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The Lead Doctors, scientists, and researchers shared new research about ways to tackle cancer at the 2026 American Society of Clinical Oncology (Asco) annual meeting, the world's largest cancer conference. Breakthroughs in Cancer Treatment The event in Chicago, attended by 40,000 health professionals, featured more than 200 sessions and 2,700 poster presentations on this year's theme, “the science and practice of translation: improving cancer outcomes worldwide”. Smart Drugs in Cancer Treatment Researchers have developed a smart drug that stops cancer cells hiding. The experimental tablet, GRWD5769, can help shrink tumours by at least 30% in six of the world’s most common forms of the disease, delegates in Chicago were told. 26 of 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers who were given GRWD5769 alongside cemiplimab had tumour reductions of at least 30%. 15 had tumour reductions of at least 30%. A Daily Pill for Pancreatic Cancer A pill that doubles survival time in patients with pancreatic cancer was presented at the conference. In a trial of 500 patients, all of whom had pancreatic cancer that had spread, the pill, daraxonrasib, doubled survival time, with fewer side-effects compared with chemotherapy. Patients who took the drug lived substantially longer, for an average of 13.2 months, compared with 6.6 to 6.7 months for patients who had chemotherapy. Safely Skipping Some Treatments Some patients can safely skip some treatments, according to research presented at the conference. A genomic test could pave the way for a new era of personalised medicine, enabling doctors to determine which patients can safely skip chemotherapy. The Optima trial, led by University College London, followed 4,000 patients with newly diagnosed breast cancer in the UK, Norway, Sweden, Australia, New Zealand and Thailand. Those with a low score on the genomic test could be treated safely with hormone therapy alone. The Future of Cancer Treatment Urgent action is required to cope with rising cancer cases. The world faces a cancer workforce crisis, experts said, with a shortage of 100 million staff expected by 2050 when 100,000 people will be being diagnosed every day. A 21% increase in cancer incidence is predicted, according to a report presented at the conference. The rate is set to rise from 165 per 100,000 people in 2025 to 200 per 100,000 in 2050.

The PlanMarcelo Bielsa has left his indelible mark on this Uruguay team. His 4-3-3 system is built for direct football, allowing his side to press their opponents high up the field and chase the ball at all times.The CoachAfter the 5-1 humbling by the US, Marcelo Bielsa was seen as the man responsible. Upon their return to Montevideo, Bielsa called a press conference to say he was not resigning, that he had “strength” to continue and admitted he was questioned by his players for his “behaviour”.Star PlayerFederico Valverde. The captain of Real Madrid arrives at this World Cup at his peak; at the age of 27 he is among the best in the world and is starting to be the leader Uruguayans hope can inspire their country to the later stages of the tournament.One to WatchMaximiliano Araújo started his career as a right-back, but earned his first move abroad, to Puebla in Mexico, thanks to his qualities as a winger.Unsung HeroFederico Viñas. The Real Oviedo striker could get his chance to shine due to the dip in form of Núñez, Bielsa’s main goal threat.Probable Starting XI

