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The Lead The United States Centers for Disease Control and Prevention (CDC) has released data showing that deaths from drug overdoses fell by nearly 14 percent in 2025, continuing a third consecutive year of decline. Drug Overdose Deaths in Decline The data released on Wednesday shows that the US saw nearly 70,000 predicted overdose deaths in 2025, down from more than 81,000 in 2024. The downward trend has been welcomed in the US, which has struggled with a devastating overdose crisis fuelled largely by synthetic opioids. The Data Analysis Overdose deaths peaked during the COVID-19 pandemic, with 110,000 recorded in 2022, a surge associated with social isolation and obstacles to accessing treatment services. Experts have attributed the decline to various factors, such as wider availability of the overdose treatment naloxone, commonly sold under the brand Narcan. The Impact Analysis Testing strips that can detect fentanyl are also more common now, and regulatory changes in China have limited access to the chemicals used to manufacture the drug. While overdose deaths declined in most US states in 2025, seven states saw increases. In Arizona, Colorado and New Mexico, overdose deaths increased by 10 percent or more. The Prediction “I’m cautiously optimistic that this represents really a fundamental change in the arc of the overdose crisis,” Brandon Marshall, a Brown University researcher who studies overdose trends, told The Associated Press news service. The administration of President Donald Trump has pointed to the decrease overall as validation of its crackdown on drug trafficking.

Michael Carrick has guided Manchester United to a third‑place finish and Champions League qualification with three matches left, yet the board still debates whether his understated style merits a full‑time appointment.The Calm Blueprint Carrick Brings to Manchester UnitedSince taking over after Ruben Amorim’s brief spell, Carrick has imposed a low‑key, possession‑oriented philosophy that mirrors the composure he displayed as a player. He favours patient buildup, tight midfield triangles and a disciplined 4‑4‑2 shape, contrasting sharply with the more adventurous tactics of his predecessor.Emphasis on “tiny details” – first touch, body position – as noted by former Middlesbrough midfielder Hayden Hackney.Maintains a narrow buildup, often resorting to a “doughnut” shape when full‑backs are unavailable.Relies on senior players such as Kobbie Mainoo and Bruno Fernandes to execute the plan.Numbers Behind United’s Late‑Season SurgeKey metrics from the final stretch illustrate both progress and lingering concerns:United secured Champions League football with three games remaining, sitting third in the league.Expected goals (xG) have dipped slightly compared with the Amorim era, while possession percentages remain above 55%.High‑turnover incidents have risen, indicating occasional loss of shape under pressure.Strategic Implications for United’s Squad and the Premier LeagueThe board’s indecision on a permanent manager sends mixed signals to the transfer market. A Carrick‑led United may prioritize:Midfield reinforcement to add “hard legs” and balance the 4‑4‑2 system.Full‑back upgrades to widen the narrow buildup.Retention of emerging talents like Mainoo to preserve the club’s cultural continuity.For the Premier League, a stable United under Carrick could re‑establish the traditional “big‑six” hierarchy, challenging the recent rise of clubs such as Liverpool and Chelsea.What the Next Season Could Hold for Carrick and UnitedIf United appoint Carrick permanently, the club will need to:Invest in a clear recruitment plan during the summer window to address squad gaps.Develop a more dynamic attacking philosophy to complement his possession base.Navigate heightened fan expectations that demand both results and an identifiable playing style.Failure to do so may see the “confidence trick” narrative resurface, risking a rapid decline once opposition teams adapt to United’s calm but predictable approach.

