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Occupied East Jerusalem – While Holy Week traditionally fills the Old City’s Christian Quarter with pilgrims and worshippers, the streets are now eerily quiet and storefronts remain shuttered.Palestinian shopkeeper Boulos, a man in his mid‑30s who asked to remain anonymous, still drags himself to his modest stall a few times a week, selling religious garments behind a half‑closed door to avoid Israeli orders that mandate closure of businesses in the quarter amid the ongoing US‑Israel conflict with Iran.After six years of pandemic‑related setbacks and successive wars, his business had only begun to recover when the October Gaza ceasefire was followed by a new wave of restrictions. “Before the war with Iran, we barely made enough to survive,” he said. “Now there is no income at all.”His only customer that day was an Ethiopian Christian woman buying a kilo of prayer candles for 35 shekels (about $11.20). “What can 35 shekels do for me?” Boulos lamented, underscoring the stark economic squeeze.Unlike many West Jerusalem shops, which have been allowed to stay open because of nearby bomb shelters, the Old City lacks such protection, leaving Palestinian businesses in the Christian Quarter effectively forced to shut. The area, heavily dependent on tourism, shows the least sign of life.Brother Daoud Kassabry, principal of the College des Frères school, described the scene as “the saddest Jerusalem I have ever seen.” Classes have been suspended for over a month, and the community feels the weight of an unprecedentedly difficult period.For the first time in centuries, Israeli police barred Cardinal Pierbattista Pizzaballa, the Latin Patriarch of Jerusalem, and other senior clergy from entering the Church of the Holy Sepulchre for Palm Sunday Mass. The Latin Patriarchate called the incident “unprecedented in centuries.”At a press conference, Cardinal Pizzaballa emphasized that while “all celebrations” have been cancelled for security reasons, “no one, not even the Pope, can cancel the liturgy of Easter.”Following the incident, leaders from Italy, France and the United States condemned the police action. Israeli Prime Minister Benjamin Netanyahu later defended the measure as a safety precaution, citing the absence of bomb shelters near the holy site, despite the cardinal’s residence being only metres away.Netanyahu’s justification raises questions about the long‑standing “status‑quo” arrangement that places custodianship of Christian and Muslim holy sites under the heads of their respective religious institutions and Jordan’s Waqf. Palestinian Christians interpret the rhetoric as evidence of an increasingly hostile environment under Israeli control.Bishop Emeritus Munib Younan recounted being spat on by Jewish yeshiva students in the Old City without any legal consequences. He now prefers to attend services in Bethlehem or a small church outside Jerusalem, where he feels “no one is pointing a gun at you.”“They want to show the world that this country is only meant for them – not Christians, not Muslims,” Younan said, reflecting a sentiment shared by many locals.Netanyahu later announced that religious ceremonies at the Holy Sepulchre would be permitted during Holy Week, but only for clergy, keeping the general public out. Observers noted the inconsistency, pointing out that Muslim worshippers have been barred from the Al‑Aqsa compound since late February, including during Ramadan, with only minimal international rebuke.The cumulative restrictions have crippled the already dwindling Palestinian Christian community, which now makes up less than 2 % of the population in Israel and the occupied territories. Traditional events such as the Way of the Cross procession and Holy Fire Saturday have been cancelled, eroding communal cohesion.Father Faris Abedrabbo of the Annunciation Latin Parish linked the current hardships to the Passion narrative, urging congregants to view their suffering through the lens of “steadfastness” – an active, spiritual resistance rather than passive endurance.Economic despair is prompting a new wave of emigration. Bishop Younan reported that many young Christians ask for help obtaining visas to the United States, Canada or Australia, fearing there is “no future” in Jerusalem. Boulos, the shopkeeper, admits he has considered leaving, noting that “they try to make us lose hope and abandon this land.”Despite the bleak outlook, Boulos continues to visit his shop, saying, “I come here to prove to myself that I still have hope, even if it feels endless.”

