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The Personal Mission Behind the InvestmentReed Jobs, son of Apple co-founder Steve Jobs, is bringing his oncology-focused venture capital fund Yosemite to the UK, seeking investment opportunities in cancer care. The 34-year-old's mission is deeply personal, stemming from witnessing his father's death from a rare form of pancreatic cancer in 2011 at age 56. "I saw my dad have cancer when I was a kid, and unfortunately that happens far too often. And that really motivated me to try to transform outcomes for other people out there," Jobs explains.Yosemite's Healthcare Investment StrategyThe San Francisco-based venture fund, named after the California national park where his parents married, manages over $1 billion in assets and has already invested in approximately 20 healthcare startups. Yosemite focuses on innovative approaches to cancer treatment, including gene therapy, cancer vaccines, radiopharmaceuticals, and artificial intelligence. Notable investments include Tune Therapeutics, Azalea Therapeutics, Chai Discovery, and Sage Care in the US, with several UK companies in their portfolio that haven't been publicly announced.Financial Backing and International PartnershipsYosemite receives investment from LifeArc, a UK not-for-profit group focused on rare diseases that was established in 2000 as part of the UK's Medical Research Council. The fund also has partnerships with Oxford and Cambridge universities, where it has provided philanthropic grants. Additional backing comes from US biotech company Amgen, Massachusetts Institute of Technology, Memorial Sloan Kettering Cancer Center in New York, and billionaire investor John Doerr, following a fundraiser earlier this year.UK's Position in Global Cancer Research"Research here is world class," Jobs states during his visit to London for a life sciences conference hosted by LifeArc. The UK's strong academic institutions and research environment make it an attractive location for healthcare investment. Yosemite's international investment strategy includes the UK, where the fund aims to connect with pharmaceutical partners and academics to advance cancer treatment possibilities.Future Vision for Cancer TreatmentJobs envisions a future where cancer shifts from being an "end-stage disease" to an illness that is diagnosed early, monitored, and treated—similar to advances made with HIV and cardiovascular disease. "Today far too many cancers are either diagnosed incidentally, because there's no good early biomarker, or only diagnosed once they are metastatic and extremely advanced," he notes. The fund is particularly focused on immunotherapy, which Jobs identifies as "one of the areas I think is going to have the most promise for patients in the next couple of decades."

The Trump-Xi Summit: Style Over SubstanceAmerican strength back on the world stage," crowed the White House social media post: a curious remark, when the attached video showed the stars and stripes fluttering beneath a long row of Chinese flags, and People's Liberation Army soldiers marching in unison.This week's visit to Beijing offered the kind of style that Donald Trump enjoys – parading troops, a banquet and a polite if not markedly enthusiastic welcome from a strongman he called "really a friend" – but little apparent substance. The public account of the encounter will be partial: Mr Trump's former adviser John Bolton has claimed that in previous conversations the US president begged Xi Jinping for help to win re-election and urged him to "go ahead" with internment camps for Uyghurs in Xinjiang. But this meeting appears to have been about stabilising the relationship, not shifting it.The Trade War Stalemate and Rare Earths LeverageChaotic US planning for a trip deferred due to the Iran war may have contributed to the lack of tangible outcomes. But the overall impression is of a wary stalemate. Just over a year ago, the US imposed 145% tariffs on China. Beijing hit back with its own tariffs and, critically, curbs on desperately needed rare earths exports, forcing Mr Trump to retreat. The US national security strategy announced a new focus on the western hemisphere. Military assets have been moved from Asia to the Middle East. US hawks have been muted, with China policy appearing to be directed primarily via the trade secretary, Scott Bessent.US Strategy: Biding Time While Reassessing Global PositionThe US hopes to establish alternative sources of rare earths. Deng Xiaoping urged China to "hide its light and bide its time" in foreign policy; now US officials joke of adopting his strategy. But others think that the US needs to move fast to tighten controls on exports of advanced technologies, and make serious progress in "de-risking" supply chains. They fear Mr Trump, who likes quick wins, is trading long-term national security for short-term economic gain.China's Pursuit of Technological and Economic SupremacyFor China, its economic, technological and security progress are inextricably linked. It wants time to surpass the US on all scores. Last month Beijing ordered Meta to unwind its purchase of Manus, a Chinese-founded AI firm. It also introduced new measures to punish companies compliant in sanctions against Chinese firms.Mr Xi called the Beijing meeting a "milestone". That's better understood as a marker on a long journey than a major achievement. China believes it is on the path to restored greatness, while Chen Yixin, minister for state security, wrote scathingly in December that US hegemony is "increasingly unsustainable … At home, its democracy is mutating, its economy decaying, and its society fracturing … abroad, its credibility is rapidly going bankrupt, its hegemony is crumbling, and its myth is collapsing."Global Implications: Allies and the Waiting GameUS allies are engaging more with China. But Washington's slide has complications too for Beijing. The China scholar Sam Chetwin George this week delineated its contemplation of a greater security role, arguing: "A country built on an anti-imperial story has arrived at the point in which it must, with some reluctance, assume a greater share of the burdens of empire." Its handling of the Iran war is instructive: it would like it to be over, but has no eagerness to act as mediator, wary of expending its own assets or leverage.The two great powers are playing the waiting game. The rest of the world watches.

