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The Lead Doctors, scientists, and researchers shared new research about ways to tackle cancer at the 2026 American Society of Clinical Oncology (Asco) annual meeting, the world's largest cancer conference. Breakthroughs in Cancer Treatment The event in Chicago, attended by 40,000 health professionals, featured more than 200 sessions and 2,700 poster presentations on this year's theme, “the science and practice of translation: improving cancer outcomes worldwide”. Smart Drugs in Cancer Treatment Researchers have developed a smart drug that stops cancer cells hiding. The experimental tablet, GRWD5769, can help shrink tumours by at least 30% in six of the world’s most common forms of the disease, delegates in Chicago were told. 26 of 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers who were given GRWD5769 alongside cemiplimab had tumour reductions of at least 30%. 15 had tumour reductions of at least 30%. A Daily Pill for Pancreatic Cancer A pill that doubles survival time in patients with pancreatic cancer was presented at the conference. In a trial of 500 patients, all of whom had pancreatic cancer that had spread, the pill, daraxonrasib, doubled survival time, with fewer side-effects compared with chemotherapy. Patients who took the drug lived substantially longer, for an average of 13.2 months, compared with 6.6 to 6.7 months for patients who had chemotherapy. Safely Skipping Some Treatments Some patients can safely skip some treatments, according to research presented at the conference. A genomic test could pave the way for a new era of personalised medicine, enabling doctors to determine which patients can safely skip chemotherapy. The Optima trial, led by University College London, followed 4,000 patients with newly diagnosed breast cancer in the UK, Norway, Sweden, Australia, New Zealand and Thailand. Those with a low score on the genomic test could be treated safely with hormone therapy alone. The Future of Cancer Treatment Urgent action is required to cope with rising cancer cases. The world faces a cancer workforce crisis, experts said, with a shortage of 100 million staff expected by 2050 when 100,000 people will be being diagnosed every day. A 21% increase in cancer incidence is predicted, according to a report presented at the conference. The rate is set to rise from 165 per 100,000 people in 2025 to 200 per 100,000 in 2050.

Executive Summary: Human‑Centric Startups Rise Amid AI Money FloodEven as AI fundraising breaks new records, founders like Brynn Putnam are raising capital for ventures that prioritize face‑to‑face interaction and tactile tech. The shift reflects a broader consumer desire for experiences that feel more human, challenging the narrative that all capital must flow to AI‑only companies.Rise of Offline‑First Startups in an AI‑Dominated MarketRecent weeks have highlighted two contrasting movements:Board – founded by Mirror co‑founder Brynn Putnam, secured a new funding round to develop in‑person games and social experiences.Cyberdeck creators – a community building whimsical DIY computers that literally encourage users to "touch grass," gaining viral attention for their analog appeal.Both illustrate a growing appetite for products that foster real‑world connection.Funding Landscape: AI vs Human‑Centric VenturesAlphabet announced an $80 billion AI fundraising commitment, underscoring the scale of corporate AI investment.Anthropic filed a confidential IPO, signaling that even AI‑focused startups are eyeing public markets.Despite this, startups like Board are attracting seed‑stage capital, indicating that investors still see value in non‑AI playbooks.Impact on Consumer Behavior and Startup StrategyThe emergence of "together tech" suggests a market correction:Consumers are gravitating toward experiences that feel tangible and social.Founders are positioning products as antidotes to screen fatigue, leveraging nostalgia and physical interaction.Venture firms are diversifying portfolios to include both AI‑heavy and offline‑first concepts.Looking Ahead: A More Balanced Startup EcosystemAnalysts expect the following trends to shape the next 12‑18 months:Continued inflow of capital into AI, but with a growing slice earmarked for hybrid models that blend digital intelligence with physical experiences.Increased media coverage and podcast discussion (e.g., Equity hosts Kirsten Korosec, Anthony Ha, and Sean O’Kane) will amplify awareness of offline‑first ventures.Potential for strategic partnerships between AI giants and tactile‑tech startups, creating new categories of smart‑physical products.