A projectile strike near Iran's Bushehr nuclear plant has resulted in the death of one person, according to the International Atomic Energy Agency (IAEA). The incident occurred amid escalating US-Israeli strikes on Iranian industrial sites, raising concerns over the safety of nuclear facilities. The IAEA confirmed that there was no increase in radiation levels after the attack on Saturday, citing Iranian authorities. The agency's Director General, Rafael Grossi, expressed deep concern about the incident, emphasizing that nuclear sites and nearby areas must never be attacked. Iran's Foreign Minister, Abbas Araghchi, claimed that the Bushehr facility had been bombed four times since the war erupted on February 28, criticizing the lack of concern for its safety. The strike damaged an auxiliary building on the site, but the main sections of the power plant were not affected. The incident has sparked a renewed call for maximum military restraint to avoid the risk of a nuclear accident. The US and Israel have been escalating their targeting of Iranian industrial sites, including petrochemical plants in the southern Khuzestan region. The Bushehr plant, Iran's only operational nuclear power plant, is located in Bushehr city and is one of the country's most important industrial and military nodes. The plant's safety has been a concern, with 198 Russian staff evacuated following the attack, according to Rosatom, Russia's state nuclear company.

Russian attacks across Ukraine have resulted in at least 15 fatalities and numerous injuries over a 24-hour period, according to Ukrainian officials. The attacks targeted various regions, including the city of Kharkiv and the southeastern city of Nikopol.In Kharkiv and surrounding areas, four people were killed and 11 injured in Russian attacks. Additionally, at least 11 people, including a child, were injured when a Russian drone struck a building in the Sumy region.The southeastern city of Nikopol was also hit, with a Russian drone striking a covered market, killing five people and wounding 25, according to Dnipropetrovsk Governor Oleksandr Ganja. In the eastern region of Donetsk, six people were killed and 10 injured over 24 hours.The Ukrainian air force reported that it had shot down or neutralized 260 of 286 Russian drones launched towards various parts of the country during overnight attacks. However, 11 drones did strike 10 locations, with debris found at six locations.In a related development, Ukrainian President Volodymyr Zelenskyy met with Turkish President Recep Tayyip Erdogan in Istanbul to discuss efforts to end the ongoing conflict. Erdogan expressed Turkey's commitment to supporting negotiations between Ukraine and Russia.The talks between Zelenskyy and Erdogan come as diplomatic efforts to end the war have stalled in recent months. The two leaders also discussed maritime safety in the Black Sea and the security of energy supplies.

A Waitrose employee with 17 years of service was dismissed after stopping a shoplifter who had stolen a display of Lindt Gold Bunny Easter eggs worth £13 each. Walker Smith, a shop assistant at a Waitrose branch in Clapham Junction, south London, described his devastation after being sacked. He had been told not to approach shoplifters but felt compelled to act after seeing the repeat offender. The incident highlights the growing concern of shoplifting in retail, with 519,381 offences recorded in England and Wales in the year to September 2025, up 5% from the previous year. Smith's manager told him off and he apologized, but the matter was escalated, leading to his dismissal. He expressed regret over his actions and worries about his future, having recently moved into his own studio flat and being diagnosed with anxiety. Retail businesses, particularly supermarkets, have seen an increase in shoplifting, prompting calls for greater support and security measures. The chief executive of Marks & Spencer has urged the government and London's mayor to crack down on retail crime. A Waitrose spokesperson stated that the company takes the safety and security of customers and employees seriously, with policies in place to address these concerns.

Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

A devastating incident unfolded at the Alejandro Villanueva Stadium in Lima, Peru, on Friday, claiming the life of one person and injuring dozens more. The event, which was a 'flag-waving' gathering, took place a day before a highly anticipated derby match between Alianza Lima and Universitario de Deportes.The Peruvian health minister, Juan Carlos Velasco Guerrero, confirmed the death and reported that 47 people were injured, with three in critical condition. Initial reports suggested that parts of the stadium's wall had collapsed, but officials later clarified that there were no structural failures.Alianza Lima expressed condolences for the casualties and pledged to cooperate fully with authorities to investigate the incident. The club promised 'total transparency' in the investigation.The Peruvian professional soccer league announced that Saturday's match would proceed as planned, emphasizing its commitment to ensuring safe environments for spectators. The league will continue to work closely with clubs and authorities to promote safety and wellbeing at sporting events.The Alejandro Villanueva Stadium, also known as Matute, was built in the 1970s and has a capacity of over 33,900 seats. Despite limited modernization, the stadium remains a 'fairly basic ground,' according to The Stadium Guide.

