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Eli Lilly, the US pharmaceutical group behind the Mounjaro weight-loss drug, is seeking to resume its investments in the UK after pausing them last year. The company is in talks with UK ministers to regularly increase NHS drug prices and end a rebate scheme. Patrik Jonsson, president of Eli Lilly's international business, expressed optimism about reaching an agreement this summer.The talks will also explore 'innovative' pricing plans, such as linking payments for anti-obesity drugs to whether the treatment helps patients return to work. This comes as the US pharmaceutical industry increases pressure on the UK, with Keir Starmer agreeing to the first increase in NHS cost-effectiveness thresholds in 27 years. The threshold was raised from £20,000 to £30,000 a year for every year of life gained to £25,000 to £35,000.Eli Lilly was one of several pharmaceutical companies that ditched or paused almost £25bn in planned investments in the UK last year. The company paused its plans to invest in a laboratory site in central London. Jonsson stated that the resumption of Eli Lilly's investment would depend on the outcome of its talks with the government.He emphasized that prices for medicines in the UK had been 'far too low for far too long' and that the threshold couldn't remain static for another three decades. The UK agreed to pay 25% more for new medicines by 2035 as part of a US-UK drug pricing deal, which could eventually reach £9bn a year.Large pharmaceutical companies have protested about a 'rebate' scheme, under which they are required to pay back a chunk of revenue from sales of branded medicines. This scheme is expected to fall in 2026, although Jonsson believes payments 'should actually get down to zero' over time.

The latest documentary about Paul McCartney, 'McCartney: The Hunt for the Lost Bass', tells the story of the 1961 Höfner bass guitar that McCartney bought for £30 in Hamburg and became an iconic part of the Beatles' image. The instrument went missing after the band split and was finally recovered in 2024 thanks to the efforts of Nick Wass, a Höfner employee, and Steve Glenister, an ambulance service worker.The film is an amiable tale with a happy ending, but it struggles to fully absorb the sadness and shame associated with the theft. The documentary reveals that the bass was stolen from the back of a Wings roadie van in Ladbroke Grove, London, in the early 1970s. McCartney only recently recalled the incident and revealed that he wasn't particularly bothered at the time, having owned a second Höfner bass.The investigation into the theft took several paths, including suspicion falling on the band Hawkwind and their roadie Michael 'DikMik' Davies. However, the true culprit was someone who stole the bass out of opportunity and later gave it to a pub landlord, leading it to end up in Hastings. McCartney reflects on the theft, saying that he and his friends might have done similar things in their youth.The documentary will be released in UK cinemas on April 2 and 4, and on BBC Two and iPlayer on April 11.

London's Metropolitan Police have made a significant U-turn in their policy towards Palestine Action supporters, arresting 18 individuals who protested outside the Met's headquarters, New Scotland Yard. The protesters, holding signs that read 'I oppose genocide. I support Palestine Action,' were arrested under terrorism legislation.The arrests come after the Met had previously stated they would adopt a 'proportionate approach' and stop arresting Palestine Action supporters following a High Court ruling in February that deemed the ban on the group as a terrorist organization unlawful. However, Deputy Assistant Commissioner James Harman announced that the force would resume arrests, citing the need to 'enforce the law as it is at the time, not as it might be at a future date.'The move has drawn sharp international criticism, including from the UN, which has warned that the ban appears 'disproportionate and unnecessary.' Amnesty International has also intervened in the court case, stating that thousands have been 'arrested for something that should never have been a crime.'The arrests took place as the rest of the city was filled with demonstrators marching against the far right. A mass sign-holding event, titled Everyone Day, has been called by Defend Our Juries at Trafalgar Square on April 11, as the government's appeal heads to court.

Chinese-born American composer Tan Dun is renowned for his eclectic and captivating works. His music has been featured in prominent projects, including the score for Ang Lee's Crouching Tiger, Hidden Dragon and the official music for the 2008 Beijing Olympics.Tan's Choral Concerto: Nine, commissioned for Beethoven's 250th anniversary, premiered with the London Philharmonic Orchestra and London Philharmonic Choir. The concerto features a vast array of percussion and choral techniques, including dramatic inhalations and hints of Mongolian throat singing.In contrast, the performance of Beethoven's Ninth Symphony was marked by fast tempos and crisp rhythms but lacked a sense of large-scale direction and magic. The 'chaos' chord in the finale was overpowered by loud brass, and despite a well-matched vocal quartet, the performance felt workaday.