The Connection Between Ebola and Deforestation For decades after the discovery of Ebolavirus in 1976, outbreaks of the disease were relatively small and contained, affecting a few hundred people at most. However, in recent years, outbreaks of Ebola have been much larger, affecting thousands and even tens of thousands of people across multiple countries. The Role of Mineral Extraction in Deforestation The conventional explanation for the increased spread of Ebola has to do with larger and more interconnected human populations. However, a more fundamental driver is the transformation of the underlying ecology of Ebola, which is being re-made, in part, by the rising global hunger for minerals to power the hi-tech economy. The increasing demand for minerals such as cobalt and gold, essential for smartphone production, is driving deforestation in the Congo basin. The Data Analysis: Deforestation and Ebola Incidence With each per cent increase in deforestation in Central Africa, the incidence of malaria and Ebola spikes by 20% to 40%. The 2014 Ebola epidemic was preceded by the loss of 85% of the forest cover in the south-west corner of Guinea, where the outbreak began. The current outbreak of Bundibugyo Ebola fits the pattern, too, being preceded by a record loss of 1.5m acres of Congo basin rainforest in 2024. The Impact Analysis: Broken Ecologies and Pandemics The hunt for minerals alters the ecology of Ebola in peculiar ways that juice the pathogen's ability to spread among us. When people expand their farms, they generally push into forests from the edges. Those who seek minerals, in contrast, plunge deep into the core of the forest. The rising price of minerals attracts people from all over, including those who don't enjoy the acquired immunity of regular forest-dwelling people. The Prediction: Preventing Future Pandemics It's only the third and relatively ignored pillar of policymaking around pandemics that can: preventing the broken ecologies that drive novel pathogens into human populations in the first place. That will mean more attention to the health of ecosystems such as the forests of the Congo basin, and how its minerals might be inside the smartphone tingling in your pocket.

The Guardian's 2025-26 Premiership Team of the Season The final round of the regular Premiership season is approaching, with playoffs yet to come. The Guardian has unveiled their team of the season for 2025-26, with players required to have appeared in at least nine league fixtures to be eligible for selection. The XV features a mix of established stars and emerging talents, with Northampton Saints particularly well-represented in the lineup. Backline Brilliance: Standout Performers in the Three-Quarters The backline showcases some of the league's most exciting talents. At fullback, George Furbank of Northampton has overcome an injury-disrupted start to re-emerge as a key cog in Saints' slick backline and is positioned to regain the England No. 15 jersey. On the wing, 19-year-old Noah Caluori of Saracens has impressed with his aerial ability, contributing 14 tries in just three games against Sale (twice) and Newcastle, and finishing the season with 18 tries in 12 Premiership matches. Midfield Mastery: Tactical Versatility and Strike Power The midfield features players who have demonstrated both tactical intelligence and finishing ability. Tommy Freeman shifts to outside center to accommodate Caluori on the wing, boasting an impressive 16 tries in 13 league matches. At inside center, Rory narrowly edges out competitors like Len Ikitau and Max Ojomoh with his ability to cut smart angles and inject vital pace at crucial moments. On the left wing, Immanuel Feyi-Waboso's return after injury has highlighted his dangerous ability when given space, with five tries in the opening two rounds and consistent ability to leave defenders behind. Halfback Excellence: Vision and Control The halfback pairing features two players who control the tempo of their respective teams. At fly-half, Billy Searle of Leicester has been a revelation this season, with his confidence and skillset underpinned by a competitive edge that has put him on England's radar. At scrum-half, Ben Spencer of Bath edges out Northampton's Archie McParland with his exceptional kicking out of hand and expert game management, though potentially feeling the effects of a long campaign after 27 matches for club and country. Forward Dominance: Power and Versatility in the Pack The forward pack features players who have consistently delivered throughout the season. At loosehead prop, Nicky Smith of Leicester has started every regular season game, earning him a long-term deal with Sale Sharks. At hooker, Gabriel Oghre of Bristol stands out for his multi-dimensional skills, including a remarkable 45-meter kick to touch from a lineout throw. In the second row, Thomas du Toit of Bath provides the power and stability that has been crucial to Bath's success. At blindside flanker, the stat-topping No. 8 has been instrumental in driving his team forward with consistent performances. Statistical Standouts and Impact Analysis The selection is backed by impressive statistics that highlight the players' contributions. Caluori's 18 tries in 12 games places him at the top of the scoring charts, while Freeman's 16 tries in 13 matches demonstrates his exceptional strike rate. Northampton's dominance is evident with four players selected, reflecting their consistent performances throughout the season. The selection also recognizes the impact of returning from injury, with Feyi-Waboso's comeback proving particularly influential for Exeter's resurgence. Future Implications for England and Club Rugby This team of the season provides insight into potential England selections for upcoming international fixtures. Furbank's return to form strengthens the fullback position, while Searle's emergence at fly-half offers an alternative to established internationals. The selection of young talents like Caluori and Feyi-Waboso suggests a bright future for English rugby, with these players expected to develop further. For clubs, the recognition of players like Smith, who has been consistently selected despite modern rotation trends, highlights the value of reliability and durability in the modern game. Looking Ahead: Playoffs and International Rugby As the playoffs approach, this team of the season provides a benchmark against which performances will be measured. Several selected players will be crucial to their teams' playoff hopes, particularly Spencer for Bath and Hutchinson for Northampton. Looking further ahead, the Six Nations and Rugby World Cup preparations will benefit from the form shown by these players, with England likely to draw heavily from this pool of in-form performers. The balance of experience and youth in this selection suggests England will be competitive on multiple fronts in the coming season.

