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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Israeli forces have fired teargas at Palestinian schoolchildren who were staging a sit-in in the occupied West Bank after settlers blocked access to their school. The incident occurred in the village of Umm al-Khair, in the southern West Bank region of Masafer Yatta.The schoolchildren, who had been due back in class on Monday for the first time in more than 40 days, had gathered near a barbed wire fence erected by Israeli settlers. The fence blocked access to the school, prompting the children and some local adults to hold an open-air class as a sit-in to demand access. Israeli troops responded by firing teargas at the protesters.Witnesses described the scene as chaotic, with children screaming and fleeing after the teargas canisters were fired. A 12-year-old girl, Sarah al-Hathaleen, recounted her experience: “We were sitting and they threw a grenade [teargas canister] at us. I got scared and started screaming and ran away.”The Israeli military stated that they had dispersed an “unusual gathering” but did not specify whether they had fired teargas. The incident highlights the ongoing tensions in the West Bank, particularly in the Masafer Yatta region, which is a known hotspot for settler violence and Palestinian home demolitions.The Masafer Yatta region has seen increased violence since the outbreak of the Iran war. More than 500,000 Israelis now live in settlements in the West Bank, which are illegal under international law, among about 3 million Palestinians. Israel has occupied the West Bank since 1967.

A comprehensive study from Denmark has concluded that taking acetaminophen, commonly known as Tylenol, during pregnancy has no effect on later autism diagnoses in children. The research, which utilized Denmark's robust national healthcare system to track more than 1.5 million children born between 1997 and 2022, including 31,098 children who were exposed to Tylenol in utero, found no significant link between Tylenol use and autism. The study's findings contradict claims made by the Trump administration, which had suggested that Tylenol use during pregnancy was a major cause of autism in children. This led to a notable 16% drop in Tylenol orders for pregnant women in emergency rooms following the announcement. However, the new study provides reassurance that Tylenol is safe to use during pregnancy for pain relief and fever reduction. According to the study, autism was diagnosed in 1.8% of children who were exposed to Tylenol and 3% of those who weren’t. A similar 2024 study in Sweden found a marginal link that disappeared after considering siblings, suggesting that autism is strongly genetic. Health officials had previously announced a label change for acetaminophen, warning of a potential link to autism, which has now been called into question. Experts, such as Jeremy Faust, an emergency physician at Mass General Brigham and a health services researcher at Harvard Medical School, have noted that the words of health officials can significantly affect behavior, as evidenced by the drop in Tylenol orders. However, Faust also emphasized that Tylenol remains one of the safest options for pain control and fever reduction during pregnancy.

Director Luca Guadagnino has come to the defense of actor Timothée Chalamet after Chalamet faced backlash for suggesting that ballet and opera are art forms that "no one cares about" anymore.Guadagnino, who cast Chalamet in his breakthrough role in Call Me By Your Name, stated that the reaction to Chalamet's comments was disproportionate. "I am not on social media and don’t understand how one [single] comment can become a planetary polemic," Guadagnino said in an interview with Italian newspaper La Stampa.Guadagnino, who made his opera debut in 2011 with a production of Verdi’s Falstaff, noted that Chalamet "could have spared himself … but he’s young, smart, sensitive, and he fears that cinema could become marginal." He emphasized the importance of nurturing all forms of imagination and uniting the arts, rather than separating them.Chalamet's remarks sparked significant backlash from the ballet and opera communities, including Jamie Lee Curtis and Whoopi Goldberg, who publicly criticized him. The Maggio Musicale Fiorentino invited Chalamet to attend Guadagnino's production of The Death of Klinghoffer, saying, "Come and see for yourself that opera is alive, kicking and actually matters to people."

More than 1,000 film and television professionals have signed an open letter opposing Paramount’s pending acquisition of Warner Bros Discovery, a deal valued at $111 billion. The signatories include high‑profile names such as Joaquin Phoenix, Ben Stiller, Mark Ruffalo, Yorgos Lanthimos, Kristen Stewart, Jane Fonda, and Emma Thompson.The letter, published on BlocktheMerger.com, warns that the merger would undermine the integrity, independence and diversity of the U.S. media sector, consolidating the number of major studios to just four and jeopardising a "vibrant future" for what it calls America’s "single most significant export" – its cultural content.Signatories argue that media consolidation already weakens competition, leading to fewer mid‑budget films, reduced independent distribution, higher production costs and fewer jobs across the ecosystem. They stress that competition is essential for both a healthy economy and a healthy democracy.Among the notable supporters are directors Denis Villeneuve, Boots Riley, Mimi Leder and Nicole Holofcener, as well as TV veterans David Chase, Noah Wyle, Ramy Youssef, Rob Delaney, Jason Bateman and Ted Danson. The letter also praises California Attorney General Rob Bonta and other state officials for scrutinising the deal.Paramount CEO David Ellison, who outbid Netflix for Warner Bros, claims the merger will boost creative output, pledging to release 30 theatrical titles annually and invest in both studios. Critics, however, remain skeptical, pointing to the Ellisons’ political ties and the risk of fewer politically‑engaged films.Recent accolades underscore the stakes: Warner Bros productions captured a record 11 Oscars in March, while Paramount films earned no nominations. The industry fears that the combined entity could further diminish quality and lead to significant job losses.Paramount has responded with a statement emphasizing that the transaction will “create a company that can greenlight more projects, back bold ideas, support talent across multiple stages of their careers, and bring stories to audiences at a truly global scale—while strengthening competition.” The letter’s authors remain unconvinced, urging regulators to block the merger to preserve competition, protect jobs, and safeguard the cultural export that defines American cinema.

