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The Lead: Unprecedented Cancer Treatment SuccessDoctors have hailed "unprecedented" trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.The Breakthrough: Amivantamab's Triple-Action ApproachThe jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.The smart jab targets cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumours grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumour.The Clinical Trial Data: Impressive Response RatesIn the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumours shrank or disappeared completely in 43 patients, including 28 whose tumours shrank significantly and 15 who saw them eradicated entirely.Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.The Impact Analysis: New Hope for Treatment-Resistant CancersKevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR), said: "These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy. This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. That is particularly significant, they said, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.The Patient Experience: Transforming Quality of LifeOne of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025. "I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I'm now on my 17th cycle of treatment and I'm very pleased with the progress so far."Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.The Future Outlook: Expanding Treatment ApplicationsThe results will be presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.Prof Kristian Helin, the chief executive of the ICR, said: "This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options. Achieving this level of tumour response and encouraging survival outcomes in such a challenging-to-treat group represents a significant step forward."

Paraguay have secured a spot at the 2026 World Cup by reverting to a gritty, defence‑first identity under Argentine coach Gustavo Alfaro, blending intensity with emerging talent such as Julio Enciso.Alfaro’s Defensive Blueprint and Formation ChoicesThe Argentinian coach arrived in August 2024 with a clear mandate: “Paraguayan DNA, intensity and clean sheets.” He has stuck largely to a classic 4‑4‑2 system, only shifting to a back‑five in the high‑altitude qualifiers against Ecuador and Bolivia. This structure emphasizes collective pressing, compact defending and quick transitions, allowing the side to absorb pressure and strike on the counter‑attack.Group D Fixture Schedule and Qualification Numbers12 June – vs USA, Los Angeles (6 pm local)19 June – vs Turkey, San Francisco (8 pm local)25 June – vs Australia, San Francisco (7 pm local)During qualifying Paraguay lost only once away (to Brazil), drew three high‑altitude matches, and sealed qualification with a 0‑0 home draw against Ecuador, prompting President Santiago Peña to declare a national holiday.Implications for South American Football and Paraguayan FansThe revival signals a shift away from the long‑standing possession‑centric approach that failed to deliver results. By prioritising defensive solidity and physical intensity, Paraguay joins a growing trend of South American teams adopting pragmatic tactics to compete on the world stage. The national euphoria also highlights football’s cultural weight in Paraguay, where a World Cup berth can trigger country‑wide celebrations.Projected Performance and Key Battles at the TournamentWith Alfaro likely to field the traditional 4‑4‑2 or an occasional 4‑2‑3‑1, Paraguay’s success will hinge on the form of star forward Julio Enciso and the midfield engine Andrés Cubas. If the side can replicate its qualifying intensity, it stands a realistic chance of advancing from Group D and pulling off at least one upset against higher‑ranked opponents.

The Struggle of Young First-Time Buyers The boss of Britain’s largest housebuilder has said it is the most challenging time to be a first-time buyer since the financial crisis, as the dream of home ownership moves increasingly out of reach for many young people. The Challenges Facing First-Time Buyers A combination of rising interest rates, higher levels of student debt and the squeeze on wages is making it “challenging, very, very difficult” for young people to get on the housing ladder, according to David Thomas, the departing chief executive of Barratt Redrow. Rising interest rates are increasing the cost of borrowing Higher levels of student debt are reducing available earnings for mortgage purposes Wage stagnation is limiting the ability to save for deposits The Impact on the Housing Market As a result, Thomas said the average age of a first-time buyer was increasing, which was among the factors leading “towards generational inequalities”. Zoopla reported that there are 6% fewer first-time buyers in the market than a year ago. The Call for Government Action Thomas is calling on the government to put in place a package focused on first-time buyers, adding that Barratt Redrow and other housebuilders have said they would be happy to contribute to such a package. The Future of Home Ownership “There are very big implications for the country if people are not getting on to the housing ladder and are going to rent on a permanent basis. Home ownership, in terms of the building of the homes, in terms of people owning their own homes, has big benefits for the country,” he said.

