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Metabolic liver disease, or MASLD, is projected to affect 1.8 billion people worldwide by 2050, according to a recent study. This significant increase is primarily driven by rising obesity and blood sugar levels globally.MASLD, previously known as non-alcoholic fatty liver disease (NAFLD), is one of the most prevalent and rapidly growing liver conditions worldwide. The condition's prevalence has already seen a 143% increase in just three decades, from 500 million people in 1990 to 1.3 billion people in 2023.The study, published in the Lancet Gastroenterology & Hepatology journal, highlights that high blood sugar is the leading driver of MASLD-related health problems globally, followed by high BMI and smoking. These factors are strongly linked to type 2 diabetes and obesity.Regional disparities exist, with north Africa and the Middle East having disproportionately higher rates of MASLD. However, there have been sharp increases in the number of people affected in countries across the world, including the UK, Australia, and the United States.Despite the growing number of cases, the overall impact on health has remained stable, suggesting that advances in treatment and care are helping people live longer and healthier lives. However, the increasing number of cases still poses a risk of serious complications such as liver cirrhosis or cancer in the future.

For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Rory McIlroy's sixth major victory at the Masters Tournament has cemented his status as a golfing great, drawing comparisons to Seve Ballesteros and other legends of the sport.McIlroy's achievement is not just about the numbers; it's about the style and excitement he brings to the game. His thrilling performances have captivated audiences, making him a must-watch for fans and a key figure in golf's popularity.The Northern Irish golfer's journey to success has been inspiring, from his humble roots in Belfast to his rise as a global superstar. His relatable personality and dedication to hard work have endeared him to fans worldwide.McIlroy's comeback at the Masters was nothing short of remarkable. Despite struggling with consistency, he managed to secure a dramatic win, showcasing his resilience and creativity on the course.His influence on golf extends beyond his own performances. McIlroy is a key figure in shaping the sport's future, and his involvement in high-profile events like the Ryder Cup has made him a leader in the golfing world.

At 19,000 miles above the lunar surface, the Artemis II astronauts heard the voice of Apollo‑13 commander Jim Lovell greeting them from beyond the grave, a message recorded shortly before his death at 97. Mission control transmitted the tribute on the morning of 6 April, when astronaut Reid Wiseman held a silk square bearing the original Apollo 8 patch—handed to him by Lovell’s son—before the crew’s launch. Launch director Charlie Blackwell‑Thompson secured a unanimous "go" from every console, a moment the author describes as a snapshot of humanity’s capacity to honor the past while reaching for the future. The ceremony stood in stark contrast to the Pentagon’s agenda. Two decades after a 2006 Iraqi kill‑board note reading “Let the bodies hit the floor,” the current defense chief pledged “death and destruction from the sky all day long” against Iran, a stance legal scholars warn could constitute a war crime. That rhetoric accompanies a proposed $1.5 trillion defense budget, including an additional $200 billion earmarked for operations against Iran—figures that dwarf NASA’s entire annual budget of $24.4 billion. Amid this fiscal disparity, crew members reflected on their place in history. Victor Glover, the first Black astronaut to travel deep space, described the view of Earth as an "oasis" in the void, while Christina Koch, the first woman to orbit the Moon, pressed her face to the window and formed a heart with her hands, calling the mission’s spirit "humility." Reid Wiseman watched the planet rotate beneath him, noting the sight of Africa, Europe, and the aurora‑lit north, saying it "paused all four of us in our tracks." Canadian astronaut Jeremy Hansen broke Jim Lovell’s 56‑year distance record and asked mission control to name a lunar feature after his late wife, Carroll. The crew agreed, designating a bright spot on the Moon as "Carroll," a tribute that will endure beyond any single lifetime. When Koch announced the spacecraft’s descent, she radioed, "We are now falling to the moon rather than rising away from Earth," a poetic reversal that underscored the mission’s symbolic return. The article recalls the author’s 2022 reflection on the James Webb Space Telescope, noting how humanity’s finest inventions now aim outward, seeking answers to our origins rather than turning inward toward conflict. Artemis II’s vessel, named Integrity, carried four breathing humans who, in a moment of collective grief, pressed their faces to the glass and imagined the faces of every loved one ever lived, captured in a single frame. Beyond the spacecraft, cultural threads wove through the mission: Hansen’s patch displayed the Seven Sacred Teachings of the Anishinaabe people, and the Chinese myth of Chang’e reminded viewers of the Moon’s timeless allure. As Carl Sagan famously wrote, "We are made of star‑stuff," the Artemis crew embodied that sentiment—not as passive observers, but as active participants in a fragile, hopeful narrative that rises above the relentless tally of bodies on Earth’s battlefields.

Plans to alter the size of HS2 trains, aimed at maximizing capacity, may result in increased costs and fewer seats, potentially leading to slower services north of Birmingham. A senior government and rail industry figure, Chris Gibb, has warned against changing the train order.The original £2bn order for 54 high-speed trains, to be built by a joint venture of Alstom and Hitachi, was placed in 2021. However, the project has been under review since the cancellation of the northern leg of HS2 by Rishi Sunak in 2023. The initial plan was for the 200-metre, eight-carriage units to double into 16-carriage trains, similar in size to a Eurostar. But this will only be feasible on the new line between London and Birmingham, as existing stations like Manchester Piccadilly cannot accommodate a 400-metre train.Gibb, a non-executive director of DfT Operator, expressed concerns that if HS2 opens with eight-coach trains, they would be full, leaving people behind. He suggested that instead of varying the train order, which could incur extra costs and delays, the government should retain the original order and plan to replace the current Pendolino fleet with longer, faster, modern versions around 2040.This approach, Gibb argued, would provide a significant increase in capacity, revenue, and a reduction in journey times on all routes without the need for further railway construction. Lord McLoughlin, former transport secretary, and Lord Berkeley, a long-term HS2 sceptic, have backed Gibb's idea, emphasizing the importance of consistent rolling stock for future use.A spokesperson for HS2 Ltd stated that no changes have been made to the original order, and they are still working closely with the manufacturer and the DfT to finalize train designs. The trains will be built in Derby and Newton Aycliffe.