For the first time, a team of researchers has successfully mapped out the intricate network of nerves within the clitoris, a crucial organ responsible for female sexual pleasure. This achievement comes almost 30 years after a similar mapping was completed for the penis. The 3D scans of two female pelvises, donated through a body donor program, have provided unprecedented detail on the five complex tree-like branching nerves running through the clitoris. The widest of these nerves measures 0.7mm across. Led by Ju Young Lee, a research associate at Amsterdam University Medical Center, the study challenges existing knowledge about the anatomy of the clitoris. For instance, previous research suggested that the dorsal nerve of the clitoris diminished as it approached the glans, but the new scans show that it continues strongly to the end. The clitoris, one of the least-studied organs in the human body, has been neglected by researchers for far too long, according to Melbourne urologist Helen O'Connell. She notes that cultural taboos around female sexuality have hindered scientific investigations, and it wasn't until 1995 that the clitoris was included in standard anatomy textbooks. The mapping of clitoral nerves is expected to inform reconstructive surgery after female genital mutilation, which affects over 230 million girls and women worldwide. A better understanding of the nerve pathways could reduce the number of women who experience a decline in orgasmic experience after surgery. This breakthrough also has implications for vulvar cancer treatment, gender reassignment surgery, and genital cosmetic surgeries. As Lee hopes to open a clitoris exhibition to expand knowledge about the organ, inspired by the Vagina Museum in London, the study marks a significant step forward in understanding female sexual function and anatomy.

For British runner Josh Kerr, the moment that makes the hairs on his neck tingle every time he watches it is Roger Bannister's historic achievement in 1954 – becoming the first person to break the four-minute mile barrier. Now, Kerr intends to stand on the shoulders of track and field's giants by attempting to break the world mile record himself at the London Diamond League in July."This record needs to be brought home," Kerr declares. "This is a British record. This is a British distance. And so it would be doing a disservice to the UK to not be doing it at home. It's why I can't do it anywhere else."The 28-year-old faces a significant challenge. The world record of 3:43.13 was set by Hicham El-Guerrouj in July 1999, while Kerr's best is a shade over two seconds slower. However, with focused training, a new shoe from sponsor Brooks, the support of his 16-strong entourage and 60,000 fans at the London Stadium, Kerr believes he can break the long-standing record."People [say:] 'The sport needs more rivalries,'" Kerr explains. "I don't agree. I think the sport needs more moments. We need a reason to watch. And so that's where this comes from. This is the time to go after these big moments. I have a big target of what time I want to hit. I think it's going to be pretty special."Kerr's credentials are impeccable. He is a world 1500m champion and an Olympic silver and bronze medalist over the same distance. Last weekend, he further demonstrated his form by winning the world indoor title over 3,000m for a second time."I've been in shape to run the record multiple times over the last couple of years," Kerr states. "And so there's specific key sessions, we will have KPIs [key performance indicators] going into it."To achieve his goal, Kerr plans to focus on running between 55 and 56 seconds pace for each of the four laps. "There's a lot of muscle memory with stuff, and so we'll do a lot of training at pace," he explains. "We're three or four months in deep into the mental training of it. There's a lot going on behind the scenes already. The whole season is towards this."While Kerr has his pacemakers "signed, sealed and delivered," he insists this will be a proper Diamond League race rather than a time trial. "There will be some restrictions," he says coyly when asked about potential rivals. "I'm not scared to race people. I think certain athletes will have obligations elsewhere. But it's not going to be a closed-off race."A crucial factor in Kerr's favor is the quality of his support team. "Danny's the mastermind behind everything," Kerr says of his coach Danny Mackey. "He's my head coach and team leader. Then you've got Julian, who's an assistant coach, and my wife, who helps with everything."The team also includes Kerr's mother as head physio, a "super-manager and assistant" called Nicole, a chiropractor, massage therapist, two strength and conditioning coaches, a performance and mental coach, a nutritionist, a full-time chef, and a videographer and social media assistant. Race agent Ray Flynn and management company Forte complete the 16-strong squad."I have a lot of respect for this record," Kerr concludes. "But I believe that I have the ability and the people around me that will help me get there. This record is one of the most important we have in track and field. The time is now. It's time for that record to be renewed."