The Need for Air Conditioning in the UK British homeowners are rapidly acquiring air conditioners as the climate crisis superheats our summers. An estimated 4m homes have an air conditioner, double the figure from three years ago. Can Air Conditioning Be Green? Because air-conditioning units use more energy than other cooling devices, this results in more carbon emissions. Using a portable unit for an average of eight hours a day during the summer would result in about 4.87kg of CO2 emissions, roughly equivalent to driving 18 miles. Options for Greener Air Conditioning One approach could be running it only when there is a high level of renewable energy on the grid – for example during the sunniest part of the day. You may choose to pre-cool rooms before the evening peak in electricity demand. Or you could power the air conditioner with a home battery that charges up during renewable energy surpluses, helping you make the most of renewables without owning them yourself. Types of Air Conditioning It’s important to note that not all air conditioners are alike. Portable versions were relatively inefficient. If you invest in built-in air conditioning, make sure you get the right size unit for the room you’ll be cooling. A wall-mounted unit powerful enough (12,000 BTU) to cool the average British bedroom costs about £750, plus £1,150 for installation. Alternative Cooling Methods Air conditioners work using the same principle as heat pumps – they move heat from one place to another with the help of a refrigerant fluid. But the devices generally referred to as “air-to-air heat pumps” are reversible and can provide heating as well as cooling. Homeowners who switched from oil or gas heating to an electric-powered air-to-air heat pump, and used it for winter heating and summer cooling, were decarbonising their homes.

Iran has reasserted its control over the Strait of Hormuz, warning that foreign commercial and military vessels will be targeted if they do not comply with regulations governing passage through the strategic waterway.Iran's Assertion of Maritime SovereigntyThe announcement came after the United States signalled that President Donald Trump was close to a decision on a potential deal with Iran, though Tehran denied an agreement had been reached. The operational headquarters of Iran’s armed forces, Khatam al-Anbiya Central Headquarters, stated that the management of the Strait is exercised with full authority by the Islamic Republic.“All ships, commercial vessels, and tankers are only required to travel through the designated routes and obtain permission from the Islamic Revolutionary Guard Corps [IRGC] Navy,” the statement added. It warned that any violation would seriously jeopardise the security of their traffic.The High-Stakes Diplomatic StandoffThe situation is defined by a clash of demands. While the US seeks a deal ensuring Iran never develops nuclear weapons, Iran is demanding the immediate release of $12bn in frozen assets before proceeding to the next phase of negotiations.US Position: President Trump stated Tehran would remove mines from the strait and end its closure with “no tolls,” while the US would lift its blockade.Iranian Position: Adviser Mohsen Rezaei accused the US of “betraying diplomacy” and making excessive demands.Regional Military EscalationMilitary posturing remains high as both sides prepare for a potential breakdown in talks. Pentagon Chief Pete Hegseth stated that Washington was “more than capable” of restarting the war if a satisfactory deal is not reached.On the ground, tensions escalated with the shooting down of a drone described as belonging to the “US-Zionist enemy” by Iranian air defences. Meanwhile, US Central Command (CENTCOM) continues to warn Iranian ships against crossing the blockade line.Navigating the Path to a DealWith President Trump’s “final determination” pending, the coming days are critical for global stability. The stalemate over the $12bn assets and the reopening of the strait suggests that a diplomatic resolution is not imminent, leaving global markets on edge regarding the flow of oil through this critical chokepoint.

The Actor's Stand for EqualityLord of the Rings star and prominent activist Ian McKellen has joined a march against the criminalisation of LGBTQ+ people in Commonwealth countries, calling it an "appalling situation." The renowned actor lent his voice and visibility to protesters in central London, highlighting the ongoing legal persecution of LGBTQ+ individuals across nations that were once part of the British Empire.The Commonwealth Walk of ShameThe demonstration, officially billed as the "Commonwealth Walk of Shame," was organized by the Peter Tatchell Foundation and the Out and Proud African LGBTI Network. After being addressed by Sir Ian and Nigerian activist Babatunde Akanwale Osunseyi, marchers set off to protest outside the high commissions of eight Commonwealth countries that criminalize LGBTQ+ people. They began at the Nigerian High Commission before proceeding to those of Uganda, Papua New Guinea, Trinidad and Tobago, Ghana, Jamaica, Bangladesh and Sri Lanka.Global Scale of Anti-LGBTQ+ LegislationThe protest specifically highlighted laws in 29 Commonwealth countries where same-sex relationships remain illegal. In six of those nations, LGBTQ+ people face life imprisonment, while Uganda and Nigeria still carry the death penalty for same-sex relationships. Despite the march not being a "huge" gathering, Sir Ian hoped that "word will get back" to people in those countries that they are supported by international voices.Colonial Legacy of DiscriminationBefore addressing the crowd, Sir Ian explained the historical context of these laws: "When Britain had an empire, it introduced into countries far away from here the laws that we had in this country, including the laws against gay people." He noted that while these laws have been repealed in Britain, they "remain stuck in the remnants of the British empire now known as the Commonwealth." The actor emphasized that much of the anti-LGBTQ+ hatred seen across Africa and Asia was "exported there" by "cruel" colonial laws.Call for Commonwealth ActionSir Ian urged Commonwealth countries to "live up to the standards and declaration of the Commonwealth and repeal" these outdated laws. He pointed out that the Commonwealth never discusses this problem on its agenda, and hoped that events like this demonstration would "nudge politicians into talking about something which is of such concern." The crowd held up signs calling for King Charles to "apologise for previous monarchs" and highlighting "75 years" of homophobic persecution within the Commonwealth.The actor stressed that this demonstration was "not about hatred" but about "a love of justice, a love of equality." As a prominent figure with global recognition, Sir Ian's participation brought significant attention to the ongoing human rights issues facing LGBTQ+ individuals in many Commonwealth nations.

