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A phase‑3 trial of retatrutide, a once‑weekly triple‑hormone injection, showed patients with type 2 diabetes cut HbA1c by up to 1.9 percentage points and shed up to 15 % of body weight after 40 weeks.Triple‑Hormone Mechanism Sets Retatrutide ApartThe drug combines analogues of GLP‑1, GIP and glucagon, targeting appetite, glucose regulation and energy expenditure simultaneously. Unlike Ozempic or Wegovy (GLP‑1 only) and Mounjaro (GLP‑1 + GIP), the added glucagon activity aims to boost metabolic rate.Trial Numbers Reveal Double‑Digit HbA1c Cuts and 15% Weight Loss930 adults with type 2 diabetes, BMI ≥ 23, not on other diabetes meds.Randomised to 4 mg, 9 mg or 12 mg retatrutide or placebo for 40 weeks.HbA1c reduction: 1.7‑1.9 pp vs 0.8 pp placebo.Weight loss: 11.5‑15.3 % vs 2.6 % placebo.Improvements in cholesterol and blood pressure observed.Serious adverse events in 14 participants (including 2 on placebo); most side effects were mild gastrointestinal issues.Potential Shift in Diabetes‑Obesity Treatment LandscapeExperts say the dual impact on glycaemic control and weight could reshape management pathways. Dr Kath McCullough (Royal College of Physicians) called the results “life‑changing,” while Dr Marie Spreckley (University of Cambridge) cautioned that head‑to‑head data against existing agents are still needed.For health systems such as the NHS, a drug delivering both outcomes may reduce long‑term cardiovascular complications and associated costs, but pricing and safety profiles will drive adoption.Next Steps: Head‑to‑Head Comparisons and Long‑Term SafetyFurther phase‑3 studies are planned to compare retatrutide directly with semaglutide and tirzepatide. Regulators will scrutinise the balance of metabolic benefits against gastrointestinal adverse events before approval.

A Hundred Days of Unfolding StalemateThe war launched by the United States and Israel against Iran has entered its third month without a decisive breakthrough. A Pakistan‑brokered ceasefire announced on April 8 has done little to stem the violence, leaving the region in a protracted, unpredictable deadlock.Ceasefire, Front‑Line Expansion, and Human DisplacementDespite diplomatic overtures, combat continues on multiple fronts:Operations have spread from Iran into Lebanon, where Israel’s advance has caused the heaviest death toll.The Strait of Hormuz remains largely closed to maritime traffic, disrupting global oil flows.More than one million people have been displaced as Israel expands its occupation of southern Lebanon, razing entire villages.Casualty and Displacement Numbers at the One‑Hundred‑Day MarkDocumented losses illustrate the human cost:3,593 people killed in Lebanon by Israeli forces.3,468 deaths in Iran attributed to joint US‑Israel actions.29 fatalities in Gulf countries from Iranian attacks.26 deaths within Israel itself.13 US soldiers killed in the broader campaign.Regional Implications of a Prolonged StalemateThe ongoing conflict threatens to destabilize the wider Middle East:Continued closure of the Strait of Hormuz could pressure global energy markets.Humanitarian crises in Lebanon and Iran risk spilling over into neighboring states.Failed peace talks heighten the risk of further escalation involving regional powers.What the Next Phase Could Hold for the Middle EastAnalysts warn that without a renewed diplomatic push, the war may settle into a low‑intensity but enduring confrontation, prolonging civilian suffering and keeping strategic waterways vulnerable. Future scenarios hinge on whether international actors can revive ceasefire negotiations or whether the conflict expands further, drawing in additional regional stakeholders.

