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Residents of Tehran and much of Iran are breathing a sigh of relief after a two-week ceasefire was announced, bringing an end to daily bombardments. The ceasefire, agreed upon by Iran and the US with mediation from Pakistan, has allowed some traffic to return to the streets of the Iranian capital during daylight hours.Despite the temporary reprieve, Tehran remains far from its usual bustling state, having been targeted by several thousand munitions since February 28. The Iranian capital is home to more than 10 million people. Air defence systems were activated for short periods several times since the ceasefire was announced overnight, but there were no reports of impacts or any official explanation for the activations.People across Tehran are debating whether the ceasefire will hold and what the future may hold for them. A young man noted, “Looks like the ceasefire will continue. I heard the Israelis are opening up their airspace more,” referring to an announcement by Israeli authorities that flights will resume from Ben Gurion Airport.However, others are more pessimistic, especially after two critical islands off southern Iran were attacked on Wednesday morning, hitting oil facilities. It is unclear who was behind the attack. The Islamic Revolutionary Guard Corps (IRGC) said it shot down a drone in the southern province of Fars.Saudi Arabia, the United Arab Emirates, Qatar, Kuwait, and Bahrain also reported attacks on their territories by missiles and drones from Iran, with Iranian state television confirming this was in retaliation for the post-ceasefire oil attacks. Tehran said it was ready to restart military operations if attacked again.On Tuesday, Iranians had been worried about the targeting of critical civilian infrastructure, such as power plants and bridges, after a threat from US President Donald Trump to end “civilisation” in a country with one of the world’s oldest civilisations. The ceasefire was announced shortly before the midnight GMT deadline that Trump had set for an agreement to be reached.The Israeli military intensified its attacks in the hours preceding the ceasefire, hitting electricity outposts, bridges, and the railway network. Warplanes also struck the Iranian Aluminium Company in Arak, damaging the country’s largest aluminium production facility.Even after the ceasefire, Israel continued attacking Lebanon, killing more than 250 people in a devastating day of attacks on Wednesday. Israel said it was targeting Iran’s ally Hezbollah, but civilian locations across Lebanon were hit.Trump hailed what he described as a decisive victory against Iran while announcing the ceasefire, but his top general emphasised that the deal only signifies a pause and combat operations could start once again if no final deal is reached. The US military said it struck 13,000 targets across Iran in less than six weeks of war.In Iran, similar proclamations of victory and celebrations were broadcast from Iranian state television. A statement from the Supreme National Security Council urged supporters of the government to trust in the system and refrain from making “divisive commentary”.The council also stressed that affairs were being overseen by Mojtaba Khamenei, who was declared Iran’s supreme leader after his father, Ayatollah Ali Khamenei, was killed on the first day of the war on February 28.

Atletico Madrid stunned Barcelona 2-0 in their Champions League quarterfinal first-leg match, with Julian Alvarez and Alexander Sorloth scoring crucial goals at Camp Nou on Wednesday.The La Liga leaders dominated the game after Pau Cubarsi was sent off for bringing down Atletico's Giuliano Simeone, who was through on goal. Alvarez whipped home a free kick, and Sorloth doubled their advantage with 20 minutes remaining, giving Atletico a strong chance of reaching the semifinals.Diego Simeone's side, who have never won the competition, reached the 2014 and 2016 finals but were beaten by rivals Real Madrid on both occasions. Barca, semifinalists last season, need a huge comeback next Tuesday in Madrid to stand a chance of lifting the trophy they last won in 2015.Barcelona started well, with Marcus Rashford, on loan from Manchester United, their main threat down the left. However, Atletico's defense held strong, and they capitalized on Cubarsi's red card to secure the win.Atletico knocked Barca out of the Copa del Rey in the semifinals in March, and this was the second of three meetings between the sides in a space of two weeks. The win gives Atletico a significant advantage ahead of the second leg next Tuesday.

