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The Meteorite Impact: A Cataclysmic Event What would it have been like to have lived through the meteorite impact that wiped out the dinosaurs 66m years ago? Writing in the Conversation, Michael Benton, of the University of Bristol, and Monica Grady, of the Open University, describe in vivid detail how it might have felt. The Initial Blast and Its Immediate Effects The first sign that something was amiss would have been a new star visible for about a week before the event. Upon its arrival, all living creatures near the impact site would have seen the bright fireball, heard its crackling noise and experienced a sonic boom before being swiftly incinerated. The Global Devastation Five minutes later, 100-metre-high mega tsunamis rolled across the Gulf of Mexico and, combined with the overheating, earthquakes, hurricanes and fires, wiped out everything within a 1,200-mile (2,000km) radius. The Long-Term Consequences Dinosaurs roaming forests on the other side of the world were still oblivious, but not for long. Within an hour, dust had circled the planet and skies had darkened. Within a day, global temperatures were dropping, and by the end of the week the world was 5C cooler. A ferocious winter lasted for more than a decade, eliminating about 75% of all species. A Warning for the Future Our ancestors were some of the lucky survivors but, sadly, Benton and Grady suggest our penchant for burning carbon is setting the scene for a similar scale of planetary catastrophe.

Early‑stage evidence from a University of Bristol randomised controlled trial suggests that the anti‑inflammatory drug tocilizumab may improve symptoms in patients with moderate‑to‑severe depression who have not responded to standard antidepressants.Trial Overview: Testing Tocilizumab for Treatment‑Resistant DepressionThe study examined whether blocking the IL‑6R receptor could alleviate depressive symptoms. Key design elements:Participants: 30 adults with moderate‑to‑severe depression unresponsive to conventional medication.Intervention: Intravenous tocilizumab versus placebo.Duration: four‑week double‑blind period.Outcomes measured: depression severity, fatigue, state anxiety, and quality of life.Key Numbers: Sample Size, Remission Rates, and NNTAlthough the trial was not powered to reach statistical significance, observed trends were notable:Depression remission: 54% in the tocilizumab group vs 31% in the placebo group.Number Needed to Treat (NNT): 5, meaning five patients would need treatment for one additional remission.For comparison, the NNT for first‑line SSRIs is approximately 7.The lack of robust statistical proof reflects the small cohort, underscoring the need for larger studies.Potential Shift in Depression Treatment ParadigmsResearchers describe the trial as an “important milestone” because it is:One of the first randomised trials to test immunotherapy for depression.The inaugural study targeting the IL‑6R pathway in this context.A proof‑of‑concept for selecting patients based on biological markers.Given that up to one‑third of depressed patients do not improve with existing pharmacotherapies, a biologically driven approach could expand therapeutic options and move psychiatry toward more personalised care.What Comes Next: Larger Studies and Clinical ImplicationsThe investigators plan to:Conduct larger, multi‑centre trials to confirm efficacy and safety.Explore longer treatment durations and dosage optimisation.Assess whether IL‑6R blockade can be combined with existing antidepressants.If subsequent trials replicate these findings, immunotherapy could become a viable adjunct or alternative for treatment‑resistant depression, potentially reshaping clinical guidelines and drug development pipelines.