The Decisive Night in EdinburghThe 2026 Scottish Premiership season reaches its climax tonight, with the title race hanging by a thread. The narrative has shifted dramatically from the start of the campaign, placing the spotlight firmly on Tynecastle. With the season's final round of fixtures approaching, the stakes could not be higher for the league leaders and their bitter rivals.The Title Scenario UnfoldsTonight presents a unique mathematical opportunity for Hearts to seal the championship. The Edinburgh club hosts Falkirk at Tynecastle, while the defending champions, Celtic, travel to face Motherwell. The outcome depends on a specific combination of results: if Hearts secure a victory and Celtic suffer a defeat, the trophy will return to the capital for the first time since 1960.Hearts vs Falkirk (8pm BST)Celtic vs Motherwell (8pm BST)Rangers vs Hibernian (8pm BST)Breaking the 66-Year DroughtHistorically, a Hearts title win at home has been a rare occurrence. The last time the club celebrated a league victory was in 1960, a gap that defines the magnitude of this potential achievement. Beyond the historical significance, the current squad has already broken a club record for points tally this season, securing a Champions League qualifier in the process. This indicates a structural shift in the club's competitiveness under manager Derek McInnes.McInnes' Pressure CookerManager Derek McInnes has publicly dismissed the notion of an easy path, acknowledging that Celtic remain the dominant force in Scottish football. Despite the pressure of a career-defining night, McInnes remains confident, stating that his team has successfully navigated challenges against heavyweights like Rangers and is prepared to face Celtic. His comments suggest a mindset focused on resilience rather than panic, emphasizing that the team is coping brilliantly despite the odds.Market Prediction: A Celtic VictoryWhile the narrative favors Hearts due to the home advantage and the historic opportunity, market analysis leans towards Celtic. Coming into the game on the back of five successive league wins, Celtic's momentum and squad depth suggest they are the favorites to navigate the pressure of a title decider. The prediction remains that Celtic will likely secure the victory, leaving Hearts to wait until their final showdown on Saturday to determine their fate.

The Western Australian Government's Climate Stance Western Australia has been known for its beautiful landscapes, beaches, and roads. However, its government has taken a stance on climate change that is concerning. They believe they shouldn't be expected to act on the climate crisis in the same way as the rest of Australia. Climate Targets and Emissions Documents released under freedom of information laws show that Western Australia's gas exports risk slowing Asia's shift to clean energy. The state's annual pollution increased by 4% last year, and its emissions have grown 17% since 2005. In contrast, other states have reduced their emissions. The Impact of Fossil Fuel Expansion The Western Australian government has continued to back fossil fuel expansions, arguing that gas exports reduce coal burning in Asia. However, experts say that gas is still a fossil fuel and contributes to greenhouse gas emissions. A US study found that liquified natural gas exports can be dirtier than coal when emissions from extraction, piping, processing, and shipping are counted. The Role of the Federal Government The Albanese government has given implicit support to Western Australia's climate position. However, experts say that the federal government should take action to address the issue. A question for the prime minister is whether he intends to do anything about Western Australia's climate targets risk. The Future of Fossil Fuel Projects A big decision lies ahead for the federal government: a verdict on the Browse development, Australia's largest untapped gas basin, is expected before the end of the year. Experts say there is a stronger than usual legal case that it could be blocked on environmental grounds, given the risk to protected species.

The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

In a California federal courtroom, Sam Altman—CEO of OpenAI—was grilled by a team of lawyers led by Steve Molo on whether he is fit to oversee the most advanced AI models, echoing questions first raised during his 2023 congressional testimony. Federal Court Examines Altman's Eligibility to Govern Advanced AI Altman testified before Senator John Kennedy in May 2023, denying equity in OpenAI while acknowledging health‑insurance compensation. During the trial, Molo highlighted Altman's undisclosed economic exposure through a limited‑partner stake in the Y Combinator fund. Witnesses, including former board members Helen Toner and Tasha McCauley, accused Altman of misleading the board in 2023. OpenAI and Microsoft representatives, such as Satya Nadella and Bret Taylor, defended the current governance structure. Implications for OpenAI Governance and Investor Confidence The courtroom focus extends beyond Altman's personal credibility to the broader question of whether OpenAI’s nonprofit board can truly control its for‑profit operations. Musk’s legal team argues that the 2023 board ouster demonstrates Altman's de‑facto control, while OpenAI’s counsel insists the board retains decisive authority. Potential Outcomes for OpenAI's Corporate Structure Judge Yvonne Gonzalez Rogers and the jury will weigh whether the existing governance model aligns with OpenAI’s mission. A ruling that limits Altman's authority could trigger restructuring of the board‑for‑profit relationship, whereas a decision affirming current controls would preserve the status quo and likely reassure investors.

