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Health Jun 01, 2026

Genomic Test Allows Millions of Women to Safely Skip Chemotherapy

A landmark international trial demonstrates that millions of women with breast cancer can safely sk…
The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.
#breast cancer #genomic testing #chemotherapy
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Tech Jun 01, 2026

Forza Horizon 6 and the Quest to Revive the Driving Sim Genre

Forza Horizon 6 offers a nostalgic return to the open-world driving genre, which dominated the 90s …
The Return of the Open RoadForza Horizon 6 has arrived, transporting players to a vibrant, compressed version of Japan. The game serves as a potent reminder of the driving sim genre's peak popularity in the 1990s and early 2000s, a time when consoles were sold on the strength of their racing titles like Ridge Racer and Gran Turismo.From Arcade Legends to Open-World GiantsThe driving genre has undergone a significant evolution. It began with electromechanical arcade machines and evolved into video game staples such as OutRun and Daytona USA. However, the landscape shifted dramatically with the rise of open-world fantasy adventures and live-service behemoths like Fortnite and Minecraft. The mainstream audience drifted toward games that offered more than just driving, such as Grand Theft Auto, which combined driving with action and exploration.The Cultural Shift in DrivingThe decline of the driving sim is not just technological but cultural. In the 90s, the car represented freedom and excitement. Today, the reality of driving often involves fuel costs, traffic congestion, and the environmental burden of ownership. This shift has made the escapist fantasy of the driving game more valuable than ever, offering an idealized vision of the road that real life cannot match.A Revival on the HorizonDespite the genre's apparent decline, the future looks promising. The upcoming release of Grand Theft Auto VI is expected to feature significant racing elements, and the indie scene is reviving the spirit of 90s arcade racers. With titles like Forza Horizon 6 proving that the genre still holds immense appeal, the "fast-car game" is poised for a comeback.
#Forza Horizon 6 #Microsoft #Video Games
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Tech Jun 01, 2026

Why I’m Grateful to the Pope for His AI Encyclical – Francine Prose’s Perspective

Francine Prose thanks Pope Leo XIV for his 40,000‑word encyclical, *Magnifica Humanitas*, which fra…
Lead: A Literary Voice Finds Moral Guidance in the Vatican’s AI EncyclicalIn a recent Guardian column, Francine Prose expresses gratitude to Pope Leo XIV for his extensive encyclical, Magnifica Humanitas: On Safeguarding the Human Person in the Time of Artificial Intelligence. She argues that the Pope’s moral framing offers a useful counter‑point to the prevailing techno‑optimism that dominates discussions about AI’s creative potential. Pope Leo XIV Issues a Groundbreaking AI EncyclicalThe Vatican’s new letter, spanning more than 40,000 words, tackles both the promises and perils of rapidly evolving artificial intelligence. It opens with a biblical analogy—choosing between a modern Tower of Babel or a city where “God and humanity dwell together”—and proceeds to trace the Church’s historical stance on labor, authority, and scientific progress. Key Data Points from the EncyclicalLength: > 40,000 words (approximately the size of a short novel)Chapter 3 titled “Technology and Dominance: The Grandeur of Humanity in Light of the Promises of AI”Explicit warnings about AI used solely to maximize profit, manipulate privacy, and exacerbate economic inequality Impact Analysis: Moral Framing Meets AI GovernanceThe encyclical’s central claim—that AI lacks experience, embodiment, and moral conscience—reinforces a growing call for human‑centered AI policy. By positioning AI as a tool that can amplify existing power imbalances, the Pope adds a religious‑ethical voice to debates traditionally dominated by technologists, legislators, and industry leaders. This could influence future regulatory approaches, especially in regions where the Catholic Church holds cultural sway. Future Outlook: How Religious Ethics May Shape AI DevelopmentProse notes that while the document may not halt AI‑driven profit motives, it provides a framework for civil society to demand accountability. If embraced by policymakers, the encyclical could inspire legislation that protects privacy, safeguards employment, and ensures AI serves the common good rather than a privileged few. Conversely, pushback from Silicon Valley suggests a contested path ahead, with tech leaders questioning the Vatican’s technical expertise. Conclusion: A Call for Human‑Centred InnovationUltimately, Prose argues that the Pope’s vision—rooted in compassion, justice, and the intrinsic value of human relationships—offers a “beneficent” compass for navigating AI’s ethical terrain. Whether the Church’s moral authority will translate into concrete policy remains uncertain, but the encyclical undeniably enriches the global conversation about technology’s role in society.
#Pope Leo XIV #Francine Prose #AI ethics
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Tech Jun 01, 2026

