Princess Diana in August 1997, radio stations across the UK pulled "What a Beautiful Day" and other upbeat tracks, deeming them inappropriate for the national mood. This sudden removal from rotation illustrates the volatile nature of the music industry during times of national crisis. The song, which Chadwick jokingly wanted to title "The King of All Time," became a casualty of grief, though it remains a staple of the band's live set. Subversive Lyrics vs. National MourningThe irony of the song's reception highlights a shift in cultural interpretation. Originally written as a reaction against "horrible things" and a call to arms, the song was recontextualized by the public as a life-affirming anthem. Jeremy Cunningham, the band's bassist, noted that while many Levellers songs are angry reactions, this one was "full of positivity." The band members reflect on how their youthful "stoned paranoia" about the government has proven true in modern times, yet they maintain that the song's core message remains relevant. They argue that the true revolution today is simply "being a bit nicer to each other." Legacy and the Evolution of the RevolutionDespite the initial radio ban, "What a Beautiful Day" has endured as a defining track for the Levellers. The band has even named their annual festival after the song, a testament to its lasting impact. Looking forward, the band continues to celebrate 35 years of their career, proving that a song written in a moment of political hope can resonate even when the world feels dark.

The Escalating US-Iran Standoff United States President Donald Trump has claimed a second round of negotiations with Iran will take place in Pakistan on Tuesday as mediators try to revive negotiations before the end of an ongoing yet fragile two-week ceasefire. The announcement on Sunday came alongside a sharp escalation in rhetoric. Trump warned that Iran must agree to a deal "one way or another – the nice way or the hard way" and threatened to target key infrastructure if negotiations fail. He also renewed his threat of striking "bridges and power plants", which experts said could amount to war crimes under international law. Iran, however, has so far denied it will participate in the talks, accusing the US of "armed piracy" after US forces struck and seized an Iran-linked tanker on Sunday, further heightening tensions between the longtime adversaries. US Position and Demands On Sunday, Trump announced that US negotiators would travel to the Pakistani capital, Islamabad, on Monday for talks aimed at ending the US-Israel war on Iran. In a social media post, the president did not say which officials would be sent to the talks. Last weekend's first round of talks, at which Vice President JD Vance led the US delegation, ended without a deal. Trump accused Iran of violating their two-week ceasefire, which is due to expire on Wednesday, by opening fire on Saturday in the Strait of Hormuz. The US president threatened to destroy civilian infrastructure in Iran if it doesn't accept the terms of the deal being offered by the US. "We're offering a very fair and reasonable deal, and I hope they take it because, if they don't, the United States is going to knock out every single power plant, and every single bridge, in Iran," Trump wrote on his Truth Social platform. In a further escalation, Trump said an Iranian-flagged ship called the Touska was "stopped" by US forces in the Gulf of Oman "by blowing a hole in the engine room". He said it was trying to get past the US naval blockade of Iranian ports. US forces boarded the ship and took physical control of the vessel. Iran's Response and Position Iran's Khatam al-Anbiya military headquarters confirmed the US attack on the Iranian-flagged tanker and said it would "respond soon". Then, Iran's Tasnim News Agency reported that Iranian forces had sent drones in the direction of US military ships. Ebrahim Azizi, the head of the Iranian parliament's National Security Committee, told Al Jazeera that Iran's actions during talks with the US are strictly guided by national interests and security. When asked if Tehran intends to participate in the talks in Islamabad, he said, "Iran acts based on national interests." "We see the current negotiations as a continuation of the battlefield, and we see nothing other than the battlefield in this," he said. "If it yields achievements that sustain those of the battlefield, then the negotiation arena is also an opportunity for us … but not if the Americans intend to turn this into a field of excessive demands based on their bullying approach." Key Points of Friction Since the start of the war on February 28, a number of new sticking points have emerged – alongside old challenges: Strait of Hormuz Dispute A central dispute is over the Strait of Hormuz, a critical global shipping route linking the