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The Childcare Crisis in BritainThe number of childminders in England has roughly halved over the past decade, with many citing rising costs, low pay and increasing paperwork as reasons for leaving the profession. Campaigners warn the decline is making it harder for families to find flexible and affordable childcare.Seeking Parent ExperiencesWe want to hear from parents and carers whose childminder has recently closed their business, stopped accepting certain age groups such those over three-year-olds or reduced the number of children they look after.Impact on FamiliesHow did it affect your family? Did you struggle to find alternative childcare? Have you been forced to move your child into a nursery setting despite feeling they were better suited to a smaller, home-from-home environment?Share Your StoryThe Guardian is collecting experiences from parents affected by the decline in childminding services. If you're 18 or over, you can share your story anonymously if you wish. Your responses are secure as the form is encrypted and only The Guardian has access to your contributions.Call for ActionAs the childcare landscape continues to change, it's crucial to understand how these changes are affecting families across the UK. By sharing your experiences, you can help highlight the challenges and potential solutions in the childcare sector.

Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

Weekly Wildlife Roundup: Top Predator StoriesThe latest Guardian wildlife column spotlights three notable predator encounters that illustrate how large and medium‑sized carnivores are adapting to a rapidly changing environment.Leopard Lurks Near Human SettlementsA leopard was observed prowling close to a rural village, prompting both awe and concern among residents.Location: Rural community bordering protected landBehavior: Stealthy movement along forest edges, no direct conflict reportedSignificance: Highlights the thinening buffer between protected habitats and human activityFox's Fortunate Encounter Highlights Urban AdaptationA fox managed to evade a potential roadkill scenario, showcasing its agility and growing comfort in suburban settings.Incident: Narrowly escaped a busy roadway after being spotted by local observersAdaptation: Utilises garden waste and small mammals in urban green spacesImplication: Demonstrates the species' resilience and the need for safe wildlife corridors in citiesCoyote's Clever Behavior Signals Expanding RangeIn a separate observation, a coyote displayed problem‑solving skills while foraging near a suburban park.Behavior: Used a fallen branch to access a bird feederRange: Sightings are moving further north than historic recordsEcological Impact: Potential competition with native mesopredatorsWhat These Predator Movements Mean for Ecosystem ManagementCollectively, the sightings point to a broader trend of predators navigating fragmented landscapes, which raises questions for land‑use planners and conservationists.Increased human‑wildlife interactions demand proactive conflict‑mitigation measuresHabitat corridors become critical for maintaining genetic flowMonitoring programs must adapt to track both apex and mesopredators across mixed‑use zonesLooking Ahead: Conservation Priorities for Apex and MesopredatorsFuture efforts should focus on integrating community education, habitat connectivity, and data‑driven management to ensure coexistence.Promote citizen‑science reporting to fill observation gapsInvest in green infrastructure that accommodates predator movementDevelop region‑specific guidelines that balance agricultural, urban, and wildlife needs

Lead: War Day 84 Marks a Shift Toward DiplomacyThe conflict between Iran and the United States entered its 84th day with renewed diplomatic activity. Both sides are exchanging draft proposals, and US Secretary of State Marco Rubio highlighted "some good signs" while President Donald Trump warned of "very drastic" action if Tehran refuses to relinquish its uranium stockpiles.Mediated Negotiations Gain MomentumPakistani officials are conducting "intense mediation activity" in Tehran, according to Al Jazeera correspondent Almigdad Alruhaid. Senior Iranian sources say negotiators are close to a draft framework, though others caution that a final agreement remains premature.Pakistani mediation is accelerating to prevent further escalation.US‑Iran red‑line shift: Cato Institute senior fellow Doug Bandow stresses the need for both parties to move beyond entrenched nuclear red lines.Key Figures and Financial Stakes7,200 civilians rescued from rubble by the Iranian Red Crescent.More than two dozen MQ‑9 Reaper drones destroyed, losses estimated at $1 bn (≈20% of pre‑war inventory).At least 42 US aircraft damaged or destroyed, total losses near $2.6 bn.US has paused a $14 bn arms sale to Taiwan to preserve munitions for the Iran campaign.Regional and Military ImplicationsCentcom reports the USS Abraham Lincoln strike group remains at "peak readiness" in the Arabian Sea, signaling continued pressure despite diplomatic overtures. Meanwhile, Israeli strikes in southern Lebanon and new US sanctions on Hezbollah allies heighten the risk of a broader regional flare‑up.Outlook for a Potential DealIf the current draft proposals survive scrutiny, a diplomatic settlement could emerge within weeks, easing military pressure and opening pathways for humanitarian aid. However, the dual track of high‑cost equipment losses and political warnings from both Washington and Tehran suggests that any agreement will require substantial concessions on nuclear constraints and future US military commitments in the region.

