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Health Apr 13, 2026

AI Breakthrough: Predicting Bowel Cancer Patients' Response to NHS Drug

Researchers have developed an AI-driven method to predict how patients with advanced bowel cancer w…
Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”
#bevacizumab #NHS #bowel cancer
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Politics Apr 13, 2026

Oil Prices Soar Above $100 as US Imposes Strait of Hormuz Blockade

Oil prices surged above $100 a barrel after the US imposed a blockade on the Strait of Hormuz, a cr…
Oil prices jumped back above $100 a barrel and global stocks fell after weekend talks between the US and Iran ended without an agreement and Donald Trump imposed a blockade of the Strait of Hormuz. The US president announced the blockade on Sunday, targeting Iranian vessels and ships that have paid a toll to Iran for passage through the strait, in an attempt to choke off the flow of Iranian oil.US Central Command said it would start at 10am ET (5.30pm in Iran and 3pm in the UK), blocking all Iranian Gulf ports and coastal areas, in effect seizing control of maritime traffic in the Strait of Hormuz. The news drove oil and gas prices sharply higher again, after the two-week ceasefire between the US and Iran announced on Wednesday prompted a sharp fall in energy prices, and crude ended the week below the psychological $100 a barrel threshold.Brent crude rose by nearly 7% to $101.74 a barrel on Monday morning, while US crude is up more than 8% to $104.69 a barrel. Gas prices also increased, with the British wholesale gas contract for May soaring by 11.7% to 122.5p a therm. Analysts at JPMorgan Chase said last week they expected oil prices to stay high in the second quarter, above $100 a barrel, before easing in the second half of the year.Most Asian stock markets fell on Monday, with Japan’s Nikkei down 0.7% and Hong Kong’s Hang Seng index losing 1%, while Chinese stocks rose slightly. Sentiment was helped by Beijing’s announcement of a 10-initiative strategy aimed at deepening ties with Taiwan. European stocks also fell, led by airlines including Lufthansa, Wizz Air, easyJet and British Airways parent IAG. The FTSE 100 index in London lost 0.4%, dropping 45 points to 10,555. Germany’s Dax fell 1%, Italy’s FTSE MiB slipped 0.7% and Spain’s Ibex was down 1.1%. With oil and gas prices rising sharply higher, energy companies such as BP and Shell are rallying.Priyanka Sachdeva, senior market analyst at the broker Phillip Nova, said: “In today’s environment, every barrel of risk added to oil markets carries an inflation price tag for the global economy.” She added: “The market reaction underscores a simple but powerful reality: Hormuz risk is not theoretical; it is structural, and it is real.”Interest rate expectations have shifted again; investors now see an 84% chance of two rate increases from the Bank of England this year to tackle rising inflation, up from 60% on Friday. Before the Iran war, the central bank was expected to cut rates. The price of gold fell 0.4% to $4,730.75 an ounce as the blockade fuelled inflation concerns, prompting traders to scale back expectations for Federal Reserve rate cuts this year.
#United States #Iran #Strait of Hormuz
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Tech Apr 13, 2026

Apple's 2027 Smart Glasses: A Strategic Shift Toward Simplicity

Apple is reportedly pivoting from high-end AR to consumer-friendly camera glasses, testing four dis…
The Pivot from Vision Pro to Everyday WearablesApple is reportedly preparing to enter the smart glasses market with a product launch targeted for 2027, signaling a significant strategic shift away from its ambitious mixed reality ambitions.Four Distinct Design PrototypesRectangular Frames: Ranging from large to slim, potentially mimicking the style of CEO Tim Cook.Oval/Circular Frames: Available in both larger and smaller sizes.Color Options: Black, ocean blue, and light brown.A Strategic Retreat from High-End ARThis move represents a retreat from the complex Vision Pro ecosystem, which faced delays and lukewarm reception. Instead, Apple is betting on a simpler form factor similar to Meta’s Ray-Ban glasses.The 2027 Roadmap: Simplicity Over ImmersionThe upcoming device will lack displays, focusing instead on camera lenses for photos, videos, calls, and music. It will also integrate with the long-promised Siri upgrade, aiming to capture the mainstream market rather than the niche enthusiast base.
#Apple #Mark Gurman #Meta
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Technology Apr 12, 2026

