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The U.S. Food and Drug Administration announced on Wednesday that it has granted expedited approval to Eli Lilly’s oral weight‑loss medication, orforglipron—marketed under the brand name Foundayo. This makes Foundayo the second GLP‑1 pill to reach U.S. consumers, following Novo Nordisk’s Wegovy tablet approved in December. Orforglipron works by mimicking a natural hormone that regulates appetite and satiety, offering a non‑injectable alternative to existing GLP‑1 injectables. David A. Ricks, Eli Lilly’s chair and CEO, highlighted that fewer than one in ten eligible patients are currently using GLP‑1 therapies, citing barriers such as cost, stigma, and perceived complexity. Unlike Wegovy, which must be taken on an empty stomach each morning, Foundayo can be taken anytime of day regardless of meals, simplifying dosing schedules. Patients will start on a low dose that is gradually increased to mitigate side‑effects. Pricing is projected at $149 per month for the initial dose, with higher‑strength formulations potentially reaching $349 monthly. While private‑insurance coverage remains uncertain, a Trump‑administration proposal could allow Medicare to cover certain patients as early as this summer, with copayments as low as $50 per month. Distribution will commence on Monday through LillyDirect’s direct‑to‑consumer channel, with broader availability in pharmacies and telehealth platforms expected shortly thereafter. The convenience of a once‑daily pill is anticipated to improve adherence, especially for individuals who avoid injectables due to needle aversion or rigid dosing requirements. The approval follows a fast‑track submission submitted only months ago, positioning Foundayo to enter the market roughly three months after Wegovy. This rapid rollout is set to intensify competition in the burgeoning GLP‑1 space, where new agents are continually emerging with claims of better efficacy and lower costs.

For theatre enthusiasts, April brings a range of exciting productions and performances. Patrick Stewart is set to read all 154 of Shakespeare's sonnets on Audible, a project that began as a pandemic hobby where he recited one sonnet each day on social media. This comprehensive collection, which includes his personal commentaries, will be available from April 7 and lasts almost four hours. In another notable production, Complicité presents 'I Don't Do Innocents', a radio play by Anne Carson directed by Simon McBurney, featuring a cast that includes Emma Corrin and Carson herself reading the stage directions. On the BBC, Sam Ryder gives a sneak preview of his Jesus Christ Superstar, which is set to appear at the London Palladium this summer, as part of the musical-theatre jamboree on iPlayer. Hosted by Jason Manford in Manchester, the event also features Victoria Hamilton-Barritt singing from Paddington: The Musical. Additionally, James Ijames' historical satire 'The Most Spectacularly Lamentable Trial of Miz Martha Washington' is set to run from April 9 to May 3. This play, which explores the life of the inaugural first lady of the US, could pair interestingly with 'Oh, Mary!' in the West End. The BBC is also celebrating the 120th anniversary of Henrik Ibsen's death with a comprehensive iPlayer season featuring various adaptations of his works, including two renditions of 'Hedda Gabler' and 'The Master Builder'. Other highlights include Rosie Sheehy's performance in 'King John' on Marquee TV and 'End' at the National Theatre, part of a trilogy by David Eldridge, which makes a compelling double bill with Stephen Poliakoff's 'Close My Eyes'. Finally, 'Back to the Future: The Musical' is set to embark on a UK tour after its run in London, with an Amazon Prime documentary offering a 'making of' insight into the show.

The United Nations Development Programme (UNDP) released a stark assessment on Tuesday, projecting that a four‑week US‑Israel conflict with Iran could slash Arab regional GDP by 3.7 % to 6 %. In monetary terms, the loss translates to a contraction of $120 billion to $194 billion, marking one of the deepest economic shocks in recent Middle‑East history. UNDP’s regional director, Abdallah Al Dardari, warned that the downturn would likely eliminate 3.7 million jobs and drive around four million additional people below the poverty line. He described the situation as exposing the “fragility of the Arab economy.” The analysis is based on a scenario of a “short but intense conflict lasting for four weeks.” Should hostilities extend beyond that window, the economic fallout could be even more severe, especially as Iran’s attacks on Gulf energy infrastructure tighten oil and gas flows through the Strait of Hormuz. Amid tightening supplies, Brent crude futures surged 4.7 % to over $118 per barrel. The report highlighted that disruptions to “strategic maritime corridors” generate “knock‑on effects on inflation, trade flows, and global supply chains,” threatening the livelihoods of interconnected economies across the region. Poverty spikes are expected to be most pronounced in the Levant and in “fragile” states such as Sudan and Yemen, where baseline vulnerability is already high and economic shocks translate quickly into welfare losses. Lebanon faces a compounded crisis after Hezbollah’s retaliatory strikes against Israel, following the US‑Israeli killing of Iran’s Supreme Leader Ayatollah Ali Khamenei on 28 February. Ongoing air strikes, evacuation orders, and widespread destruction of residential areas, transport networks, and public services have triggered large‑scale displacement. Al Dardari concluded with a plea: “We hope the fighting will stop tomorrow, as every day of delay has negative repercussions on the global economy.”