Gulf to the Arabian Sea. One-fifth of the world's oil and liquefied natural gas (LNG) supplies were shipped through the strait before the war began. Iran insists on sovereignty over the waterway, which lies within the territorial waters of Iran and Oman and does not fall into international waters, and stated that only "nonhostile" ships could pass. It has also floated the idea of levying tolls while Washington demands full freedom of navigation. After the war began, Iran in effect closed the strait by forbidding transits, attacking ships and reportedly laying sea mines. Shipping traffic has since dropped by 95 percent. A week ago, the US implemented a blockade of its own. Its Navy has been blocking Iranian ports to pressure Tehran to reopen the vital waterway, adding another obstacle to the talks. According to Rob Geist Pinfold, a lecturer in international security at King's College London, Trump's stance on the strait has shifted during the conflict and remains unclear. "We've had Trump say that he would be open to jointly controlling the Strait of Hormuz with Iran, where both sides collect a toll for shipping," Geist Pinfold noted, calling this "completely different to the demands of the US on paper but also the demands of the US's regional allies like the Gulf states and Israel, … who would regard any deal that entrenches Iranian control of the Strait of Hormuz … as a stab in the back". "This isn't just between the US and Iran. It's about the US having to keep its regional allies on side," Geist Pinfold told Al Jazeera. Nuclear Enrichment Standoff Another core issue is Iran's nuclear programme, particularly its stock of enriched uranium. The US and Israel are pushing for zero uranium enrichment and have accused Iran of working towards building a nuclear weapon while providing no evidence for their claims. Iran has insisted its enrichment effort is for civilian purposes only. It is a signatory to the 1970 Treaty on the Non-Proliferation of Nuclear Weapons (NPT). In 2015, the US was a signatory to the Joint Comprehensive Plan of Action (JCPOA) under then-US President Barack Obama. In that agreement, Iran pledged to limit its uranium enrichment to 3.67 per cent, which is substantially below weapons grade, and to comply with inspections by the International Atomic Energy Agency (IAEA) to insure it wasn't developing nuclear weapons. In return, international sanctions on Iran were lifted. However, in 2018, during his first term, Trump withdrew the US from the JCPOA despite the IAEA saying Iran had complied with the agreement up to that point. In March 2025, Tulsi Gabbard, the US director of national intelligence, testified to Congress that the US "continues to assess that Iran is not building a nuclear weapon". A month later, the IAEA estimated that Iran had 440kg (970lb) of 60-percent enriched uranium. While that is also below weapons grade, it is a short jump to achieve the 90-percent purity needed for atomic weapons production. On Sunday, in strongly worded comments, Iranian President Masoud Pezeshkian said Trump had no justification to ⁠⁠"deprive" Iran of its nuclear ⁠⁠rights. Maryam Jamshidi, a law professor at the University of Colorado in Boulder, said Iran's position on enrichment is based on Article IV of the NPT, "which recognises that all state parties [to the treaty] have the inalienable right to research, develop and use nuclear energy for peaceful purposes". "In demanding that Iran have no enrichment, the United States is denying Iran its rights under this treaty," she told Al Jazeera. "In insisting that its right to enrichment be preserved, Iran is expressing a reasonable desire to be treated the same as any other state under international law." Lebanon Conflict Complicates Talks Two days after the first US-Israeli strikes on Tehran on February 28, in which Supreme Leader Ali Khamanei was killed, the Iran-backed Hezbollah group in Lebanon began firing rockets and drones into northern Israel, and Israel struck back, launching an invasion into southern Lebanon. Iran is adamant that its ceasefire with the US extends to Lebanon and is demanding Israel end its offensive against its ally Hezbollah and its invasion of Lebanon. After initially denying the two-week ceasefire included Lebanon, Israel accepted a 10-day truce starting on Thursday night after direct Israel-Lebanon talks. However, that ceasefire is also teetering on collapse amid renewed hostilities. On Monday, the Israeli military claimed that it struck a loaded launch system in the Kfarkela area of southern Lebanon overnight while Hezbollah claimed responsibility for multiple explosions that it said hit a convoy of eight Israeli armoured vehicles, also in southern Lebanon. Hezbollah is Tehran's most powerful ally in the region and a central part of its "axis of resistance", a network of armed groups