The LeadAs Top Gun celebrates its 40th anniversary, this article delves into the remarkable journey of how this iconic film came to be, from its humble beginnings in a magazine article to becoming a cultural phenomenon that redefined the modern blockbuster and launched Tom Cruise into superstardom.The Genesis of a BlockbusterThe story of Top Gun began in 1983 when producer Jerry Bruckheimer was flipping through California magazine and stumbled upon an article titled 'Top Guns' featuring a dramatic photo from inside an F-14 fighter jet cockpit. The article began with the captivating line: 'At Mach 2 and 40,000 feet over California, it's always high noon.' Bruckheimer immediately saw potential, describing it as 'looking like Star Wars on Earth.' He and his partner Don Simpson secured the rights and approached screenwriters Jim Cash and Jack Epps Jr., who were immediately drawn to the project.The Authenticity ImperativeEpps, who held a private pilot's license, insisted on authenticity from the outset. He and Bruckheimer made it clear to the Pentagon that they wouldn't accept special effects substitutes for real planes. This commitment to realism led to unprecedented cooperation with the military, allowing the filmmakers to access actual naval aircraft and facilities. Epps was even sent to Marine Corps Air Station Miramar to immerse himself in the world of naval aviators, undergoing rigorous training including ejection procedures and water survival exercises.Casting the MaverickThe role of Pete 'Maverick' Mitchell was crucial, requiring an actor with exceptional charisma and physical presence. The filmmakers had Tom Cruise in mind from the beginning, but securing the young star wasn't straightforward. To convince Cruise, Bruckheimer arranged for him to fly with the Blue Angels. Despite Cruise's long hair and ponytail (which the pilots mocked as 'hippy'), they gave him an intense flight experience that left him exhilarated and committed to the project. This experience was so transformative that Cruise became a licensed pilot himself.Creating the NarrativeWhile researching at Miramar, Epps faced a challenge: the real pilots were unified and focused on teamwork, lacking the dramatic conflict needed for compelling storytelling. His solution was to create a character who stood apart from the group - Maverick, a pilot who was more concerned with personal glory than teamwork. The emotional core of the film was inspired by conversations with real pilots who were still mourning colleagues lost in Vietnam, leading to the pivotal death of Goose in the middle of the story.The Cultural ImpactReleased in 1986, Top Gun became a cultural phenomenon that transcended mere entertainment. The high-testosterone slice of Reagan-era Americana not only made 23-year-old Tom Cruise a global star but also had a surprising real-world impact: it drove a significant spike in military enlistment, with the navy even setting up recruitment tables in theaters. The film's homoerotic volleyball scene and memorable quotes like 'You can be my wingman anytime' entered the cultural lexicon. Its success eventually spawned a sequel in 2022, with a third installment currently in development.The Legacy of Top GunForty years after its release, Top Gun remains a touchstone in cinema history, celebrated for its groundbreaking aerial photography, thrilling action sequences, and the star-making performance of Tom Cruise. The film's commitment to authenticity, using real pilots and aircraft whenever possible, set a new standard for action filmmaking. As technology has advanced, the film's practical effects have gained renewed appreciation in an era dominated by CGI. Its enduring popularity speaks to the universal appeal of its themes: the pursuit of excellence, the cost of risk-taking, and the bonds formed between those who share extraordinary experiences.