Artemis II Astronauts Return to Earth After Record-Breaking Moon Flyby

The Artemis II astronauts, including Reid Wiseman, Victor Glover, Christina Koch, and Jeremy Hansen…
The Artemis II astronauts received a thunderous welcome home on Saturday after completing a record-breaking flyby of the moon. The crew of four, consisting of commander Reid Wiseman, pilot Victor Glover, Christina Koch, and Canada's Jeremy Hansen, arrived at Ellington Field near NASA's Johnson Space Center and Mission Control in Houston. During their nearly 10-day mission, the astronauts voyaged deeper into space than the moon explorers of decades past, reaching a maximum distance of 252,756 miles (406,771km) from Earth. They also captured views of the lunar far side never witnessed before by human eyes. The mission revealed a new side of our planet with an Earthset photo, showing our blue marble setting behind the gray, pockmarked moon. Koch described the experience, saying, "Honestly, what struck me wasn’t necessarily just Earth, it was all the blackness around it. Earth was just this lifeboat hanging undisturbedly in the universe," Koch said. "Planet Earth, you are a crew." The homecoming was poignant, as they returned to NASA's Houston base on the 56th anniversary of the launch of Apollo 13. The Artemis II mission is a crucial step towards NASA's goal of landing astronauts on the moon by 2028. Wiseman issued a rallying cry to the rows of blue-flight-suited astronauts at Saturday's celebration, saying, "It is time to go and be ready – because it takes courage. It takes determination, and you all are freaking going and we are going to be standing there supporting you every single step of the way in every possible way possible."
#you #artemis #moon
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Sports Apr 12, 2026

Birmingham's 2-0 Win Over Wrexham Slashes Playoff Hopes and Delays Promotion Quest

Birmingham City secured a 2-0 victory at St Andrew’s, delivering a severe setback to Wrexham’s chas…
Birmingham City defeated Wrexham 2-0 at St Andrew’s, a result that pushes the Red Dragons further from the Championship playoff places. The loss leaves Wrexham four points behind sixth‑placed Hull City with only four games remaining.After a 5-1 drubbing by Southampton, the defeat marks Wrexham’s first back‑to‑back losses since August. Manager Phil Parkinson tried to steady the mood, saying, “We’ve had a tough week, but we’re not down and out yet. People may write us off, but inside the dressing room we’re still fighting.”Goals came from Carlos Vicente, who headed in his third goal for Birmingham since joining in January, and Christoph Klarer, who added a second‑half strike to seal the win.Wrexham’s attack was virtually silent – they failed to register a single shot on target, and goalkeeper James Beadle had little to do. In contrast, Birmingham’s keeper Arthur Okonkwo made several first‑half saves, keeping the hosts in control.The victory gave Birmingham their first win in over a month and lifted them to 15th place in the league table. The hosts dominated possession, forcing early saves from Okonkwo and creating chances for Ibrahim Osman and August Priske, though those early efforts were thwarted.In the second half, a well‑timed delivery from Kai Wagner allowed Vicente to rise highest at the far post and head home. Later, a corner from Paik Seung‑ho found Klarer, who muscled past Max Cleworth and finished confidently.Substitutes Josh Windass and Nathan Broadhead were introduced by Parkinson in a bid to spark Wrexham’s attack, but the visitors could not muster any meaningful threat in the final quarter.Birmingham manager Chris Davies praised his side’s performance: “We were excellent throughout. When the opposition doesn’t have a shot on your goal and you score two – we could have scored five – that’s everything.”
#birmingham #wrexham #but
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Sports Apr 12, 2026

Wout van Aert Ends Decade-Long Paris‑Roubaix Curse, Outsprints Tadej Pogacar for First Victory

Belgian rider Wout van Aert shattered a ten‑year jinx by winning the 2026 Paris‑Roubaix, beating wo…
Wout van Aert broke a ten‑year drought at the Paris‑Roubaix on Sunday, out‑sprinting world champion Tadej Pogacar in one of cycling’s toughest cobbled classics. Both Van Aert and Pogacar suffered punctures during the race, as did their fellow Belgian rival Mathieu van der Poel, who endured two mechanical issues and was unable to contest the final sprint. Van Aert’s victory secured his second Monument title, following his 2020 Milan‑San Remo win. After neutralising Pogacar’s repeated attacks on the cobbles, Van Aert unleashed a decisive burst of speed on the Roubaix Velodrome, crossing the line ahead of the world champion. Jasper Stuyven completed the podium, finishing 13 seconds behind the winner. Van der Poel, who was chasing a fourth consecutive Paris‑Roubaix triumph, fell to fourth place after a mechanical problem on a treacherous sector cost him more than two minutes. “It’s everything to me, it’s been a goal since I first did this race. I stopped believing a lot of times but I would start believing again the next day,” Van Aert said, reflecting on the personal significance of the win after years of bad luck in the “Queen of the Classics.” The Visma‑Lease a Bike rider dedicated his victory to former teammate Michael Goolaerts, who tragically died after a cardiac arrest in the 2018 edition of the race. “Arriving for a final sprint with the world champion and beating him in a sprint is very special,” he added. Pogacar entered the race after clinching the first two Monument classics of the season – the Milan‑San Remo and the Tour of Flanders – and was aiming to become the first Tour de France champion to win Paris‑Roubaix since Bernard Hinault in 1981.
#Wout van Aert #Paris‑Roubaix #Tadej Pogacar
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World Economy Apr 12, 2026