Daniel Peretz, the Southampton goalkeeper on loan from Bayern Munich, has expressed his pride in representing Israel during a tumultuous period marked by war and geopolitical conflict. With his family in Tel Aviv, Peretz shares the challenges of balancing his international duties with the safety concerns of his loved ones.Peretz's excitement about facing Arsenal in the FA Cup quarter-finals is palpable, but he also acknowledges the gravity of the situation in Israel. His family adheres to air raid sirens by heading to bunkers and safe rooms, a routine that has become all too familiar. Despite the distance, Peretz stays connected with his family, ensuring they are safe and focused on their instructions.When asked about playing for Israel being bittersweet, Peretz notes that the only bitter aspect is not qualifying for the World Cup and not playing at home. Israel's home games have been held in Hungary for the past three years, but Peretz hopes for a future where they can play at home with their fans.Peretz is known for his positive outlook and has a close relationship with his idol, Manuel Neuer. He recalls his first encounter with Neuer, feeling nervous but inspired. Peretz also shares his experiences with Harry Kane's penalty techniques, noting that saving one in 10 against Kane is a good statistic.As Southampton prepares to face Arsenal, Peretz emphasizes that while they have respect for their opponents, they are not afraid. He believes that if anyone doubts their abilities, they shouldn't participate. With a 14-game unbeaten run in all competitions, Peretz and his team are confident in their abilities.Peretz's future at Southampton is also a topic of discussion, with a £7m buy option in place. He is open to staying but acknowledges that promotion to the Premier League could impact his decision. For now, he is focused on finishing the season strongly.

Israel’s military announced plans to bomb the Sohmor and Mashghara bridges spanning the Litani River in the western Bekaa Valley, stating they are being used by Hezbollah. The threat comes as Israeli forces intensify a ground invasion that began in early March. Al Jazeera reporter Obaida Hitto described the two spans as “the main arteries for goods, for people, for movement” between the rest of Lebanon and the western Bekaa. He warned that their destruction would effectively isolate the western Bekaa, making it extremely difficult for residents to reach the hub of Chtoura, hospitals, and other essential services. According to the same source, Israel has already demolished at least six other bridges over the Litani River since the offensive escalated in early March, signalling a systematic effort to sever transport links. Human‑rights organisations have condemned the targeting of civilian infrastructure, arguing that the strategy appears designed to isolate the region and contravene international humanitarian law. The deepening ground operation, announced last week, also includes plans to raze “scores of residential homes,” raising further concerns about the scale of civilian displacement. On Friday, the South Lebanon Water Establishment reported that Israeli strikes damaged critical water facilities in Ibl al‑Saqi and al‑Maysat, and impaired solar‑power installations at several stations. The authority called the attacks a “clear and explicit violation of all international conventions and norms” protecting civilian services. In the same wave of violence, the National News Agency (NNA) confirmed that four people were killed across Lebanon on Friday, including two worshippers exiting a mosque in the western Bekaa town of Sahmar. Since the conflict erupted on 2 March, more than 1.2 million people have been forced from their homes, according to UN data. Lebanon’s Ministry of Public Health cites a death toll of 1,345 and over 4,000 wounded nationwide. The fighting has also claimed the lives of at least three United Nations peacekeepers this week, with two additional peacekeepers seriously injured after an explosion near a UN position in al‑Adaissah. UNIFIL spokesperson Kandice Ardiel urged all parties to respect the safety of peacekeepers, emphasizing that combat activities must not endanger UN personnel.