The Power of Football in RecoverySarah Rhind, a 42-year-old goalkeeper and Street Soccer charity coordinator, has a powerful message about how football saved her from heroin addiction. In her recently published autobiography, "Scars Under The Jersey," Rhind details her journey through addiction, recovery, and the transformative role football played in her life. "I can wholeheartedly say that without it I wouldn't be in the position that I'm in now – if I was even lucky enough to still be here," she states emphatically.From Participant to Coordinator: Football as LifelineWhat makes Rhind's story particularly striking is her journey from participant to coordinator at Street Soccer, a charity that provides free sessions for at-risk and socially disadvantaged people. Before working for the organization, Rhind was a participant who relied on the weekly sessions to stay clean. "There were times where I'd come through a really rough weekend, struggling with thoughts of using and relapsing but hadn't done it," she recalls. "There were many times where the reason was literally: 'If I use, I can't go to football on Tuesday.'"Mental Health and the Pitch: A Sanctuary from NoiseRhind describes football as a sanctuary from the "mental noise" that consumed her life. "My mind is 24/7 from the minute I wake up to the minute I go to sleep at night; it's 20 tabs open and they're all about different things," she explains. "When I'm on the pitch and playing football the focus is just on that, because that was most important. It's like a transition happens. I get my boots on and step on to the pitch and I find it is the only place that I am able to leave the mental noise."Breaking Barriers: Women's Football and InclusionNow representing Scotland at international events like the Homeless World Cup (2015) and playing in the Scottish top flight with Hamilton Academical, Rhind is passionate about creating opportunities for women in football. She notes that women of her age have "missed out so much" compared with younger generations benefiting from the growth of the women's game. "I hear all the time: 'I'm not fit enough, not strong enough, I can't play football,'" she says. "When did society become so about having to be really good at something that you can't just try it or to have fun with it?"The Healing Power of StorytellingWriting her autobiography was a cathartic experience for Rhind, who found the process to be "an incredible platform for healing." She particularly struggled with documenting moments of suicidal thoughts, noting that "it had taken me a couple of weeks to actually be able to write a sentence out about being suicidal." The act of writing, however, became therapeutic. "I just wrote it and I remember it so clearly: I just sat and looked at that sentence and realised what a powerful form of therapy that process had been," she reflects.A New Chapter: Continuing the JourneyFor Rhind, recovery is an ongoing process. "Life is hard and that's always going to be the case; things are going to keep happening," she acknowledges. "But, hopefully, I can keep building my toolbox of coping mechanisms for dealing with those things when they come, and keep talking." Through her work with Street Soccer and sharing her story, Rhind continues to help others find their path through darkness, using football as both a literal and metaphorical lifeline.

The Lead: Spain's Coaching Philosophy Finally Gains Recognition As Spain prepares for the World Cup, national team coach Luis de la Fuente reflects on the journey that took him from teaching in the Spanish federation's classrooms to leading his country to European Championship glory. The coach who never played for the senior national team has overseen a generation of Spanish football that has produced some of the world's most successful coaches and players. The Coaching Classroom: Where Spain's Football Leaders Are Born On the ground floor of the Spanish football federation's headquarters in Las Rozas are two classrooms covered with photos of everyone who has played for la selección. More than 800 men are there, but Luis de la Fuente's picture is missing—his international playing career only took him as far as the under-21s. This is where he taught; it is also, he says, where he learned, his pupils not alone in going on to big things. De la Fuente spent three years teaching at the federation from 2017, while also coaching Spain's under-19s and under-21s. He taught two subjects on the federation's Uefa pro licence coaching course: the evolution of football and team building. In his classes sat future coaching greats including Lionel Scaloni, Xabi Alonso, Xavi Hernández, and Raúl—names that would go on to shape football at the highest levels. The Global Impact of Spanish Coaches From Spain it was not only Fabián Ruiz, David Raya and Martín Zubimendi who were in Budapest recently but also the managers: Luis Enrique, De la Fuente's predecessor, and Mikel Arteta. The week before, Unai Emery lifted the Europa League. Pep Guardiola bade farewell as perhaps the most influential coach the Premier League has had. And Xabi Alonso has been appointed at Chelsea, Andoni Iraola at Liverpool. "This is a process that goes back a long time; at last it seems people are starting to appreciate it," De la Fuente says. "That appreciation should have happened ages ago. With trophies, it becomes more visible but the