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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

The men’s Vitality Blast launched on Friday, and within three days 17 matches across the South, North and Central‑West groups have already set the tone for a season of high‑octane cricket.The Blast Kicks Off with 17 Matches Across Three GroupsOpening fixtures saw the Warwickshire Bears suffer two early defeats, while Somerset maintained a 100% record, crushing Hampshire and the Bears in succession. The women’s finals day is slated for Friday 17 July at the Oval, followed by the men’s showdown on Saturday 18 July at Edgbaston.17 matches completed in the first three daysThree regional groups: South, North, Central‑WestKey venues: The Oval, Edgbaston, Headingley, Lord’sStat Sheet: High‑Scoring Chases and Early UpsetsSeveral innings highlighted the format’s explosiveness. Moeen Ali smashed five sixes as Yorkshire chased down 194 against Derbyshire, with Andrew Tye and Hasan Ali sealing the win with four balls to spare. In another thriller, Surrey recovered from 56‑4 to chase 144, thanks to a partnership between Sam Curran and Laurie Evans. Zak Crawley posted an unbeaten 75 to guide Kent to a 199 chase against Sussex.30.5 overs required for the Bears vs Gloucestershire matchWarwickshire reduced to 48‑6 by South African pacersYorkshire’s win: 4 balls remainingWhy the T20 Blast Is Reshaping County CricketThe rapid pace and lucrative prize money are drawing international talent back to the county circuit, as seen with the involvement of Hasan Ali and Andrew Tye. Smaller counties benefit from the exposure, while larger clubs leverage star power to boost attendance. The format also offers fringe players—like the Curran brothers—a platform to showcase all‑round abilities, influencing future England selections.Looking Ahead: Finals Day and the Race for the CrownWith Somerset unbeaten and Kent topping the South Group, the early leaderboard suggests a tight contest. The upcoming finals day on 17‑18 July will likely set the narrative for the second half of the season, and teams that can blend experienced internationals with emerging county talent stand the best chance of lifting the trophy.

The Historic VictoryIn a stunning upset at the Norway Chess tournament in Oslo, French grandmaster Alireza Firouzja defeated world No. 1 Magnus Carlsen in the opening round. The 22-year-old secured his first victory against Carlsen in classical chess despite playing with a sprained ankle sustained from falling off a stage at the previous week's Bucharest Grand Chess Tour event.This victory marks one of the most high-profile successes by a physically injured grandmaster since Tilburg 1985, when England's Tony Miles shared first prize while playing prone from a massage table due to a back injury. Carlsen, who has won the Norway Chess tournament six of the past seven years, was visibly unsettled by Firouzja's resilient performance.Tournament DynamicsNorway Chess employs a unique scoring system that adds strategic complexity to the competition. A win in classical chess counts for three points, while a loss yields zero. Draws are immediately replayed as Armageddon games, with White receiving 10 minutes on the clock and Black seven minutes. A draw on the board counts as a win for Black, with the Armageddon winner scoring 1.5 points and the loser 1.This system creates immediate pressure, as Carlsen's classical loss in round one put him at a disadvantage despite nine rounds remaining. Firouzja continued his strong form by winning his classical game in round two against India's Praggnanandhaa Rameshbabu, reclaiming his place in the world top 10 in live ratings.Carlsen's StrugglesCarlsen faced further challenges in the tournament, suffering losses in both round two and three. His defeat by Praggnanandhaa in round three was particularly chaotic, with the Indian grandmaster describing the result as "like tossing a coin." Carlsen spent excessive time reacting to White's surprise novelty 6 h4!? in the Najdorf Sicilian, responding weakly after 28 minutes with 6...h6?! and remaining under pressure for much of the game.The tournament's time control proved particularly brutal, with only a 10-second increment at move 41, where players typically have an additional half hour. Carlsen eventually showed his championship form in round four, defeating world champion Gukesh Dommaraju in a repeat of their matchup from last year's infamous table punch incident.Women's Chess in the SpotlightThe Norway Chess tournament also aims to elevate the profile of women's chess, with the women's event offering equal prize money—a significant break from longstanding tradition. Women's world champion Ju Wenjun leads the women's section, though early results show Bibisara Assaubayeva of Kazakhstan in the lead with 7 points after four rounds.This commitment to gender equality in chess prizes reflects broader efforts to increase visibility and support for women in the sport, addressing the historical disparity in recognition and opportunities between male and female players.International MatchupA significant development in the chess world is the upcoming eight-game classical match between American grandmaster Hans Niemann and Russian Ian Nepomniachtchi in Belgrade. This rare encounter between top players from the US and Russia is arguably the most important East-West match since the Boris Spassky vs. Bobby Fischer confrontation in 1972.Both players are ambitious to reach the world's top 10—Niemann for the first time and Nepomniachtchi after recently dropping below it. Their match comes amid heightened geopolitical tensions, adding another layer of significance to this competition between chess representatives from opposing nations.

