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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

American consumers are watching gasoline and airline fares climb, while economists warn that the war in Iran will keep pressure on prices across the U.S. economy.“The good old days are gone,” said Christopher Tang, a professor at UCLA’s Anderson School of Management who studies global supply chains. “We see gasoline prices rising now, but that’s only the tip of the iceberg; everything will become more expensive.”Since the conflict began in late February, crude oil has surged past $110 a barrel. The rally is tied to Iran’s leverage over the Strait of Hormuz, a narrow chokepoint through which roughly 20% of the world’s oil passes.In a recent address, President Donald Trump claimed the United States is “totally independent of the Middle East” and has “plenty of gas.” However, Brookings Institute’s energy‑security director Samantha Gross reminded listeners that oil is a globally traded commodity and the U.S. still imports significant volumes, meaning American consumers will face the same high prices as the rest of the world.Iran has either halted shipments through the strait or imposed a toll of up to $2 million per vessel. Tankers are forced to take longer routes or pay the fee, inflating logistics costs for all downstream users.Major logistics players are already passing those costs on. Amazon announced a 3.5% surcharge for third‑party sellers, while UPS and FedEx have introduced fuel surcharges exceeding 25%. The United States Postal Service will add an 8% surcharge to transportation rates starting 27 April, noting the charge is “less than one‑third of what our competitors charge for fuel alone.”When the prices go up, they rarely come back down— Christopher Tang, UCLACountries have dipped into strategic oil reserves to blunt the shock, but economists such as Virginia Tech’s David Bieri warn that refilling those stockpiles will require buying oil at today’s elevated prices, keeping the upward pressure on the market.Higher oil costs ripple beyond fuel. Crude is a key feedstock for chemicals, pharmaceuticals and fertilizers, meaning the surge could translate into higher prices for prescription drugs and groceries.Cornell University’s agricultural economics professor Christopher Wolf explained that diesel, a major input for farm equipment and fertilizer production, is also climbing, raising the cost of both crop cultivation and livestock raising.Retailers and food processors are already adjusting. “If we anticipate higher costs, we start raising prices early to avoid a sudden shock later,” Wolf said, describing a “rational expectations” approach.The Independent Grocers Alliance warned that a 10‑15% rise in fuel costs could lift food prices by 2‑4% by mid‑summer, underscoring the broader impact on household budgets.Although President Trump expects the United States to exit the Iran conflict within two to three weeks, experts agree that even a swift resolution will not instantly reverse the price spikes.The strait’s strategic importance means the political risk premium on oil will linger. “You never know when this could flare up again,” said Northeastern University’s Ravi Ramamurti, adding that the effect is likely to be persistent.As Tang summed up, “When the prices go up, they rarely come back down.”

