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The UK is bracing for possible gaps on supermarket shelves this summer as the ongoing conflict in Iran threatens to disrupt carbon dioxide (CO2) supplies, a critical component in the food industry. CO2 is essential for the humane slaughter of livestock, packaging of fresh meats and produce, and production of fizzy drinks and beer.Government ministers are reportedly drawing up contingency plans for a 'reasonable worst-case scenario' if the Strait of Hormuz, a key shipping lane, remains closed. This could lead to shortages of CO2, impacting supplies of chicken, pork, and fizzy drinks.The business secretary, Peter Kyle, has reassured the public that ministers are making contingency plans to deal with possible consequences of the Iran war. The government has invested £100m to reopen the mothballed Ensus bioethanol plant on Teesside to mitigate potential CO2 shortages.The CEO of Tesco, Ken Murphy, has expressed confidence in the company's ability to manage supply chains, stating that they have 'seen nothing at this point' in terms of problems within their supply chain caused by CO2 availability issues. However, the UK is one of Europe's largest users of CO2, and any disruption could have significant impacts on the food industry and beyond.

A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Bayern Munich pulled off a stunning 4-3 victory over Real Madrid in a thrilling Champions League quarterfinal match, securing their spot in the semifinals with a 6-4 aggregate score. The game saw late drama as Luis Diaz scored in the 89th minute and Michael Olise netted in stoppage time.The match was marked by controversy as Real Madrid's Eduardo Camavinga received a red card in the 86th minute for a foul on Harry Kane. This turning point allowed Bayern to capitalize and seal their win.Harry Kane expressed his elation post-match, feeling 'amazing' about the win and reaching the milestone of 50 goals this season. He attributed the success to the team's hard work and collaboration.In another quarterfinal action, Arsenal advanced to the semifinals after a nervous goalless draw against Sporting Lisbon, clinching a 1-0 aggregate victory. They will face Atletico Madrid in the next round.

A Pakistani delegation headed by Army Chief General Asim Munir arrived in Tehran on Wednesday, bearing a fresh message from Washington and urging the launch of a second round of negotiations between the United States and Iran. The effort comes as the two‑week ceasefire that halted hostilities last week is set to expire on April 22, leaving a narrow window to end a war that has claimed more than 4,000 lives across the Middle East, primarily in Iran and Lebanon. The initial round of talks, held in Islamabad on April 11‑12, marked the most significant direct engagement between Washington and Tehran in decades. Mediated by Pakistan, the sessions lasted over 20 hours and featured both indirect and direct exchanges between U.S. Vice President JD Vance and senior Iranian officials led by Parliament Speaker Mohammad Bagher Ghalibaf. Despite covering core issues—nuclear programme, sanctions relief, frozen assets and control of the Strait of Hormuz—the talks concluded without a memorandum, with Vance asserting that Iran “did not accept our terms” and that the U.S. requires a “fundamental commitment” to forego nuclear weapons. President Donald Trump has described the conflict as “very close to being over” and hinted that a second round could resume within days, possibly in Islamabad. However, Pakistan’s Prime Minister Shehbaz Sharif is currently on a four‑day tour of Saudi Arabia, Qatar and Turkey to rally regional backing, making a rapid return to Islamabad uncertain. U.S. officials have offered an “in‑principle” agreement to extend the ceasefire, yet a Reuters‑cited source confirmed that Washington has not formally committed to an extension. Meanwhile, Turkish President Recep Tayyip Erdogan expressed optimism, stating that “there can be no negotiating with clenched fists.” Key sticking points remain: Nuclear programme: The United States and Israel demand a complete halt to uranium enrichment, accusing Iran of weaponization despite a lack of public evidence. Iran maintains its enrichment is for civilian use and cites its obligations under the 1970 Non‑Proliferation Treaty. Strait of Hormuz: One‑fifth of global oil and LNG passes through this chokepoint. Since the February strikes, shipping through the strait has dropped by 95 %. Iran permits passage for “non‑hostile” vessels and seeks the right to levy tolls, while the U.S. insists on unrestricted navigation. Lebanon/Hezbollah: Iran demands that Israel cease its offensive against Hezbollah. While Tehran claims the ceasefire covers Lebanon, both the United States and Israel reject this, and Israel continues attacks on Hezbollah positions. Complicating the diplomatic landscape, President Trump announced a naval blockade of Iranian ports, adding pressure on Tehran and potentially hindering any imminent talks. With the ceasefire deadline looming and regional actors issuing mixed signals, the prospects for a renewed U.S.–Iran dialogue hinge on whether Pakistan can secure a consensus among the parties before the window closes.

