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Eli Lilly, the US pharmaceutical group behind the Mounjaro weight-loss drug, is seeking to resume its investments in the UK after pausing them last year. The company is in talks with UK ministers to regularly increase NHS drug prices and end a rebate scheme. Patrik Jonsson, president of Eli Lilly's international business, expressed optimism about reaching an agreement this summer.The talks will also explore 'innovative' pricing plans, such as linking payments for anti-obesity drugs to whether the treatment helps patients return to work. This comes as the US pharmaceutical industry increases pressure on the UK, with Keir Starmer agreeing to the first increase in NHS cost-effectiveness thresholds in 27 years. The threshold was raised from £20,000 to £30,000 a year for every year of life gained to £25,000 to £35,000.Eli Lilly was one of several pharmaceutical companies that ditched or paused almost £25bn in planned investments in the UK last year. The company paused its plans to invest in a laboratory site in central London. Jonsson stated that the resumption of Eli Lilly's investment would depend on the outcome of its talks with the government.He emphasized that prices for medicines in the UK had been 'far too low for far too long' and that the threshold couldn't remain static for another three decades. The UK agreed to pay 25% more for new medicines by 2035 as part of a US-UK drug pricing deal, which could eventually reach £9bn a year.Large pharmaceutical companies have protested about a 'rebate' scheme, under which they are required to pay back a chunk of revenue from sales of branded medicines. This scheme is expected to fall in 2026, although Jonsson believes payments 'should actually get down to zero' over time.

Ukrainian President Volodymyr Zelenskyy has arrived in Jordan as part of his tour to strengthen defence ties in the Gulf region, amid the ongoing conflict with Russia. Security is the top priority, and it is crucial that all partners make necessary efforts toward it, Zelenskyy emphasized.Zelenskyy's visit comes after Ukraine has agreed to cooperate on defence with Qatar, Saudi Arabia, and the United Arab Emirates. Kyiv's anti-drone experts have also been deployed to these countries as Iran targets infrastructure there using drones that Russia has also used during its war with Ukraine.The Ukrainian president has been seeking support from the Gulf states as the Russia-Ukraine war continues, with no end in sight. More than four years since Russia launched a full-scale invasion, Kyiv is struggling to cover its budget deficit and fund domestic weapons production.Ukraine has intensified retaliatory attacks on Russian infrastructure, including refineries, oil depots, and ports, arguing that they were justified targets to sever revenues funding Russia's offensive. A drone strike triggered a fire at Russia's Baltic port of Ust-Luga, which was hit for the second time in several days.According to the Russian regional governor, Alexander Drozdenko, damage was sustained at the port, the fire is now under control, and there were no casualties from the attack. He added that 36 drones were destroyed overnight in the region.

Iran has agreed to permit 20 Pakistani-flagged vessels to transit the Strait of Hormuz, a crucial waterway for global oil supplies. This development is seen as a significant step towards alleviating the severe energy crisis affecting the region.Pakistan's Foreign Minister, Ishaq Dar, announced the agreement, stating that two ships will cross daily under the arrangement. He described Iran's decision as 'a harbinger of peace' and a 'welcome and constructive gesture'.The Strait of Hormuz has been effectively shut since the United States and Israel launched coordinated strikes on Iran on February 28, triggering a war that has resulted in significant loss of life and disruptions to global markets. The conflict has killed about 2,000 Iranians and over 1,100 people in Lebanon.The strait is a critical passage for oil supplies, with an estimated 2,000 vessels stranded on either side. This blockade has caused oil prices to surge past $100 a barrel, up by roughly 40 percent. The Islamic Revolutionary Guard Corps (IRGC) has turned the strait into a checkpoint, requiring ships to submit cargo details and receive clearance codes.At least two vessels have reportedly paid $2 million per crossing, settled in Chinese yuan, to secure passage. Iran's parliament is now moving to legalize this arrangement as a potential source of revenue.This agreement is the result of intense Pakistani diplomacy, with Army Chief Field Marshal Asim Munir speaking to US President Donald Trump and Foreign Minister Dar holding calls with his Iranian and Turkish counterparts.