The Inflation Conundrum For such an uncannily successful politician, Donald Trump exhibits a perplexing political myopia. His most recent own-goal was endorsing Ken Paxton, a state attorney general, against four-term senator John Cornyn in the Republican primary for Senate in Texas. Trump's Inflationary Gambits What truly screams “I want us to lose the midterms” is what Trump is doing about inflation, which is becoming his most vulnerable issue. According to a New York Times/Siena poll of registered voters earlier in May, Trump’s approval on handling the cost of living is underwater by 42 percentage points. The Data Analysis Inflation rose at the fastest pace in three years in April, driven by the Iran war and other factors. The nationwide average price of regular gasoline is hovering around $4.50 a gallon, about $1.30 higher than a year ago. Consumer prices increased 3.8% in the year to April, their highest annual rate in two years. The Impact Analysis People’s attitudes about inflation are difficult to parse. They think less about the alphabet of indices policymakers focus on, such as CPI and PCE, and more about how much the price of eggs and gas have risen since they last remembered. The Prediction This may not be statistically robust, but since George HW Bush lost to Bill Clinton in 1992, there has been only one presidential election in a year with inflation as high as it is today. The incumbent, George W Bush, lost to Barack Obama.

The United States men’s national team has confirmed a 26‑man roster and will face Senegal (Charlotte) and Germany (Chicago) as its last tune‑ups before the 2026 World Cup. With a mid‑cycle coaching change and a star striker in a prolonged scoring slump, the friendlies are a decisive laboratory for Mauricio Pochettino to lock in his starting XI and bench options. USMNT’s Final Warm‑up Schedule and Tactical Uncertainties Pochettino admitted he has a provisional XI in mind but remains open to adjustments after training sessions. The coach is unlikely to field a full‑strength side in both matches, preferring to experiment with formations that could shift between a 3‑2‑5 in possession and a 4‑4‑2 or 5‑3‑2 out of possession. Pulisic’s Goal Drought: Numbers That Matter Since 1 January, Christian Pulisic has taken 38 shots for Milan without scoring. In March friendlies he added 6 more attempts with no goal. He has logged 1,164 consecutive minutes for club and country – roughly 13 full matches – without finding the net. The striker’s dry spell is a focal point; a goal before the tournament could restore confidence and influence his role, potentially moving him from a half‑time substitute back to a starter. Defensive Options: Freeman’s Role and the Wing‑Back Conundrum The squad lists ten defenders, suggesting flexibility between a back‑four and a back‑three with wing‑backs. Alex Freeman emerges as a versatile option, having featured in all eight post‑Gold Cup friendlies and capable of operating as a traditional right‑back or a wide centre‑back in a three‑man defence. Freeman played all but three minutes of the US’s six‑match Gold Cup run. He started three of Villarreal’s final La Liga games at right‑back. His performance will determine whether he backs up Sergiño Dest or competes with Joe Scally for minutes. Bench Firepower: Reyna, Balogun and the Emerging Super‑Sub The expanded roster creates room for impact substitutes. Gio Reyna is the most obvious candidate, despite limited club minutes (520 Bundesliga minutes across 19 games for Borussia Mönchengladbach). His last season with over 625 league minutes was 2020‑21. Striker depth includes Folarin Balogun, who offers quick‑turn‑and‑shoot ability, and the contrasting styles of Ricardo Pepi (13 goals in 35 caps) and Haji Wright (7 goals in 20 caps). Both could earn bench minutes as tactical switches in the latter stages of matches. What the Friendlies Reveal About USMNT’s World Cup Prospects If Pulisic breaks his drought against Senegal, he may retain a starting spot, allowing Pochettino to rotate other attackers. Conversely, a strong showing from Reyna or Balogun could cement a super‑sub role that changes the team’s late‑game dynamics. Defensive clarity—whether the US adopts a three‑centre‑back system with wing‑backs or sticks to a traditional back‑four—will hinge on Freeman’s performances and Dest’s fitness. The outcomes of these two matches will shape the tactical blueprint for the group‑stage opener against Paraguay on 12 June.