For many supporters, the final weeks of the football calendar feel both interminably long and suddenly over. The emotional roller‑coaster is now hitting two very different clubs at opposite ends of the English pyramid.Cambridge United have unexpectedly dropped out of the automatic promotion spots in League Two, just as the run‑in intensifies. Their recent draw against Swindon and a late‑minute error by keeper Jake Eastwood at Cheltenham have left them scrambling for points, with upcoming fixtures against Notts County and league leaders Bromley looming.Meanwhile, Tottenham Hotspur appear to be heading for a relegation battle. A 3‑0 defeat to Nottingham Forest has left them winless in the league since late December, and they sit perilously close to the bottom three as they prepare for a Sunday clash at the Stadium of Light.The club’s turmoil is compounded by the recent appointment of Roberto De Zerbi. While his résumé includes a solitary win in 13 games at Palermo, no victories in nine outings at Benevento, and just two points from five matches at Brighton, his impact at Tottenham remains uncertain. His early apology over comments about Mason Greenwood has done little to soothe a fanbase already on edge.Supporters across the country are feeling the same strain. From West Ham’s uneasy anticipation of a Wolves encounter to Liverpool fans fearing a slip below Everton, the anxiety is universal. Even lower‑league followers—whether in Ipswich, Middlesbrough, Oxford, Leicester, Harrogate, Barrow or Newport—are caught in the same cycle of hope and dread as promotion and playoff hopes hang in the balance.Amid the gloom, a few clubs enjoy relative peace. Fans of Paris Saint‑Germain and Bayern Munich can likely breathe easier, while clubs like Coventry and Lincoln savor modest successes.In the end, the season’s drama underscores a simple truth for football lovers: the joy of the game is inseparable from its inevitable panic, frustration, and the ever‑present possibility of triumph—or heartbreak—just around the corner.

In a stark address delivered as the cease‑fire in the Iran conflict teetered, IMF Managing Director Kristalina Georgieva warned that the war will leave a permanent scar on the global economy, slowing growth beyond the IMF’s original projections for 2026. Georgieva noted that, had the hostilities not erupted six weeks ago, the Fund would have been poised to raise its 2026 growth outlook. Instead, even the most optimistic scenario now entails a downgrade, and a swift return to pre‑war conditions appears unlikely. The uncertainty surrounding the cease‑fire—exacerbated by divergent positions of Washington and Tehran—has already pushed oil prices higher, reflecting fears of continued disruptions to shipments through the Strait of Hormuz, a vital conduit for world energy supplies. According to the IMF’s upcoming World Economic Outlook, the conflict’s “scarring effects” will translate into lower living standards worldwide. The Fund had previously forecast global growth of 3.1% in 2026, a modest slowdown from 3.2% in 2025, buoyed by a tech‑driven investment surge. Georgieva emphasized that the war arrived when the economy was riding “considerable momentum” from technology investment and supportive financial markets. She outlined the mechanisms of damage: damaged infrastructure, supply‑chain interruptions, eroded confidence, and prolonged uncertainty over oil and gas production in the region. These factors will depress growth regardless of whether a peace agreement is ultimately reached. Georgieva highlighted that the most vulnerable will be net oil‑importing nations, poorer economies and small island states, which stand to feel the brunt of higher energy costs and reduced trade flows. She urged governments to avoid unilateral measures such as export bans or price controls, warning that such actions could "pour gasoline on the fire" and further destabilise markets. With many countries already carrying elevated debt levels and higher borrowing costs, the IMF chief called for targeted, temporary assistance to protect the most at‑risk households. She cautioned against broad tax cuts or blanket energy subsidies, which could stoke inflation and strain fragile public finances. Central banks, she added, should keep policy rates steady while remaining ready to act against inflationary pressures. Bank of England Governor Andrew Bailey, who also chairs the Financial Stability Board, echoed the IMF’s concerns, describing the conflict as a "very big shock" that has heightened market volatility. He stressed that the situation remains fluid and that policymakers must stay vigilant. Overall, the IMF’s message is clear: the Iran war will reshape the global growth trajectory for the foreseeable future, and coordinated, prudent policy responses are essential to mitigate its lasting impact.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil tanker workers stuck in the Gulf for six weeks are reaching their limit, with mental health concerns escalating due to the prolonged standoff. A crew member, who spoke to the Guardian, revealed that the situation is becoming increasingly unbearable.The worker, one of 20,000 seafarers trapped by Iran's chokehold on the Strait of Hormuz, expressed frustration and despair, stating that any hope of being freed had evaporated. The crew member's tanker is anchored near dozens of loaded tankers, with many feeling unwilling and unable to traverse the strait, even if a ceasefire allowed them to do so.90% of the crew on the tanker want to exercise their right to refuse to sail, citing safety concerns. The situation has taken a toll on the crew's mental health, with one member suffering a 'mental breakdown' and being checked on regularly by colleagues.The International Transport Workers' Federation (ITF) has received about 1,000 inquiries from seafarers on 300 different vessels, with 20% seeking repatriation. The union and other organizations are trying to provide support, but the situation remains dire.The shipping companies are expected to find new crew members willing to work in hazardous areas, offering double pay and promotions. However, the workers stuck on the tankers hope that their vessel will be taken to anchorage to allow new crew to take their places.The situation has reignited calls for shipowners to replace their crews with mariners willing to offer relief, highlighting the human cost of the conflict.

