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Health Apr 13, 2026

AI Breakthrough: Predicting Bowel Cancer Patients' Response to NHS Drug

Researchers have developed an AI-driven method to predict how patients with advanced bowel cancer w…
Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”
#bevacizumab #NHS #bowel cancer
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Tv And Radio Apr 13, 2026

Guardian's Weekly Podcast Picks: History Fails, Bizarre News, True‑Crime Thriller, Celebrity Chat and Northern Quirks

The Guardian highlights five new weekly podcasts ranging from a history‑focused series that debunks…
History’s Greatest Fails pairs author Elizabeth Day with historian Dan Jones to explore celebrated historical missteps. After a witty reunion anecdote about their Cambridge days, the duo tackles the myth of Richard III’s villainy and promises a future episode on Henry VIII and Anne Boleyn, dubbed the "Ross and Rachel of early modern history."Strangely follows presenters Poppy Damon and Luke Jones as they plunge into off‑beat news stories, such as the macabre tale of a surgeon who amputated his own legs and the obscure origin of Neil Hopper’s "eunuch‑maker" moniker. The show balances factual depth with a tongue‑in‑cheek tone.Passenger Seat is a slow‑burn true‑crime podcast produced by Pennsylvania writer Tom Joudrey. The inaugural season recounts the 2012 kidnapping of Jennifer Hurst in Ohio, unraveling the puzzling motive behind the crime and the surprising gratitude she later expressed in court.Big Bro With Kid Cudi marks rapper Kid Cudi’s entry into the "celebrity podcast industrial complex". His first interview features Kylie Jenner, who drops the usual Kardashian PR veneer to discuss family dynamics, her upcoming acting role in the film The Moment, and a brief nod to Timothée Chalamet.Northern News reunites comedian Amy Gledhill with Ian Smith to spotlight odd and delightful headlines from the north of England that often slip under the radar. Regular contributors such as Stevie Martin, Alison Spittle and Phil Wang add extra comic flair.
#widely #available #episodes
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Video Apr 13, 2026

Israel's One-Day Strike in Lebanon Leaves Dozens Dead – Identifying the Victims

A recent Al Jazeera report documents the individuals killed by Israeli forces in Lebanon during a s…
The article from Al Jazeera outlines the people who lost their lives in Lebanon as a result of Israeli military action on a single day, emphasizing the personal tragedies behind the headline numbers. By naming each victim, the report seeks to humanize the casualties and draw attention to the broader humanitarian consequences of the ongoing hostilities between Israel and Lebanon.While specific details such as ages, occupations, or hometowns are listed in the original piece, the overarching message is clear: the conflict’s impact is deeply personal, affecting families and communities across the region. These individual stories serve as a stark reminder of the cost of continued violence and underscore calls for de‑escalation and protection of civilians.
#these #people #israel
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News Apr 12, 2026

Trump Orders Immediate US Navy Blockade of Strait of Hormuz After Failed US‑Iran Talks, Raising Ceasefire Concerns