On a surprisingly quiet evening at Wembley, England’s 1-0 defeat to Japan unfolded in a half‑hour that was more ceremonial than competitive. The opening thirty minutes were fluffy and formless, offering little in the way of decisive play but plenty of clues about the team’s underlying issues.For manager Thomas Tuchel, the concession of the opening goal will likely linger in post‑match analysis sessions. The loss adds another chapter to what critics describe as the “never‑ending story of England footballdom,” where each friendly serves as a diagnostic test rather than a showcase of progress.Injuries and omissions forced Tuchel to field a makeshift side featuring Phil Foden, Morgan Rogers, Cole Palmer and Kobbie Mainoo. The line‑up lacked traditional power runners and aerial threats, resembling a “false nine” formation that felt experimental but ultimately failed to generate a clear tactical identity.Japan’s solitary goal came after Palmer lost possession in an attacking area, leaving a void that England’s midfield could not fill. The Japanese attack exploited the space, threading a pass through the centre of England’s formation and scoring with ease. The goal underscored England’s lack of pressure and positional awareness in the defensive third.Despite the disappointment, the match offered a glimpse of individual talent. Harry Maguire and Dan Burn were deployed on set‑pieces, and Jude Bellingham remained an unused asset, highlighting the depth of options available for the upcoming World Cup.Atmospherically, the match resembled a village fête more than a high‑stakes international fixture. Pre‑match entertainment featured a medley of music, fireworks and quirky performances, creating a backdrop that contrasted sharply with the on‑field performance.Analysts noted that England’s approach felt like an attempt to dress up “borrowed tactical clothes” rather than a coherent game plan. The lack of a defined structure left the side vulnerable to Japan’s disciplined, technically sound play.Looking ahead, Tuchel now faces the task of reconciling his experimental selections with the need for a pragmatic, battle‑ready squad. The friendly serves as a reminder that, while England possesses individual brilliance, the team must resolve its tactical ambiguities if it hopes to contend seriously for the 2026 World Cup.

The United Kingdom is reinforcing its military presence in the Gulf with an additional deployment, bringing the total number of troops to 1,000. This decision is in response to what Defence Secretary John Healey described as an 'expanding threat' from Iran.Healey, speaking from Qatar where he met UK troops, confirmed that the UK will send more Typhoon jets to Qatar, as well as the Sky Sabre anti-drone and missile system to Saudi Arabia, Bahrain, and Kuwait. He emphasized that these deployments are for defensive operations only.The announcement comes after Donald Trump criticized the UK for refusing to 'get involved in the decapitation of Iran.' Trump stated that the USA would no longer be there to help its allies, suggesting they needed to 'start learning how to fight for yourself.'In response to Trump's comments, Healey reiterated that the UK's decisions are guided by Britain's interests and the need to defend its people and allies in the region. He highlighted that Gulf leaders will judge the UK by its actions, not words, and that the UK continues to engage in defensive operations in the Middle East.Healey also discussed the threat posed by Iranian drones and missiles, which are now targeting universities, steel works, and aluminium plants in the Gulf. He revealed that during his tour of the Middle East, he had discussed options for trying to reopen the Strait of Hormuz, which has been impacted by Iranian actions.The UK's Ministry of Defence confirmed that the Sky Sabre system and a team of operators from the Royal Artillery would move to Saudi Arabia this week. The system is capable of intercepting munitions and aircraft and will be integrated into broader Saudi and regional air defenses.

