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The United States has issued a threat to demolish Iran's critical infrastructure, including bridges and power plants, if Tehran does not open the Strait of Hormuz by early Wednesday. This move, described by President Donald Trump as 'Bridge Day', has raised concerns among experts, who warn that it could amount to war crimes.Iran has approximately 300,000 bridges and technical structures, with only about 185 exceeding 100m in length. Five of the country's most prominent bridges are at risk:1. Persian Gulf Bridge (Qeshm Island): A 3.4km-long unfinished bridge connecting Qeshm Island to Bandar Abbas, representing an investment of up to $700m. Destroying it would erase decades of national planning and impact Iran's hopes for a direct link to the island.2. Lake Urmia Bridge (Shahid Kalantari Bridge): A 1.7km-long bridge connecting Tabriz and Urmia, cutting the driving distance between the cities from 240km to 130km. An attack could trigger an ecological disaster by dumping steel pilings and concrete into the shrinking Lake Urmia.3. Sadr Multilevel Expressway: An 11km-long bridge in Tehran, supporting millions of commuters daily. An attack could cause massive urban casualties, destroy a key transport artery, and plunge Tehran's emergency evacuation systems into chaos.4. Karun 4 Arch Bridge: A 378m-long bridge in Chaharmahal and Bakhtiari province, crucial for connecting Shahr-e-Kord and Izeh. Bombing it risks causing secondary damage to the hydroelectric facility, potentially leading to fatal flooding.5. Ghadir Cable-stayed Bridge (8th Bridge): A 1,014m-long bridge in Ahvaz, spanning the Karun River. Destroying it would cut the city in two, choking off daily movement and emergency services in a province already battered by air strikes.

Deep in the Democratic Republic of Congo (DRC), a tireless conservationist is working to safeguard the future of the critically endangered Grauer's gorilla. Dominique Bikaba, founder and executive director of Strong Roots Congo, has dedicated his life to protecting these majestic creatures and their habitats.Bikaba's journey into conservation began in 1992, driven by a desire to mediate tensions between park authorities and displaced communities. His work is deeply personal, rooted in his own experiences growing up near Kahuzi-Biega national park, where his family was displaced in the 1970s. The park, a sanctuary for Grauer's gorillas, elephants, and a rich array of wildlife, is a landscape of immense biological wealth and political fragility.The Grauer's gorilla, the largest subspecies of primates, can weigh up to 250kg (39st). However, their numbers have drastically declined due to conflict, slash-and-burn agriculture, and hunting for bush meat. Before the conflicts, there were approximately 17,000 Grauer's gorillas; by 2016, that number had dwindled to around 3,800.Bikaba's organization, Strong Roots Congo, aims to create a biodiversity corridor linking Kahuzi-Biega national park with Itombwe nature reserve. This ambitious project seeks to secure 1m hectares of land for wildlife and Indigenous communities, formalizing customary land rights and promoting coexistence. So far, Strong Roots has helped establish 23 community forests, covering about 600,000 hectares.Bikaba emphasizes the importance of community-led conservation. "What we are doing is putting communities back together, so they can thrive together as they have done for centuries," he says. His approach contrasts with traditional conservation models that often cast local people as threats. Bikaba believes that humans are part of nature and that there is much wisdom to be learned from communities living in forests.Despite the challenges posed by ongoing conflict in eastern DRC, Bikaba remains committed to his work. "If there is one thing we should avoid in life, it's war," he says. "If there is a way we can stop war in this region, we should do it. No matter the cost."