development, the way it is structured and conducted, the work done by coaching schools at regional and national federations, was always an example to everyone." The Philosophy of Teaching Football "It would be easy to now say Scaloni stood out but it is true that there were some who had something a bit different," De la Fuente reflects. "That restlessness, how they would challenge you: 'I don't see it.' Scaloni debated everything, argued. We're similar too, a parallel in our paths. He starts at the under-20s, then made his way into the senior squad and won it all. He had to, we both did: it was win, win, win, win, because if we hadn't..." Within six years teacher and pupil would be European and South American champions respectively. Those successes should have brought a class reunion at the Finalissima in Qatar but war forced postponement. "Two don't play if one doesn't want to; we were mad keen to play," De la Fuente says. "It was a pity. I don't think politics will be a problem this summer: football is something that can bring people together of all creeds, ideologies, races and religions." The Future: Spain's World Cup Ambitions "Who would have thought it?" De la Fuente asks, reflecting on his journey to the senior national team. His first big senior job came past 60, having worked in Spain's youth structure for a decade. Scaloni, 40 when thrust into the seniors, hadn't worked at a club. "Life provides these moments. And nothing was given to us for free. It's all through work, work and more work..." "In the end, sporting success is fleeting. But I remember my teachers... So when I had the chance to work at the RFEF [federation], I thought: it's my job to shape people." With Spain heading to the World Cup as one of the favorites, De la Fuente's philosophy of developing both players and coaches continues to bear fruit on the world stage.

The Rise of Tech-Savvy Farmers in KenyaKericho County, Kenya – A typical Saturday morning starts before sunrise for Chepkorir Rotich, a farmer in Kiboito village in western Kenya's Kericho County. By then, Rotich has already milked her cows and sold the milk, fed her chickens, and headed back to pluck vegetables for orders already placed. Her work starts this way every day, and she does it with passion.When the 33-year-old mother of two left college more than a decade ago, she was excited and ready to join the formal employment sector and secure a full-time job."I thought I would be employed as a business administrator, but after looking for a job for too long, I accepted contract offers in three different companies," she says. "The highest paid me about $200 in a month. While living in Nairobi, that wasn't enough."From Job Seekers to Agricultural EntrepreneursA lack of white-collar jobs has kept young Kenyans like Rotich out of employment, leaving them to innovate ways to survive and earn a living. In doing so, many youths have resorted to agriculture and other fields, with many using digital as well as vocational skills to stay ahead of the game.Digital Transformation of Kenyan AgricultureRotich, for example, uses social media to market her produce and to learn how to practice agriculture using modern methods. Social media helps her share knowledge with young people who comprise a large portion of her nearly 50,000 followers. She also runs a YouTube channel where she shares her knowledge of farming.The Food and Agriculture Organization of the United Nations (FAO) reports that the average African farmer is 60 years old, something Rotich refutes, saying the presumed age of farmers has made many young people shun agriculture instead of embracing it as a way to earn a living going into the future."I think the reason they say that is because of access to land on which to do agriculture, which is mostly owned by older people," Rotich tells Al Jazeera. "In my case, I started farming in the compound of my rented house, and by the end of each month, my landlord owed me money after settling the rent because I sold him milk and vegetables. So, it's all about passion and consistency among the youth."Kiringai Kamau, a lecturer at the University of Nairobi with expertise in agricultural economics, agribusiness, and food systems, says young people should take up agriculture as full-time employment since they are the ones who can effectively understand and deploy technology."To do this, we have established the devolution agroecology and AI learning centre in Murang'a University, where we will be pushing to have the centre train the youth who will be going into agriculture to be able to link with the agricultural data ecosystem, deriving from the infrastructure that will be provided, and also giving information to the county and country, and any other professionals that may be interested in data coming there," he tells Al Jazeera.Derrick Ngigi, the technical head at Global Open Data for Agriculture and Nutrition (GODAN), says that while youth are embracing agriculture, technology also plays a role in providing them with opportunities."For example, content creation in agriculture brings a lot of opportunities, such as creating content around modern farming methods, which has been generating revenue for the youth," Ngigi says.AI Tools Revolutionizing Farming PracticesAbout five kilometres outside Kiboito, at Kaptoroi village, Geoffrey Kiprop is busy cleaning his cowshed after feeding his cattle for the