Tottenham Hotspur have sacked manager Igor Tudor after just 44 days in charge, with the club struggling to avoid relegation from the Premier League. Tudor managed the team for seven games, securing only one point from his five league matches.The final straw came with last Sunday's 3-0 home defeat by Nottingham Forest, which left Tottenham one point and one place above the bottom three. A potential demotion to the Championship would be catastrophic for the club's prestige and revenues.Tudor's departure comes amid a backdrop of human tragedy, with the manager informed of the death of his father, Mario, after the Forest game. The club aimed to handle the situation with sensitivity towards the Croatian manager.Tudor's brief tenure included two Champions League matches against Atlético Madrid, with Tottenham ultimately losing 7-5 on aggregate. His time at Spurs began with a difficult period, including league defeats to Arsenal, Fulham, and Crystal Palace.The club has gone 13 league games without a win, their worst run since 1934-35 when they were relegated from the old Division One. Tudor's approach and tactics were questioned, particularly his decision to substitute goalkeeper Antonin Kinsky after just 17 minutes in the first leg against Atlético Madrid.Tudor had been tasked with bringing organisation, intensity, and competitive edge to the squad, but ultimately failed to achieve this. The club is now searching for a new manager, with Bruno Salter set to take training in the interim.

Germany's Autobahn, the world's only democracy without a blanket speed limit on motorways, has long been a symbol of freedom and technological mastery for driving enthusiasts. Lutz Leif Linden, president of the Automobile Club of Germany (AvD), has reached speeds of 400km/h (249mph) on the road, describing the experience as 'like an airplane.'The country's love affair with fast cars dates back to the late 1800s, with Carl Benz patenting the first 'vehicle powered by a gas engine'. The success of the German car industry, which created jobs, gave citizens freedom to travel, and brought in tax revenues, has cemented motorized vehicles in the national psyche.Despite the International Energy Agency (IEA) urging drivers to slow down to cushion the price shock from the biggest blow to oil supply in history, Germans remain opposed to a blanket speed limit. Public opinion has shifted, with a majority supporting the Tempolimit among voters of all big parties except the far-right Alternative für Deutschland and the market-liberal Free Democrats.Researchers have made the case for slowing down in terms of money, fuel, and lives. A study found a speed limit of 130km/h would lead to nearly €1bn a year in societal benefits, cut greenhouse gas emissions from road transport by 2.2%, and reduce toxic air pollutants. However, opponents argue a blanket ban is unnecessary and cite the time saved over long distances and the appreciation of freedom to set their own speed.The industry has found itself in a crisis as high energy prices and competition from China on electric vehicles have resulted in factory closures and job losses. Germany led efforts to water down an EU ban on the sale of combustion engine cars from 2035. A spokesperson for VDA, Germany's biggest car lobby, described the climate impact of a blanket speed limit as 'minimal' and 'increasingly insignificant' as the car fleet becomes more electrified.

The boss of Asda, the UK's second-largest fuel retailer, has warned of temporary shortages at petrol pumps due to the ongoing conflict in the Middle East. Allan Leighton, executive chair of Asda, stated that the company has been experiencing high demand from drivers as fuel prices have surged over the past four weeks.Leighton emphasized that the temporary shortages have only affected the odd pump at a small number of Asda's petrol forecourts, typically when customers arrive at a time the retailer is waiting for a fuel delivery. He added that these shortages are temporary and addressed quickly.Petrol and diesel prices have climbed significantly since the US and Israel began their campaign against Iran on 28 February. The average price of petrol in the UK rose above 150p a litre for the first time since May 2024, reaching 150.11p, according to the RAC. Diesel prices have also increased, averaging 177.68p a litre.Leighton rejected claims that fuel retailers might be 'profiteering' from the crisis by raising their prices, stating that Asda's profit margin is coming under pressure from higher fuel costs. He also noted that the government is benefiting from the situation through increased tax revenue.The global price of oil has moved higher again, climbing 2.5% to almost $111 a barrel. This increase is likely to keep petrol and diesel prices higher in the coming weeks, affecting motorists during the Easter weekend.

The UK music industry is facing a significant disparity in executive roles, with black professionals underrepresented in senior positions despite black music generating £24.5bn out of £30bn in revenue over the past 30 years. A recent report by UK Music found that 80% of UK music revenue has been generated by black music, but industry figures are highlighting that black people are still excluded from top executive roles. According to the 2024 UK Music Diversity Report, 22% of the music industry workforce identify as Black, Asian or minority ethnic, compared with 46% of London's population. Eunice Obianagha, head of diversity at UK Music, emphasized the need for investment in genres such as "grime, garage and lovers rock" to support black music innovation. Charisse Beaumont, CEO of Black Lives in Music, noted that racial pay gaps and barriers to career progression are preventing black professionals from gaining executive roles. Industry experts, including Zeon Richards and Jasmine Dotiwala, stress that ensuring black people secure higher industry positions is crucial for driving cultural understanding and nuance. Mykaell Riley, professor of black music at the University of Westminster, argued that black music should be taught in schools to recognize its significant influence on popular music.

