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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

At the Oxford Brookes Headington campus, a group of over 100 students are working tirelessly to build the fastest and best-designed race car possible for this year’s Formula Student competition.The Oxford Brookes Racing (OBR) team, the UK’s most prestigious Formula Student team, has won more design awards than any other UK university and frequently secures top spots in the international race held annually at Silverstone.Success in the competition is crucial as it gets the team noticed by the industry, where a handful of engineering jobs can have upwards of 10,000 applicants. Several OBR alumni are currently working in every Formula One team.“A lot of the coverage on TV is based around the drivers, but not really the actual engineers,” said Thomas Cawdery, a team manager and third-year motorsports technology student. “This is what you don’t see in Formula One. The engineers who make it happen.”The OBR team is entirely run by students and operates out of two buildings, where scores of people are working hard – cutting and shaping carbon fibre chassis by hand, and running simulations on computers. Students of all ages are teaching and learning from one another.While actual Formula One cars have much more power than the students are allowed for safety reasons, the complexity of the cars is very similar. “They’re the same if not more complex than Formula One cars,” Cawdery said.The OBR team surpasses industry expectations in some aspects, particularly in terms of gender balance. Unlike most Formula One teams, where only about 10% of engineers are women, OBR has a much better gender balance.Emma Deery, a first-year mechanical engineering student, finds the inclusive environment encouraging. “In the industry, a lot of women find themselves the only woman on their team. Here it’s different. We have a lot more women and a lot of women in leadership roles.”The OBR team will compete for the top spot this summer against 102 other teams from 27 countries. The competition is a useful recruitment tool for big industry names, as it showcases innovative engineering skills.Ross Brawn, the legendary former team principal, once said, “There are two really innovative forms of motorsport left. One of them is Formula One and the other one is Formula Student.”

Les Kiss is set to take over the Wallabies in July, inheriting a side desperate to climb back to the top of world rugby. He faces a tight schedule – 14 months and 19 Tests – before the 2027 Rugby World Cup that Australia will host. Describing his mandate, Kiss stresses that he is not aiming for a radical overhaul. "It's not a revolution, it's evolution," he told the Guardian. "Core values like discipline, accountability and strategic planning stay firmly in place." What makes Kiss an outlier is his background: a former rugby league international who never played union at senior level. He says this forced him to "earn his stripes" in the union code, learning that culture and standards in the locker room drive performance on the field. His personal story is rooted in a family that escaped the Hungarian Revolution and settled in Bundaberg, and a playing career that saw him sprint down the wing before a knee injury sidelined him for four years. Those experiences, he believes, forged the resilience he now brings to coaching. After a stint in marketing and junior coaching, Kiss transitioned to union coaching, first as a defence coach for the Springboks (2001‑02), then as an assistant with Ireland (2009‑15), director of Ulster Rugby, and finally a three‑year spell with London Irish in the Premiership. Returning to Australia in 2024 to lead the Queensland Reds, he guided the franchise to its most prolific try‑scoring season in three decades, back‑to‑back quarter‑final appearances and record crowd numbers. The Reds sit 4‑2 in the 2026 Super Rugby Pacific season and are eyeing a top‑four finish. Kiss’s coaching philosophy centres on connection. "Coaching is about rapport and building something strong together," he says, adding that he is fully invested and treats every team like family. His transition to the Wallabies will be smoothed by a close partnership with current head coach Joe Schmidt. The two have shared roughly 40 Tests, developing a strong rapport that Kiss believes will help him "understand the breakdown" and set the right structures for success. The emerging "Kiss army" already includes former All Blacks staffer Scott McLeod as defence coach, analyst Eoin Toolan, set‑piece specialist Tom Donnelly, scrum guru Mike Cron, and consultant Laurie Fisher. Skills coach Mick Byrne and U20s boss Chris Whitaker also remain on board. While his new responsibilities grow, Kiss assures fans he remains 100% committed to the Reds, vowing not to let the franchise down despite his expanding duties. On the player front, Kiss highlights a blend of seasoned talent and fresh faces that could power Australia’s World Cup campaign. The likes of Mark Nawaqanitawase, Max Jorgensen, former winger Dylan Pietsch, and NRL convert Zac Lomax are poised to add dynamism, while 18‑year‑old prodigy Treyvan Pritachard offers a glimpse of the future. Ultimately, Kiss believes the Wallabies embody a uniquely Australian style – inventive, physical, and expressive – forged in backyard games and a culture of resilience. "The Australian way isn’t formulaic; it’s about solving problems on the field in our own special way," he concludes.

