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Following US and Israeli strikes that killed senior Iranian figures, concerns have emerged about the power dynamics within Iran's leadership. The country's response to these actions and the implications for the region are significant.This episode of 'The Take' examines the key players in Iran's system, how decisions are made, and the potential impact of losing top figures on Iran's response to the ongoing conflict with the US and Israel.Key topics include:The structure of Iran's leadership and decision-making processesThe role of senior figures and their influence on policyThe potential consequences of their loss for Iran's stance on the US-Israel conflictThe analysis features insights from Ali Hashem, a senior Al Jazeera correspondent, providing a deeper understanding of the complexities at play.

The United States is reportedly contemplating a daring military operation to confiscate Iran's reserves of highly enriched uranium, a move that experts warn would be fraught with significant challenges and risks.Ensuring Iran does not possess nuclear weapons or the capability to produce them using enriched uranium has been a primary objective for the US during negotiations with Iranian officials over the past year. This goal was also cited as a justification for the US bombing of Iranian nuclear facilities during last year's 12-day war with Israel and for initiating the ongoing conflict in February, despite ongoing talks with Iran at the time.Iran possesses approximately 440 kilograms (970 pounds) of uranium enriched to 60 percent, a level at which it becomes considerably easier to reach the 90 percent threshold required to produce a nuclear weapon. This amount theoretically could be used to produce more than 10 nuclear warheads, according to International Atomic Energy Agency chief Rafael Grossi.Iran asserts that its nuclear program is exclusively for civilian energy purposes, despite enriching uranium far beyond the required threshold. Iranian officials have expressed openness to discussing a reduction in the level of enrichment during past negotiations but have refused to dismantle the country's nuclear program entirely, citing national sovereignty concerns.In 2015, the former Obama administration negotiated the Joint Comprehensive Plan of Action (JCPOA) with Iran and other nations, under which Iran agreed not to enrich uranium to high levels and to undergo frequent inspections. However, Trump withdrew the US from this agreement during his first term as president.Challenges in Accessing and Transporting the UraniumAny military ground operation to extract the uranium would face substantial chemical, logistical, and tactical hurdles. Isfahan, where about half of the enriched uranium is believed to be stored, is over 480 kilometers (about 300 miles) inland, far from the nearest US naval ships. This would necessitate transporting US forces, possibly alongside Israeli troops, over a long distance through an active warzone, accompanied by heavy equipment.Securing a substantial perimeter around the site and holding that territory for the duration of the operation would be required, all while mitigating the risk of constant fire from Iran. Experts describe this as a risky and infeasible operation.Storing and Handling the UraniumIf the US were to successfully extract the uranium, it would likely be stored in the form of hexafluoride gas, which is difficult to handle and reacts with water to produce extremely toxic chemicals. The uranium hexafluoride must be stored in small, separated canisters to prevent neutrons from multiplying out of control.Any damage to these canisters could trigger the release of toxic chemicals, posing a radiological hazard. An alternative would be to destroy the cylinders on the spot using Army Nuclear Disablement Teams, but this would result in chemical contamination and environmental hazards.Previous Operations and Potential AlternativesIn 1994, US forces undertook a secret operation dubbed Project Sapphire to remove weapons-grade uranium from Kazakhstan. A similar operation for Iran is being considered, but it would require coordination with Iranian authorities and the IAEA, and a cessation of hostilities.A less risky approach would be for the US to negotiate a deal with Iran, resulting in the stockpile being left in place but under international oversight, being downblended, or being removed with Iranian agreement.

Argentina has taken a significant step in its diplomatic relations with Iran by expelling the Iranian charge d'affaires in Buenos Aires, Mohsen Tehrani. This move comes in response to Iran's rejection of Argentina's decision to blacklist the Islamic Revolutionary Guard Corps (IRGC) as a 'terrorist' group.The Foreign Ministry of Argentina stated that Iran's response contained 'false, offensive and unfounded accusations against the Argentinian Republic and its highest authorities.' The ministry emphasized that these statements constitute unacceptable interference in Argentina's internal affairs and a deliberate misrepresentation of decisions adopted in accordance with international law and national law.Iran's Foreign Ministry had condemned Argentina's move against the IRGC, calling it an 'action against Iran's security and national interests.' Tehran accused Argentina of making this decision 'under the influence of inducements and pressures from the genocidal and occupying Zionist regime,' referring to Israel.The designation of the IRGC as a 'terrorist' group by Argentina follows similar moves by the US in 2019 and the European Union in January. Argentina's President Javier Milei, who has taken staunchly pro-Israel positions, described himself as 'the most Zionist president in the world.'The relationship between Argentina and Iran has been strained, particularly over the 1994 bombing of a Jewish centre in Buenos Aires, which an Argentinian court ruled was carried out by Iran. Iran has denied its involvement in the attack.Milei's government cited the 1994 attack in its decision to blacklist the IRGC. The Argentinian Ministry of Foreign Affairs accused Iran of failing to cooperate with the probe or hand over suspects in the case, stating that 'The Argentine Republic will not tolerate grievances or interference from a State that has systematically failed to comply with its international obligations and that persists in obstructing the progress of justice.'