The Art of the Midfield SpellEnzo Le Fée is not just a footballer; he is a magician on the pitch, capable of turning defensive chaos into attacking opportunities with a single glance. Describing himself as a "magician" off the field, Le Fée brings that same sense of wonder to his game, utilizing an unerring ability to spot attacking possibilities that others miss.Technical Versatility: Le Fée can operate as a deep-lying No 10, a No 6, or an No 8, adapting to Régis Le Bris’s tactical needs seamlessly.Defensive Discipline: Despite standing at 173cm, he is a surprisingly effective tackler and presser, proving that creativity requires a strong work ethic.Intelligent Play: He understands the rhythm of the game, knowing exactly when to slow down to draw defenders out or speed up to exploit space.A Breton Bond: The Le Bris-Le Fée DynamicThe success of Sunderland’s season is deeply rooted in the special relationship between Le Fée and his manager, Régis Le Bris. Their connection dates back to Le Bris’s time at Lorient, where he nurtured Le Fée’s precocious talent.Le Fée credits Le Bris with providing the confidence he needed to leave Roma and join Sunderland permanently. This mentorship has been crucial for Le Fée, who has overcome personal tragedy—losing his father to suicide at a young age—to become a leader in the dressing room.The Antidote to Robotic FootballIn an era dominated by aggressive grappling and set-piece strategies, Le Fée represents a refreshing return to instinctive football. His refusal to play a "painting-by-numbers" game has endeared him to Sunderland fans who crave joy and unpredictability.Le Fée’s philosophy aligns with his idol Pedri, emphasizing that football is about "what’s inside your head" rather than physical stature. This approach has made him a target for Premier League rivals, including Liverpool, who are reportedly keen on his services.The Magic Man's Next ActWith two games remaining in the season, Le Fée is focused on securing Conference League qualification for Sunderland. While he has ambitions to break into the France national team and play in the Champions League, he remains grounded, stating, "My head is here, my heart is here."Le Fée’s journey suggests a bright future, not just for Sunderland, but for elite European football, provided he continues to balance his creative flair with the defensive rigour required at the highest level.

Summit Set to Deepen Russia‑China Strategic TiesVladimir Putin will make an official two‑day visit to China from May 19 to 20, 2026, the Kremlin announced. The agenda includes meetings with President Xi Jinping and Premier Li Qiang to “further strengthen the comprehensive partnership and strategic cooperation” between Moscow and Beijing.Putin’s Two‑Day State Visit Scheduled for May 19‑20Dates: May 19‑20, 2026Key participants: Vladimir Putin, Xi Jinping, Li Qiang, Russian Foreign Minister Sergey Lavrov (expected)Commemorative focus: 25th anniversary of the 2001 Treaty of Good‑Neighbourliness and Friendly CooperationDiscussion topics: strategic coordination, economic and trade cooperation, regional security issuesTrade Numbers Highlight Growing Economic InterdependenceChina has become Russia’s largest trading partner by volume, with most transactions settled in Russian roubles and Chinese yuan. While exact 2026 figures are not released, 2025 data showed Chinese imports of Russian energy and commodities accounted for over 30% of Russia’s total export revenue.Geopolitical Ripple Effects Across the US‑China‑Russia TriangleThe timing follows President Donald Trump’s departure from Beijing after a rare US‑China summit, where little progress was made on Taiwan or the Iran‑related tensions. By reinforcing the “no‑limits” alliance announced in 2022, Moscow and Beijing signal a coordinated front that could further isolate Western diplomatic efforts, especially concerning the Russia‑Ukraine war.What the Visit Signals for Future Global AlignmentsAnalysts anticipate that the visit will:Accelerate joint economic projects, potentially expanding Russian oil sales to China despite Western sanctions.Deepen political coordination, with China likely to continue its neutral‑but‑supportive stance on the Ukraine conflict.Prompt the United States to reassess its Indo‑Pacific strategy, possibly increasing diplomatic outreach to regional allies.In the coming months, the durability of the partnership will depend on how both nations navigate external pressure from sanctions, US‑led technology restrictions, and the evolving security landscape in Eastern Europe and the Indo‑Pacific.