At the start of 2026 Pakistan was sitting on a surplus of imported liquefied natural gas (LNG). Three consecutive years of falling demand – from a peak of 8.2 million tonnes in 2021 to 6.1 million tonnes by late 2025 – were driven by cheap solar panels and reduced industrial activity. The government responded by quietly selling excess cargoes abroad and shutting down domestic wells to avoid over‑pressurising pipelines. Any gas that could not be diverted would have been pushed into household networks at a loss, adding billions to the sector’s crippling debt. Everything changed on 28 February when the United States and Israel launched the "Epic Fury" operation against Iran. The strikes killed Supreme Leader Ali Khamenei and targeted missile sites, air defences and military infrastructure. Iran retaliated with hundreds of missiles and drones, choking traffic through the Strait of Hormuz – a chokepoint for roughly 20 % of global oil and gas. As part of its retaliation, Iranian drones hit Qatar’s Ras Laffan Industrial City on 2 March, the world’s largest LNG export hub. Qatar, the second‑largest LNG exporter after the United States, declared force majeure and halted all production, releasing it from contractual delivery obligations. The fallout was immediate. Qatar’s forced shutdown cut its LNG output by 17 % and disrupted the supply chain that fuels Pakistan, which sources almost all of its imported gas from Qatar and the United Arab Emirates. Pakistan’s LNG arrivals plummeted from 12 shipments in January to just two in March. Monthly cargo data from the Oil and Gas Regulatory Authority (OGRA) show that the country received between eight and twelve shipments a month through 2025, but only two arrived after the conflict began. Price pressure followed. On 13 February state‑owned Pakistan State Oil and Pakistan LNG Limited bought eight cargoes at an average of $10.47 per MMBtu (totaling $257.1 million). By 12 March the two cargoes that did arrive cost $12.49 per MMBtu – a 19 % increase in just one month. Long‑term contracts have left Pakistan with little flexibility. Two government‑to‑government agreements with Qatar, spanning 15 and 10 years, commit the country to nine shipments a month. Even as domestic demand fell – LNG’s share of Asian markets dropped from ~30 % in 2020 to ~18 % in 2025 – the contracts remained binding. Solarisation has been a double‑edged sword. By 2025 Pakistan installed 34 GW of solar capacity, with about 25 GW feeding the national grid, driving an 11 % decline in overall electricity demand between 2022 and 2025. Gas‑fired power plants built for imported LNG are now under‑utilised, especially during daylight hours. Analysts warn that the surplus was predictable. “Pakistan’s energy planning has been locked into long‑term contracts with little room for adjustment,” says Haneea Isaad of the Institute for Energy Economics and Financial Analysis (IEEFA). The resulting circular debt now stands at 3.3 trillion rupees (≈ $11 billion), and the government is negotiating to off‑load 177 unwanted shipments worth $5.6 billion through 2031. With Qatar’s LNG shipments effectively halted, the country faces a potential shortfall of more than 21 % of its power generation capacity. The National Electric Power Regulatory Authority confirmed that LNG supplies are under force majeure, while coal imports from South Africa and Indonesia continue. To mitigate the gap, Pakistan is reviving domestic gas production that had been throttled during the surplus period. Roughly 350–400 million cubic feet per day of domestic gas were previously held back for LNG imports, now being released to the grid. Nevertheless, analysts caution that even with restored domestic gas, imported coal and hydropower, “the energy shortage may persist, especially during the peak summer months.” Summer pressure is already building. The State of Industry Report 2025 recorded peak electricity demand of over 33,000 MW last summer, while winter demand sits around 15,000 MW, helped by solar generation of 9,000–10,000 MW daily. Furnace oil, the primary backup fuel, now costs 35 rupees per unit (≈ $0.12), more than double since the Strait of Hormuz disruption. Consumers with grid electricity face higher bills and possible outages; industrial users reliant on gas risk production cuts; those equipped with rooftop solar and battery storage are best insulated. “Returning to the spot market is unlikely given Pakistan’s dire financial position, and competing with wealthier nations would price the country out,” Isaad warns. “The realistic outcome may be planned load‑shedding of two to three hours daily.”

Britain is confronting the most severe energy shock since the early 1970s, as exports of oil, gas and fertiliser from the Middle East have abruptly stopped. The government says a response plan exists, but details remain vague. It is unclear whether the UK is better prepared for the fallout from Donald Trump’s war with Iran than it was for the pandemic six years ago. Ministers are sending a "we have your back" message to the public while simultaneously signalling to financial markets that any assistance will be limited and targeted. Contingency planning is especially difficult when dealing with an unpredictable leader like Trump. Britain’s heavy reliance on imported energy and food means that reassurance can only hold for a short time. The economy entered the conflict already on shaky ground: unemployment rose steadily throughout 2025 and growth stalled to a virtual standstill in the final quarter of that year. The sudden loss of Middle‑East energy and fertiliser supplies now adds a colossal supply shock. Last year, Trump’s “liberation day” tariff hikes served as a dry run for a far more serious confrontation. This time, the war is taking place in a region that is both volatile and crucial to the global economy. In the past two weeks, the repercussions have been felt across Asia – the Philippines declared a state of emergency, Sri Lanka introduced a four‑day work week, and South Korea announced budget measures to help households cope with soaring energy bills. The continent is the most dependent on Gulf‑exported energy, making the impact there the sharpest. The International Monetary Fund warned that the shock will drive higher prices and slower growth worldwide. Shortages push fuel and food prices up, eroding disposable income, prompting businesses to cut staff, and increasing the risk of recession. The UK, already projected to be one of the poorest‑performing major economies in 2026, could see its fresh graduate cohort face a brutal job market. Trump’s claim that the war could end within two or three weeks appears desperate. Even a rapid cease‑fire would leave substantial collateral damage, creating a stagflation scenario that could hurt Republican prospects in the upcoming mid‑term elections. British officials hope a swift resolution will limit economic damage, allowing a short‑term inflation spike to subside and the Bank of England to resume interest‑rate cuts. Treasury plans include scrapping the planned autumn fuel‑duty rise and providing targeted help for the poorest households, though the path is unlikely to be that simple. Currently, the Treasury is hesitant to act boldly for fear of unsettling bond markets. History – the 2008 banking collapse and the 2020 pandemic – shows that governments can act decisively without triggering a market backlash, using tools such as aggressive rate cuts, increased borrowing, and quantitative easing. The Bank of England has warned of a "substantial negative supply shock" and is expected to soften markets for future rate cuts, which are inevitable. Finance Minister Rachel Reeves could mitigate labour‑market pain by reversing recent increases in employers’ National Insurance contributions, subsidising public transport, and even lowering speed limits to conserve energy. The war, like the pandemic and Russia’s invasion of Ukraine, underscores the fragility of global supply chains and the need for greater British self‑reliance. Investing heavily in renewable energy is essential, but the UK also imports roughly 40% of its food and has not run a manufacturing trade surplus since 1982. In a world of disrupted supply lines, a robust plan for economic self‑sufficiency is more urgent than ever. Larry Elliott is a Guardian columnist.