The transition from live piano accompaniment in silent cinemas to recorded soundtracks marked a turning point for movie‑goers; the Vitaphone disc system of 1926 and the optical Movietone process that followed gave films a reliable, repeatable musical identity.Sunrise: A Song of Two Humans (1927) was the first feature to have its music and sound effects printed directly onto the film strip, allowing audiences to hear orchestrated pieces by Chopin and Gounod in perfect sync with the picture.King Kong (1933) showcased Max Steiner’s pioneering use of the orchestra to drive narrative, mood and scene transitions, laying the groundwork for the symphonic Hollywood score that dominated the mid‑20th century.Citizen Kane (1941) gave Bernard Herrmann a platform to break from the lush, “Hollywood” sound, delivering a stark, atmospheric score that emphasized psychological tension and set a new standard for dramatic underscoring.Blackboard Jungle (1955) introduced Bill Haley’s Rock Around the Clock as the film’s musical spine, proving that popular rock could boost a movie’s commercial appeal and ushering in the era of song‑driven soundtracks.Forbidden Planet (1956) featured the first entirely electronic score, created by Louis and Bebe Barron using magnetic‑tape techniques; the pioneering use of the theremin and other electronic textures opened a fresh sonic frontier for sci‑fi cinema.Breakfast at Tiffany’s (1961) highlighted Henry Mancini’s “symphonic pop” style, marrying a timeless hit – Moon River – with a jazzy, contemporary score that demonstrated how pop sensibilities could coexist with traditional orchestration.2001: A Space Odyssey (1968) is remembered more for its curated classical pieces than Alex North’s original score, yet the film’s bold juxtaposition of Ligeti, Strauss and Khachaturian proved that pre‑existing music could become an integral narrative force.American Graffiti (1973) assembled over 40 period songs, weaving them into the story’s fabric and proving that a soundtrack could function as a cultural time‑capsule, influencing countless later productions.Star Wars: A New Hope (1977) revived the full‑orchestra tradition when John Williams delivered a heroic, leitmotif‑rich score that re‑ignited audience love for symphonic film music and set a template for blockbuster scoring.Crimson Tide (1995) marked Hans Zimmer’s breakthrough, blending aggressive electronic pulses with a powerful orchestral choir to create the modern, hybrid sound that now defines many high‑budget action films.These ten milestones illustrate how film music has continually evolved— from live accompaniment to electronic experimentation—while retaining a core purpose: to deepen storytelling and shape audience emotion. The legacy of these scores is celebrated each April at the London Soundtrack Festival, underscoring their lasting influence on both cinema and popular culture.

Former Iranian Foreign Minister Mohammad Javad Zarif presented a comprehensive peace roadmap in Foreign Affairs on Friday, seeking to move beyond a temporary cease‑fire in the war that erupted on February 28 after coordinated US‑Israeli strikes on Iran. The plan urges Iran to place limits on its nuclear program under international monitoring, including a commitment to never pursue nuclear weapons and to blend its enriched uranium below 3.67 %. This would address the International Atomic Energy Agency’s estimate that Iran holds roughly 440 kg (970 lb) of uranium enriched to 60 %—a level close to the 90 % threshold needed for a bomb. Zarif also proposes a mutual non‑aggression pact with the United States, coupled with the immediate lifting of all US sanctions and United Nations Security Council resolutions against Tehran. To secure regional stability, he suggests forming a regional fuel‑enrichment consortium that would involve China, Russia and the United States alongside Iran and its Gulf neighbours, using West Asia’s sole enrichment facility. Additionally, a broader security framework could include Gulf states, UN Security Council powers and possibly Egypt, Pakistan and Turkey to guarantee freedom of navigation through the Strait of Hormuz, which Iran has largely blocked since the conflict began. Beyond security, Zarif calls for “mutually beneficial trade, economic and technological cooperation” between Iran and the United States, framing the roadmap as a “well‑timed off‑ramp” for President Donald Trump, who recently warned Iran it had 48 hours to negotiate a deal or face “all hell”. Gulf officials reacted sharply. UAE diplomatic adviser Anwar Gargash dismissed the proposal as ignoring Iran’s aggressive missile and drone attacks on Gulf infrastructure, calling the strategy “hubris & strategic failure.” Former Qatari Prime Minister Hamad bin Jassim Al Thani acknowledged the plan’s cleverness but warned that the war has “eroded the trust built over years” and increased regional danger. The United States has offered a 15‑point cease‑fire plan, while Pakistan, Turkey and Egypt continue to push for direct talks, yet no substantive progress has emerged. Should the roadmap gain traction, it could reopen the Strait of Hormuz—through which one‑fifth of global crude oil and natural gas normally flows—alleviate the economic shockwaves rippling through world markets, and reshape the geopolitical landscape of the Middle East.

The conflict between Iran, the US, and Israel has taken a severe turn with a series of coordinated attacks on Iranian universities and infrastructure. A research center at Shahid Beheshti University in Tehran was recently bombed, leaving it in ruins. This attack is part of a larger pattern of civilian sites being targeted by the US and Israel. Over 30 universities have been impacted since the start of the war on February 28, according to Hossein Simaei Saraf, the Iranian minister of science, research, and technology. The attacks have not only damaged educational facilities but also research centers, including those working on domestically made satellites and infectious diseases. The Pasteur Institute in Tehran, a renowned center for vaccine development and biological products, was also attacked, sustaining significant damage and disrupting health services. The World Health Organization (WHO) confirmed the damage and noted that no casualties were reported. In addition to educational and healthcare facilities, over 20 healthcare facilities have been targeted since March 1, according to WHO Director-General Tedros Adhanom Ghebreyesus. The attacks have also affected schools, houses, and businesses, resulting in over 2,000 deaths and widespread destruction. The economic sector has not been spared, with petrochemical and steel factories being destroyed in recent bombardments. The US and Israel have also targeted critical infrastructure, including power plants and water desalination plants, which are civilian targets protected under international law. The Iranian government and the Islamic Revolutionary Guard Corps (IRGC) have vowed to retaliate and escalate attacks across the region. The situation has drawn international condemnation, with over 100 US legal experts expressing concerns about potential war crimes and violations of international humanitarian law.