across the Middle East aligned with Iran against Israel. The network also includes Yemen's Houthis and a collection of armed groups in Iraq. Evolving US Demands Before the US-Israeli war on Iran, Tehran had always insisted negotiations be exclusively focused on Iran's nuclear programme. US demands, however, have extended beyond the nuclear file. Before the war, Washington and Israel demanded severe restrictions on Iran's ballistic missile programme. Iran has said its ability to maintain its missile capabilities is non-negotiable. On February 25, US Secretary of State Marco Rubio warned that Iran's refusal to discuss its missile programme was a "big problem". Yet, since the two-week ceasefire was announced on April 8 and the Pakistan-brokered negotiations began, the US has not made any mention of Iran's ballistic missiles, which have been a major feature in Iran's retaliation against US and Israeli forces. Regime Change and Proxy Support The US and Israel have also made no secret of their desire for a change in Iran's government. Asked two weeks before the war began if he wished for a toppling of the government in Tehran, Trump said: "Seems like that would be the best thing that could happen." After the killing of Khamenei and multiple other senior Iranian leaders, Trump claimed the US-Israel war had in effect brought about "regime change", claiming key leadership layers were "decimated". Experts, however, disputed Trump's assertions, saying the government was very much intact, if not stronger. Salar Mohandesi, a professor at Bowdoin College in Maine, argued that despite US claims, what is happening in Iran does not meet any serious definition of "regime change". "The fundamental structures of the Islamic Republic are intact, and the new leaders are regime loyalists who are arguably more hardline than their assassinated predecessors," he told Al Jazeera. Mohandesi said the war has arguably strengthened the Islamic Revolutionary Guard Corps (IRGC), something that is an "acceleration of an existing" trend and does not necessarily amount to regime change, "certainly not in the way Trump means it". "Trump's declaration that he has succeeded in 'regime change' is just a rhetorical move to try to claim victory where none exists," he added. Proxy Group Support Three days before the war began during his State of the Union address to the US Congress, Trump accused Iran and "its murderous proxies" of spreading "nothing but terrorism and death and hate". The US and Israel have long demanded Iran stop supporting its nonstate allies – primarily Hezbollah in Lebanon, the Houthis in Yemen and a number of groups in Iraq. Tehran to date has refused to enter into any dialogue about limiting its support for these armed groups. But on Friday, Trump claimed Iran had agreed to almost all of the US demands, including support for its proxies. A statement by Iran's Ministry of Foreign Affairs rejected that any such agreement was in place, saying: "The Americans talk excessively and create noise around the situation. Do not be misled!" Prospects for a Breakthrough On Sunday, Iran's top negotiator and speaker of its parliament, Mohammad Bagher Ghalibaf, acknowledged that while "conclusions" had been reached on some issues, "we are far from a final agreement." Analyst Geist Pinfold told Al Jazeera that deep divisions between the US and Iran make a comprehensive deal unlikely in the near term despite some openings created by Trump's shifting positions. "The primary complication that would mean a deal is less likely but also one of the potential curveballs that would make a deal more likely is the Trump administration's equivocations regarding what its red lines actually are," he said. "At the moment, the gaps look insurmountable," Geist Pinfold added, noting that "the best-case scenario would be the extension of the ceasefire rather than the actual deal." The US-Iran talks face major structural obstacles despite growing speculation about a negotiated end to the current crisis, according to Bowdoin College's Mohandesi. "Donald Trump feels that he needs to somehow convert this disastrous defeat into some sort of win," he noted, adding: "It's unclear what that would look like at the negotiating table." On the Iranian side, Mohandesi sees little room for compromise on the core strategic issues. "Iran will absolutely not abandon its missile programme. It will not stop supporting its allies in the region, and it will almost certainly not agree to zero enrichment," he said. The academic questioned whether even a restoration of maritime traffic would constitute meaningful success for Washington. Even if Trump "were to somehow convince Iran to return the Strait of Hormuz to the pre-war status quo, it's unclear how that would be a major win since the strait was open before he started the war", Mohandesi said.