The Gulf Cooperation Council (GCC) Secretary-General, Jassim al-Budaiwi, has urged the United Nations Security Council (UNSC) to take immediate action to stop Iranian attacks on Gulf countries, which he described as a 'flagrant violation' of international law and the UN Charter.Speaking at the UNSC, al-Budaiwi called on the council to 'take all necessary measures' to bring an end to Iran's attacks on Gulf countries and to protect maritime corridors and guarantee uninterrupted maritime navigation through strategic waterways in the region.The GCC chief also emphasized the need for the six GCC states – Saudi Arabia, Qatar, Bahrain, Oman, Kuwait, and the United Arab Emirates – to be included in any talks or deals with Iran 'to enhance regional security and prevent further escalation or repetition of such attacks in the future.'Iran has been carrying out daily missile and drone attacks across the Middle East, including in Arab Gulf nations, since the US and Israel launched a war against the country on February 28. These attacks have struck civilian sites, including critical energy facilities, and have effectively closed the Strait of Hormuz, a key Gulf waterway through which about one-fifth of the world's oil and liquified natural gas supplies transit.The situation has sent global energy prices skyrocketing, and frustrations are growing across the Gulf as the US-Israeli war on Iran drags on. According to Al Jazeera's Zein Basravi, 85 percent of the projectiles fired by Iran have targeted Gulf countries, with the UAE being the hardest hit.

Former Iranian foreign minister Kamal Kharazi has been seriously wounded in an apparent assassination attempt that killed his wife, as US-Israeli strikes continue to pound Iran for a fifth week.Iranian media on Thursday reported that Kharazi's home in Tehran was targeted the previous day in an air strike. The official was hospitalised with serious injuries, according to newspapers Shargh, Etemad and Ham Mihan.“We have seen what looks like an assassination attempt against the former foreign minister, Kamal Kharazi … We don’t know why he’s been targeted. He has been gravely wounded, and his wife was killed,” said Al Jazeera’s Mohamed Vall, reporting from Tehran.Air strikes were reported on Thursday across Iran, including in Tehran, Isfahan and Shiraz. Four people were reported killed in Larestan, in southern Iran.Meanwhile, the spokesperson of the armed forces’ unified command said Tehran will press on with the Middle East war until the US and Israel face “permanent regret and surrender”, the semiofficial Tasnim news agency reported.Ebrahim Zolfaghari, spokesperson of the Khatam al-Anbiya central headquarters, said US and Israeli assessments of Iran’s military capabilities were “incomplete” and that Tehran would step up its military actions, with “more crushing, broader and more destructive” attacks in store for its adversaries.The threat followed comments by US President Donald Trump that Washington would hit Iran “extremely hard” within weeks, although Iran was “essentially decimated” and the US was on track to achieve its military objectives.More than 1,340 people have been killed in Iran since the US and Israel launched joint air strikes on February 28. At least 24 people have been killed in Israel, as well as 13 US soldiers in the region.

Iran launched a new barrage of missiles at Israel following President Donald Trump’s televised claim that Washington had "destroyed the Iranian military" and was on the brink of completing its war objectives. Trump’s address, delivered hours after he asserted that Tehran had requested a ceasefire—a claim Tehran promptly denied—also featured a pledge to "finish the job" and a statement that the core strategic goals of the United States were "nearing completion." Iranian President Masoud Pezeshkian emphasized that Iran holds no hostility toward the peoples of the United States, Europe or neighboring states, while urging the American public to question the motives behind the continued conflict. In Tehran, the war has intensified: US‑Israeli air campaigns continue to cause casualties and infrastructure damage, and Iranian forces persist with missile and drone counter‑attacks. Foreign Minister Abbas Araghchi warned that, despite receiving messages from Washington, "trust remains at zero" for any negotiation. Senior political figure Kamal Kharazi, a former foreign minister, was seriously wounded when a strike hit his home in Tehran, killing his wife. Kharazi had been involved in back‑channel talks through Pakistan aimed at reviving negotiations. In the Gulf, the United Arab Emirates reported intercepting incoming Iranian missiles and drones, and a tanker off Doha sustained damage from a projectile, though no casualties were reported. President Trump publicly thanked Gulf allies, pledging that the United States would not allow them to be harmed. Within the United States, analysts such as Trita Parsi of the Quincy Institute noted that Trump’s speech offered little new information, essentially summarising recent tweets and suggesting a lack of a clear operational plan. Israel’s military confirmed that its air‑defence systems were actively intercepting Iranian missiles, but the attack wounded 14 civilians, including an 11‑year‑old girl, near Tel Aviv. Israeli officials said the timeline outlined by Trump aligns with Prime Minister Benjamin Netanyahu’s assessment of the campaign. Regional spill‑over continued: an Israeli strike on Beirut killed a senior Hezbollah commander and at least seven civilians, while an air strike on Iraq’s Anbar province killed seven fighters and injured 13 at a military healthcare clinic. On the economic front, the World Bank expressed "extreme concern" about the conflict’s impact on inflation, employment and food security, and is consulting member states on emergency measures. Despite the turmoil, global equity markets rallied and oil prices fell after Trump’s optimistic remarks, indicating short‑term investor relief.