The Lead: Preserving Environmental HistoryOver four years in the 1820s, Charles Waterton built a 9ft-high, 3-mile-long wall around the parkland and lake of Walton Hall in Yorkshire, creating what could be the world's first nature reserve. Now, the overlooked achievements of this innovative reserve and the crumbling wall that still surrounds Waterton's former home are being remembered through WallFest, a programme of 60 community events organised by a charity dedicated to protecting the wall and preserving its legacy.The Historic Wall: Engineering Environmental ProtectionThe wall, built between 1820-1824, was designed to be fox- and poacher-proof, enclosing Waterton's estate and creating a sanctuary for wildlife. After completing the wall and banning hunting and shooting, Waterton recorded 5,000 wildfowl on his lake and 123 species of birds, including those widely persecuted at the time, such as herons and kestrels. The boundary allowed hedgehogs and so-called vermin, like weasels, to roam freely through his reserve.Waterton's Environmental Legacy: A Pioneer Ahead of His TimeWaterton, an eccentric, controversial and pioneering environmentalist, implemented innovative conservation practices long before they became mainstream. He built nest boxes, special banks for sand martins and innovative bird hides, and offered local people sixpence for every hedgehog they brought into his reserve. Unlike sportsman-naturalists of the day, Waterton abhorred shooting and got into fistfights with armed poachers, thwarting their attempts to kill birds by placing dummy birds made from metal and wood in the trees.Waterton's environmentalism began after experiencing the natural wonders of the rainforests of Guyana, where he managed his father's sugar plantations. Upon returning to his family home in rapidly industrializing West Yorkshire, he was dismayed at the polluted state of waterways, woodlands stripped of birdlife and workers looking ill.The Conservation Challenge: A Wall in PerilToday, the historic wall has collapsed in places and is in urgent need of repair. Some sections have completely deteriorated, threatening the physical boundary that Waterton created and the historical significance it represents. The Friends of Waterton's Wall charity was created after Covid when local residents realized the wall they walked beside daily might not last another century.Waterton also launched one of the first known environmental legal actions, against a nearby soap works for releasing pollutants that killed trees and damaged his lake. Despite his visionary environmentalism, Waterton is mostly remembered for his eccentricity rather than his groundbreaking conservation efforts.WallFest: Community Action for HeritageThe WallFest events, taking place during May around the village of Walton, West Yorkshire, and in Waterton's former home (now a hotel), will help raise funds to repair the crumbling wall. The festival includes a short film supported by David Attenborough and various community activities designed to raise awareness of both the wall's condition and Waterton's environmental legacy."We're keen to raise the profile of the first nature reserve in the world," said John Smith, the chair of trustees of Friends of Waterton's Wall. "Waterton was a pioneering environmentalist, probably the first in this country. We also want to raise the profile of the wall itself and the need to preserve our heritage for future generations."The Future Outlook: Rediscovering an Environmental PioneerAccording to Barbara Phipps, a local resident and author of a biography of Waterton, his historical portrayal as "an amusing and strange fellow," in the words of Charles Darwin, was partly because he was a Catholic and was discriminated against, being excluded from mainstream careers in politics, law and the military.John Whitaker, a curator at Wakefield council's museums and castles and a trustee of the charity, also attributed the lack of acclaim for Waterton to his Catholicism. "He was a marginalised aristocrat, which is a weird situation to be in. He was never in the establishment. He was massively affectionate and incredibly progressive in many ways but also hugely contradictory."As WallFest aims to raise both funds and awareness, there's hope that Waterton's true legacy as an environmental pioneer will be properly recognized and that the historic wall will be preserved for future generations to appreciate.