Berkeley, one of Britain’s largest housebuilders, said it will cease buying new land and impose a hiring freeze as it confronts the impact of the Iran war and broader geopolitical volatility on the UK property market.The FTSE 100 company warned that a reduced likelihood of further interest‑rate cuts and soaring regulatory costs could weigh heavily on its business, prompting cost‑cutting measures that also include using fewer subcontractors.In a significant outlook revision, Berkeley now expects to generate more than £1.4 billion in pre‑tax profit between 2027 and 2030, a stark increase from the roughly £450 million it had forecast for the current year and 2027.Market reaction was swift: the company’s shares plunged up to 18 % on Wednesday morning, later recovering to sit about 13 % lower, making Berkeley the worst performer on the FTSE 100 that day.Berkeley’s statement noted that early‑2026 sales showed modest recovery, but “recent geopolitical events and the macro‑economic consequences, including reduced potential for further rate cuts, could reduce confidence in a near‑term market recovery.”The firm cited “unprecedented” increases in costs and regulation, alongside weak buyer demand, as reasons for halting land purchases, arguing it can no longer achieve a sufficient rate of return on new sites due to a continuous rise in tax and regulatory burdens.These challenges arrive as the UK government pushes to meet ambitious new‑home building targets, while the sector grapples with higher taxation, new building‑safety rules, and longer planning timelines—Berkeley estimates approvals now take about 12 months longer than before.The ongoing war in Iran has amplified inflation fears, lifted mortgage rates above 5 % and heightened mortgage‑cost pressures for consumers, according to Moneyfacts data.Competitors such as Barratt, Redrow and Persimmon have also suffered, each losing more than 20 % of their market value, underscoring the broader stress across the housing‑construction industry.Berkeley, headquartered in Surrey, employs over 2,500 people and focuses on brownfield regeneration projects. It holds land sufficient for 50,000 homes with an additional pipeline for 10,000 homes in London and the south‑east, but will slow construction on existing sites to match market demand and regulator approvals.

Unilever’s latest strategic move pairs its food portfolio – home to brands such as Hellmann’s, Knorr and Marmite – with US condiment specialist McCormick in a deal valued at $44.8 bn. While the transaction will deliver $15.7 bn in cash to Unilever, the bulk of the consideration is equity‑based, giving Unilever shareholders a 55% stake in the enlarged McCormick and leaving Unilever itself with a modest 10% holding. The structure marks a departure from Unilever’s recent clean‑break divestitures, such as the outright sales of its Flora spreads and Lipton tea businesses and the spin‑off of its ice‑cream division (including Ben & Jerry’s) last year. Instead, investors now face a complex share‑exchange that ties their fortunes to a company that will assume significant debt to fund the acquisition. CEO Fernando Fernández framed the transaction as “another decisive step in sharpening our portfolio”, yet market reaction was swift: Unilever’s share price slid 7% on the announcement. The decline underscores investor scepticism that the merger will unlock genuine value. From a financial perspective, Unilever’s food arm contributes annual sales of $12 bn – outpacing McCormick’s $8 bn – and enjoys higher growth (2.7% vs 2%) and superior margins (24% vs 17%). These metrics suggest Unilever could have retained a more profitable segment rather than ceding control to a partner with weaker performance indicators. Critics argue that the combined entity will be a sprawling conglomerate of global powerhouses like Hellmann’s and Knorr alongside niche brands such as French’s mustard and Old Bay seasoning. The anticipated synergies, described by McCormick’s Brendan Foley as “maximal adjacency” and “end‑to‑end flavour experiences”, remain unproven, especially given the modest cash component and the dilution of Unilever’s ownership. Ultimately, the success of the merger hinges on whether the new food business can generate growth that justifies the equity swap and the added debt burden. For now, the market’s 7% share‑price dip reflects a cautious outlook on the promised “trapped value” that Unilever hopes to unlock.