GSK Reports Promising Early Results for Ovarian and Womb Cancer Drug

GSK has announced positive early results for its ovarian and womb cancer drug, Mocertatug Rezetecan…
GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.
#gsk #cancer #drug
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Economy Apr 12, 2026

Global Economy Faces Biggest Oil Shock in Decades as US-Israeli War on Iran Escalates

The US-Israeli war on Iran has triggered the biggest energy shock of the modern age, with oil and g…
The world's finance ministers and central bank governors are gathering in Washington for the half-yearly meetings of the International Monetary Fund and the World Bank, with the global economy in a perilous spot. The US-Israeli war on Iran, coming soon after the Covid pandemic and Russia's invasion of Ukraine, has triggered significant economic turbulence.Even if a durable peace deal in the Middle East can be reached, there will still be permanent economic scars. The conflict has caused damage to infrastructure, heaping further pressure on already struggling households. This is the biggest energy shock of the modern age, with oil and gas prices surging, inflation rising, and borrowing costs increasing.The IMF has said it will cut its growth forecasts for 2026 when it publishes its flagship world economic outlook. In every scenario, growth is slower and inflation higher. Households worldwide will feel the pain, with the world's poorest bearing the brunt.The fund's managing director, Kristalina Georgieva, has urged officials to work together, warning that "go-it-alone actions" may have appeal but would ultimately make matters worse. The IMF cautions that any energy support should be targeted and temporary to limit the costs of blanket support and avoid stoking inequality.For central banks, the fund urges them to remain vigilant, with financial markets expecting interest rates to be kept on hold or raised to prevent high inflation from becoming entrenched. The economic problems are interlinked with political instability, making it a challenging situation for governments worldwide.
#International Monetary Fund #oil prices #United States
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Technology Apr 12, 2026

The AI Art Heist: A Threat to Creativity and Humanity

The article discusses the impact of generative AI on the art world, with artists seeing their work …
The rise of generative AI has sparked concerns about its impact on the art world. Artists are seeing their work stolen and used to train AI models without consent or compensation. This has led to a heated debate about the role of AI in creative industries and the need for regulation.In 2022, the author, an artist, first started to see knock-offs of their work generated by AI image generators. The tech industry's approach has been to move fast and break things, with little regard for the consequences. The author argues that this is the greatest art heist in history, with billions of images harvested from the internet without credit, compensation, or consent.The tech lords knew what they were doing, with venture capitalist Marc Andreessen claiming that enforcing copyright law would “kill” the entire industry. The industry's narrative of inevitability is a way of getting people to comply in advance. The author notes that people seemed utterly unprepared to question the impact of AI on creative industries.In response, journalist Marisa Mazria Katz and the author launched an open letter demanding to keep AI-generated images out of newsrooms. The letter attracted thousands of signatures from around the world. Other artists have fought back in more powerful ways, including a lawsuit against leading image-generation companies Midjourney and Stability AI.The author argues that the tech elite's anti-humanism is revealed in their attacks on art. They shun human interaction and its serendipities, annoyances, and joys. The author notes that friction is the basis of all pleasure and that learning to make art is also friction.The impact of AI on creative industries has been devastating, with many artists out of work and entry-level illustration gigs annihilated. The audience will have to get used to the fact that generative AI is a tool to discipline and eliminate the human worker. The author argues that this is sold as progress, but it is actually a dystopian future.The author draws parallels with the luddites, who fought against the “satanic mills” and were skilled artisans fighting for their way of life. Artists too are fighting for a way of life, and if they are too disorganised to triumph, that will be everyone’s loss. The author concludes that AI companies' scraping may have started with the work of illustrators, but it has grown to encompass everything else, including culture, education, sanity, and our very imaginations.
#work #tech #companies
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