The War Economy: A Billionaire’s Perspective from the FrontlineUkraine is reeling from its heaviest aerial raid in months, with at least 25 people killed in the night sky. In the aftermath, Rinat Akhmetov, the country's wealthiest oligarch and owner of Shakhtar Donetsk, gives a rare interview from a location outside Kyiv. This conversation marks the 90th anniversary of the club and the 30th year of Akhmetov's leadership, offering a unique insight into how the war has reshaped his personal and professional life.From Coal Traders to Champions: The Akhmetov StrategyAkhmetov’s rise from a child in 1970s Donbas to the owner of one of eastern Europe’s most influential football clubs is a story of calculated risk and strategic foresight. His journey began not in football, but in the volatile economy of the 1990s.The Proximity of Danger: Akhmetov was five seconds away from death when his business partner and predecessor, Akhat Bragin, was killed in a stadium explosion in 1995. This tragedy left the club abandoned, with players earning as little as $200 or $300 a month.Industrial Expansion: Leveraging the collapse of the Soviet Union, Akhmetov moved from trading coke and coal to acquiring cheap stakes in metallurgy plants. He revitalized the Yenakiieve plant, where workers previously earned $45 a month, transforming it into a globally competitive enterprise.Breaking the Mold: To break Dynamo Kyiv's dominance, Akhmetov hired foreign managers like Nevio Scala and Mircea Lucescu. He argued that a patriot is someone who works for Ukraine's benefit, regardless of origin, a philosophy that yielded 22 trophies over 12 years.The Financial Toll of Occupation and the Iron and Steelworks of AzovstalThe conflict in Donbas has been devastating for Akhmetov’s industrial empire. Since the occupation began in 2014, his businesses have suffered severe losses. The Azovstal iron and steelworks became a global symbol of Ukraine's resilience during the 2022 siege, though it came at a massive cost to the local economy.Shakhtar was forced to flee their home, losing the Donbas Arena—a stadium that once held 40,000 to 50,000 fans—to the occupying forces. The club's relocation to Lviv and Poland turned them into a powerful ambassador for the Ukrainian state, using the Conference League semi-finals to keep the world's attention on the war.Shakhtar as a Symbol of Ukrainian ResilienceAkhmetov reveals that Shakhtar has always been pro-Ukrainian, evidenced by their 2007 decision to use the Ukrainian spelling of their name over the Russian one. However, the full-scale invasion has crystallized this identity. The club is now viewed globally as a symbol of the fight for independence, sovereignty, and freedom.The Road to Donbas: A Promise Kept and BrokenFor years, Akhmetov maintained a moral imperative: he vowed not to attend another game until Shakhtar returned to their beloved Donbas Arena. This promise was broken last month when he returned for the Conference League quarter-final following the death of his long-time manager, Mircea Lucescu. The spontaneous decision was driven by emotion, as the players' applause during the warm-up moved him to tears. It marks a significant moment in the club's history, signaling a potential return to the region that birthed them, even as the war continues.

Crystal Palace's Historic Win Crystal Palace has won the Europa Conference League, adding to their FA Cup win last year. This victory marks a significant milestone for the team under Oliver Glasner's management. Arsenal's Chance Against PSG Arsenal is set to face PSG in the Champions League final, aiming for their most successful season ever. The team's strategy, particularly in attack and defense, will be crucial against PSG's strong lineup. Key Factors in the Champions League Final Arsenal's attack vs PSG's defense Player fitness, especially at right-back for both teams The performance of key players like Havertz and Gyökeres Other Football News The podcast also discusses Anthony Gordon's potential move to Barcelona and Paul Watson's new book. Listeners can submit their questions for discussion.

Chris Richards sidelined for Germany friendly, World Cup future uncertainChris Richards will not travel with the United States squad for the final World Cup tune‑up against Germany, as head coach Mauricio Pochettino announced in the pre‑match press conference on 5 June 2026. The defender’s status for the tournament in North America is now “decidedly in doubt”.Ankle injury at Crystal Palace ends defender’s pre‑World Cup run‑outRichards suffered the setback in Crystal Palace’s penultimate Premier League match versus Brentford, where Palace manager Oliver Glasner later described the damage as “torn ligaments” in his ankle. The injury forced him to miss the league finale against Arsenal and the UEFA Conference League final versus Rayo Vallecano.Injury date: late May 2026 (Crystal Palace vs Brentford)Matches missed: Arsenal (Premier League finale), Rayo Vallecano (Conference League final)USMNT friendly missed: Germany (12 June)Roster implications and squad depth numbersThe United States named a 26‑man squad that includes five centre‑backs and two versatile full‑backs capable of shifting centrally. This depth reduces the immediate need for a like‑for‑like replacement, but the window for a medically‑related squad change closes 24 hours before the group‑stage opener on 12 June, giving Pochettino until 11 June to decide.Impact on USMNT defensive strategy ahead of the World CupRichards’s absence forces Pochettino to rely on Mark McKenzie as the primary centre‑back, with Tim Ream and Alex Freeman providing flexibility on the flanks and in central positions. The reduced rotation options increase the importance of squad cohesion during the final training camp at the National Training Center.Looking ahead: decision deadline and possible replacementsPochettino indicated that a “minimum‑risk” approach will guide the final call. If Richards cannot be cleared by the 11 June deadline, the United States will likely promote McKenzie‑Ream‑Freeman combinations or consider a late call‑up from the broader pool of American defenders playing in Europe.