early morning. The 32-year-old earned a bachelor's degree in information technology in 2017 but has never secured formal employment.Like Rotich, Kiprop has been surviving on contract work, such as jobs doing systems development and maintenance for schools. He says that the highest-paid contract was for 15,000 Kenyan shillings ($116). But now, he makes about 7,000 Kenyan shillings ($54) a day through farming.Kiprop also practices mixed farming, rearing cows for milk and chickens for eggs and meat, while also planting crops such as tea, coffee, capsicum, cabbage, and beans.He uses modern technologies to raise his crops and livestock and takes advantage of his IT training, which he utilises to ensure maximum profits.Examples of the tools he uses include the Plantix app, which he says helps detect crop disease and malnutrition using AI after he simply takes a photo of the crop and uploads it. The app also gives the farmer the weather forecast and the best crop practices to perform in line with current weather conditions."My favourite is the Virtual Agronomist. This is an AI-enabled platform where I use Google Maps to capture the coordinates of my crop field and then specify the types of crops I am growing," Kiprop explains. "In return, the Virtual Agronomist will enable me to know the size of the plots under farming. It also generates a nutrient plan by sampling the soil in the farm, guiding me in what the soil is missing in terms of nutrients and the exact amount to add," he tells Al Jazeera.For his cows, Kiprop also uses an AI tool to manage their health and production."Also, I use the Digicow app, which assists the farmer in managing dairy farm practices by tracking all the day-to-day activities in the dairy farm, which includes recording the amount of milk sold and used by the farmer, dairy inputs like feed and health practices, thus allowing the farmer to know if he's making a profit or not," Kiprop says.Financial Benefits of Tech-Enhanced FarmingBoth Rotich and Kiprop demonstrate that farming with AI tools can be more financially rewarding than traditional employment paths for educated young Kenyans. While contract work offered Rotich a maximum of $200 per month and Kiprop's highest contract paid 15,000 Kenyan shillings ($116), Kiprop now earns approximately 7,000 Kenyan shillings ($54) daily through his tech-enhanced farming operations.The Future of Agriculture in KenyaBoth Rotich and Kiprop agree on one thing: agriculture also comes with its own challenges, and one has to be deeply passionate and consistent to make something out of it."Consistency is key," says Rotich. "It's something that many young people lack, and they quit very early before they can break even and realise profits. One has to do things many times to be able to finally get it and learn from the mistakes made before."

The LeadThomas Tuchel was unhappy with England's "freestyle" performance in the first half of their 1-0 win over New Zealand but the head coach was pleased with Jude Bellingham's impact as a substitute in Tampa. Harry Kane's goal just before half-time was the difference in a forgettable encounter at Raymond James Stadium.Tuchel's Tactical Concerns"I'm OK with it," was the German's forthright assessment of England's display. "I'm not super-happy about it. I like the second half more than the first half. We played more from our positions and that's why we played with more speed and off the ball we played with a bit more bite. The first half we were out of positions and it was a bit too much freestyle."Tuchel explained that his "freestyling" comment mainly related to positional awareness. "We were lacking width so players were coming inside and narrowing ourselves down and slowing ourselves down and changing positions for too long," he said. "We were taking crosses, a lot of long-range shots, normally not our style of play. We played a lot of long balls, we played a lot of long passes. That was not part of training in the last four days."Match ChallengesThere were other factors behind England's lack of flow. They fielded different XIs in each half, the pitch was awkward and the heat was difficult to master. "We had one training in the sun and now this match felt really, really odd," Tuchel said. "But it's good that we're exposed because that's why we're here. We wanted it that way and we need to get used to it because it will come at some point."Bellingham's ImpactBellingham was handed the captain's armband after replacing Morgan Rogers at half-time and the Real Madrid midfielder pressed his case to start in the No 10 role when England open their campaign against Croatia on 17 June."Jude has the decisiveness and he has the bite," Tuchel said. "This is a key characteristic. You can see that he comes back from an injury and is full of energy and happy to be back on the pitch. He had his break, unfortunately, in a decisive part of the season. But you can see now that he is actually in a sweet spot. He comes back, he's fresh, he wants to play and he's in top shape."Kane's ImportanceKane's 79th goal for England, who head to Orlando to face Costa Rica in their final warm-up game on Wednesday, underlined the captain's importance to the side. "He's always there to score," Tuchel said. "It's a decisive goal. Harry is in top shape and I think that when the pressure comes and the tournament starts, that will bring the best out of all our players."

