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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Sudan, one of the world's most impoverished countries, has been ravaged by a civil war that began in 2023. The conflict, driven by a power struggle between the army and the paramilitary Rapid Support Forces (RSF), has left the nation unrecognizable. Over 40,000 people have been killed, and about 14 million – a quarter of the population – have been forced to flee their homes. Civilian infrastructure across the country has been extensively damaged.“We are not just facing a crisis – we are witnessing the systematic erosion of a country’s future,” Luca Renda, the United Nations Development Programme’s (UNDP’s) resident representative in Sudan, told Al Jazeera. A report by the UNDP and the Institute for Security Studies highlights the scale of Sudan’s economic collapse. Even under the most optimistic scenario of peace being achieved in 2026, Sudan would still lose an estimated $18.8 billion in gross domestic product (GDP) by 2043.The war has had a devastating impact on Sudan's infrastructure and basic services. $6.4 billion was lost in GDP in 2023 alone, reflecting a simultaneous collapse across all major parts of Sudan’s economy. The destruction of infrastructure has triggered displacement and made it difficult for people to secure adequate housing or access basic services. Up to 40 percent of power generation capacity has been lost, and key water infrastructure has been destroyed or seized, cutting communities off from clean water and sanitation.The labor market has also been severely affected, with agriculture – once the backbone of Sudan’s economy – severely hit. Cultivated land has shrunk, adversely impacting rural livelihoods. Average incomes have fallen back to levels last seen in 1992. About 90 percent of manufacturing activity has been destroyed in key economic hubs, eliminating thousands of jobs.The oil industry has suffered significantly, with oil output falling amid widespread instability and infrastructure damage. The Khartoum refinery, which previously processed up to 100,000 barrels per day, has been out of operation since July 2023. Key infrastructure, including pipeline routes carrying crude to Port Sudan, has been hit.The collapse of the Sudanese pound and supply chains has caused a sharp rise in living costs. Food prices have surged, with four pieces of bread now costing about 1,000 pounds, an amount that had previously bought six pieces. Wages have failed to catch up with inflation, leaving many households without access to necessities. Nearly half the population is now experiencing acute food shortages.The economic collapse has had a profound impact on Sudan's people, with 34 million people in need of assistance and 19 million facing acute food shortages. The war has caused death, trauma, and profound loss, casting a long shadow over Sudan’s future and dimming the prospects of a generation whose lives are being shaped by violence. If the conflict continues to 2030, Sudan’s economy in 2043 would be about $34.5 billion smaller than it would have been without the war, and GDP per capita would drop by roughly $1,700.

President Donald Trump announced on Fox Business that he will dismiss Federal Reserve Chair Jerome Powell should the governor refuse to leave his post when his term concludes on May 15. The statement, made during an interview with Maria Bartiromo, underscored the president’s willingness to act, saying he “has wanted to fire him, but I hate to be controversial… he will be fired.” Legal scholars and policy analysts quickly cautioned that the president’s threat is not grounded in statutory authority. Skanda Amarnath, executive director of the think‑tank Employ America, told Al Jazeera that the administration is already losing a court battle over an attempt to remove Fed Governor Lisa Cook and would likely face the same outcome if it pursued Powell’s removal. The controversy emerges as the Senate Banking Committee prepares to consider Kevin Warsh, Trump’s nominee to succeed Powell. Warsh’s hearing is scheduled for next Tuesday, but his confirmation remains uncertain. North Carolina Senator Thom Tillis has pledged to block the nomination until the ongoing federal criminal probe into Powell’s conduct concludes. If the Senate fails to confirm a new chair, Powell would remain at the helm until a successor is appointed, extending the period of tension between the White House and the central bank. Trump also referenced a separate investigation into a costly Fed building renovation, noting that U.S. Attorney Jeanine Pirro has not indicated any change in the probe’s direction. However, a federal prosecutor later reported that the investigation uncovered no evidence of criminal wrongdoing. Critics argue that Trump’s broader agenda seeks to increase political control over the Fed’s seven‑member board, aiming to install members who share his economic outlook. Currently, the president has appointed three board members, and one seat—held by Governor Stephen Miran—has technically expired, which would need to be vacated for Warsh to join. Powell has framed the investigation as a pretext to undermine the Fed’s independence in setting monetary policy, a charge that resonates with concerns about preserving the central bank’s autonomy amid political pressure. Overall, the standoff highlights a clash between executive ambition and the institutional safeguards designed to keep monetary policy decisions insulated from short‑term political influence.