The recent ceasefire between the United States and Iran may provide temporary relief, but the oil crisis triggered by their conflict is far from over. After 40 days of fighting, the two nations agreed to a two-week ceasefire, with negotiations set to begin in Pakistan's capital, Islamabad.One of the key points in Iran's 10-point proposal is allowing shipping to resume through the Strait of Hormuz, a critical waterway through which 20 percent of the world's oil and gas is shipped during peacetime. The strait has been effectively closed since the start of the war, causing global oil and gas prices to soar.Following the announcement, oil prices dropped to $92 on Wednesday, down from over $110 for much of the war. However, delays in restarting production and transport mean the energy crisis is far from over. For ships to continue operating, they need certainty about security during the next two weeks of the ceasefire.Even with the waterway reopened, it will take weeks for large oil tankers – now scattered thousands of miles away – to return to the Gulf to collect the millions of barrels sitting in large reservoirs. With very few tankers able to load or unload and their onshore storage full, producers began shutting wells, causing regional oil output to plummet despite efforts to reroute limited volumes via overland pipelines.Economists warn that the true impact on grocery bills will likely persist throughout 2026 and into 2027. Additionally, it will take years for the Gulf energy industry to repair facilities damaged or destroyed during the war.Shipping data shows that combined exports from Iraq, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates fell from 469 million barrels in February to 263 million barrels in March – a decline of 206 million barrels, or 44 percent. Iraq's crude exports have been hit the hardest, falling 82 percent from 94m barrels in February to 17m in March.The 206 million barrels of Gulf oil lost since the start of the war would fill approximately 103 Very Large Crude Carriers (VLCCs), the workhorse supertankers of the global energy trade. A single VLCC stretches nearly 330 metres (1,080 feet) in length, nearly the same height as the Eiffel Tower in Paris.To put that in more practical terms, if you drove a pick-up truck that averages 24 miles per gallon (or 10 litres per 100km), one barrel of crude oil would carry you about 730km or 450 miles. That is about the distance from New York City to Cleveland, Ohio.For much of the war, oil has traded above $100 per barrel, hitting a peak of nearly $128 on April 2. The value of 206 million lost export barrels at various oil prices is significant, with Brent crude being the global benchmark.

As the clock ticked down to President Donald Trump’s 8 p.m. deadline to force the reopening of the Strait of Hormuz, the six‑week Middle East conflict teetered on the brink of a far more devastating escalation.Trump’s rhetoric had escalated dramatically, with his Truth Social posts warning that the United States would unleash strikes capable of “decimating every bridge and power plant in Iran” and that “a whole civilisation will die tonight.” Legal experts labeled the language as bordering on a genocidal threat.Amid the rising tension, a series of rapid developments unfolded on Tuesday:12:06 GMT – Trump announced a plan to target Iran’s civilian infrastructure, promising total destruction of bridges and power facilities.15:21 GMT – Iranian media confirmed that US strikes hit Kharg Island, the nation’s primary oil‑export hub, but reported no significant damage.15:40 GMT – In the UN Security Council, China and Russia vetoed a Bahraini resolution aimed at protecting commercial shipping in the Strait of Hormuz, arguing the draft was biased against Tehran.16:54 GMT – Qatar’s defence ministry reported a successful missile interception, while the United Arab Emirates warned of a barrage of missile and drone attacks.18:23 GMT – Iran’s envoy to Pakistan, Reza Amiri Moghadam, signalled a “step forward” after a “critical, sensitive stage,” praising Pakistan’s “positive and productive” peace efforts.19:17 GMT – Pakistani Prime Minister Shehbaz Sharif appealed to Trump to extend the deadline by two weeks, urging Tehran to keep the Strait open as a goodwill gesture.20:25 GMT – Iran warned it would target US and Gulf‑allied energy infrastructure, threatening to block regional oil and gas supplies for years.20:41 GMT – Joint US‑Israeli airstrikes struck the Amirkabir Petrochemical Plant in Mahshahr, Iran, prompting local assessments of damage.With less than ninety minutes remaining, diplomatic channels intensified. Pakistani officials, including the military chief Asim Munir, facilitated talks that culminated in a two‑week, double‑sided cease‑fire announced by Trump at 22:45 GMT. The United States claimed to have received a “workable” 10‑point proposal from Tehran.Iranian Foreign Minister Abbas Araghchi quickly confirmed the truce, stating Iran would honor it provided attacks on its territory ceased. Sharif then invited both Iranian and US delegations to Islamabad for further negotiations aimed at a permanent settlement.Early Wednesday, Trump’s tone shifted dramatically. In a Truth Social post he hailed the cease‑fire as a potential “Golden Age for the Middle East,” celebrating the pause in hostilities and the reopening of the Strait of Hormuz.The episode underscores how last‑minute diplomacy, spearheaded by Pakistan, averted a catastrophic escalation and opened a narrow window for a broader peace process in a region long mired in conflict.