The Evolution of Bazball Four years after England's first Test under Brendon McCullum against New Zealand at Lord's, the two teams meet again with England looking to evolve their approach. England's Shift in Strategy McCullum's side will look to build on their success in the 2022 series, where they chased down testing targets to seal victory, with Jonny Bairstow scoring 394 runs at a strike rate of 120.12. The Data Behind the Success Before 2022, only three English players had scored more than 300 runs in a series at a strike rate above 85. Since then, another 10 players have achieved this feat, including Bairstow against New Zealand. The Impact on the Team McCullum emphasized the need for England to 'evolve slightly' while maintaining their core identity, stating: 'We know they're going to do things really well for a long period of time. Our job is to find a way to be able to compete with that style, yet also disrupt it when we've earned the right to be able to do so.' The Future Outlook As England looks to build a sustainable and successful team, McCullum is focused on embedding an identity that will allow young talent to flourish, saying: 'You're trying to build a team which ultimately is successful, wins the big series, does it with an identity and a style of play, but is also the smartest team in the world when it comes to tactics and implementing those.'

Authors and Readers Share Their Favorite Reads of May In a recent article, The Guardian shared recommendations from writers and readers on the books they enjoyed in May. The list includes a diverse range of titles that have captured the hearts of readers. Recommendations from Madeleine Thien Madeleine Thien, author of 'The Book of Records', shared her favorite reads, including: Dorothy Tse's 'City Like Water', a novel translated from Chinese by Natascha Bruce Karen Hao's 'Empire of AI' Hsiao-Hung Pai's 'Scattered Sand: The Story of China's Rural Migrants' Hannah Lillith Assadi's 'Paradiso 17' Michael Ondaatje's selected poems, 'The Distance of a Shout' Stephen's Recommendation Stephen, a Guardian reader, recommended: Francis Spufford's 'Nonesuch', a mystical and captivating read set in early wartime London Sufiyaan Salam's Recommendations Sufiyaan Salam, author, shared his favorite reads, including: Monika Radojevic's 'Strangerland', a story about immigrant parents' love story in pre-smartphone London Alan Moore's 'From Hell', a graphic novel weaving together London's past, present, and future The Oxford Shakespeare, for its insight into the playwright's life and times Sue's Recommendation Sue, a Guardian reader, recommended: Lisa Ridzén's 'When the Cranes Fly South', a moving story about love, friendship, and the end of life

The Approval of Poke on Apple's Messages for Business Poke, a startup that turns using AI agents into something as simple as sending a text message, has become the first AI agent approved to run on Apple's Messages for Business platform. This platform, previously limited to partnered businesses such as airlines, retailers, and hotel chains, offers a standardized interface for business messaging that supports both automated chat systems and live agents. How Poke's AI Agent Works Poke, launched in March, is designed to be accessible to everyday users who don't have the technical skill set or inclination to work with command-line tools or more complex agentic systems. The AI service operates over SMS, Telegram, and WhatsApp, and now, it will be able to add iMessage to its supported platforms. Poke can help with common activities like daily planning, managing calendars, tracking health and fitness, controlling smart homes, editing photos, and more, all via text message. The Business Model and Impact Poke has relayed some 100 million messages to date. The startup will pay Apple on a per-user basis, with a pricing model significantly lower than Meta AI. This approval and business model open up new opportunities for Apple, as it allows consumers to interact with businesses through iMessage's interface directly. The Future of AI Agents on Apple's Platform Getting Apple's approval required Poke to verify it could offer live support and that its AI agent was clearly identified as such. The approval process took a couple of months, and it will likely take other companies a similar amount of time to get through this process. The future of AI agents on Apple's Messages for Business platform looks promising, with Poke being the first but potentially not the only one. The Prediction As Apple prepares for its Worldwide Developers Conference, where it's expected to introduce an AI-optimized version of Siri and other AI tools, the approval of Poke on its Messages for Business platform signals a growing support for AI agents. It's likely that more AI agents will be integrated into the platform, providing users with a wider range of services and businesses with new ways to interact with customers.