Anthropic reaches valuation of $965bn, beating OpenAI to become world's most valuable AI firm

Anthropic has raised $65bn in funding, valuing the company at $965bn and making it the world's most…
The Lead: Anthropic's Historic ValuationAnthropic, the AI firm behind the Claude chatbot, announced on Thursday it had raised $65bn in funding to value the company at $965bn post-money. The move makes Anthropic the world's most valuable AI startup, eclipsing its competitor OpenAI.The Rise of a New AI PowerhouseThe deal marks an exceedingly successful period of growth for Anthropic, which was once considered to be a smaller player in the global AI arms race. The widespread adoption of its products by large enterprise businesses, especially following its release of powerful coding assistants late last year, has turned it into a dominant player in the industry.Financial Impact: A Reshuffled AI IndustryAnthropic's new valuation cements a reshuffling of the AI industry's power dynamics, putting a dollar figure on Claude's increased cultural and commercial prominence. The deal is also likely to have implications for this year's blockbuster slate of initial public offerings, which includes rivals OpenAI and SpaceX.Industry Implications: Safety Focus vs. Market DominanceIn addition to orienting its business more towards enterprise and coding services than some of its consumer-forward competitors, Anthropic has also postured itself as a more safety-focused company. One of Anthropic's co-founders was present earlier this month at Pope Leo's release of a more than 43,000-word encyclical which warned against the dangers of AI and called for a reining-in of the technology.The firm is also still locked in a legal battle with the Pentagon following its refusal earlier this year to remove safeguards that would allow Claude to be used for mass domestic surveillance or lethal autonomous weapons systems, which could kill people without human input.Future Outlook: Geopolitical and Political InfluenceThe White House was forced to ease its feud with Anthropic somewhat in recent weeks, however, after the company announced that it was withholding the release of its latest Mythos model over cybersecurity concerns. The episode sparked a small-scale geopolitical crisis as nations worried about vulnerabilities to financial systems and critical infrastructure.Anthropic is additionally set to be an influential force in the US midterm elections, pouring millions into lobbying efforts and Super Pacs aimed at candidates and legislation that aligns with its views on regulating AI. The firm has called for more government oversight of the technology, breaking with other tech industry leaders and OpenAI which advocate for a more lax regulatory framework.The AI Funding Race ContinuesThe company's valuation underscores the enormous amounts of money still flowing into the AI industry, despite widespread public distrust of the technology. Anthropic's valuation follows OpenAI raising $122bn in March to be valued at $852bn, with the possibility it will seek a $1tn IPO later this year.
#Anthropic #OpenAI #Claude
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Economy Jun 01, 2026

What the Netherlands Can Teach the UK About Tackling the Youth Jobs Crisis

A new government‑backed report warns that Britain faces a "lost generation" as NEET numbers top one…
A shock government‑backed report this week warned of the danger of a “lost generation” of young people in Britain, as the number of 16‑ to 24‑year‑olds not in education, employment or training (NEETs) rose to more than 1 million, roughly 13.5% of the cohort.Rising NEET Numbers Spark Alarm in the UKOfficial UK statistics show that 13.5% of young people are not in work or college, climbing to 15.8% among 18‑ to 24‑year‑olds – nearly one in six. The report, authored by former Labour cabinet minister Alan Milburn, warns that without decisive action the country could see a sustained “lost generation”.Comparative NEET Rates: UK vs NetherlandsUK NEET rate (16‑24): 13.5% overall, 15.8% for 18‑24 year olds.Netherlands NEET rate (15‑29, adjusted): 5.3% last year, consistently below 5% for over a decade.Potential impact: Matching the Dutch rate could move 600,000 more 18‑ to 24‑year‑olds into learning or earning.Why Dutch Vocational Pathways Keep Youth EngagedThe Dutch system centres on three pillars: strong vocational secondary education (MBO), a welfare safety net that prioritises engagement and rehabilitation, and financial incentives for employers. Around 70% of Dutch 16‑ to 19‑year‑olds in upper secondary education attend an MBO school, and 35% of under‑25s later study at technical or professional universities. By contrast, only 22% of UK 18‑ to 21‑year‑olds were on vocational courses in 2024.Technical education is treated as “the foundation of the economy”, with work‑based learning embedded in curricula – many students combine four days of school with one day of on‑the‑job training.Policy Levers Behind the Dutch Low NEET RateThe 2004 Work and Social Assistance Act devolved welfare programmes to municipalities, creating personalised, localised support that addresses mental health and long‑term illness. Local councils provide tailored engagement programmes, subsidised employment, and specialised training, preventing young people on incapacity benefits from falling through the cracks.Employers receive fiscal incentives, such as payroll‑tax cuts and direct subsidies that cover up to 70% of wages for chronically unemployed youth, as highlighted by the Youth Futures Foundation. Rotterdam’s city council, led by Tim Versnel, funds up to 70% of wages for young chronically unemployed people and offers holistic support covering mental resilience, substance‑use treatment, and financial literacy.What the UK Could Adopt to Reverse the TrendTo emulate the Dutch success, the UK might consider:Expanding vocational pathways and integrating work‑based learning into secondary education.Devolving youth‑welfare services to local authorities for more personalised support.Introducing targeted fiscal incentives for businesses hiring young workers, including wage subsidies and tax relief.Adopting a whole‑of‑life approach that combines education, mental‑health services, and financial literacy for chronically unemployed youth.While cultural and structural differences mean a direct copy is impossible, the Dutch experience offers a roadmap for reducing Britain’s NEET rate and revitalising its youth labour market.
#United Kingdom #Netherlands #Youth unemployment
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Sports Jun 01, 2026