Iran and the United States each declared a triumph after agreeing to a two‑week ceasefire that was announced just before President Donald Trump’s deadline to force Tehran’s surrender. The conflict, which began on 28 February, has already claimed 2,076 lives in U.S.–Israel strikes on Iran and has caused thousands more deaths across the region. The fighting has also shocked global energy markets, stranding oil tankers and pushing prices to unprecedented levels. Trump announced on Truth Social that the United States would halt bombing Iran after receiving a “workable” 10‑point ceasefire proposal, adding that “almost all of the various points of past contention have been agreed to.” Iran, for its part, said it would reopen the Strait of Hormuz to commercial traffic, even as some citizens denounced the government’s perceived capitulation. Both parties are set to resume Pakistan‑mediated talks in Islamabad on Friday, though analysts warn that earlier red lines may resurface. Key terms of the Tuesday agreement: the United States will suspend air strikes for two weeks, citing that it has already achieved its military objectives and is close to a “definitive agreement concerning long‑term peace.” Iran’s foreign minister, Abbas Araghchi, pledged to halt “defensive operations” and to allow safe passage through the Strait of Hormuz, while also indicating willingness to fund reconstruction from fees collected on transiting ships. Domestic reaction in Iran remains volatile. University of Tehran professor Foad Izadi noted that the public’s pessimism stems from two prior escalations—June’s 12‑day war and the February 28 strikes—both of which occurred amid ongoing negotiations. Earlier demands: The United States had presented a 15‑point plan on 25 March, calling for a 30‑day ceasefire, immediate reopening of the Strait, Iran’s de‑commissioning of its nuclear facilities, a total ban on uranium enrichment, handover of nuclear stockpiles to the IAEA, cessation of support to regional proxies, strict limits on ballistic missiles, and a full lift of sanctions, among other items. Iran responded with a 10‑point proposal that emphasized a non‑aggression commitment from the United States, controlled passage through the Strait, acceptance of its enrichment programme, comprehensive sanctions relief, withdrawal of U.S. combat forces, compensation for war damages via shipping fees, and a binding UN Security Council resolution. Both sides have already made concessions. Iran moved from demanding a permanent ceasefire to accepting a two‑week pause, and it shifted from insisting on reparations to proposing reconstruction funding from Strait fees. The United States, meanwhile, has softened its demand for an “unconditional” Iranian surrender and has not reiterated its earlier insistence on dismantling Iran’s missile capabilities. One of the most contentious issues remains the status of Lebanon. While Pakistan’s prime minister said the ceasefire would extend to Lebanon, Israeli Prime Minister Benjamin Netanyahu denied any such inclusion, and Israel launched a major bombing campaign in Beirut shortly thereafter, killing hundreds. Looking ahead, analysts highlight that the United States is unlikely to concede on the complete withdrawal of its roughly 50,000 troops stationed across 19 Middle Eastern sites—a demand Tehran has placed on the table. The outcome of the upcoming talks will hinge on whether Washington can accommodate Tehran’s broader political and economic requests without compromising its strategic objectives.