The Lead: WWDC 2026 Anticipation Builds As Apple's Worldwide Developers Conference, WWDC 2026, approaches, excitement is building around what Apple has in store for us this year. From Siri's overhaul to new Apple Intelligence updates, there's a lot to look forward to. Siri's Major AI Upgrade and Standalone App The most anticipated announcement is a major AI upgrade to Siri, transforming it into a more conversational assistant capable of understanding context, handling multi-step tasks, and interacting more naturally across apps and services. The revamped Siri will leverage Google's Gemini technology to enhance its capabilities. Additionally, recent leaks from Bloomberg have unveiled a standalone Siri app that aims to compete with advanced AI chatbots like ChatGPT, Claude, and Gemini. Apple may also introduce a feature reminiscent of messaging apps, enabling users to set timers for automatically deleting conversations after 30 days, a year, or keeping them indefinitely. Apple Intelligence Updates According to The Information, Apple plans to introduce an AI agent integration with the app store. While details are scarce, agents allow users to delegate tasks such as booking reservations, managing everyday tasks, editing documents, or controlling smart home devices. Camera and Photos App Enhancements A new 'Visual Intelligence' section is anticipated to be introduced within the Camera app, taking the place of the previous Visual Intelligence feature found in the Camera Control button. This upgrade will introduce a dedicated Siri mode that exists next to options like Photo, Video, Portrait, and Panorama. The Visual Intelligence feature leverages Google Image Search to accurately identify objects captured by the user. In addition, the Photos app is set to receive exciting enhancements powered by Apple Intelligence. These may include intelligent scene recommendations for optimizing photos, automatic object removal for cleaner images, and an innovative AI photo editing feature that allows users to request edits simply by using natural language. Other Expected Updates Apple is set to upgrade the Image Playground app, introducing higher-quality image generation, more artistic styles, better character consistency, and richer editing controls. The interface for creating new images will be simplified, offering fewer controls and a 'describe a change' option for editing. Additionally, we might see a suggested Genmoji feature that proposes custom emojis based on users' media and text interactions. Users may also be able to generate AI wallpapers that reflect various themes and moods. Notable updates are rumored to be coming to the Wallet app, particularly a new bill-splitting feature that will simplify sharing expenses among friends or family. Users will be able to photograph a receipt and generate payment requests to different parties effortlessly. Alongside this, the Wallet app will also include a 'Create a Pass' option that enables users to generate digital passes from physical items such as movie tickets, concert passes, or gym membership cards. The Future of AI-Powered Siri Apple is expected to enhance its AI-powered Siri experience across its devices, as well as likely incorporate more AI features and stability updates.

The Lead: Why Reducing Screen Time Matters NowSmartphone use has become a pervasive habit, with platforms deliberately designed to keep users hooked. Recent court rulings against Meta and YouTube underscore the growing recognition of digital addiction as a public‑health issue, prompting a surge of practical advice for users seeking balance.Expert Evidence on Phone AddictionProf. Marcantonio Spada, emeritus professor of addictive behaviours at London South Bank University, compares phone use to substance addiction, highlighting intermittent reinforcement from notifications and videos. Psychotherapist Hilda Burke observes that excessive scrolling often leads to low mood, anxiety, and a “hangover” of wasted time.Financial Penalties for Tech PlatformsIn March 2026, a US court ordered Meta and YouTube to pay a combined $6 million for designing addictive platforms.The ruling signals that regulators may increasingly hold tech companies accountable for the mental‑health impacts of their design choices.Behavioral Impact of Screen OveruseSearch interest for “phone addiction” has risen steadily over the past decade in the UK.Users report disrupted sleep, reduced concentration, and strained relationships.Over‑monitoring tools can create anxiety, but modest alerts can serve as a wake‑up call.Understanding these patterns helps frame the need for concrete habit changes.The Roadmap for Sustainable Digital HabitsTrack your usage: Use built‑in tools like Android’s Digital Wellbeing or iOS Screen Time to see actual minutes spent.Schedule screen‑free periods: Start with short “wait training” intervals and expand to full days, as Burke does on Sundays.Change your lockscreen: Replace distracting icons with neutral images to reduce impulse checks.Set app limits: Impose daily caps on social media and entertainment apps.Create physical boundaries: Keep phones out of reach during meals, workouts, or bedtime.Replace scrolling with activities: Engage in reading, walking, or hobbies that provide intrinsic reward.By combining awareness, modest monitoring, and structured breaks, individuals can break the cycle of compulsive scrolling and improve overall wellbeing.