World champion boxer Terence Crawford was found guilty of careless driving on Monday and ordered to pay a $75 fine stemming from a traffic stop last year that led to a gunpoint incident. The incident occurred on September 28, hours after Crawford's hometown of Omaha held a parade to celebrate his unanimous-decision victory over Canelo Álvarez in a super middleweight championship fight.Crawford was stopped by police after officers observed his vehicle driving recklessly. During the stop, Crawford's head of security informed an officer that he was carrying a legal firearm, and seconds later, another officer spotted a gun on the floorboard. With guns drawn, officers ordered everyone out of the vehicle. Crawford claimed he had leaned over to tell the officer that he also had a legal firearm, but the officer didn't hear him. Police confirmed that all occupants of the vehicle were legally permitted to carry firearms.The traffic stop led to an internal investigation by the Omaha police chief into the officers' actions, which was found to have been lawful. In addition to the $75 fine, Crawford was ordered to pay $49 in court costs. This incident comes after Crawford announced his retirement in December with a 42-0 record and 31 knockouts, making him the first male boxer to capture three unified division titles.

Dr. James Noyes, a prominent advocate for gambling reform, has urged the UK government to pause the implementation of affordability checks for online gamblers. Noyes, who initially proposed the idea of affordability checks in 2020, expressed concerns that the current pilot scheme has raised serious questions that need to be addressed before proceeding.Noyes' call for a pause echoes similar concerns raised by senior figures in the horse racing industry, which fears that the checks could disproportionately affect racing bettors and cost the industry tens of millions of pounds in revenue.The Gambling Commission launched a pilot study on financial risk assessments in September 2024 to assess a two-tier system of checks. However, Noyes and others have raised concerns over the lack of transparency and inconsistent data in the pilot scheme.Noyes emphasized that while affordability checks were initially proposed as a worthy idea, their implementation must be carefully considered to avoid impeding the majority of gamblers from engaging in a lawful activity. He also highlighted the need for a gambling ombudsman to ensure proper treatment of consumer redress and rights.A spokesperson for the Gambling Commission stated that the regulator is working on financial risk assessments with a focus on removing friction for consumers. The Commission has yet to publish a final report on the pilot and has not issued an update on its progress since the spring of 2025.

The Olivier Awards, a prestigious event in the theatre world, recently took place, and among the many memorable moments were the quotes shared by the winners. Host Nick Mohammed kicked off the ceremony with a lighthearted remark about the opening gondola scene from Phantom of the Opera, joking that it wasn't Cunard's boat, but rather Andrew Lloyd Webber's mode of transportation.Cole Escola, playwright of Oh, Mary!, expressed gratitude to a rather unconventional recipient: "my amazing husband, who doesn’t exist". This humorous comment set the tone for a night filled with both laughter and heartfelt acknowledgments.Elaine Paige, a special award winner, shared the secret to her long-lasting career, attributing her success to her father's motto: "perseverance furthers". This insight into her personal life added a touching element to the evening.Rachel Zegler, winner of the best actress in a musical for her role in Evita, recalled her experience performing in the Palladium balcony, calling it "the honour of a lifetime". Her sentiment encapsulated the pride and gratitude felt by many of the winners.Rosamund Pike, best actress winner, reflected on the challenges of balancing life and art, acknowledging the support of her family and partner. Her words resonated with the audience, highlighting the importance of a strong support system.The ceremony also saw Jack Holden win the surprise best actor award, who, upon hearing his name, jokingly asked, "It was definitely me, was it?". This lighthearted moment brought humor to the event.Throughout the evening, winners shared their appreciation for their loved ones and mentors. James Hameed thanked his dad, who had come to London to chase his dreams, showcasing the impact of family on one's journey to success.

Justin Rose secured a joint‑third place at the 2026 Masters, ending the tournament two shots behind defending champion Rory McIlroy. The result marked Rose’s third top‑six finish in his last eight major appearances. After a heartbreaking playoff loss to McIlroy at Augusta in 2025, Rose entered Sunday’s final round with the lead on the back‑nine but ultimately carded a final‑round 70 following a stumble at the famed Amen Corner. Reflecting on his performance, Rose said, "In the last two years I’ve really re‑kicked and re‑energised my career. I now have a lot of belief that there’s plenty of runway ahead." The 45‑year‑old, who claimed a PGA Tour victory in February, believes his recent form positions him to compete for future major titles. Rose emphasized that the majors are the events that drive his preparation: "These are the tournaments I focus on, the ones that make me put in that extra mile to show up and stay in these great arenas." His record at Augusta is notable, with eight top‑10 finishes and two runner‑up finishes, underscoring his affinity for the course. Rose cited veterans such as Freddie Couples and Bernhard Langer as inspirations, noting that the layout of Augusta rewards deep course knowledge and a personal playing style. Englishman Tyrrell Hatton also made headlines, posting a spectacular final‑round 66 that included six birdies and an eagle, propelling him to a joint‑third finish – his best performance in a major to date. Hatton explained his approach: "I try not to treat majors any differently – I go out every day, every round, every shot, and give it my best. I’m looking at ways to fine‑tune my preparation, perhaps more putting early in the week, to feel even more ready." Now in his tenth Masters, Hatton highlighted his steady improvement, citing recent top‑10 finishes at the U.S. Open and a rise from a tied‑fourteenth to a tied‑ninth in the last three years at Augusta.