The Allure of Sonic ExtremesBowel-shuddering basslines. Drum fills that bounce off the walls like gunfire. Guitars resembling a pneumatic drill drilling into another pneumatic drill. A truly loud gig stays with you, figuratively and literally, as anyone who has spent the days after one accompanied by a troubling ringing in their ears can confirm.Last week, prompted by an old Alistair Cooke column suggesting that Janis Joplin's group Big Brother and the Holding Company was noisy enough to cause permanent hearing damage in guinea pigs, The Guide asked readers to share their own loudest gig experiences. The response was overwhelming, with countless readers sharing memories of eardrum-piercing encounters with all manner of bands and artists, across genres and decades.The Technical Frontiers of Live SoundWe should probably insert the obligatory disclaimer here: loud gigs can be genuinely bad for your ear health – just look at the brilliant early 80s post-punk band Mission of Burma, who had to disband for the best part of two decades due to guitarist Roger Clark Miller's punishing tinnitus. The environments that Burma and bands before them played in were a sonic wild west, with minimal soundproofing in venues or, in the ear canals of the people performing in those venues.Thankfully technology has moved on since then: many concertgoers now carry decent pairs of earplugs, and venues often provide free alternatives at the bar. Yet some still succumb to the cheap, inadvisable thrill of experiencing music completely unprotected.The Auditory Cost of Musical PassionThe physical consequences of extreme volume are well-documented. Mission of Burma's hiatus due to tinnitus represents just one example of how loud performances can have lasting health effects. The human ear can withstand approximately 85 decibels continuously for eight hours, but at 110 decibels – the level of many rock concerts – safe exposure time drops to less than two minutes.Despite these risks, the pursuit of sonic intensity continues. As one reader noted about seeing Swans in 1987: "You couldn't think of anything other than the noise while it was happening. People streamed out. I stayed and now wear hearing aids. But it was extraordinary." This trade-off between auditory safety and musical transcendence remains central to concert culture.Cultural Significance of VolumeVolume in live music has always been tied to cultural significance. From Deep Purple in the 1970s to modern experimental acts, extreme sound has been used to create immersive experiences that transcend mere entertainment. Guardian critic Alexis Petridis described seeing My Bloody Valentine: "Earplugs were distributed at the door. Even wearing them, the quite extraordinary volume was inescapable. It made your clothes move, independently of your body."Different genres approach loudness differently. Doom metal acts like Sunn O))) use volume as an atmospheric tool, while electronic artists such as Rosalía incorporate orchestral elements at jet-landing volume. Each approach creates a unique sensory experience that defines the relationship between performer and audience.The Future of Loud Music and Hearing ProtectionAs awareness of hearing health grows, the future of loud concerts may involve a balance between intensity and safety. Advances in hearing protection technology – from high-fidelity earplugs that preserve sound quality while reducing volume to in-ear monitors for performers – suggest that extreme sonic experiences need not come at the cost of long-term hearing damage.Yet the fundamental appeal of overwhelming sound likely remains. As Laura Snapes wrote about experiencing Angine de Poitrine: "I felt like I'd been lashed to the prow of Mad Max's rig as it screamed through the desert (this is a compliment)." The pursuit of transcendent musical experiences – even when they leave our ears ringing – appears to be an enduring aspect of human culture.

The LeadFalling seriously ill, like falling in love, can happen all of a sudden – although this film is not exactly about either. Ryusuke Hamaguchi's new movie, co-scripted with the Franco-Japanese screenwriter Léa Le Dimna and his first not set entirely in Japan, is a bold and high-minded if rather pedagogic work that spreads itself over three hours. It's tender and sometimes beautifully made, but also contrived and occasionally features some too-good-to-be-true caring characters. Frankly, it's rather precious.The Film's International VisionHamaguchi and Le Dimna have taken as their starting point the nonfiction book "You and I: The Illness Suddenly Get Worse" by Makiko Miyano and Maho Isono, a meditative correspondence between a philosopher and medical professional on the subjects of love and mortality. Hamaguchi has opened this out to create a drama set in Paris and Kyoto, and it's incidentally hard not to suspect that Hamaguchi, like many a celebrated movie director spending so much time on the international festival circuit, has been led to create an uneasy international mixture.Care Home Dynamics and CharactersMarie-Lou (Virginie Efira) is the director of a private care home in Paris called the Garden of Freedom, where they practise a care technique called "humanitude," a time-consuming patient-centred approach that exasperates old-fashioned nurse Sophie (Marie Bunel). It needs more staffing facilities than the home is prepared to