Martin Ho arrived at Tottenham in July, inheriting a side that had slumped to 11th place the previous season. Within months the club has risen to fifth in the Women's Super League, just three points shy of matching their record 32‑point tally from 2021‑22. With three league games remaining, Spurs are set to face Chelsea in an FA Cup quarter‑final, while a recent League Cup exit saw them lose 2‑1 to Manchester United. Ho, who began coaching at 17 after an unfulfilled stint at Everton’s academy, describes the campaign as a success so far, noting the progress from a “rudderless” squad to a more cohesive unit. He acknowledges the boldness of such a claim before the season ends, especially after consecutive 5‑2 defeats to Manchester City and Arsenal, but stresses that the club’s trajectory is positive. Only two new signings – Norway forward Cathinka Tandberg and Japan defender Toko Koga – joined the roster in the summer, a deliberate move by Ho to assess the existing squad first. "I needed to see the players with my own eyes and apply my coaching methodology," he explained. Ho’s approach draws on his experience as an assistant at Manchester United under Casey Stoney and Marc Skinner, and his earlier head‑coach role at Norwegian side SK Brann. He spent time learning the club’s culture, fanbase and values before implementing changes. Key to the transformation was a psychological reset. Ho told his players that the team must look forward and abandon the disappointment of the previous season. "We asked them to play bravely, press higher and accept that mistakes are part of growth," he said. The 5‑1 loss to Manchester City early in the season became a catalyst. Ho observed that the squad’s response demonstrated a shift in mentality, prompting him to reinforce belief and challenge the players to improve. Consistency has been elusive – three wins from eight league matches – but the side has shown signs of potential, and January brought additional reinforcements. Looking ahead, Ho warns against over‑inflated expectations. "If we promise Champions League football now and fail, it harms everyone," he cautioned, noting that European competition would be premature for a club still building its foundation. He emphasizes the need for steady, sustainable progress rather than a flash‑in‑the‑pan surge. "We must evolve the squad, staff, processes and investment together," Ho said. With a limited pool of elite talent, attracting and retaining players remains a challenge. Ho stresses creating an authentic environment that offers clear development pathways, saying, "When players see their value and a clear route forward, they stay and improve." Born in Liverpool to a Chinese father and English mother, Ho credits his upbringing for his holistic coaching philosophy. He often remarks that coaches are like thieves, constantly borrowing ideas from one another, and strives to adapt those influences into a style that reflects his own vision for Tottenham Women.

The deployment of reflective mirrors on satellites and the launch of thousands more satellites into low Earth orbit could have significant consequences for human health and ecosystems. Leading sleep and circadian rhythm researchers have raised concerns about the potential disruption to natural night-time light environments.The US Federal Communications Commission (FCC) is considering plans by Reflect Orbital to illuminate parts of the Earth at night using reflective satellites, as well as applications from SpaceX that could dramatically expand satellite numbers in low Earth orbit.2,500 researchers from over 30 countries have expressed concerns that altering the light-dark cycle could disrupt biological clocks that regulate sleep and hormone secretion in humans and animals, migration in nocturnal species, seasonal cycles in plants, and the rhythms of marine phytoplankton.Prof Charalambos Kyriacou, president of the European Biological Rhythms Society (EBRS), emphasized that "plants need the night" and that eliminating it could have global implications for food security.Reflect Orbital aims to use satellites equipped with large reflective mirrors to redirect sunlight onto areas roughly 5km to 6km wide "on demand", with brightness adjustable "from full moon to full noon".Meanwhile, SpaceX has proposed launching up to 1m satellites to create a giant solar-powered computing network in orbit designed to run artificial-intelligence workloads.Ruskin Hartley, chief executive of DarkSky International, noted that scientific studies have already shown that the existing number of satellites in orbit has increased diffuse night sky brightness by roughly 10%.Experts warn that if current trends in satellite launches and debris generation continue, night sky brightness could increase substantially over the coming decade, approaching the threshold astronomers have set for preserving naturally dark skies.

Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.