Following the collapse of US‑Iran peace negotiations in Pakistan, President Donald Trump announced …
President Donald Trump declared that the U.S. Navy will commence a blockade of the Strait of Hormuz immediately after peace talks between Washington and Tehran in Pakistan ended without an agreement. In a social‑media post, Trump labeled Iran’s actions as “extortion” and warned that American warships would hunt down and interdict any ship that has paid Iran a toll to traverse the waterway, while also beginning mine‑clearing operations. Iran’s Revolutionary Guard responded that civilian vessels may still cross the strait under “specific regulations,” but any military craft attempting entry would be deemed a breach of the cease‑fire and would be “dealt with severely.” Since the February 28 war launched by the United States and Israel, Iran has effectively taken control of the strategic chokepoint, a route that carries about 20% of the world’s oil and liquefied natural gas shipments. Traffic has now dwindled to a trickle, sending shockwaves through the global economy and raising alarm among Gulf Cooperation Council (GCC) states. Al Jazeera correspondents noted that the rhetoric from the White House has amplified “alarm bells” across the GCC, where leaders had hoped the two‑week ceasefire would evolve into a longer‑term peace framework. Oman’s foreign minister, Badr Albusaidi, urged on social media that the ceasefire be extended and that all parties make “painful concessions” to avoid a return to war. Trump’s statements also included a stark threat: any Iranian forces that fire on U.S. or “peaceful” vessels would be “blown to hell.” He claimed the blockade would involve “other countries” and that the United Kingdom, along with “a couple of other nations,” were dispatching minesweeper vessels to assist – a claim the British government has not confirmed. Domestic criticism emerged quickly. Democratic Senator Mark Warner told CNN he “doesn’t see how blockading the strait will compel Iran to open it,” questioning the strategic logic behind the move. Iran denied U.S. allegations that two of its warships had recently passed through the strait for mine‑clearing, warning that any military vessel attempting such a passage would meet a “strong response.” Tehran officials have floated the idea of instituting a post‑conflict toll system for vessels using the waterway, a prospect that could further entrench Iran’s leverage over global energy flows. Analysts warn that heightened tensions in the Hormuz corridor could push oil prices higher, amplifying inflationary pressures worldwide. As the situation unfolds, mediators continue to press both sides to resume diplomatic talks and avoid a broader escalation.
#strait #iran #trump
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Sports Apr 12, 2026

Manchester City Thrash Chelsea 3-0, Closing Gap on Premier League Leaders Arsenal

Manchester City secured a crucial 3-0 victory over Chelsea, narrowing the gap to six points behind …
Manchester City reignited the Premier League title race with a commanding 3-0 victory over Chelsea at Stamford Bridge on Sunday. The win saw Pep Guardiola's side close the gap to six points behind leaders Arsenal, with a game in hand, setting the stage for a crucial showdown at the Etihad Stadium on April 19.The match turned in City's favor immediately after halftime, with Nico O'Reilly and Marc Guehi scoring within six minutes. Jeremy Doku sealed the win with a third goal in the 68th minute, capitalizing on poor Chelsea defending. This victory came on the heels of Arsenal's surprise 2-1 home defeat to Bournemouth on Saturday, giving City a lifeline in the title chase.City are now just six points behind Arsenal and have a game in hand. A win against Arsenal next weekend would bring them within three points and potentially set up a thrilling finale to the season. Chelsea, meanwhile, have won only one of their last seven matches and are facing increasing pressure on their manager, Liam Rosenior.In other Premier League action, Tottenham's relegation struggles continued with a 1-0 loss to Sunderland, while Nottingham Forest drew 1-1 with Aston Villa and Crystal Palace beat Newcastle 2-1.
#city #league #chelsea
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Video Apr 12, 2026

Varsha Gandikota and Jeremy Scahill Question the Drivers Behind U.S. Foreign Policy

The article examines who shapes United States foreign policy, featuring analysis and commentary fro…
The piece delves into the question of who truly directs U.S. foreign policy, presenting the perspectives of journalists Varsha Gandikota and Jeremy Scahill. Both commentators explore the influence of political actors, institutional mechanisms, and external pressures that determine America’s global strategy. While the discussion does not introduce new data, it highlights the ongoing debate over the balance of power between elected officials, bureaucratic agencies, and interest groups in shaping international decisions.
#who #running #foreign
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News Apr 12, 2026

Mumbai Mourns Asha Bhosle, the 92‑Year‑Old Voice Behind Over 12,000 Bollywood Classics