The reliance on oil revenue has significant implications for countries like Iran and Nigeria, as well as the broader African continent. Economic diversification remains a crucial goal for these nations to mitigate the risks associated with fluctuating oil prices and global energy trends.Africa, in particular, faces a complex situation, as many countries on the continent are heavily reliant on oil exports to drive economic growth. This oil dependency can make these nations vulnerable to external economic shocks and limit their ability to invest in long-term sustainable development.Iran and Nigeria, as two of Africa's largest oil producers, are working to diversify their economies and reduce their dependence on oil revenue. This process involves investing in alternative sectors, such as agriculture, manufacturing, and renewable energy, to create a more resilient and sustainable economic foundation.

Walking into Scisters Salon & Apothecary in southern California reveals what's immediately absent: no wall of plastic bottles, no chemical tang, and minimal waste. The salon's shelves feature large refill containers of shampoo and conditioner, houseplants adorn the space, and hair clippings are composted. The only trash can is a small basket mostly collecting clients' personal items, creating an environment that co-owner Melissa Parker notes clients immediately comment on: 'It smells good in here.' That never happens in a conventional salon.Opened 15 years ago by Parker and Easton Bajsec in La Mesa near San Diego, Scisters has evolved into one of the region's most prominent low-waste salons, diverting up to 99% of its refuse from landfills. Their business transformation addresses a significant industry problem: the beauty sector generates substantial waste, with North American salons sending an estimated 63,000lbs of hair to landfills daily, plus hundreds of tons of used foil and leftover hair dyes.The turning point came when Bajsec watched a documentary about the zero-waste movement while Parker developed health problems linked to prolonged exposure to salon chemicals. Studies have found that hairdressers' exposure to harmful chemicals such as formaldehyde, ammonia and sulfates puts them at higher risk of asthma, skin conditions, reproductive illnesses and cancer. Rather than leave the industry, they transformed their business.They eliminated perms due to formaldehyde exposure and moved away from big-name products despite green marketing claims. When existing alternatives didn't meet their standards for performance, ingredient transparency and waste reduction, they created their own line. Element, launched in 2019, is made in a California lab and sold in refillable glass and aluminum containers, featuring recognizable ingredients like organic aloe, wheat protein and castor oil.The salon's waste reduction strategies extend beyond product packaging. They implemented hair composting, foil recycling, and replaced waxing with sugaring—a compostable hair-removal technique. They switched to LED lighting, installed water-efficient showerheads, and use washable cloths instead of paper towels. Though they still offer hair bleaching (which releases ammonia), they mitigate risks with industrial air filtration and air-purifying plants.Bajsec acknowledges that 100% zero waste is impossible due to regulatory constraints on reusable gloves and plastic pump tops. The salon ships its minimal plastic waste to Green Circle Salons for specialized processing, paying $200 per box. Despite this cost, Parker notes the overall approach has been financially beneficial: 'Overall, it's actually less expensive. We're not outsourcing to other beauty brands. We're mindful about systems.'Their commitment to sustainability proved critical during the COVID-19 pandemic. When mandatory closures threatened their survival, they pivoted to refill sales, meeting clients in the parking lot. This refill model kept revenue flowing, allowing them to pay full rent while many neighboring tenants struggled. 'Going green has been the greatest thing we've done for our business financially,' Parker says. 'We accidentally created a point of differentiation.'Denise Baden, a professor of sustainable business at the University of Southampton, confirms that eco-friendly practices often reduce costs. 'It's a misunderstanding that to be eco-friendly, you have to spend more money. In fact, usually, it's the reverse,' she notes, adding that hairdressers are uniquely positioned to influence their communities.Now, Parker and Bajsec are helping other salons adopt similar practices through speaking engagements and an online guide. 'We get calls from other salons all the time,' Bajsec says. 'It's not sustainable if we're the only ones doing it.'