The escalating geopolitical tensions in the Middle East have triggered a worldwide energy crisis that is affecting lives far from the conflict zones. Alagesan, 35, a small business owner in Coimbatore, India, faces the potential collapse of his roadside drink and snack shop due to an acute shortage of liquefied petroleum gas (LPG) caused by the conflict."I am far away from the Middle East, but my life is affected," Alagesan stated. "The gas cylinder is not available because of the war. I don't know what to do."The closure of the Strait of Hormuz – through which one-fifth of the world's oil travels – has created a critical supply disruption, pushing international oil prices to approximately $100 per barrel. This surge is translating into higher costs for gasoline, petrol, and numerous consumer goods, placing significant pressure on households and economies globally.In response to the crisis, the International Energy Agency (IEA) has issued a series of recommendations including remote work where feasible, reduced highway speed limits, shifting from private vehicles to public transportation, carpooling, electric cooking alternatives, and avoiding non-essential air travel."The war in the Middle East is creating a major energy crisis, including the largest supply disruption in the history of the global oil market," stated IEA Executive Director Fatih Birol. "In the absence of a swift resolution, the impacts on energy markets and economies are set to become more and more severe."Individuals worldwide are implementing various coping strategies in response to fuel shortages and price increases. Many have restricted driving to essential journeys only, increased cycling, and utilized public transportation more frequently.In regions with cooler climates, heating oil usage has been drastically curtailed due to "skyrocketing prices," with some households heating only single rooms, burning wood, and adding extra layers of clothing. Others have cancelled vacations, citing inappropriate fuel consumption during heightened demand.While some expressed relief at having electric vehicles and solar panels providing "control" over their energy sources, many with limited public transport options have no alternative but to continue driving to work and essential activities, forcing difficult budget adjustments elsewhere.In India, where 60% of LPG is imported and 90% of it passes through the Strait of Hormuz, the crisis has led to severe rationing. Gangesh, 57, from Kerala, reported "most hotels are suffering the worst shortage" with "a large number of eateries shutting down leading to unemployment." One woman noted a "35-day wait for the next instalment of gas cylinders."The personal stories of adaptation continue across continents. Sue, 73, in the UK has "banned" car use except for hospital trips, opting for bicycles and a tricycle instead. Katie, 71, in Massachusetts faces impossible choices between food and gasoline for her son's essential medical care, requiring 100-mile round trips."We now consider carefully almost every mile we must drive and are trying to cut back expenses every way we can," Katie explained.In the UK, where an estimated 1.7 million households rely on heating oil, and in Northern Ireland where it serves as the primary heating source for nearly two-thirds of households, the crisis has reached critical levels. David in Londonderry expressed concern about "additional and immediate increases" in fuel costs, particularly for those with respiratory conditions requiring stable temperatures.Anne*, 50, in Perthshire, Scotland, saw the price of 1,000 liters of paraffin jump from £600 to £1,450, forcing her family to use firewood cut from fallen trees instead. "It's laborious work," she noted. "Hot-water bottles are also good. Very old school."Amanda*, 48, in Devon, UK, has only about three weeks of heating oil remaining: "I have had to turn it off as I do not have the extra money to pay the current prices. It's difficult because you obviously want to keep them [her sons] warm, and you feel guilty that you can't provide for them."Meanwhile, Alex, 46, in New South Wales, Australia, has reduced driving and increased public transport use, not only due to rising costs but also to avoid "panic buying" that could leave her without fuel. "War isn't about security or defending borders. War is what greed looks like in public," she reflected.

A cooking gas crisis in India has forced a mass exodus of workers from the country's vital textile industry, according to reports. The shortage of LPG (liquefied petroleum gas) has created significant disruptions to both household needs and industrial operations.The textile sector, which employs millions of workers across India, has been particularly hard hit as workers have been compelled to leave their jobs and return to rural areas in search of alternative cooking fuel sources. This mass migration represents a serious challenge to India's manufacturing economy and could have long-term implications for the country's industrial output.While the full extent of the crisis remains unclear, industry experts warn that the prolonged energy shortage could lead to further production shutdowns and economic instability in regions heavily dependent on textile manufacturing.

The ongoing conflict involving Iran has created a severe energy shockwave across Asian nations, prompting governments to implement extraordinary measures to cope with the economic fallout. Fuel rations have been introduced in several countries as energy supplies become increasingly constrained and volatile.In response to the economic pressure, governments have begun distributing cash handouts to citizens and businesses to mitigate the impact of rising energy costs. These emergency interventions highlight the far-reaching economic consequences of the geopolitical tensions in the Middle East.Asian markets, heavily dependent on energy imports from the region, are experiencing significant price volatility and supply chain disruptions. The situation has forced policymakers to balance immediate economic relief with long-term energy security strategies.