The Billionaire's Challenge to Women's FootballIt has been a bad week for Michele Kang, the billionaire women's football investor. On Wednesday the Uefa director of women's football, Nadine Kessler, was firm on the enforcement of rules prohibiting clubs with the same owner from playing each other in European competitions, dealing a blow to Kang, who has ambitions of taking London City Lionesses into Europe's premier competition, but also owns the tournament's most decorated side, OL Lyonnes.Then, across the weekend, Kang teams suffered two continental final defeats, with Lyonnes losing 4-0 to Barcelona in the Champions League final before her US outfit, Washington Spirit, fell short in the Concacaf W Champions Cup with a 5-3 reverse to the Mexican side Club América.Barcelona's Talent Pipeline vs. Financial MuscleSpeaking to the Catalan TV channel Esport3 in Oslo on Saturday evening, the Barcelona goalkeeper Cata Coll made some pointed remarks about money in football after their emphatic victory, and her words went viral. "There has been criticism but we have shown the team we are," she said. "Money isn't everything. We are privileged to have La Masia and all the girls that have come up to the first team: Aïcha Cámara, Carla [Julià Martínez], [Martine] Fenger, [Clara] Serrajordi, all of them. They are incredible. It says everything and that's why I say it."Many have assumed it was a jab at Kang and the use of her wealth to pursue glory in women's football, with Barcelona's talent pipeline apparently delivering an antidote to such an approach. There have been frustrations that Kang's teams have been sniffing at Barcelona's door in recent years, poaching the head coach Jonatan Giráldez, who led Barça to their second and third European titles, first planting him in post at Washington Spirit before switching him this season to Lyonnes, another of her Kynisca Sports International multi-club ownership group.The Financial Distortion in Women's FootballGiráldez isn't the only Barcelona employee to have been recruited by the big-spending Kang. The midfielder Ingrid Engen joined Lyonnes last summer and the defender Jana Fernández was acquired by London City from the Catalan club. Meanwhile, talk of potential rogue bids for Aitana Bonmatí have circulated in past seasons, while London City are believed to have made Alexia Putellas, soon to be out-of-contract, a large offer to play in the WSL.Clubs are seemingly irritated with Kang's spending because to entice superstars to fledgling projects she is offering fees and wages that are distorting the market, driving it beyond what many view as sustainable growth. Except, given the opportunity, every club would probably do it. Yes, huge men's clubs could do the same, given the large sums at their disposal, but often choose not to in the name of sustainability and gradual growth.Barcelona's Own Financial ChallengesHowever, while the constantly emerging talent from La Masia is both laudable and enviable, Barcelona are not a model women's football club, or a salve to the model being championed by Kang.Kang is one of many to have exploited the strict financial rules of La Liga, with the money trouble experienced by the men's side recently affecting every section of the club, from the women's team to the youth academy and basketball, handball and futsal teams. To lower the wage bill, players have been allowed to leave that may have been kept under different circumstances.The team that have powered Barça to four European titles contains several key players at the end of their contracts. Alongside Putellas, the quartet of Mapi León, Marta Torrejón, Salma Paralluelo and Caroline Graham Hansen are nearing the end of their deals. At some stage Barça will need to undergo their next evolution, but to what extent that is done on their terms, or forced by financial pressure, remains to be seen.The Future of Investment Models in Women's FootballSaturday's Champions League final was my eighth in nine years – the Covid-19 pandemic prevented me from attending the 2020 final between Lyon (now Lyonnes) and Wolfsburg in San Sebastián. The game has come a long way since my first, in Kyiv in 2018, when the host city was the same as the one for the men's Champions League final and the women's final cowered in its shadow.In Oslo the huge numbers pouring into Uefa's fan park, that featured a line of mini-pitches where girls' teams played all day, reflected the impact the final can now have on a city. Women's football has also changed a lot, but in some ways it is very similar. In 2018 Lyon lifted their fifth of what has become eight European titles, the efforts of the former club owner, men's and women's, Jean-Michel Aulas, repeatedly delivering for the French team. Aulas committed more resources to the women's team than most other European clubs and Kang is now doing the same sort of thing, but more aggressively, in a world where many of the top women's clubs are increasing investment.The problem is, there is no alternative model put forward by any of the biggest clubs. Each one walks the same path, in slightly different ways, perhaps getting annoyed at how others have gone the same route. Most men's Premier League clubs do not want an alternative funding model – because it might show fans there is another way of doing things. As it stands, those owners can take money out of clubs to boost their personal wealth.So, yes, Coll is right, but behaving like Barcelona are the morally superior club is misleading.