The Global Financial Network Behind a Nationalist Party The far-right Reform UK party, led by the firebrand populist Nigel Farage, is on the rise, doubling down on calls for tougher border controls and anti-immigration rhetoric. But a look at its finances tells a different story, with money flowing across borders. While Reform UK says it aims to strengthen the rule of law by prioritising parliamentary sovereignty, cutting immigration, and reducing the influence of international bodies, many of its financial backers, political relationships and ideological allies extend beyond the United Kingdom and into international networks. Within this network is a small number of individual donors, including its largest backer, Thailand-based crypto investor Christopher Harborne. Farage himself is a global networker. In December, he flew to Abu Dhabi at the expense of the United Arab Emirates to attend events and meet officials, despite building a political brand centred on opposition to immigration from regions such as the Middle East. The UK political finance system allows unlimited donations on the condition of openness, Sam Power, an expert in political financing, electoral regulation and corruption at the University of Bristol, told Al Jazeera, noting that "anybody can donate as much as they want as long as they're permissible". While transparency was meant to balance this freedom, in practice, with opaque donations, gifts, and weak lobbying rules undermining scrutiny, the system is "no longer fit for purpose in British electoral law", he said. Duncan Hames, director of policy, Transparency International UK, said in a statement that British democracy is becoming "a plaything for the super-rich". "Political parties are growing ever more dependent on a tiny number of mega-donors, and the impact of that money on our politics is clear: it buys privileged access, political influence, and even seats in the House of Lords," he said. Donations have long been a function of the British political system, Power explained, but what Reform UK has done is that it has "supercharged" the scale. "British politics has always had a bit of a representation problem, in the sense that a small number of wealthy people have an outsized influence, but we have never seen the number this small and the money this big," Hames said. International Donors and Financial Flows Reform UK relies heavily on donations, about two-thirds of which come from wealthy individuals. At the heart of this set-up sits Harborne, a British-Thai billionaire businessman who is currently the largest single donor to a UK political party in history, having contributed more than 22 million pounds ($30m) to Reform. In 2025 alone, he donated 12 million pounds ($16.3m). His relationship with Farage has also been shrouded in controversy. The Guardian recently revealed Reform UK's leader had received a 5 million-pound ($6.8m) gift from Harborne that was not initially declared in early 2024, weeks before Farage announced his bid to become an MP and run in Clacton. Under House of Commons rules, new MPs must register all "registrable benefits" received in the 12 months before their election. The Conservative Party referred Farage to the parliamentary standards commissioner for investigation, questioning why such a large sum was hidden from the public. Farage said the money was gifted to him "so that I would be safe and secure for the rest of my life". Harborne has made much of his fortune from his 12 percent stake in Tether, a cryptocurrency that Farage now regularly promotes on media appearances. Global Travel and Speaking Engagements In December, the UAE paid approximately 1,000 pounds ($1,360) for Farage to visit Abu Dhabi and forked out $9,000 for Paddock passes at the 2025 Abu Dhabi Grand Prix, as shown in the UK Parliament Register of Members' Financial Interests. The Financial Times, quoting people familiar with the matter, reported Reform UK treasurer Nick Candy had arranged the trip as the UAE's leadership "was keen to speak with Reform owing to a shared opposition to the Muslim Brotherhood". Harborne is also estimated to have spent an estimated 25,000 pounds ($33,900) flying Farage out to the Maldives for a three-day trip that the Reform UK leader listed as a "humanitarian aid mission". Farage is also flown around the world to speak at various events. In November, Bassim Haidar, a Lebanese-Nigerian billionaire entrepreneur and prominent donor to Reform UK, spent about 55,000 pounds ($74,528) to fly out Farage and two of his aides to the United States for a "speaking engagement and charity event", according to the register. Haidar uses Dubai as his primary business headquarters, while his main European residential base is in Greece. In February 2025, GB News, a media outlet which has produced biased coverage about Muslims according to a recent study, paid Farage 7,924 pounds ($10,737) to cover the Conservative Political Action Conference (CPAC), an annual gathering of conservatives in the US, organised by the American Conservative Union, at which he also held a speech. CPAC covered the cost of his accommodation. The Future of UK Political Financing Reform UK has committed to doing the "bare minimum to comply with electoral law on transparency", Power said. The party appears "uninterested in giving you information unless they are absolutely forced to", a trend he expects to continue. However, small changes in the law are being applied. After Harborne's gift was revealed, the UK government unveiled a planned 100,000-pound ($135,611) cap on how much British citizens living abroad could donate in a year, as well as a temporary ban on all donations made in cryptocurrencies. Power said ultimately, the system of political donations in the UK will not halt overnight, but some form of compromise needs to be met. He proposed a "democracy backstop" to cap donations at 1 million pounds ($1.35m). "It just moves us towards just taking the poison out a little bit," he said.

The LeadAt first glance, it looks like any high-end cinema: booming surround sound, a razor-sharp 4K projector and rows of reclining seats. But instead of clutching popcorn, a headset records brain activity and a heart rate monitor wraps around the arm while infra-red cameras capture every blink and fidget. This is the University of Bristol's one-of-a-kind cinema laboratory where researchers are studying how people respond to what they see on screen.The Neuroscience of Immersive CinemaProf Iain Gilchrist, a neuropsychologist at the University of Bristol who is leading the project, describes it as "a cinema, but for me it's also a research lab where the technology is turned on the audience to understand at what points are they completely immersed." Audience members are wired up to sensors measuring brain activity and heart rate, while infrared cameras track where they are looking and whether they are fidgeting.The researchers are less interested in individual biometric responses than in pinpointing the moments when those signals become most synchronised – a sign that audiences are highly engaged with what is unfolding on screen. "The data we are collecting here will allow us to understand how the audience's understanding of the story is shaped by particular scenes and inform decisions about the most impactful edit," Gilchrist said.Testing Alternative Film Cuts with Biometric DataThis week, audiences were invited into the cinema for the first time to have their reactions measured while watching Reno, a short science-fiction film that explores humanity's relationship with artificial intelligence. Different groups were shown alternative cuts of the same movie, and the findings will be used to help its director, Rob Hifle, refine the final edit."It's going to be really interesting to see how the audience engages with the characters, and whether I've got the story beats in the right place," Hifle said. He emphasized that the experiment wasn't about "paint-by-numbers" filmmaking but about "using the data to help the film resonate better with the audience." He noted that normally when editing a film, it's just the director and editor, but "it's essential to get more data to see if it sinks or swims."Industry Impact and Creative PotentialWhile Prof Amanda Lotz at Queensland University of Technology questioned whether such tools could solve the industry's real challenge in today's fragmented media landscape, Prof Tim Smith at the University of the Arts London called the project "a radical scientific advancement that can provide precise, moment-by-moment insights and give film-makers the insights needed to craft the future of cinema."Gilchrist acknowledged that the approach could appeal to advertisers and be useful in education, including university lecture halls. "Typically, I stand in front of 300 students, some of whom are half asleep or not as engaged as they could be. There's a real opportunity to get a sense, moment by moment, of how engaged they are with what I'm telling them," he said.The Future of Audience-Driven Creative ContentMost importantly, Gilchrist hopes the technology could motivate creatives to be more adventurous with the content they create. "Mainstream television, whether it's a streaming service or terrestrial, tends to be relatively conservative because making it is quite high risk. We want to de-risk that process and give directors the creativity to try something different," he explained."It's not about telling a director: this is what you should do. Rather, it's: here's another tool in your kit to determine what might and might not work," Gilchrist concluded. Eventually, he said, the technology could be applied beyond cinema to other forms of creative media, potentially revolutionizing how content is created and consumed across multiple platforms.