T20 Blast 2026: Early Season Thrills, Surprising Upsets and Rising Stars

The 2026 Vitality Blast returns with 17 matches played in its opening weekend, delivering dramatic …
The men’s Vitality Blast launched on Friday, and within three days 17 matches across the South, North and Central‑West groups have already set the tone for a season of high‑octane cricket.The Blast Kicks Off with 17 Matches Across Three GroupsOpening fixtures saw the Warwickshire Bears suffer two early defeats, while Somerset maintained a 100% record, crushing Hampshire and the Bears in succession. The women’s finals day is slated for Friday 17 July at the Oval, followed by the men’s showdown on Saturday 18 July at Edgbaston.17 matches completed in the first three daysThree regional groups: South, North, Central‑WestKey venues: The Oval, Edgbaston, Headingley, Lord’sStat Sheet: High‑Scoring Chases and Early UpsetsSeveral innings highlighted the format’s explosiveness. Moeen Ali smashed five sixes as Yorkshire chased down 194 against Derbyshire, with Andrew Tye and Hasan Ali sealing the win with four balls to spare. In another thriller, Surrey recovered from 56‑4 to chase 144, thanks to a partnership between Sam Curran and Laurie Evans. Zak Crawley posted an unbeaten 75 to guide Kent to a 199 chase against Sussex.30.5 overs required for the Bears vs Gloucestershire matchWarwickshire reduced to 48‑6 by South African pacersYorkshire’s win: 4 balls remainingWhy the T20 Blast Is Reshaping County CricketThe rapid pace and lucrative prize money are drawing international talent back to the county circuit, as seen with the involvement of Hasan Ali and Andrew Tye. Smaller counties benefit from the exposure, while larger clubs leverage star power to boost attendance. The format also offers fringe players—like the Curran brothers—a platform to showcase all‑round abilities, influencing future England selections.Looking Ahead: Finals Day and the Race for the CrownWith Somerset unbeaten and Kent topping the South Group, the early leaderboard suggests a tight contest. The upcoming finals day on 17‑18 July will likely set the narrative for the second half of the season, and teams that can blend experienced internationals with emerging county talent stand the best chance of lifting the trophy.
#Vitality Blast #Moeen Ali #Yorkshire
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Sports Jun 01, 2026

Mo Hunt on England’s Unstoppable Women’s Rugby Dominance and Her Road to Recovery