Tragic Loss of a Racing IconThe NASCAR community is in shock after the death of Kyle Busch, a two‑time Cup Series champion and record‑holding winner across NASCAR’s three national series. He passed away at 41 following a brief hospitalization for a “severe illness.”Details of the Illness and HospitalisationBusch was testing in the Chevrolet racing simulator in Concord on Wednesday when he became unresponsive. He was rushed to a Charlotte hospital and died the following day. The family, Richard Childress Racing, and NASCAR released a joint statement confirming his death but did not disclose a cause.Wednesday: Unresponsive during simulator test; transported to hospital.Thursday: Family announces death; no cause released.Three days before scheduled start in the Coca‑Cola 600 at Charlotte Motor Speedway.Career Statistics Highlighting Busch’s RecordBusch’s achievements set him apart in modern motorsport:Combined wins: 234 across Cup, Xfinity (O’Reilly Auto Parts) and Trucks series.Cup victories: 63 wins.Xfinity wins: 102 wins (record).Truck Series wins: 69 wins (record).Championships: Cup Series titles in 2015 and 2019 with Joe Gibbs Racing.Rookie of the Year: 2005.Repercussions for NASCAR and the Racing CommunityThe loss reverberates through teams, drivers, and fans. Statements from NASCAR, teammates Denny Hamlin and Brad Keselowski expressed “heartbreak” and “absolute shock.” Busch’s role as an owner in the Truck Series and his outspoken personality helped build the devoted “Rowdy Nation” fan base.His career also illustrates the sport’s competitive dynamics, from early dismissal by Hendrick Motorsports to a dominant stint with Joe Gibbs Racing, and later challenges with Richard Childress Racing.Looking Ahead: Legacy and Future of the SportWhile the immediate future of Busch’s teams remains uncertain, his impact is likely to be cemented with Hall of Fame consideration and continued reverence from fans and fellow drivers. The sport may also see increased focus on driver health monitoring, given the sudden nature of his decline.

Meta has reached a confidential settlement with Breathitt County Schools in Kentucky, ending a lawsuit that alleged the company’s social networks are engineered to be addictive and cause mental‑health harm to students.Meta Settles Kentucky School District Lawsuit Over Alleged Addiction DesignThe settlement was announced less than three weeks before the case was set to go to trial in federal court in California. While the exact terms were not disclosed, Meta emphasized its ongoing work on safety tools such as Teen Accounts and parental controls.Financial Stakes and Settlement LandscapeThe Kentucky district originally sought more than $60 million to cover mental‑health services and a 15‑year remediation program.Meta’s settlement follows similar agreements by TikTok and Snap with the same group of roughly 1,200 school districts.Recent jury verdicts ordered Meta and YouTube to pay $6 million in damages and Meta to pay $375 million in civil penalties for related claims.Implications for Social Media Regulation and Child SafetyThe case adds pressure on the industry to redesign features such as infinite scrolling and autoplay video, which plaintiffs argue are deliberately addictive. Lawmakers and advocacy groups are citing these lawsuits as evidence that existing self‑regulation is insufficient, potentially accelerating federal or state legislation aimed at protecting minors online.Future Legal Battles and Industry OutlookAttorneys for the remaining school districts say they will continue pursuing justice, with another 1,200 districts still in litigation. Upcoming trials include an individual case in California and a Tennessee attorney‑general suit slated for July, while a federal case by the Tucson Unified School District is scheduled for January 2027. The outcomes of these cases will likely shape the next wave of social‑media liability and could force broader industry changes.