Legendary Indian playback singer Asha Bhosle, who recorded more than 12,000 songs across seven deca…
Asha Bhosle, the iconic voice of Bollywood for over seven decades, has died at age 92 in Mumbai, according to her family. The two‑time Grammy nominee passed away on Sunday at Breach Candy Hospital, where she had been admitted for "extreme exhaustion" and a chest infection. Her son, Anand Bhosle, confirmed the news to reporters, stating, "My mother passed away today. Her last rites will be held tomorrow at Shivaji Park in Mumbai." Throughout her prolific career, Bhosle recorded more than 12,000 songs in multiple Indian languages, shaping the soundscape of Bollywood cinema from the 1970s through the 1980s and beyond. Prime Minister Narendra Modi expressed his sorrow, describing himself as "deeply saddened" by the loss of a cultural legend whose music resonated across generations. The nation now prepares to bid farewell to a figure whose contributions to Indian music remain unparalleled, with funeral services set for Shivaji Park, a venue symbolic of her enduring legacy.
#bhosle #her #asha
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Politics Apr 12, 2026

US‑Iran Negotiations Collapse in Pakistan: Key Factors Behind the Deadlock

The piece examines why the United States and Iran failed to reach an agreement during their talks i…
The report outlines the abrupt end of the United States‑Iran dialogue held in Pakistan, noting that the parties left without a formal accord. Analysts attribute the breakdown to deep‑seated mistrust, divergent strategic objectives, and pressure from regional actors, all of which complicated the negotiation process.While the talks were intended to address longstanding issues such as nuclear safeguards and regional security, the lack of a mutually acceptable framework proved insurmountable. Observers point to the broader geopolitical context—particularly the United States' shifting policy in the Middle East and Iran's internal political calculations—as pivotal in shaping the outcome.In the aftermath, diplomatic channels remain open, but the failure underscores the challenges of reconciling competing interests in a volatile region. The article suggests that any future engagement will need to confront these core disagreements head‑on to avoid a repeat of the current stalemate.
#United States #Iran #Pakistan
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Sports Apr 12, 2026

City's 3-0 thrashing of Chelsea slashes Arsenal's lead and reignites title chase

Manchester City dismantled Chelsea 3-0 at Stamford Bridge, cutting Arsenal's nine‑point advantage t…
Manchester City delivered a decisive 3-0 victory over Chelsea at Stamford Bridge, a result that reduced Arsenal's nine‑point cushion to six and gave Pep Guardiola's side fresh impetus in the Premier League title race.City seized control early in the second half, with Nico O'Reilly heading in from a Rayan Cherki cross in the 51st minute. Six minutes later, Cherki’s incisive play produced a disguised pass to Marc Guéhi, who finished to make it 2-0. A third goal followed as a swift counter‑attack saw Cherki again on the ball, delivering a cross that O'Reilly converted, sealing the win.The match also highlighted individual milestones: Cherki notched his 10th league assist, becoming the first debutant since Dimitri Payet (2015‑16) to reach double‑digit assists in a Premier League season. Meanwhile, Guéhi recorded the first away player to keep two clean sheets at Stamford Bridge in a single campaign, having previously done so with Crystal Palace.Strategically, the win narrows the gap to Arsenal, leaving City six points behind with a game in hand. Should City overcome Arsenal at the Etihad this weekend, they could overtake the Gunners and re‑establish themselves as front‑runners for the title.Chelsea, hampered by the absence of injured captain Reece James and the suspension of Enzo Fernández, struggled to match City’s intensity. Their disciplinary record remains a concern, having amassed the league's highest number of yellow cards for dissent (16). Despite moments of promise from Cole Palmer, Pedro Neto and João Pedro, the Blues lacked the cutting edge in the final third and were out‑classed in midfield.Guardiola’s halftime adjustments proved pivotal; the team increased tempo, sharpened passing angles, and pressed higher, turning a sluggish first half into a dominant second‑half display. The victory not only restores confidence after a recent FA Cup win over Liverpool but also underscores City’s ability to respond swiftly to rivals’ slip‑ups, a pattern that has defined many of their recent title pursuits.
#Manchester City #Chelsea #Arsenal
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