Nigel Farage, the leader of Reform UK, is facing a standards investigation after a $6.7 million personal gift from Thailand‑based billionaire Christopher Harborne was disclosed. The inquiry arrives just days after Reform UK emerged as the top winner in England’s local and regional elections.Details of the Gift and the Parliamentary InquiryThe Parliamentary Commissioner for Standards opened a probe to determine whether Farage breached rules that require MPs to declare donations received in the year before an election within one month of taking office. Farage maintains the money was a personal, unconditional gift intended for his security and not a political donation.Gift amount: $6.7 million (≈£5 million)Donor: Christopher Harborne, billionaire and crypto investor based in ThailandPurpose claimed by Farage: personal security ahead of the 2024 national electionInvestigation announced: 13 May 2026Financial Scale and Funding BreakdownElectoral Commission data shows that about two‑thirds of Reform UK’s funding last year came from Harborne, underscoring the donor’s outsized influence on the party’s finances.Reform UK’s total funding (2025): roughly £7.5 millionHarborne’s contribution: ~£5 million (≈66%)Political Repercussions for Reform UK and the UK ParliamentThe probe intensifies scrutiny of Reform UK’s rapid rise, especially after it topped national opinion polls and secured victories in traditionally Labour‑leaning councils. Opponents argue the overseas funding contradicts Farage’s populist image, while the party’s deputy leader Richard Tice contends voters were already aware of the gift.Potential sanction: suspension from the House of Commons for 10 days or moreConsequence of a 10‑day suspension: triggers a recall petition, possibly leading to a by‑electionPotential Outcomes and Future ScenariosIf the commissioner finds a serious breach, Farage could face suspension and a recall petition, jeopardising his seat. Even without a breach, the episode may fuel calls for tighter rules on foreign donations and could affect Reform UK’s momentum ahead of the next general election.

The Global Obesity Landscape: Not a Uniform EpidemicA continuing rise in obesity around the world is not inevitable, research suggests, with rates in some countries levelling off or potentially in decline. Researchers say focusing on what has been described as a global epidemic of obesity hides large variations in trends across different countries, sexes and age groups.Majid Ezzati, a professor of global environmental health at Imperial College London and author of the study, said: "I think the thing that's really important is this diversity exists even across countries that have really similar economic, environmental, technological features. So countries may look the same on the surface of it but obesity looks different."Comprehensive Analysis Reveals Complex PatternsWriting in the journal Nature, the international team, which involved a network of almost 2,000 researchers, described how for each country they calculated the change in the prevalence of obesity each year between 1980 and 2024. They drew on data from 4,050 population-based studies involving 232 million participants aged five years and above.They found that the prevalence of obesity increased in almost all countries over the 45-year period. However, in most high-income countries, a rapid rise in the prevalence of obesity has been replaced by a slower increase, a plateau, or a potential decline.Regional Variations in Obesity PrevalenceThe rate of growth in obesity is slowing in adults in the US and UK, reaching a prevalence of 40-43% and 27-30% respectively in 2024. Obesity is increasing steadily in Finland, has plateaued in Germany and may have started to decline in France, where 24-25%, 20-23% and 11-12% of adults respectively were thought to have the condition in 2024.Slowdowns were often seen in children and adolescents before adults. For the former group, the slowdown started as early as 1990 in Denmark and rates stabilised in most high-income countries by the mid-2000s. Obesity has plateaued in boys and girls in the UK, US, Germany and Japan at prevalences of 10-12%, 20-23%, 7-12% and 3-7% respectively.Meanwhile, obesity among young people and adults in many low-income and middle-income countries continues to rise and in some cases this is accelerating.Understanding the Drivers Behind Divergent TrendsThe team say it is important now to unpick what is behind the trends in different countries. The situation is complex: while there may be shared reasons for obesity, such easy access to unhealthy foods or a decrease in physical activity, the team say country-specific factors rooted in social, economic and policy considerations could also be important, from perceptions around body image to the presence or absence of interventions such as healthy school meals.Naveed Sattar, a professor of metabolic medicine at the University of Glasgow, who was not involved in the work, said the study highlighted how obesity trends were diverging sharply across countries. "English-speaking nations are doing particularly poorly, with the UK now among the countries with the highest obesity levels worldwide," he said.Sattar said it was encouraging that some countries appeared to have reached a plateau in obesity rates. "Understanding what has worked in those settings is crucial as it could help shape more effective public health strategies for the UK," he said, although he noted there could be country-specific aspects or customs at play.Future Outlook and Potential InterventionsHe said the rapid rise in obesity across many developing countries was especially concerning, not least as it could result in increases in diabetes and cardiovascular conditions.He added: "Looking ahead, it will be important to see how wider use of effective weight-loss medicines affects obesity trends, particularly in the UK and the United States. Recent signs of stabilisation in the USA suggest there may be room for cautious optimism. Combining evidence-based medicines with strong public health measures could begin to shift obesity rates in the right direction."