Recent headlines suggesting a Christian revival in Britain, based on a YouGov survey claiming increasing church attendance, have been dramatically undermined by the revelation that the data was fraudulent and subsequently withdrawn. This incident has sparked serious concerns about the integrity of polling data in an era of advancing artificial intelligence.The Bible Society's 2024 report, which claimed church attendance was rising particularly among young people, has become a case study in how AI-generated bogus responses are infesting online surveys. Researchers warn that this vulnerability extends beyond religious statistics to potentially distort our understanding of broader social trends.David Voas, a quantitative social scientist at University College London, emphasized the difficulty of correcting such misinformation once it spreads. "The amount of effort required to correct it is an order of magnitude higher than the effort needed to disseminate it in the first place," he stated, noting that this problem affects polling companies beyond just YouGov.The growth of AI has exacerbated this issue, according to Sean Westwood, an associate professor at Dartmouth College. "The assumption with survey research – that someone gives coherent, logical answers, they're a real person – that assumption is now broken," he explained. Westwood warned that AI models pose an existential threat to our understanding of society.Westwood detailed how AI can be weaponized: "A single sentence of instruction is enough to systematically bias its answers on political polls or geopolitical questions, while keeping its demographic profile intact so the manipulation is invisible to standard screening." Even without explicit instructions to cheat, AI can identify what a researcher is testing and produce data that confirms the hypothesis.The problem is particularly acute with surveys targeting younger demographics. Courtney Kennedy, vice-president of methods and innovation at Pew Research Center, noted that "bogus respondents tend to respond in the affirmative, no matter what is asked" – a positivity bias that inflates estimates. Younger respondents are also more likely to be misrepresented by fraudulent participants.As AI technology rapidly evolves, researchers face a constant challenge. "A researcher might design a clever new trap that catches today's models, but model development moves so fast that the fix is likely obsolete within months," Westwood cautioned.In response, YouGov has implemented detection methods including identity checks, device fingerprinting, and real-time threat scoring. However, the incident serves as a stark reminder of the vulnerabilities in modern polling systems as AI continues to advance.

Speculation surrounding Igor Tudor's position at Tottenham Hotspur has led to Sean Dyche being linked as a potential replacement. However, Dyche has quashed these rumors, stating he is not in talks with the club.During an appearance on talkSPORT, Dyche laughed off the speculation, saying he was having a pint in a London pub when someone approached him about potential talks with Spurs. He responded, 'I’m sat next to you having a pint of Guinness, so it’s unlikely – unless you work for Spurs!'Dyche did, however, praise Tottenham as a 'brilliant club' and acknowledged the pitfalls of being asked about potential jobs while being a manager. He mentioned that when you're a manager, you know you'll get asked about potential positions, and you try to be respectful, especially when it comes to a massive club like Tottenham.Tudor is currently dealing with the death of his father Mario, and Spurs are without a fixture until April 12. The team has struggled recently, with five defeats in seven matches under Tudor, placing his job at risk.

The Women's Super League and WSL2 are gearing up for an exciting derby weekend, with six local rivalries set to be reignited. This weekend's schedule has been criticized for potentially diluting the impact of these matches by staging too many high-profile games simultaneously.On Saturday, Everton host Liverpool, Manchester United welcome Manchester City, and Arsenal entertain Tottenham, all within a span of six hours. The attendances for these matches are expected to be high, with over 45,000 tickets sold for the north London showdown at the Emirates Stadium.While the initial numbers are encouraging, there is an argument that staggering these derbies across the season may draw greater cumulative focus. The buildup to the Merseyside derby at Goodison Park has felt low-profile this time, overshadowed by the Manchester derby at Old Trafford.The WSL's growth timeline and dependence on stadium availability and broadcast partners must be considered. The league's scheduling strategy, including timing the opening weekend to coincide with the September men's international window, is crucial for its development.This weekend's matches promise to be close-fought affairs, with the top two teams going head-to-head at Old Trafford. Arsenal's Kim Little has signed a new one-year contract, and Tottenham's Martin Ho has extended his stay with the club.