The Word Puzzle ChallengeEarlier today I set you these two word puzzles. Here they are again with solutions.Exploring Homonyms in EnglishA homonym is a word that has the same pronunciation as, or is spelt identical to, another word with a different meaning.For example, the letter "a" has the homonym "eh".What's interesting about "eh" is that it does not contain the letter it sounds like. There's no "a" in "eh".Find another five letters in English that have homonyms that do not contain the letter they sound like.(One of the words may be a tad obscure, unless you know some Caribbean geography. Or like crossword puzzles.)These five letters (excluding "a") spell a common word. What is it?Solution to the First PuzzleQ -cueU – ewe or yewI – eyeC – see or seaK – cayAs I was writing this I though of a sixth, X = "Ecks", the pural of Eck, the Scottish diminutive of Alex. But proper names don't count. (Scrabble rules.)The Second Challenge: Same Spelling, Different PronunciationsFind the homonyms below. Each pair of meanings describes a word that is spelt the same but pronounced differently. The words are listed in alphabetical order.(Second option) (Switch back and forth)(Suitable) (Commandeer)(Satisfied) (Components)(Conference attendee) (Assign)(Price reduction) (Disregard)(Way in) (Enrapture)(Incorrect) (Disabled)(60 seconds) (Tiny)(In attendance) (Give)(Fruit and vegetables) (Generate)(Deny) (Rubbish)(Distress) (Surprise victory)Solution to the Second PuzzleAlternateAppropriateContentDelegateDiscountEntranceInvalidMinutePresentProduceRefuseUpsetThe Value of Language PuzzlesWord puzzles like these homonym challenges not only entertain but also enhance our understanding of language complexities. They highlight the fascinating quirks of English pronunciation and spelling that make the language both challenging and delightful.Future of Word ChallengesAs digital platforms continue to evolve, word puzzles are finding new audiences and formats. The timeless appeal of language challenges ensures they will remain popular across generations, adapting to new technologies while preserving their core educational value.I hope you enjoyed these. Eyal bee Bach inn too weak's.Sources: 1 Gerry Reynolds 2 Ryan McCormackI've been setting a puzzle here on alternate Mondays since 2015. I'm always on the look-out for great puzzles. If you would like to suggest one, email me.