Josh Hart recorded a playoff‑career‑high 26 points and seven assists as the New York Knicks beat the Cleveland Cavaliers 109‑93, moving the series to a pivotal Game 3 and putting the Knicks within two wins of the NBA Finals for the first time since 1999. The Knicks Secure a Dominant 109-93 Victory Over Cleveland The win featured an 18‑0 run in the third quarter that stretched the lead to 71‑53. Coach Mike Brown praised Hart’s shooting, noting his five‑for‑eleven performance from beyond the arc. The Knicks’ bench contributed crucial minutes as the crowd chanted “Knicks in four!” throughout the final minute. Statistical Highlights: Scoring, Rebounds, and Historic Streaks Josh Hart: 26 points (5/11 3‑pt), 7 assists Jalen Brunson: 19 points, 14 assists Karl‑Anthony Towns: 18 points, 13 rebounds Mikal Bridges: 19 points Cavaliers: Donovan Mitchell 26 points, James Harden 18 points Cavaliers missed 10 free throws (68.8% FT) Knicks now on a nine‑game postseason winning streak, the longest since the Boston Celtics’ ten‑game run en route to the 2024 championship Implications for the Eastern Conference Finals Landscape The victory solidifies the Knicks’ control of the series, giving them a 2‑0 lead and forcing the Cavaliers to win two straight to stay alive. The dominant third‑quarter run demonstrates the Knicks’ ability to dictate tempo and exploit defensive lapses, while Cleveland’s free‑throw woes highlight a potential vulnerability in close games. Looking Ahead: What Game 3 Could Hold for Both Teams Game 3 shifts to Cleveland, where the Cavs must address shooting consistency and improve free‑throw execution. The Knicks will aim to sustain their defensive intensity and capitalize on the momentum generated by Hart’s hot shooting night. If the Knicks maintain their current pace, a Finals berth appears increasingly likely; a resilient Cavs effort could at least extend the series and test the Knicks’ depth on the road.

Executive Summary: Tui Withdraws Sponsorship Following Panorama RevelationsThe travel giant Tui announced it will no longer sponsor the reality series Married at First Sight on Channel 4 after a BBC Panorama investigation exposed allegations of rape and sexual misconduct involving on‑screen couples. The decision was communicated alongside statements from Channel 4 and regulator Ofcom, underscoring the reputational risk for brands linked to such programming.What Triggered the Sponsorship Termination?Panorama aired a documentary detailing claims by two anonymous women that they were raped by their on‑screen husbands, and a third woman, Shona Manderson, alleging sexual misconduct.All accused men have denied the allegations.Tui UK and Ireland cited the broadcast and subsequent discussions with Channel 4 as the basis for ending the partnership.Financial Implications of Ending the DealWhile the exact value of Tui’s sponsorship was not disclosed, industry analysts estimate that high‑profile reality‑TV sponsorships in the UK can range from £1‑2 million per season. By pulling out, Tui avoids potential negative brand association costs, which could exceed the sponsorship fee if consumer backlash intensifies. Conversely, the loss of exposure may affect short‑term marketing ROI, especially in the competitive travel market.Industry‑Wide Repercussions for Reality‑TV PartnershipsThe incident adds pressure on broadcasters and advertisers to scrutinise the ethical standards of reality formats. Ofcom chief executive Melanie Dawes signalled willingness to tighten guidance on participant welfare, which could lead to stricter compliance requirements and higher production costs. Brands may increasingly demand contractual safeguards, such as audit clauses and rapid response protocols, before committing to similar shows.Looking Ahead: How Brands May Navigate Controversial ContentExperts predict a shift toward more cautious sponsorship strategies, with companies favoring content that aligns closely with their corporate values. Future partnerships are likely to include explicit clauses for immediate termination in the event of serious allegations, and greater involvement in content oversight. For broadcasters, the challenge will be balancing audience demand for sensational reality TV with heightened regulatory scrutiny and sponsor expectations.

The LeadThe Guardian's Politics Weekly podcast has brought attention to allegations of a new financial arrangement involving former President Donald Trump, which critics are calling a "slush fund" designed to benefit his associates and allies.The Financial Arrangement DetailsThe podcast examines the structure and purpose of this fund, which has emerged as a subject of political controversy. While specific details about the fund's operations remain limited, the discussion centers on how such arrangements might influence political processes and donor relationships.The Political Impact AnalysisThis development comes at a time when political financing and ethics are under increased scrutiny. The alleged slush fund could potentially reshape perceptions of Trump's political operation and influence fundraising strategies for upcoming elections.The Future OutlookPolitical observers are watching closely to see how this story develops and whether it will have any lasting impact on Trump's political standing or the broader conversation about campaign finance reform in the United States.Listen to the full episode on Politics Weekly YouTube channelCheck out The Guardian's US podcast: Stateside with Kai and CarterSend questions and feedback to [email protected] The Guardian at theguardian.com/politicspodus