Veteran scrum‑half Mo Hunt reflects on England’s continued supremacy in women’s rugby, her season‑e…
Mo Hunt entered the 2026‑27 season fresh from a World Cup triumph and a record‑breaking Six Nations opener, only to see her campaign halted by a medial collateral ligament injury. Despite the setback, she remains optimistic about her recovery and the future of England’s women’s rugby programme.The Season‑Ending Injury That Halted a Star’s CampaignDuring England’s opening Six Nations match against Ireland, played in front of a record crowd of 77,000, Hunt pulled up with a knee injury that was later diagnosed as a medial collateral ligament tear. She confirmed a three‑month rehabilitation period, meaning she will miss the remainder of the domestic Premiership Women’s Rugby season and the current Six Nations campaign.Numbers Behind England’s Recent DominanceEight consecutive Six Nations titles – a record streak for the Red Roses.Five grand slams in a row, highlighted by a victory over France in Bordeaux.England’s World Cup win over Canada attracted a record home crowd (exact figure not disclosed) and secured a second World Cup medal for Hunt.Gloucester‑Hartpury entered the league with a home semi‑final and an unbeaten run since November 2024.Depth and Resilience: Why England Keeps WinningCoach and players credit the squad’s depth – with more than 10 players unavailable during the Six Nations, the team still secured the title. Hunt highlighted the seamless transition of younger talent such as Lucy Packer taking the No 9 shirt and the readiness of players like Nel Metcalfe, Tatyana Heard, and Alex Matthews returning from injury or surgery.The club environment at Gloucester‑Hartpury, described by Hunt as “strength in depth,” mirrors the national set‑up, allowing the Red Roses to adapt without losing performance levels.Looking Ahead: Hunt’s Recovery and Future AspirationsHunt aims to be fit for England’s upcoming WXV fixtures in September and October, and she has set her sights on the inaugural women’s British and Irish Lions tour to New Zealand in 2027. She remains involved as a fan, supporting teammates from the sidelines and planning to watch matches from “The Shed” at Kingsholm.Her determination to return to the pitch underscores a broader narrative: England’s women’s rugby continues to thrive on a blend of veteran leadership and emerging talent, ensuring the dominance is likely to persist beyond individual setbacks.
#Mo Hunt #England Women’s Rugby #Gloucester-Hartpury
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Sports Jun 01, 2026

Kang's Spending Sparks Debate: Barcelona's Model vs. Financial Power in Women's Football

Billionaire investor Michele Kang's spending in women's football has sparked resentment despite Bar…
The Billionaire's Challenge to Women's FootballIt has been a bad week for Michele Kang, the billionaire women's football investor. On Wednesday the Uefa director of women's football, Nadine Kessler, was firm on the enforcement of rules prohibiting clubs with the same owner from playing each other in European competitions, dealing a blow to Kang, who has ambitions of taking London City Lionesses into Europe's premier competition, but also owns the tournament's most decorated side, OL Lyonnes.Then, across the weekend, Kang teams suffered two continental final defeats, with Lyonnes losing 4-0 to Barcelona in the Champions League final before her US outfit, Washington Spirit, fell short in the Concacaf W Champions Cup with a 5-3 reverse to the Mexican side Club América.Barcelona's Talent Pipeline vs. Financial MuscleSpeaking to the Catalan TV channel Esport3 in Oslo on Saturday evening, the Barcelona goalkeeper Cata Coll made some pointed remarks about money in football after their emphatic victory, and her words went viral. "There has been criticism but we have shown the team we are," she said. "Money isn't everything. We are privileged to have La Masia and all the girls that have come up to the first team: Aïcha Cámara, Carla [Julià Martínez], [Martine] Fenger, [Clara] Serrajordi, all of them. They are incredible. It says everything and that's why I say it."Many have assumed it was a jab at Kang and the use of her wealth to pursue glory in women's football, with Barcelona's talent pipeline apparently delivering an antidote to such an approach. There have been frustrations that Kang's teams have been sniffing at Barcelona's door in recent years, poaching the head coach Jonatan Giráldez, who led Barça to their second and third European titles, first planting him in post at Washington Spirit before switching him this season to Lyonnes, another of her Kynisca Sports International multi-club ownership group.The Financial Distortion in Women's FootballGiráldez isn't the only Barcelona employee to have been recruited by the big-spending Kang. The midfielder Ingrid Engen joined Lyonnes last summer and the defender Jana Fernández was acquired by London City from the Catalan club. Meanwhile, talk of potential rogue bids for Aitana Bonmatí have circulated in past seasons, while London City are believed to have made Alexia Putellas, soon to be out-of-contract, a large offer to play in the WSL.Clubs are seemingly irritated with Kang's spending because to entice superstars to fledgling projects she is offering fees and wages that are distorting the market, driving it beyond what many view as sustainable growth. Except, given the opportunity, every club would probably do it. Yes, huge men's clubs could do the same, given the large sums at their disposal, but often choose not to in the name of sustainability and gradual growth.Barcelona's Own Financial ChallengesHowever, while the constantly emerging talent from La Masia is both laudable and enviable, Barcelona are not a model women's football club, or a salve to the model being championed by Kang.Kang is one of many to have exploited the strict financial rules of La Liga, with the money trouble experienced by the men's side recently affecting every section of the club, from the women's team to the youth academy and basketball, handball and futsal teams. To lower the wage bill, players have been allowed to leave that may have been kept under different circumstances.The team that have powered Barça to four European titles contains several key players at the end of their contracts. Alongside Putellas, the quartet of Mapi León, Marta Torrejón, Salma Paralluelo and Caroline Graham Hansen are nearing the end of their deals. At some stage Barça will need to undergo their next evolution, but to what extent that is done on their terms, or forced by financial pressure, remains to be seen.The Future of Investment Models in Women's FootballSaturday's Champions League final was my eighth in nine years – the Covid-19 pandemic prevented me from attending the 2020 final between Lyon (now Lyonnes) and Wolfsburg in San Sebastián. The game has come a long way since my first, in Kyiv in 2018, when the host city was the same as the one for the men's Champions League final and the women's final cowered in its shadow.In Oslo the huge numbers pouring into Uefa's fan park, that featured a line of mini-pitches where girls' teams played all day, reflected the impact the final can now have on a city. Women's football has also changed a lot, but in some ways it is very similar. In 2018 Lyon lifted their fifth of what has become eight European titles, the efforts of the former club owner, men's and women's, Jean-Michel Aulas, repeatedly delivering for the French team. Aulas committed more resources to the women's team than most other European clubs and Kang is now doing the same sort of thing, but more aggressively, in a world where many of the top women's clubs are increasing investment.The problem is, there is no alternative model put forward by any of the biggest clubs. Each one walks the same path, in slightly different ways, perhaps getting annoyed at how others have gone the same route. Most men's Premier League clubs do not want an alternative funding model – because it might show fans there is another way of doing things. As it stands, those owners can take money out of clubs to boost their personal wealth.So, yes, Coll is right, but behaving like Barcelona are the morally superior club is misleading.
#Michele Kang #Barcelona FC #Women's Football
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Sports Jun 01, 2026