Across the AI ecosystem, firms from Uber to Priceline are confronting token bills that dwarf their original forecasts, sparking a rush to build visibility, auditability, and guardrails around AI spend. Tokenomics Foundation Aims to Impose Cost Discipline on AI Tokens The Linux Foundation announced the creation of the Tokenomics Foundation, a standards body designed to codify metrics, definitions, and best practices for AI token usage—mirroring the FinOps movement that tamed cloud spend. Executive director J.R. Storment described the climate as an "existential crisis" for many enterprises, with budgets blown out by 3‑fold in early 2026. Escalating Bills Highlight the Scale of the Problem Uber exhausted its entire 2026 AI coding budget by April. Microsoft revoked Claude Code licenses for developers after a rapid cost surge. A Priceline employee reported a routine Cursor contract renewal that was 4‑5× more expensive than prior terms. One unnamed firm allegedly incurred a $500 million Claude bill after failing to set usage limits. Developer surveys from Faros AI show per‑developer token consumption rising 18.6× in nine months. Goldman Sachs projects global token usage to multiply 24‑fold by 2030. Emerging Market of AI Spend Management Tools Start‑ups and established vendors are racing to fill the visibility gap: Pay‑i offers granular tracking, measurement, and optimization of GenAI investments. Paid provides developer‑level cost dashboards and value‑based billing. Platforms such as Jellyfish, Waydev, and Faros AI deliver AI‑agent monitoring to prove ROI. Legacy cloud‑cost players like Ramp, Datadog, and New Relic are adding token‑level observability and GPU monitoring. At the upcoming FinOps X conference, AWS is expected to unveil new financial‑management features for enterprise AI spend. Standardization and Optimization Expected to Shape AI Economics The Tokenomics Foundation plans to release a canonical definition of “tokenomics,” open specifications, and novel metrics such as cost‑per‑intelligence and tokens‑per‑watt. Early adopters like OpenRouter-style model routers already shift queries to cheaper models, a practice that could become industry‑wide. Analysts argue that the greatest ROI will come from moving the broad middle tier of users from low to moderate token consumption rather than encouraging heavy‑use outliers. As Nishant Gupta of Salesforce notes, AI token economics demand a new operational muscle set, and the coming standards may provide the assembly line the industry still lacks.

Anthropic Files Confidential IPO Amid $65 B FundraiseAt the Bloomberg Tech conference, co‑founder Daniela Amodei confirmed that Anthropic has submitted a confidential registration statement to go public, following a $65 billion financing round that valued the company at $965 billion.Revenue Explosion and Compute Spend Highlight Growth TrajectoryAnnualized revenue reached $47 billion in May 2026, up from roughly $9 billion at the end of 2025.The partnership with xAI adds compute capacity costing Anthropic about $1.25 billion per month.Fundraise: $65 billion at a $965 billion valuation.Capital Needs Drive Public‑Market StrategyAmodei emphasized that the “big upfront cost” of training and serving large models makes public capital essential. She contrasted Anthropic’s measured compute‑capacity approach with rivals that are building their own data centers.Market Implications for AI Spending and Corporate AdoptionWhile some firms such as Uber question AI ROI, Amodei argues that AI use cases—coding, finance, legal, health care—remain primary efficiency drivers. The IPO could signal confidence that corporate AI budgets will stay robust despite short‑term skepticism.Future Outlook: IPO Timing, Valuation Pressure, and Sector GrowthAnalysts expect Anthropic’s IPO to occur later in 2026, with valuation pressure from peers like OpenAI and xAI. If AI spending stabilizes, the company’s “little more demand than supply” philosophy may sustain its growth, while a slowdown in corporate AI budgets could temper the market’s enthusiasm.