The prospect of a renewed U.S. oil blockade has sparked concerns across Havana’s tobacco fields, where the cigar industry remains a cultural and economic cornerstone. Analysts warn that restricting oil supplies could disrupt the energy‑intensive processes essential for curing, rolling, and transporting premium cigars, potentially undermining production volumes and export revenues. Cuba’s cigar sector accounts for a significant share of the island’s foreign‑exchange earnings, with premium brands commanding premium prices in markets worldwide. A sustained energy shortage would not only raise operational costs but could also force producers to scale back output or seek alternative, less efficient energy sources, eroding the competitive edge that Cuban cigars have long enjoyed. Beyond the immediate economic impact, the blockade could deepen existing tensions in U.S.-Cuba relations. The move may be interpreted as a strategic lever to pressure the Cuban government, yet it also risks alienating stakeholders in the global tobacco trade and could invite retaliatory measures. While the full extent of the blockade’s effect remains uncertain, experts stress that any disruption to the cigar supply chain would reverberate through related sectors—tourism, agriculture, and logistics—exacerbating the island’s broader fiscal challenges. Policymakers on both sides are therefore urged to weigh the economic costs against geopolitical objectives before implementing such a measure.

The Energy Information Administration (EIA) is set to transition from voluntary pilots to a mandatory nationwide survey, compelling data centers to publicly disclose their energy usage and power bills. This regulatory shift aims to bring a rapidly expanding industry into the fold of federal oversight, addressing concerns over its escalating environmental footprint. From Pilot to Nationwide Regulation The EIA's strategy involves a phased approach, beginning with targeted pilot surveys in key regions. These initial studies focused on 196 companies across Texas, Washington state, and the Washington, D.C.-Northern Virginia metro area. The agency anticipates completing these pilot surveys by September, after which it will roll out a comprehensive, mandatory questionnaire covering data centers nationwide. Political Catalyst: The initiative was spurred by a letter from Sens. Josh Hawley and Elizabeth Warren urging the EIA to monitor the industry's energy consumption. Implementation Timeline: While the mandatory survey date is not yet set, the EIA expects to finalize the methodology following the September pilot completion. Strategic Focus: The surveys will specifically target the details of power bills, providing granular data on electricity demand. Why the Grid is Under Pressure Requiring data centers to reveal their power usage is a critical step for grid stability and environmental planning. As the technology sector, particularly AI, drives a surge in data center construction, the strain on the national power grid becomes increasingly apparent. By mandating transparency, the EIA aims to provide policymakers with the data needed to manage load balancing and prevent potential energy shortages. The Future of Data Center Compliance This move signals a new era of regulatory scrutiny for the tech industry. We can expect that once the mandatory data is collected, the EIA will use it to model future energy scenarios. This could lead to stricter efficiency standards or targeted infrastructure investments in regions with the highest concentrations of data center activity.

While the world focuses on diplomatic efforts to end the war on Iran, Israel has intensified its military actions in Gaza, resulting in a significant escalation of the humanitarian crisis. The number of aid trucks entering Gaza has drastically decreased, violating the October 2025 ceasefire agreement with Hamas. According to the Government Media Office in Gaza, there have been 2,400 military violations by Israeli forces since then, leading to the deaths of over 700 Palestinians.Recent attacks have resulted in significant casualties, including 11 Palestinians killed on Tuesday, with two being children. The intensity of these attacks spiked during peak regional tensions, with Israeli forces bombing Gaza on 36 out of 40 days between February 28 and April 8, while Israel and the US were engaged in a bombing campaign against Iran.The situation in Gaza has deteriorated to the point where economic experts describe it as an 'engineered, compounded famine'. The number of aid trucks entering Gaza is severely limited, with only 41,714 aid and commercial trucks entering over the past six months, representing just 37% of the agreed-upon 110,400 trucks. The fuel situation is even more critical, with only 1,366 fuel trucks entering out of a promised 9,200.Palestinian officials and economic experts argue that Israel is using a 'technical and commercial deception' to inflate the number of aid trucks entering Gaza. This has led to a severe shortage of basic commodities, with bread production plummeting to 200 tonnes daily, far below the 450 tonnes required to feed the population.The crisis has evolved into a complete collapse of the Palestinian economy, with unemployment soaring to 80% and the destruction of over 160,000 jobs across various sectors. The population has lost its purchasing power, forcing civilians into life-threatening situations.The international community has been urged to pressure Israel to open the crossings and prevent a humanitarian catastrophe. The situation in Gaza remains critical, with 18,000 people still trapped, waiting for life-saving medical treatment abroad.