Formidables v Expendables: PSG v Arsenal Champions League Final Preview

The Champions League final promises a classic showdown between PSG's formidable attacking unit and …
The Ultimate Showdown in BudapestAs the European club football season approaches its climax, all eyes turn to Budapest for Saturday's Champions League final between Paris Saint-Germain and Arsenal. This highly anticipated match pits two contrasting styles against each other: PSG's swashbuckling attack against Arsenal's titanium defense. The encounter, scheduled for 5pm BST, represents the culmination of what the article playfully calls the 'Bigger Cup'.Clash of Football PhilosophiesPSG, the defending champions, arrive in Budapest having dismantled Inter Milan 6-0 in last season's semi-final - the most one-sided result in Champions League final history. Under Luis Enrique, the French champions have evolved into what the article describes as 'Pass, Shoot, Goal' - a team unshackled from anxiety and riding an attacking groove so ruthless that few opponents have been able to live with them. Having secured the Ligue 1 title with ease, they also benefit from approximately 7,000 collective extra minutes in their legs compared to their English opponents.Arsenal's Defensive MasteryArsenal, meanwhile, have emerged as the 'Expendables' - a grizzled band of defenders and midfielders masters of the dark arts. Having won their first league title in 22 years, this Champions League final represents the pinnacle of an already stellar season. The article notes that Arsenal's unique ability to control games and defend leads makes them particularly dangerous in knockout competitions. Mikel Arteta's side also has the advantage of knowing how to defend a one-goal lead in finals, having perfected this approach throughout their campaign.Strategic Implications for English FootballThis final carries significant implications beyond the two teams involved. Should Arsenal triumph, they would complete an unprecedented treble of European trophies for English clubs with buildings in their names - a playful reference to the naming rights of Arsenal's Emirates Stadium. The article also notes the contrast in league game time, with Declan Rice having accumulated more minutes in the Premier League than PSG's Ousmane Dembélé and Kvicha Kvaratskhelia combined.The Perfect Final NarrativeAs the article concludes, this matchup represents the perfect Champions League final narrative - silk against steel, magic versus muscle, the unstoppable force meeting the immovable object. PSG's attacking prowess, exemplified by their 6-0 demolition of Inter last season, faces Arsenal's defensive resilience that has carried them through their most challenging campaign in decades. Regardless of the outcome, football fans are promised a classic encounter between two teams at the peak of their powers.
#PSG #Arsenal #Champions League
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