Dozens of professional clowns paraded through the streets of La Paz on Monday, demanding the repeal of a government decree that would restrict extracurricular activities in schools and jeopardise their earnings.Clad in full face paint and their trademark red noses, the performers gathered outside the Ministry of Education to denounce a February‑issued mandate that obliges schools to deliver 200 days of instruction annually. The rule effectively bans holiday parties and other special events—the primary venues where clowns are hired to entertain children.“This decree will economically affect all of us who work with children,” warned Wilder Ramírez, a union leader known as Zapallito. He added that “children need to laugh,” questioning whether the education minister had ever experienced a childhood.The decree, signed by President Rodrigo Paz, stipulates that celebrations may no longer be authorised on regular school days, though they could be organised voluntarily on weekends. Officials said they would consider the clowns’ feedback when drafting the 2027 school‑year regulations, but the promise offered little consolation to the protesters.Elías Gutiérrez, spokesperson for the Confederation of Artisanal Workers of Bolivia, stressed that the measure will shrink their income at a time when the country faces its worst economic crisis in decades. Revenues from natural‑gas exports have plummeted, and a shortage of US dollars has driven up import costs, deepening the financial strain on informal workers.Joining the clowns were tailors who create costumes for children’s events, photographers who cover school festivities, and other artisans dependent on the seasonal market. The demonstrators marched through central La Paz, blowing whistles and setting off small fireworks, while one participant brandished a sign accusing the government of “taking away smiles, and taking work away.”

The 2026 International Booker Prize shortlist has been unveiled, marking the award's 10th anniversary. Daniel Kehlmann, Marie NDiaye, and Yáng Shuāng-zǐ are among the six authors competing for the top honor.The annual prize celebrates the best works of fiction translated into English, with the winning author-translator pair receiving £50,000, split equally.The shortlisted authors and their works are:Daniel Kehlmann - 'The Director', translated by Ross BenjaminMarie NDiaye - 'The Witch', translated by Jordan StumpYáng Shuāng-zǐ - 'Taiwan Travelogue', translated by Lin KingRene Karabash - 'She Who Remains', translated by Izidora AngelShida Bazyar - 'The Nights Are Quiet in Tehran', translated by Ruth MartinAna Paula Maia - 'On Earth As It Is Beneath', translated by Padma ViswanathanThe judging panel, chaired by author Natasha Brown, praised the shortlisted books for capturing moments from across the past century, saying they 'reverberate with history' and offer 'hope, insight and burning humanity.'The winner will be announced on May 19, with each shortlisted title receiving £5,000.

Chinese dissident artist Gao Zhen, renowned for his satirical sculptures of Mao Zedong, has been tried in China on charges of 'defaming national heroes and martyrs'. His wife and a human rights group reported the trial.Gao, 69, was detained in 2024 during a visit to China from the US. He faces a maximum three-year prison sentence. The trial took place behind closed doors in Hebei province and ended without a verdict.Gao is known for his sculptures criticizing the 1966-1976 Cultural Revolution, a period of social turmoil and political persecution in China. His works include 'Miss Mao', featuring Mao with a Pinocchio nose and breasts, and 'Mao's Guilt', a bronze statue of Mao kneeling remorsefully.Gao's wife, Zhao Yaliang, and their seven-year-old son, a US citizen, are under exit bans and cannot leave China. Gao suffers from malnutrition and various health conditions, including lumbar spine disease and chronic knee and eye conditions.The trial highlights China's strict control over artistic expression and its efforts to suppress dissent. EU diplomats attempted to attend the trial but were blocked from entering the court.

Cheltenham, the home of National Hunt racing, has made the unprecedented decision to cancel its three remaining meetings this season to address significant drainage problems on its home straight. The move impacts a combined total of nearly 25,000 spectators who were expected to attend the April and May fixtures.The issues came to light in January when a hole appeared in the home straight during the Trials meeting, delaying a race by 29 minutes. Subsequent assessments, including ground-penetrating radar surveys, led to the decision to undertake major drainage works over the summer.Jon Pullin, clerk of the course, emphasized that while drainage improvements are typically carried out at the end of each season, the scale of this project and Cheltenham's particularly dry summers necessitated bringing the work forward. The focus of the repairs is where the hole was discovered, which has caused challenges in other track areas.The next card at Cheltenham will be the first afternoon of the two-day Showcase fixture on October 23. Four races from the April meeting will be relocated to Market Rasen, Warwick, and Sandown, with the hunter-chase fixture on May 1 being staged at Warwick on the same evening.Guy Lavender, Cheltenham's chief executive, stated that the decision was made with careful consideration, highlighting the importance of giving the racing surface time to recover and allowing the grounds team to prepare for the next season.