Thousands of Iranians assembled in Tehran for the funeral of senior IRGC naval commander Alireza Tangsiri, who was killed in an Israeli strike, vowing steadfast resistance even as the United States issued stark warnings.The ceremony took place on the 47th anniversary of the Islamic Republic, a milestone that marks the 1979 revolution that ended the centuries‑old monarchy.This year’s commemoration carries added weight as the capital endures relentless U.S.-Israeli bombardments that began on February 28."This war has lasted a month. No matter how long it takes, we will keep fighting," declared Moussa Nowruzi, a 57‑year‑old pensioner, adding, "We will resist until the end."Among the mourners, a young boy brandished a sign reading "Revenge", while massive Iranian flags fluttered as crowds filled Enghelab Square, the heart of the city named after the revolution.Chants of "God is greatest, Khamenei is the supreme leader" echoed through the square, and a man was seen sobbing in the arms of a woman dressed in black.Participants also honored relatives lost in the conflict, their faces displayed on placards, as Tangsiri’s coffin was carried slowly through the gathering.Tangsiri, one of the IRGC’s longest‑serving senior officers, was credited with orchestrating the closure of the Strait of Hormuz to vessels aligned with the United States and Israel during the ongoing war.Later that day, U.S. President Donald Trump addressed the nation on television, reiterating that the war was inevitable and that America intended to "finish the job" in Iran.Trump previously claimed that Iran’s president had sought a truce—a statement Tehran denied—and warned that bombardments would continue until the Hormuz waterway was "open, free, and clear."Funeral attendees dismissed the president’s threats. "We have heard Trump say things that even the American public finds confusing," said Homa Vosoogh, 36, adding, "His statements do not affect us."Government employee Mohammad Saleh Momeni echoed the sentiment, asserting that Trump "cannot translate his words into action" and reaffirming their loyalty to Iran’s leadership.While the United States and Israel initially framed their campaign as a push for regime change, Trump’s stance has since wavered.According to the report, air strikes have claimed the life of Supreme Leader Ayatollah Ali Khamenei, who led Iran for 36 years, yet the governing structure remains functional, retaining its missile and drone capabilities.Portraits of the late leader and his son Mojtaba Khamenei, who has yet to appear publicly, dominate public spaces throughout Tehran."They believe killing our commanders will weaken us, but it will not," Momeni asserted, describing the adversaries’ misconceptions.Despite a wave of anti‑government protests that peaked in January, a segment of the population continues to harbor hopes for political reform.

Iran launched a fresh wave of missiles toward Israel in what appears to be a direct response to U.S. President Donald Trump’s recent televised address. In that speech, Trump asserted that Washington had effectively destroyed the Iranian military and was on the brink of fulfilling its war goals in the region. The presidential remarks came just hours after Trump claimed that Iran had asked for a ceasefire. Tehran promptly denied the request, emphasizing that it had not sought any pause in hostilities. This escalation underscores the volatile dynamics of the Middle East, where diplomatic rhetoric from Washington can quickly translate into kinetic actions on the ground. The missile barrage not only heightens the risk of broader conflict between Iran and Israel but also places the United States in a precarious position, having publicly declared a near‑victory over Tehran while its ally faces direct attacks. Analysts note that Trump's statements may be aimed at bolstering domestic support by portraying a decisive end to a protracted regional struggle. However, the Iranian denial of a ceasefire request suggests that diplomatic channels remain strained, and the likelihood of further military exchanges is increasing. Regional observers warn that continued missile exchanges could destabilize already fragile peace efforts, potentially drawing in additional actors and complicating any forthcoming negotiations.

The ongoing closure of the Strait of Hormuz, a crucial oil and gas shipping route blocked by Iran since the US-Israeli attacks began, is having ripple effects around the world. If the strait remains closed, transport blockages across the Middle East could cause significant shocks to food and medicine supplies in the UK.UK Foreign Secretary Yvette Cooper is hosting a meeting with 35 other countries to discuss reopening the strait. Experts warn that a prolonged closure could lead to food price inflation doubling in England and medicine shortages due to disrupted supply chains.Impact on Food SuppliesProf Tim Lang from City St George's, University of London, warns that 'all bets are off' for food supplies if the crisis continues. Rising fossil fuel prices will impact food transportation and production, as fuel is used to transport food and produce fertilizers and other inputs.The farming sector is already facing problems, with dairy production hit due to delayed fertilizer purchases and salad vegetable and dairy producers facing disruptions. Iranian imports like pistachios and saffron are also affected.Impact on Medicine SuppliesWhile there's no hard evidence of medicine shortages yet, price increases are being seen, which can signal disruptions in the medicine supply chain. Iran does not manufacture many medicines but affects the sector through rising energy costs and transport links between major pharmaceutical-producing countries and the UK.David Weeks from Moody's notes that shortages are driven by delays in petrochemical precursors for active pharmaceutical ingredients. Medicine stockpiles in European countries, including the UK, can last up to six months, but long-term conflicts could lead to more severe shortages.