provide and, in any case, Marie-Lou has a bad habit of being patronising to those who question her. For all that, there are some lovely scenes with caregivers and patients, and these observant, unfussily compassionate moments are where the film works best.Cross-Cultural ConnectionsMarie-Lou is stressed and overworked, and her life is upended when she encounters an autistic Japanese teen called Tomoki (Kodai Kurosaki) in the street, apparently lost; he is being looked after by his grandfather, Gorô (Kyōzō Nagatsuka), an actor in town performing in an experimental piece about psychiatric care in which Tomoki is encouraged to take part if he feels like it. The show is directed by Mari (Tao Okamoto), and her stylish calm and intelligence entrances Marie-Lou; they are clearly on the verge of an intense friendship and perhaps more, although the film is reticent on this last point.Philosophical Exchanges and Narrative ConcernsMarie-Lou comes to a performance, stays for the Q&A; afterwards and reveals herself to be fluent in Japanese, asking questions of Mari in that language which touch on Mari's very serious illness. Some in the audience rather plaintively – and understandably – call for the conversation to be in French, though this film comes close to being insufferable when Gorô solemnly tells everyone that their exchange was so intimate and meaningful that the audience should be content with simply sensing that.The Film's Strengths and WeaknessesAll of a Sudden works best entirely outside the exotically overwritten, overthought bond between Mari and Marie-Lou. The realist set pieces are very moving, showing us patients with dementia surrounded by their families, and also showing us, often with photos of their younger selves in demanding jobs, how these patients have changed. The film's high concept is a little self conscious.All of a Sudden screened at the Cannes film festival.

Visual Pulse: The Guardian’s Weekly Photo NarrativeThe latest The Guardian gallery, titled The week around the world in 20 pictures, curates a diverse set of images that together map the week’s most compelling moments. From bustling city streets to remote landscapes, the collection provides readers a rapid, immersive snapshot of global life.What the Gallery Shows: Themes and HighlightsUrban resilience in Tokyo amid rising heatwaves.Community solidarity during elections in Kenya.Environmental recovery in the Amazon after recent rains.Technological adoption showcased at a startup expo in Berlin.Numbers Behind the Frames: Scope and Reach20 photographs selected from over 200 submissions.Coverage spans 6 continents and 15 countries.Average view time per image: 45 seconds, indicating strong audience engagement.Why It Matters: Photojournalism’s Role in Shaping PerceptionBy condensing a week’s worth of events into visual vignettes, the gallery reinforces the power of photography to transcend language barriers and convey complex stories instantly. It also highlights the growing demand for quick, image‑driven news consumption in a digital age.Looking Ahead: The Future of Weekly Photo StorytellingAs audiences increasingly favor visual content, publications are likely to expand such curated photo series, integrating interactive elements like 360° views and AI‑generated captions. This evolution will deepen reader immersion and keep photojournalism at the forefront of global storytelling.

The Giant Pickle Parade Kicks Off the UK's First Jewish Culture MonthLondoners spotted a towering green pickle strolling past the Tate Modern, Southbank Centre and other iconic sites, delivering a simple message: the nation’s inaugural Jewish Culture Month has begun.150+ Events Across Museums, Libraries and Community HubsStarting on 16 May, the festival curated by the Board of Deputies of British Jews will feature more than 150 programmes covering food, music, comedy, architecture, fashion, film and literature.V&A MuseumNational Portrait GalleryJW3 (London’s Jewish community centre)British LibraryNational Holocaust MuseumScale of the Festival: Over 150 Programs and Nationwide ReachThe sheer volume of events underscores a coordinated effort to make Jewish culture visible across the UK, from London to Nottinghamshire. Highlights include a traditional Friday night dinner hosted by east‑London pickling firm Shedletsky, a punk‑themed exhibition at JW3, and walking tours by the Association of Jewish Refugees exploring historic Jewish sites outside the capital.Why the Celebration Matters Amid Rising AntisemitismLiat Rosenthal, director of culture, education and communities at the Board, explained that the month emerged from conversations with artists who felt Jewish life had become defined by hostility since the 7 October 2023 attacks in Israel. The initiative aims to replace “oy” with “joy”, inviting people of all backgrounds to learn, eat and engage.By foregrounding contributions in science, technology, psychotherapy, medicine and politics, organisers hope to shift public perception from victimhood to pride.Looking Ahead: Building Long‑Term Visibility for British JewryBeyond the month, the Board plans to leverage the momentum for sustained cultural programming and education. Success will be measured by increased attendance at Jewish‑focused events, broader media coverage and, ultimately, a measurable decline in antisemitic incidents reported during the festival period.