Tehran has issued an uncompromising demand for $270 billion in reparations for the devastation wrought by United States and Israeli strikes since the war began on 28 February. The figure, disclosed by government spokeswoman Fatemeh Mohajerani in an interview with Russia’s RIA Novosti, aggregates both direct and indirect losses across a wide range of sectors. Iran’s UN envoy asserted that five regional states must contribute to the compensation, alleging that their territories served as launchpads for attacks on Iranian soil. In parallel, Tehran floated a Strait of Hormuz protocol that would levy a tax on vessels transiting the strategic waterway, earmarking the proceeds for reconstruction. The war has battered Iran’s critical infrastructure: oil and gas complexes, petrochemical plants, steel and aluminium factories, as well as military installations have been repeatedly struck. Damage extends to bridges, ports, railways, universities, research centres, power stations and desalination plants, while countless hospitals, schools and civilian homes have been either damaged or razed. In the aviation sector, Maghsoud Asadi Samani, secretary of the Association of Iranian Airlines, reported that 60 civilian aircraft have been rendered inoperable, with 20 completely destroyed. Iran now operates roughly 160 passenger planes, many of which are decades old and suffer from parts shortages due to stringent US sanctions. The airline industry estimates losses exceeding 300 trillion rials (≈ $190 million) over just 40 days of conflict, compounded by the loss of anticipated revenue from the Nowruz holiday period. Despite the extensive damage, Iranian officials have signalled no willingness to make major concessions in forthcoming negotiations with Washington, including on nuclear enrichment. Hard‑line parliament spokesman Ebrahim Rezaei warned that extending the recent two‑week ceasefire would merely allow the US and Israel to replenish their arsenals, urging the United States to either recognise Iran’s rights—particularly over the Strait of Hormuz—or return to hostilities. Financially, Iran allocated close to $8 billion to its military in 2024, according to SIPRI, and has pledged to triple that budget following previous missile exchanges with Israel. Yet the economy remains strained by years of sanctions, mismanagement and corruption. Compounding the economic strain, the government‑imposed near‑total internet shutdown—affecting over 90 million users—has been estimated to cost the nation up to $80 million per day. Afshin Kolahi of the Iran Chamber of Commerce warned that the blackout equates to losing the output of four B1‑class bridges and two medium‑capacity power plants each day. While a limited “Internet Pro” service is being offered to select users, the majority of the population remains confined to a state‑controlled intranet, prompting widespread calls for internet freedom. These intertwined military, economic and digital pressures underscore the high stakes of the anticipated US‑Iran talks, with Tehran demanding acknowledgment of its losses and a pathway to rebuild a war‑torn nation.

Chinese President Xi Jinping has met with Russian Foreign Minister Sergey Lavrov, calling for closer and stronger strategic coordination between Beijing and Moscow. The meeting took place in the Great Hall of the People in Beijing, where Xi emphasized the need to firmly defend their legitimate interests and safeguard the unity of Global South countries.Xi described the stability and certainty of China-Russia relations as particularly precious in an international landscape marked by change and chaos. This comes as the world faces growing fears over the shutdown of the Strait of Hormuz, which could trigger a global food crisis as critical fertiliser and fuel exports are blocked.Lavrov told a news conference after meeting Xi that Moscow could compensate for China’s energy shortages as shipping through the strait remains choked. China and Russia are not formal military allies but maintain extremely close economic and political ties, with Xi signing a 'no limits' strategic partnership with President Vladimir Putin in 2022.The visit by Lavrov to Beijing this week also included meetings with other leaders, such as Spanish Prime Minister Pedro Sanchez, Abu Dhabi’s Crown Prince Mohamed bin Zayed Al Nahyan, and Vietnamese leader To Lam. In talks with Sanchez, Xi warned that the world was facing 'chaos and turmoil' and 'a contest between justice and force', urging closer cooperation.

"The failure is big," Liverpool midfielder Ryan Gravenberch declared after the Champions League loss to Paris Saint-Germain. The defeat not only eliminates Liverpool from Europe but also seals a season that will finish trophyless. Manager Arne Slot has repeatedly insisted that the future looks very bright for Anfield, yet the club’s reality is starkly different. A business model built on lucrative broadcasting and commercial revenues now faces a potential top‑five miss, a scenario that would be financially and reputationally humiliating for a side that spent nearly £450 million on its squad last summer. Slot’s request for three seasons to steer Liverpool’s transition is under intense scrutiny. In the past 16 days Liverpool have played five matches: three defeats, two aggregate exits totalling 8‑0, and a solitary league win sparked by 17‑year‑old Rio Ngumoha. The pattern underscores a season riddled with setbacks. Sporting director Richard Hughes observed that despite a respectable xG of 1.94 against PSG, Liverpool’s performance fell short, a symptom of deeper issues. The situation worsened when forward Hugo Ekitiké collapsed with a suspected Achilles injury in the 27th minute, likely ruling him out for the remainder of the campaign. His absence further hampers the newly assembled £320 million front line of Alexander Isak, Hugo Ekitiké and Florian Wirtz, who have barely featured together. Slot’s tactical gamble of starting Isak after a four‑month hiatus and deploying a back five at the Parc des Princes backfired. Isak managed only five touches before being substituted at halftime, illustrating that a Champions League quarter‑final is not the venue for experimentation. After the second leg, Slot attempted to inject optimism, stating, "The good thing is Alex is back" and reiterating that the club can compete with Europe’s champions on home soil. Critics argue this positivity is misplaced, especially as Liverpool scrambles through the run‑in with key players missing. With six league games remaining, a fit Isak could be the difference between securing Champions League qualification and enduring further humiliation. Both Isak and Wirtz must begin to justify their hefty transfer fees, despite recent injury concerns and underwhelming output. In a candid interview with Ziggo Sport, Gravenberch summed up the mood: "No, actually not. It’s disappointing. We have to pick ourselves up as Sunday is waiting. We still have six matches in the league and we just want to play in the Champions League next year as well." He added that the season feels plagued by setbacks—late goals conceded and missed chances—making this a tough, failure‑laden campaign from which the squad must learn.