The Historical Detective's QuestIn the spring of 2011, author Raf Nicholson embarked on a PhD journey to document the history of women's cricket, only to find a startling lack of resources at the MCC library at Lord's. The women's cricket section contained merely three books, including Rachael Heyhoe Flint's 1978 autobiography. This discovery sparked a decade-long mission to uncover the hidden history of women's cricket, culminating in his book 'The Women in Whites: A History of Women's Cricket in England' published in June 2026.The Lancashire Cowshed TreasureThe breakthrough came when Nicholson was directed to the Women's Cricket Association archive, stored in a former cowshed in a tiny hamlet eight miles east of Blackpool. There, amidst garden furniture and farming equipment, he discovered historical treasures including minute books dating back to 1926 when the WCA was formed, scrapbooks, letters, tour diaries, and newspaper cuttings. Spending two weeks in the summer, Nicholson made daily six-mile round trips from a nearby B&B; to meticulously document these invaluable materials.Pioneers of the Women's GameThrough his research, Nicholson brought to light key figures in women's cricket history. Betty Archdale, captain of the 1934-35 Australian tour, earned the nickname 'Hitler' for her distinctive leadership style. Myrtle Maclagan, daughter of an army officer, demonstrated exceptional cricket prowess with seven for 10 in the first women's Test and the first Test hundred in women's cricket. Marjorie Pollard, the WCA founder, maintained strict dress codes that required women to play international cricket in skirts until 1997, believing 'trousers are beyond the pale'.Overcoming Financial and Social BarriersResearch revealed the constant financial struggles faced by the WCA and women's cricket players. England batter Chris Watmough described writing hundreds of letters begging for financial support for the 1968-69 tour to Australia and New Zealand, which resulted in sponsorship from lingerie brand Berlei. Coach Ruth Prideaux had so little money for the 1993 World Cup that players slept on blow-up mattresses in her living room and trained by running along Eastbourne beach. Norma Izard famously borrowed a wok from MCC kitchens to burn a miniature bat, creating the first Women's Ashes trophy in 1998.Preserving a LegacyMany of the pioneering women Nicholson researched and interviewed have since passed away, but their stories live on through his book. The research journey also led to the MCC acquiring the complete WCA archive in 2017, moving the historical materials from the Lancashire farm to Lord's. This collection now serves as a valuable resource for future researchers, ensuring that the rich history of women's cricket is preserved and accessible for generations to come.