Rory McIlroy has revealed that weeks of preparation at 'home course' Augusta National played a crucial role in his successful Masters defence. The Northern Irish golfer spent considerable time at Augusta in the lead-up to the Masters, rather than participating in PGA Tour events, despite struggling with a back injury.McIlroy's preparation involved simulating a tournament by playing with a single ball, a strategy inspired by advice from golf legend Jack Nicklaus. This approach allowed him to feel comfortable with the course and make informed decisions about his shots.After securing his sixth major win, McIlroy expressed his satisfaction with his preparation, stating, “I joked last week that this place feels like my home course”. He emphasized the importance of getting to know the course and being prepared for various situations.McIlroy's victory joins an exclusive group of golfers who have retained the Green Jacket, including Jack Nicklaus, Nick Faldo, and Tiger Woods. With this win, McIlroy believes he can focus on playing his game and increasing his chances of winning more majors.The article also mentions Scottie Scheffler's comments on the course conditions, particularly on Friday afternoon when McIlroy birdied six out of Augusta's closing seven holes. Scheffler suggested that the firmness of the course was not equal on Thursday and Friday, but acknowledged that the weather and wind conditions also played a role.

Sam Neill, the veteran actor celebrated for his memorable performances on screen, is set to answer readers' questions in an upcoming interview with The Guardian. Neill's iconic roles include his portrayal in Jurassic Park, where he famously removes his sunglasses and gazes at a towering Brachiosaurus, a scene that has become etched in cinematic history.Born in Northern Ireland and raised in New Zealand, Neill's diverse filmography showcases his versatility as an actor. He has appeared in a range of films, from period dramas like My Brilliant Career to thrillers such as Dead Calm, which is set to be released in 4K later this year. His recent projects include Godzilla x Kong: Supernova, alongside Kaitlyn Dever and Matthew Modine.Neill's career has been marked by his ability to take on idiosyncratic, director-led projects, often playing characters with a unique blend of gruffness and warmth. His performances in Sweet Country and Rams have been particularly noted for their depth and nuance.In addition to his film work, Neill has also made headlines for his memoir, Did I Ever Tell You This?, in which he openly discusses his experience with stage-three blood cancer and his journey towards remission. When asked about his mortality, Neill expressed a pragmatic view, stating, “I’m not afraid to die, but it would annoy me”.Readers are invited to post their questions for Sam Neill by 6pm BST, Thursday 16 April, and The Guardian will publish his answers in their reader interview series. This provides a unique opportunity for fans to engage with one of cinema's most beloved actors and gain insight into his life and career.

Rory McIlroy has made history by winning his second Masters title, holding off a strong challenge from world No 1 Scottie Scheffler to claim a one-shot victory at Augusta.This impressive win cements McIlroy's status as one of golf's all-time greats, making him only the fourth player in the tournament's 90-year history to win successive titles at Augusta. McIlroy's sixth major puts him level with Nick Faldo and one beyond the great Spaniard Seve Ballesteros, who won five.Donald Trump, the former US President who has played golf with McIlroy in the past, was quick to congratulate the Northern Irishman on his achievement. Using his Truth Social platform, Trump wrote: 'Congratulations to Rory McIlroy on another Great Championship, The Masters! He performed tremendously under intense pressure, something which few people would be able to even think about doing. With each year, Rory is becoming more and more a LEGEND!'Trump also expressed his excitement for McIlroy's next appearance at the Cadillac Championship at Trump National Doral in Miami later this month, praising the quality of professional golfers today.

‘Departures’ arrives in UK and Irish theatres on 17 April, offering a sharply observed portrait of a man navigating the aftermath of a breakup. The story centers on Benji, a thirty‑something who, after parting ways with his charismatic trainer Jake, plunges into a haze of parties, substance use and fleeting encounters in an attempt to dull the ache of lost love. The film tackles weighty subjects—body‑image insecurity, familial rejection and the pressures of toxic masculinity—yet it avoids sentimentality by leaning into a darkly comic tone and a poppy visual palette. Its elliptical editing stitches together present‑day self‑destruction with fragmented memories of Jake, creating a nonlinear rhythm that mirrors the disorienting experience of a broken heart. Ey​re‑Morgan not only co‑writes and co‑directs but also embodies Benji, delivering a performance that feels both self‑deprecating and raw. His on‑screen chemistry with David Tag’s Jake provides the emotional anchor of the film, allowing the audience to glimpse the genuine connection that fuels Benji’s subsequent turmoil. Despite its strengths, the movie leans heavily on voice‑over narration, which at times hampers momentum, especially during emotionally charged scenes. The tendency to verbalise feelings rather than let the cinematography speak can feel redundant, and the multiple flashbacks occasionally drift into over‑exposition. Overall, ‘Departures’ stands as a thoughtful exploration of love, identity and the search for authenticity, while also showcasing the burgeoning talent emerging from northern England’s film scene.