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The LeadRobert Smith, a distinguished pharmacologist and professor at St Mary's medical school in London (now part of Imperial College), has died aged 92. His groundbreaking work on how genetic variations affect drug responses helped shape the field of personalized medicine.The Discovery of Debrisoquine PolymorphismBob became well known for his role in the discovery of "debrisoquine polymorphism." In 1975, as one of five volunteer researchers who took debrisoquine, a blood pressure medication, he was the only one to suffer adverse effects (hypotension) and collapse. This led to the discovery of a genetic polymorphism where certain individuals cannot break down specific drugs efficiently. While Bob described this as an "accident waiting to happen," it positioned him at the forefront of pharmacogenetics.Awards and RecognitionSmith's contributions to pharmacology were formally recognized when he became the first recipient of the Paton prize in 1998 for his work in understanding how genes affect drug response. His academic achievements included becoming professor of pharmacology in 1978 and serving as deputy dean of the medical school from 1980-88.Impact on Medicine and SportsSmith's research fundamentally changed how medical professionals understand drug responses, paving the way for personalized medicine approaches. Beyond human medicine, he applied these principles to horse racing, chairing the UK Horserace Scientific Advisory Committee (1979-99) and its pan-European equivalent (1992-2005). He also served as a director of the Horseracing Forensic Laboratory in Newmarket during the 1990s, helping shape anti-doping protocols.Enduring LegacySmith never fully retired, continuing his research as emeritus professor until publishing his last paper in 2020. His legacy extends beyond scientific contributions to include the principles, warmth, kindness and generosity he embodied throughout his career. His work continues to influence pharmacology and personalized medicine, ensuring his impact will be felt for generations to come.

The Cosmic Vision of Nancy Holt Land artist Nancy Holt (1938-2014) was a master at using her work to place the body, and wider humanity, in a global, cosmic context. Holt and the other land artists of her generation wanted to break out of the restrictions of traditional art forms, using land, nature, and the world itself as their medium. Goodwood's Expansive Exhibition Goodwood provides a fitting setting for the biggest UK exhibition of Holt's work to date – an expansive, lush estate in the middle of the rolling West Sussex countryside. The exhibition features two major sculptural installations placed around the grounds: Ventilation System and Hydra's Head. Architectural and Cosmic Connections In Ventilation System, a huge metallic mechanism pokes out of the vegetation around the main gallery, with tubular aluminum pipes snaking through the landscape and back into the building. This installation exposes the hidden structures of our built environment, making the building's respiratory system visible and giving it a bodily quality. The Hydra's Head Installation Visitors walk through an idyllic meadow down into a gleaming white chalk quarry to find six concrete pools filled with water, arranged like the head of the Hydra constellation. These pools create a profound experience of outer space, reflecting trees, birds, the sky, and even the viewer's own face – essentially creating a portrait of the individual within the vast universe. Indoor Works and Their Limitations The gallery space contains photographs, diagrams, and poems that struggle to match the imposing power of the outdoor installations. Series of photos document waymarkers in the countryside and an English forest where Holt buried a poem for her partner Robert Smithson. Other works include light installations and documentation of her famous Sun Tunnels in the Utah desert. The Legacy of Land Art Holt's work represents a significant shift in artistic expression, moving beyond traditional mediums to engage directly with the environment and cosmic themes. Her installations challenge viewers to consider their place within the vastness of the universe, creating a dialogue between the individual and the cosmos. Future of Cosmic Land Art While this exhibition provides valuable insight into Holt's vision, there's opportunity for future shows to more fully embrace the monumental scale that defined her most powerful works. As environmental and cosmic concerns continue to gain prominence, land art that connects humanity to the universe may see renewed interest and appreciation.