The Comedian Who Refuses to Stay SilentNish Kumar has built a career on being unafraid to speak his mind, even when it means confronting fellow comedians like Jimmy Carr about their decisions to perform in controversial venues. The British stand-up, known for his articulate and politically charged humor, recently discussed his confrontations with comics who participated in the Riyadh comedy festival, calling it part of the "cultural-washing of a repressive regime." Kumar's upcoming tour, "Angry Humour from a Really Nice Guy," reflects his concern that comedy has been "co-opted by charlatans in service of autocrats." Despite his willingness to court controversy, Kumar admits there are moments when he questions his approach, joking that "you should not be allowed to give interviews" when discussing fellow comedians.The Confrontation Over Comedy EthicsKumar's most notable public clash came when he confronted Jimmy Carr about his decision to appear on Jordan Peterson's podcast, which Kumar described as "a radicalisation event that's happening on an unprecedented scale." His criticism extends to other comics who performed in Saudi Arabia, including Bill Burr, Dave Chappelle, and Jack Whitehall. Kumar alleges that some comics "signed a contract agreeing to not have a go at MBS [Mohammed bin Salman, the crown prince of Saudi Arabia]" and expressed particular frustration with those who have complained about cancel culture while participating in such events. "I don't want to hear about free speech from any of these cunts again," he stated emphatically. These confrontations highlight Kumar's commitment to what he sees as ethical boundaries in comedy, even when it means alienating his peers.A Career Forged in Debate and DeterminationNow 40, Kumar has been performing stand-up for two decades, though his love for comedy began much earlier. At age five, he was studying The VHS of The Simpsons, analyzing its intricate references and in-jokes. His influences included Chris Rock and the sketch show Goodness Gracious Me, which helped him see comedy as a viable path for someone of his background. "Until then, the only people I'd seen do comedy were either white or African American. You see a bunch of Indians doing it, you think: Oh, this is viable for me." Kumar's early career involved temping while struggling to make inroads in comedy, buoyed only by "the persistent encouragement of my friends." His big break came in 2015 when his fourth fringe show was nominated for an Edinburgh comedy award, followed by regular TV appearances and eventually becoming a household name after joining The Mash Report in 2017.The Impact of a Progressive Voice in ComedyKumar's outspoken progressive politics made him both celebrated and controversial. His appearances on Question Time prompted social media abuse, and figures like Piers Morgan and Andrew Neil criticized him for an "anti-British" episode of Horrible Histories. Despite these controversies, Kumar believes his involvement in culture wars ultimately did more harm than good. "It's a fucking relief. It didn't do anybody any good; me being in the conversation didn't benefit any of the causes that I was passionate about. I worry sometimes that it actually actively hindered them." Despite this, his influence has grown internationally, with The New York Times suggesting he might be "the angry progressive standup the US badly needs." His cross-generational appeal has also expanded, with audiences ranging from 14-year-olds to septuagenarians, reflecting his ability to connect with diverse audiences through his blend of political commentary and personal vulnerability.Anger and Authenticity in a New Era of ComedyAs he approaches his 40s, Kumar continues to refine his approach to comedy that balances anger with authenticity. He has been open about his mental health struggles, including diagnoses of PTSD and ADHD, which inform his work. His upcoming tour "Angry Humour from a Really Nice Guy" suggests a continued commitment to comedy that challenges both audiences and the industry itself. Despite his success in the US, where he performed his new show and appeared on Have I Got News for You, Kumar's material remains rooted in UK concerns, with American audiences showing enough interest in British politics to appreciate his takes on figures like Angela Rayner. As he continues to navigate the complexities of comedy that both entertains and provokes, Kumar remains committed to what he sees as the essential role of comedy in holding power accountable, even when it means making enemies in the process.

The Lead Kyrgyzstan, a mountainous, landlocked Central Asian nation, has historically been one of the region's poorest economies. However, its fortunes changed four years ago when it emerged as a key hub for goods bypassing embargoes imposed on Russia. Kyrgyzstan's Growing Trade with Russia From 2021 to 2022, the annual value of Kyrgyzstan's exports to Russia leaped from $393m to $1.07bn, including products such as luxury cars and microchips. Some of these products, like microchips, are known as 'dual-use,' meaning they are imported to third countries like Kyrgyzstan as civilian goods and then re-exported to Russia, where they may be utilized in military hardware. The Data Analysis 2021: $393m in exports to Russia 2022: $1.07bn in exports to Russia The Impact Analysis The recent shutdown of companies suspected of aiding Russia is a significant move by Kyrgyzstan to avoid being sanctioned itself. This decision comes after the European Union imposed an embargo on certain electronic goods to Kyrgyzstan for rerouting such products to Russia. The country's close relationship with Russia, including mutual defense agreements and Russia's significant influence, makes this move crucial. The Prediction As Kyrgyzstan navigates its relationships with Russia, the European Union, and other global players, it is likely to face increased pressure to comply with international sanctions. The country's economic partnership with China, which borders Kyrgyzstan to the east, may also play a significant role in shaping its future. With growing discontent among its intellectual elites, activists, and younger generations, Kyrgyzstan's stance on Russia's influence may continue to evolve.