The Rise of Sound Baths in Wellness Culture In an era where digital detoxes and mindfulness practices have become mainstream, a new wellness trend has emerged: sound baths. These experiences, where participants pay to lie on mats while practitioners play singing bowls, chimes, and gongs, have seen online interest rise exponentially in the last decade. From Sydney Harbour settings to high-end wellness clubs with surround-sound chambers, the industry is capitalizing on claims that these sonic experiences can "soothe and calm your nervous system" with sounds that "penetrate every cell in your body." But as this trend grows, questions arise about whether these expensive experiences deliver on their promises. The Science Behind Sound and Relaxation "There's a rich field of music psychology that's all about the impacts of different types of sounds on human psychology and human physiology," explains Dr Vince Polito, a senior lecturer in psychological sciences at Macquarie University. Experts suggest that while specific frequencies may not have the mystical healing properties claimed by practitioners, the experience can still be beneficial. Dr Sandra Garrido, a senior research fellow at the University of Sydney's school of psychology, notes that "like anything in the wellness space, its benefits can definitely be talked up." The effects of sound or music on wellbeing largely relate to how we perceive and interpret those sounds, rather than specific types or frequencies. Research Evidence on Sound Meditation Studies on sound baths and similar practices offer some insight into their potential benefits. A 2016 observational study found that people who participated in a meditation session involving Tibetan singing bowls reported feeling less tension, anger and fatigue afterward. Another randomized controlled trial in breast cancer patients linked Tibetan sound meditation to improved cognitive function and mental health. However, researchers note that mindfulness meditation itself has been independently linked to improvements in anxiety, depression and insomnia, making it difficult to isolate the specific effects of sound. Sound Baths vs. Music Therapy While sound baths have gained popularity in wellness circles, they differ significantly from music therapy, a regulated profession with a long history of therapeutic use. "There are long histories of using music and sound in therapeutic ways," says Dr Amanda Krause, a senior lecturer in psychology and president of the Australian Music and Psychology Society. Music therapists work with a range of clients in schools and hospitals, using music listening or production to improve psychological and physical health. Unlike sound bath practitioners, music therapists are registered professionals with standardized training and ethical guidelines. The Social Connection Factor One potential benefit of sound baths that researchers acknowledge is the social aspect of the experience. "Historically, throughout most of human history... music has been about social connection," Garrido explains. "It's only in the last 100 years or so that we've had the capacity to go home and listen to music on our own in an isolating kind of way." The communal experience of a sound bath can create a sense of connection that's increasingly rare in our digital, often isolated lives. "Communally listening to music in the experience of a sound bath can be a 'helpful, healthy thing,'" Garrido adds. The Future of Sound Wellness As the wellness industry continues to evolve, sound baths may find their place alongside other mindfulness practices, though perhaps not as the "miracle cure" some marketing suggests. "I've been to them myself," Garrido admits. "I enjoy them, they can be relaxing, it's a nice experience – but I wouldn't pay too much money for it." The future of sound wellness likely involves a more balanced approach that acknowledges both the potential benefits of focused listening and the importance of not overclaiming what the science can support. As with many wellness trends, the key may be finding practices that work for individuals without requiring expensive or mystical explanations.

The Discovery of Tool Use in Bees Bumblebees can use tools to solve a problem, according to experiments that demonstrate their remarkably advanced cognitive abilities. The bees were given an adapted version of an experiment that, 100 years ago, first demonstrated chimpanzees could work out how to retrieve an out-of-reach banana by stacking boxes. The Experiment and Its Findings In the latest research, bees were shown to be able to roll a polystyrene ball to a specific location and climb on to it in order to access an artificial flower on a low ceiling. The findings challenge the longstanding assumption that insects operate purely on instinct and mindless trial-and-error learning. The Implications of Bee Intelligence “Most people think insects are reflex-based machines,” said Dr Olli Loukola, a behavioural ecologist at the University of Oulu, Finland, and senior author. “That they can’t have any emotional states or feel pain. Some people don’t even realise that they have brains. I hope that these results change the worldview about that.” The Complexity of the Challenge The bees, which were only a couple of weeks old, were first trained to associate a blue artificial flower with a reward of sugar water. During the test, the flower was moved to the ceiling of a transparent petri dish-style chamber whose ceiling was too high for them to reach, but with insufficient space for them to hover. A ball was also introduced into the chamber. To reach the flower, the bee had to roll the ball under it and climb on top – a behavioural sequence they had never previously encountered or been trained to perform. The Results and Their Significance In the most basic version of the test, 75% of the bees were successful in reaching the flower. “This is essentially an insect version of the classic ‘box-and-banana’ problem,” said Loukola. “The animal must realise that an object can be repositioned and then used as a tool to reach an otherwise inaccessible goal. What stands out about the result is that this kind of spontaneous problem solving is now demonstrated in an insect.” The Future of Bee Research “We are not claiming that bees think like humans,” said Loukola. “But our findings show that miniature brains can generate flexible solutions to novel problems in ways we are only beginning to understand.”