Executive Overview: A High‑Profile VC Event Targets Defense, AI, and Capital TrendsStrictlyVC is hosting an exclusive evening on June 18, 2026 that brings together the venture‑capital community, defense innovators, and AI pioneers. The agenda is designed to surface actionable insights that go beyond headlines, giving attendees direct access to the people shaping the next wave of hard‑tech companies.Event Blueprint: June 18 Gathering at The Aerospace Corporation CampusThe conference will be held at the Aerospace Corporation Campus in El Segundo. The venue choice underscores the event’s focus on aerospace and defense breakthroughs.Location: The Aerospace Corporation Campus, El Segundo, CADate & Time: Thursday, June 18, 2026 – EveningFormat: Curated talks followed by networking sessionsAttendance Snapshot: Curated Audience and Speaker Line‑upSeats are limited to maintain a high‑touch environment. The speaker roster includes:Ethan Thornton, founder of Mach Industries – “Built for a New Era of Defense Technology”Delian Asparouhov (Founders Fund) & Saif Khawaja (Shinkei Systems) – discussion on the rise of physical AICarter Reum, co‑founder and partner at M13 – “Finding the Next Big Thing”Strategic Implications: Why Defense‑Tech and Physical AI Are Redrawing the VC PlaybookThe event highlights three intersecting trends reshaping capital allocation:Hard‑tech acceleration: Founders like Thornton prove that defense and autonomy can be built at venture‑scale speed.Physical AI emergence: Robotics and automation are moving AI out of the cloud and into tangible products, opening new market categories.Long‑term investment focus: Investors such as Reum are shifting from hype‑driven bets to durable, mission‑critical businesses.These dynamics suggest a pivot from pure software playbooks toward capital‑intensive, high‑barrier sectors.Looking Ahead: How the Dialogue May Shape Funding Flows and Innovation PipelinesParticipants are likely to emerge with fresh deal‑sourcing criteria, emphasizing:Proof of manufacturing scalability for defense hardware.Demonstrated integration of AI into physical systems.Clear pathways to government contracts and long‑term revenue streams.In the months following the event, we can expect increased seed and Series A activity in hard‑tech domains, as well as a rise in strategic partnerships between venture firms and defense contractors.

The Verdict on Richard Gadd's Bleakest Work YetRichard Gadd returns to television with 'Half Man,' a project that stands in stark contrast to the psychological thriller of his previous hit, 'Baby Reindeer.' While the show is technically proficient, the Guardian's review suggests it is so relentlessly bleak and violent that it borders on 'torture pornography.' The article argues that despite the intense performances and clever framing, the show lacks the emotional light required to be considered a success in traditional television terms.A Descent into 'Torture Pornography' and Unrelenting ViolenceThe core of the critique centers on the show's brutality. The protagonist, Ruben, is depicted as a mindless thug whose temper reaches violent peaks, with beatings described as 'numerous and graphic.' The review notes that the show is so dark that even its subplot about a suicidal cancer patient is considered one of its 'least depressing aspects.' The characters are trapped in a cycle of misery and self-medication, creating a viewing experience that is difficult to stomach.Half Man as a Referendum on the Baby Reindeer ControversyA significant portion of the analysis focuses on the show's meta-commentary on the 'Baby Reindeer' controversy. The plot involves a character writing a book about his experiences, leading to a press conference where he is frustrated by journalists demanding to know if it is based on a real person. This serves as a 'right of reply' for Gadd, who was stalked and abused in real life. However, the review suggests this self-interrogation is overshadowed by the sheer unpleasantness of the content.The Future of Dark TV: Is Unpleasantness a Substitute for Substance?The article draws comparisons to other dark series like 'Black Mirror' and 'The Leftovers,' noting that while those shows eventually pivoted to irony or absurdism to alleviate the gloom, 'Half Man' remains trapped in its misery. The review concludes that the show feels like it was made by a '14-year-old emo acting out to get noticed,' contrasting it with 'Adolescence' which is described as a show about men made by men. This raises questions about the sustainability of pure, unyielding despair in modern television.