The Lead Bangladesh has sought a new assistance programme from the International Monetary Fund (IMF) as it struggles with the economic consequences of the US-Israel war on Iran. The South Asian country is facing an energy crisis, supply chain disruptions, and rising fuel prices. What Has Bangladesh Asked For? The IMF's mission chief for Bangladesh, Ivo Krznar, announced that Bangladesh has requested a new IMF-supported programme. The size and precise terms of the requested financial aid package have not been disclosed, but Bangladesh's government said in March it was seeking $2bn in loans from various donors. How Badly Has Bangladesh Been Hit by the Iran War? Energy Crisis The war on Iran has caused a worldwide energy crisis, with fuel prices soaring to about $100 a barrel, up from $66 before the war. Bangladesh, which imports 95% of its oil and liquefied natural gas needs, has been severely affected. The country has raised fuel prices by 10-15% and halted production at most fertiliser factories. Garment Industry The ready-made garment industry, which accounts for over 80% of Bangladesh's export earnings, has also been hit. Shipping disruptions have pushed up import costs, and work orders are expected to decline by 20-25% in the next season. Cost of Raw Materials The disruptions to supply chains have impacted other industries in Bangladesh, with raw material prices for plastic products rising. The price of resin, a key raw material, has spiked to $1,500-1,600 per tonne, up from $900-950. Rising Foreign Debt Costs Bangladesh's external debt has risen in recent years, and the country is facing higher foreign-currency repayment pressures. The IMF warned that the Iran war risks triggering an increase in debt levels worldwide. What Is Bangladesh's History with the IMF? Bangladesh is already in the middle of a $5.7bn IMF programme that began in 2023. The country has agreed to move quickly to put a new programme in place, with the World Bank approving a $350m loan to help manage rising fuel import costs. Is the War Deepening a Debt Crisis More Broadly? The Iran war has exacerbated existing debt burdens across Africa, Asia, Latin America, and other regions. Sri Lanka, for instance, suffered a financial collapse in 2022 and secured a $3bn IMF programme in 2023.

The RSF Attack on Civilians A force affiliated with the paramilitary Rapid Support Forces (RSF) has killed at least 27 people, including elderly residents, in an attack on villages west of Bara in Sudan's North Kordofan state, according to the Sudan Doctors Network. The Cairo-based medical NGO said the attacks took place on Thursday in the al-Murrah area, describing them as “a new crime targeting unarmed civilians in areas with no military presence”. The Humanitarian Crisis in Sudan Sudan has been engulfed in civil war since April 2023, when long-running tensions between the Sudanese army and the RSF erupted into a full-scale conflict that has killed hundreds of thousands of people and displaced millions. The Kordofan region has become one of the war's main battlegrounds, with fighting intensifying across several fronts, including through drone attacks. The Impact on Civilians The Sudan Doctors Network said that “targeting villages and civilian areas and executing citizens in such a brutal manner constitutes a flagrant violation of international humanitarian law and all norms and conventions that prohibit attacks on civilians, especially amid the catastrophic humanitarian conditions people are enduring because of the ongoing war”. The group added that the “continued attacks on civilians and safe villages” are worsening the humanitarian crisis and forcing more families into displacement, suffering and the loss of their livelihoods. The Food Security Situation The attacks come as more than 40 percent of Sudan's population faces acute hunger, according to a report released on Thursday by the United Nations-backed Integrated Food Security Phase Classification (IPC). The report said nearly 19.5 million people across the country are facing severe food insecurity as the conflict drives what aid agencies describe as one of the world's worst humanitarian crises. The Call to Action The Sudan Doctors Network also called on the “international community and human rights and humanitarian organizations to condemn these violations and act urgently to protect civilians and stop the repeated attacks on residential areas by pressuring RSF leaders to end violations against civilians”.