Lamine Yamal, Barcelona's rising star, has reaffirmed his commitment to winning the UEFA Champions League with the club. A day after their quarterfinal elimination by Atletico Madrid, Yamal expressed his determination on Instagram, stating that he will not give up on his promise to capture the trophy with Barcelona.“We are Barca, and we will be back where we belong,” Yamal said. “My parents taught me that a man’s word always has to be fulfilled … we’ll bring it to Barcelona.” This statement comes after Barcelona's 2-1 win over Atletico Madrid on Tuesday, which wasn't enough to overcome a 2-0 deficit from the first leg.Yamal, who scored one of Barcelona's goals, had similar sentiments after their 2025 semifinals loss to Inter Milan, vowing not to stop until he fulfills his promise. His inspiration, LeBron James, was evident as his Instagram profile featured James holding the NBA trophy in 2016.Barcelona's president-elect, Joan Laporta, criticized the refereeing in both legs against Atletico, calling it “shameful” and “inadmissible.” The club plans to file a formal complaint with UEFA. Despite the setback, Barcelona leads La Liga by nine points over Real Madrid.Coach Hansi Flick emphasized that the young team will learn from their mistakes and improve. With their next match against Celta Vigo, Barcelona aims to bounce back and move forward in their quest for Champions League glory.

A group of 19 UN experts has denounced Israel's attack on Lebanon, which occurred a day after the US and Iran agreed on a ceasefire, as illegal and a blatant violation of the UN Charter. The experts are calling on UN member states to halt all arms transfers to Israel while there is credible evidence of serious violations of international humanitarian and human rights law.The condemnation comes as Israel continues to pound areas of southern Lebanon, resulting in at least 16 deaths, including four paramedics, according to Lebanese state media. The experts also expressed concern over the forced displacement of over 1.2 million people and the targeted destruction of homes, particularly in predominantly Shia areas of the south, which they described as a form of collective punishment that points to ethnic cleansing.The UN experts emphasized that Israel's actions constitute crimes against humanity and urged Israel to cease all military operations in Lebanon. The situation has been a point of tension in US-Iran negotiations, with Tehran pushing for Lebanon to be included in the ongoing ceasefire. Israeli Prime Minister Benjamin Netanyahu has stated that Israel will continue to target Hezbollah wherever required, despite diplomatic efforts towards a ceasefire.

A high-level Pakistani delegation, led by Army Chief Asim Munir, has arrived in Tehran to facilitate fresh negotiations between Iran and the United States, with a fragile truce set to expire on April 22.The talks aim to address key issues, including Iran's nuclear program, control of the Strait of Hormuz, and compensation for wartime damages. Pakistani Interior Minister Mohsin Naqvi is also joining mediation efforts in Tehran.US President Donald Trump has expressed optimism about a potential deal, stating that the world should brace for an “amazing two days” as the war with Iran is close to over. The White House has also indicated that additional talks with Iran would likely go forward in Islamabad.Despite these developments, US military maintains its naval blockade on all Iranian ports, which Iran's military has slammed as a violation of the ceasefire. Iran has threatened to retaliate by blocking trade through the Red Sea, Gulf, and Sea of Oman if the US does not lift its blockade.Mediators are pushing for a compromise on three main sticking points – Iran's nuclear program, control of the Strait of Hormuz, and compensation for wartime damages. Sources indicate that Pakistani mediators are optimistic about a potential major breakthrough on the nuclear front.