The Lead: This Week's Entertainment HighlightsThis week's entertainment landscape offers a diverse array of critically acclaimed shows and films, from hilarious comedies to chilling horror. Channel 4's "Make That Movie" stands out as one of the funniest shows of the year, while Netflix's "The Four Seasons" returns with a brilliant second season. Horror fans can explore the disturbing world of "Backrooms," while Marvel offers a stylish take with "Spider-Noir."TV Comedy Gold: Make That MovieChannel 4Summed up in a sentence Last One Laughing finalist delivers one of the funniest shows of the year, with this mockumentary about a director who makes awful films.What our reviewer said "So ostentatiously silly that it deserves to be paraded around the streets." Stuart HeritageRead the full reviewFurther reading "People are like: you're a crackpot": how Sam Campbell became comedy's oddball superstarNetflix Triumph: The Four Seasons ReturnsNetflixSummed up in a sentence Tina Fey triumphs again with the return of this comedy about a group of middle-aged friends who reunite during holidays throughout the year.What our reviewer said "Even more perspicacious, poignant and hilarious than the first." Chitra RamaswamyRead the full reviewMarvel's Stylish Take: Spider-NoirPrime VideoSummed up in a sentence In Marvel's witty homage to the hard-boiled films and fictions of the 40s – which can be watched in colour or black-and-white – Nicolas Cage plays Ben Reilly, who gave up being superhero "the Spider" five years ago.What our reviewer said "Everything is shot with style and confidence." Lucy ManganRead the full reviewFurther reading The life of PIs: the strange case of 2026's resurgence of hard-boiled detectivesHidden Gem: PoniesNow/Sky AtlanticSummed up in a sentence Emilia Clarke and Haley Lu Richardson have heaps of fun as two widows who become cold war spies in this espionage comedy-drama.What our reviewer said "It's a mashup of genres and tropes, but it is its own thing too – and an unexpected treat at that." Lucy ManganRead the full reviewHorror Innovation: BackroomsIn cinemas nowSummed up in a sentence A debut from 20-year-old director Kane Parsons that examines memory, reality and fear in an icily disturbing horror, in which Chiwetel Ejiofor accesses an infinite series of hidden rooms that all feel creepily askew.What our reviewer said "Backrooms progressively raises its game towards the big finish with jump scares, squirm scares and tiny shiver scares. There is real fascination in exploring this vast, invisible city state of fear." Peter BradshawRead the full reviewFurther reading Are you sitting uncomfortably? How Backrooms upended the horror movieMusic and Bromance: Power BalladIn cinemas nowSummed up in a sentence Nick Jonas and Paul Rudd star in a comedy of bromance and betrayal from Irish writer-director John Carney that brilliantly brings together Rudd's washed-up wedding singer and Jonas's insecure ex-boyband superstar.What our reviewer said "Power Ballad is about making it and dreaming big, about every busker never giving up on hopes of one day being mega. But as so often with Carney, it's about something else, usually left unacknowledged in movies about music or any sort of show business: the terrible binary of success and failure." Peter BradshawRead the full reviewUnexpected Pairing: TunerIn cinemas nowSummed up in a sentence Playing a piano tuner with super-sensitive hearing, Leo Woodall's relationship with Dustin Hoffman is a tender highlight in this safe-cracking thriller.What our reviewer said "What a pair they are; they are a real pleasure to watch in an easy, unforced drama that mixes romcom moments with a relaxed crime thriller. It's like the Safdie brothers in chill-out mode." Cath Clarke