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The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

Executive Summary: Australia’s Rise to Fourth‑Largest Black Truffle ProducerSince the mid‑1990s, Australia has built a thriving black truffle industry, now ranking behind Spain, France and Italy. Recent research explains how environmental factors and orchard practices gave Australian truffles a competitive edge.Scientific Investigation Uncovers Soil and Microbial AdvantagesResearchers from Michigan State University, led by associate professor Gregory Bonito, sampled soil and truffle microbiomes from 24 orchards across France, Spain, Italy and Australia. By sequencing DNA they compared fungal diversity and identified key differences that favour black truffle growth in Australian soils.Numbers Behind the Boom: Orchard Expansion and Fungal Diversity GapsMore than 400 truffle orchards now operate across every Australian state except the Northern Territory.Half a million host trees (primarily oaks and hazelnuts) were planted since the first introductions in 1995.Soil analysis revealed 4,415 distinct fungal types in Australian sites versus 6,575 in European sites.Australian orchards host 75% fewer mycorrhizal fungi species, reducing competition for black truffles.Implications for Global Truffle Markets and Australian AgricultureThe reduced fungal competition gives Australian truffles a near‑monopoly in their orchards, supporting higher yields and premium prices for exporters. Growers like Stuart Dunbar of Yarra Valley Truffles are already leveraging these insights to optimise planting dates, soil structure and irrigation, reinforcing Australia’s reputation in the high‑end culinary market.Future Outlook: Scaling Production and Preserving Microbial QualityContinued research will focus on maintaining the distinctive truffle microbiome that underpins flavor, despite vastly different soils. Expansion of orchards must balance ecological stewardship with market demand, ensuring Australia remains a top‑tier supplier while protecting the delicate underground ecosystem.

Scientists have observed a unique survival strategy among the Barbary macaques of Gibraltar: intentional soil consumption, or geophagy. The troops, which number approximately 230 individuals, are increasingly turning to the red clay and tar-clogged soil of the Rock to settle their stomachs after consuming the processed snacks provided by tourists. This behavior appears to be a direct physiological response to the disruption of their gut microbiomes caused by a diet high in fats, sugars, and salts. Key Developments Observation of Geophagy: Researchers recorded 44 instances of soil eating by 44 different monkeys between summer 2022 and spring 2024. Seasonal Patterns: Soil consumption and junk food intake peak during the holiday season and drop significantly in winter when tourist numbers fall by 40%. Troop Differences: Monkeys in the most tourist-heavy areas, such as the top of the Rock, are twice as likely to eat junk food and soil compared to isolated groups. Specific Diets: The macaques have developed a distinct taste for human fare, favoring Magnums and Cornettos over sorbet, and have even learned to favor specific soil types, such as the red clay found across Gibraltar or tar-clogged soil from road potholes. Data & Market Impact Approximately 20% of the macaques' total caloric intake comes from human-provided junk food. This statistic underscores the scale of the ecological shift occurring in the territory. The correlation between proximity to tourists and the frequency of geophagy suggests that the monkeys are not instinctively eating dirt, but are actively self-medicating to mitigate the negative effects of a processed diet. Why This Matters This phenomenon highlights the unintended consequences of wildlife tourism. While feeding monkeys is often viewed as a harmless interaction, it fundamentally alters the animals' nutritional needs and digestive health. The reliance on junk food disrupts the delicate balance of the gut microbiome, which is essential for nutrient absorption and immune function. For the local ecosystem and tourism industry, this raises concerns about the long-term health of the macaque population, which is a major attraction for visitors to Gibraltar. Expert Insight Dr. Sylvain Lemoine, a primate behavioural ecologist at the University of Cambridge, explains that the soil acts as a buffer for the digestive system. “We think that eating this junk food disrupts the composition of the microbiome, and we know that bacteria and minerals in soil can help recompose the microbiome,” Lemoine stated. However, Dr. Paula Pebsworth of the University of Texas at San Antonio warns that while geophagy is a coping mechanism, it is not a perfect solution. She notes that the soil near the monkeys is often contaminated with pollutants from non-electric vehicles, potentially introducing new toxins into the animals' systems. What Happens Next Future research must prioritize analyzing the soil samples for heavy metals and pollutants to fully understand the risks of this behavior. Furthermore, there is a pressing need for stricter enforcement of wildlife protection laws. As Dr. Pebsworth suggests, the most effective management approach is to reduce or eliminate the provisioning of human foods, allowing the macaques to return to a natural diet and reducing the reliance on geophagy as a digestive crutch.

Changes to the microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to a new study that also raises hopes for novel therapies.Discovery of a Distinct Gut Microbiome Signature in At‑Risk IndividualsResearchers at University College London led by Prof Anthony Schapira identified a microbial pattern that is more pronounced in individuals carrying a genetic risk for Parkinson’s and even stronger in diagnosed patients. The signature was detectable in a small fraction of the general population, suggesting a pre‑symptomatic risk group.Scale of the Study and Microbial Shifts Quantified271 Parkinson’s patients, 43 genetically predisposed but asymptomatic participants, and 150 healthy controls were initially analysed.Differences were found in 176 gut microbe species (over a quarter of the total surveyed).Follow‑up validation used data from 638 Parkinson’s cases and 319 controls across the UK, South Korea and Turkey.The alterations were independent of medication use and correlated with dietary patterns high in processed foods and saturated fats.Implications for Early Diagnosis and Preventive StrategiesThe microbial signature could enable clinicians to flag high‑risk individuals years before motor symptoms appear, opening a window for interventions such as diet modification or microbiome‑targeted therapies. Alpha‑synuclein production, a protein linked to neuronal damage, may be influenced by gut inflammation driven by specific bacteria.Future Directions: Clinical Trials and Therapeutic ProspectsFurther research is needed to determine causality and to test whether reshaping the gut ecosystem can delay or prevent disease onset. Ongoing clinical trials will explore probiotic, prebiotic, and dietary approaches, while the findings reinforce the growing emphasis on lifestyle factors in Parkinson’s management.