Washington, D.C. – The U.S. Senate voted 47‑52 to reject a resolution that would have limited President Donald Trump’s power to wage war against Iran, marking the fourth defeat of the measure despite weekly attempts by lawmakers. The vote follows a two‑week ceasefire agreed upon last week, though subsequent negotiations in Islamabad failed to produce a longer‑term deal. Both sides have indicated openness to a second round of talks. President Trump’s earlier threats, including a statement on April 7 that a “whole civilisation will die tonight,” intensified congressional calls for constraints on his war‑making authority. Party lines largely dictated the outcome: Republican Rand Paul voted in favor, while Democrat John Fetterman broke with his party to oppose the resolution. Supporters argue that Trump acted beyond constitutional limits when he joined Israel in launching the February 28 offensive. The U.S. Constitution reserves the declaration of war for Congress, allowing presidents to act unilaterally only in cases of immediate self‑defence. Senator Chris Murphy, speaking before the vote, described the conflict as a “bungled, mismanaged war” that has failed to meet the administration’s objectives. He criticized the lack of transparency and oversight, noting that the war is costing “billions of dollars every week,” has claimed “over a dozen American lives,” and is destabilising economies worldwide. Republican Senator Jim Risch defended Trump’s actions, dismissing the resolution as “same old, same old” and asserting that the president has both the right and duty to act. The House of Representatives is slated to consider its own war‑powers resolution this week, with a higher likelihood of passage given growing wariness among some Republicans. Even if both chambers approved the measure, Trump could veto it, requiring a two‑thirds supermajority to override. Under the War Powers Act of 1973, Congress must either authorize the military action or approve a 30‑day extension when the conflict reaches its 60‑day mark at the end of April. Failure to do so would legally compel the president to begin withdrawing forces. U.S. blockade updates: U.S. Central Command reported that no vessels have successfully breached the blockade of Iranian ports in the Strait of Hormuz over the past 48 hours, with nine ships complying with orders to turn back. The U.S. Navy warned that vessels attempting to transit will be boarded for interdiction and seizure. Treasury Secretary Scott Bessent announced a forthcoming set of financial measures described as the “financial equivalent” of military attacks, while noting that some sanctions had been lifted to ease soaring global energy prices. White House spokesperson Karoline Leavitt said the administration has not formally requested an extension of the ceasefire, which is set to expire next week, but expressed optimism about a second round of talks in Islamabad. Iran’s state‑run television reported that a high‑level Pakistani delegation arrived in Tehran to coordinate new negotiations. Meanwhile, Major‑General Ali Abdollahi of the IRGC warned that the ongoing naval blockade could jeopardise the fragile ceasefire, describing it as a “prelude to a violation of the ceasefire.”

US President Donald Trump has launched a scathing attack on Italian Prime Minister Giorgia Meloni, one of his key European allies, over her stance on the conflict with Iran. In an interview with the Italian daily Corriere della Sera, Trump expressed his disappointment, stating, “I’m shocked at her. I thought she had courage, but I was wrong.”Trump's criticism centers on Meloni's refusal to join the US-Israel coalition against Iran, a stance that has put her at odds with Trump. “She’s unacceptable because she doesn’t mind that Iran has a nuclear weapon and would blow up Italy in two minutes if they had the chance,” Trump said. This statement underscores the deepening divide between the US and Italy on the issue.Meloni, who has been Italy's leader since October 2022, was once considered one of Trump's closest allies in Europe. However, their relationship has soured recently. Trump noted that they had not spoken in a long time, adding, “She doesn’t help us with NATO. She doesn’t want to help get rid of a nuclear-weaponed Iran. Very sad … She’s much different than I thought,” highlighting his disappointment in Meloni's shift away from his policies.The rift between Trump and Meloni comes as Italy has suspended a defense agreement with Israel, which involves the exchange of military equipment and technology research. This move follows accusations by the Italian government that Israeli forces fired warning shots at a convoy of Italian peacekeepers in Lebanon. Tensions between Italy and Israel have been escalating, adding another layer of complexity to the situation.In response to Trump's comments, Meloni's allies and political opponents rallied to her defense. Foreign Minister Antonio Tajani emphasized Italy's commitment to Western unity and mutual respect, stating, “We are and remain staunch supporters of Western unity and steadfast allies of the United States, but this unity is built on mutual loyalty, respect, and honesty.” Elly Schlein, leader of the centre-left Democratic Party, condemned Trump's “serious lack of respect” and reiterated Italy's constitutional repudiation of war.