Several readers have voiced alarm over the unfolding US‑Israel war on Iran, describing it as a chaotic and unjustified conflict that threatens regional stability and global order.One contributor likens the situation to a “spectacle of two rogue nations armed with nuclear weapons fighting to prevent a third from acquiring similar capabilities,” warning that the resulting chaos could embolden other territorial disputes, from China’s claim on Taiwan to Argentina’s claim on the Falklands. The writer urges individuals to emulate the anti‑apartheid boycott campaign, suggesting a coordinated boycott of US and Israeli products and a disengagement from the upcoming FIFA World Cup as potential levers to pressure the belligerents.Another letter critiques the tone of the original editorial, arguing that the war’s justification—purported nuclear compliance and regime change—was merely “grist to throw into the media mill.” The author characterises President Trump’s approach as a personal crusade, describing it as a “hyperbolic truth” that seeks to vent anger and claim divine credit, with the war ending only when Trump’s interest wanes.A third commentator questions the UK’s role, noting that despite initial resistance, British bases have quietly accommodated US and Israeli forces, mirroring the pattern seen in Gaza. The writer warns that the conflict could inflict a “disaster for our economy and that of Europe” that may last for years, calling the war both “immoral” and “illegal” and urging a policy reversal.Concern is also expressed about China’s silence. Citing a recent Guardian editorial, a reader points out that Beijing’s proclaimed “major‑country diplomacy” has not translated into constructive mediation, similar to its restrained stance on the Ukraine war. The letter argues that the global benefits of peace outweigh any short‑term advantage China might gain from allowing two wars to continue, and calls on allies of China to press the government into action.Collectively, these letters highlight a growing perception that the war in Iran is driven more by political posturing than by clear strategic objectives, and they advocate for a combination of economic pressure, public dissent, and diplomatic engagement to halt the escalation.

A stunning visual recap of the week's top stories, curated by photographer Jim Powell, has been published by The Guardian. The selection of images provides a glimpse into global events and everyday life across various countries.The photographs, presented in a gallery format, highlight significant moments that have shaped the week. While specific details about each image are not provided, the collection offers a unique perspective on international news and culture.Published by The Guardian on April 3, 2026, this visual series is a testament to the power of photography in storytelling and global connectivity.

US senators have strongly rebuked Ticketmaster for increasing ticket fees following a regulatory crackdown on hidden charges. This move has been described as a 'bait and switch' tactic, leaving consumers with higher costs.The Federal Trade Commission (FTC) had mandated Ticketmaster to disclose all concert ticket fees upfront, known as all-in pricing, starting last May. In response, the company removed the order processing fee charged at the end of a transaction. However, documents obtained by the Guardian reveal that Ticketmaster simply raised other fees to offset the loss, potentially violating the FTC's ban on misleading fees.Senator Richard Blumenthal from Connecticut expressed his concerns, stating, 'Ticketmaster seems to believe it has a get-out-of-jail-free card to ignore antitrust and consumer protection laws. The FTC is going to have to choose whether to protect consumers and enforce the law, or cave to Ticketmaster lobbyists.'The FTC had sued Ticketmaster and its parent company, Live Nation Entertainment, last September for hiding mandatory fees until the end of the transaction. Ticketmaster claims it complies with the FTC's all-in pricing rules.In response to the criticism, Ticketmaster stated, 'Since May 2025, tickets on Ticketmaster.com have displayed the full price upfront in line with the FTC's all-in pricing rule. We also provide explanations of fees during the purchase process and maintain a dedicated page with additional information.'Senator Elizabeth Warren from Massachusetts also criticized Ticketmaster, saying, 'Too many giant monopolies think the law doesn’t apply to them, and it’s American families who are forced to pay the price.'An ongoing federal trial is examining whether Ticketmaster operates an illegal monopoly in the live music industry. The company denies these allegations.

Friko, the Chicago‑based indie outfit, is gearing up for the launch of their second LP, Something Worth Waiting For, slated for 24 April. The record, described as a “radiant ramble” through modern indie rock, reflects the band’s recent touring experiences and explores themes of yearning, growth, and stability.The lead single, "Choo Choo", bursts with a road‑trip vibe, pairing vocalist‑guitarist Niko Kapetan’s urgent, quavering delivery with guitarist Korgan Robb’s atmospheric riffs. Critics note a vocal timbre reminiscent of Modest Mouse’s Isaac Brock and Sparks’ Russell Mael, while the track’s lyrical nods to classic American road food add a playful, homespun charm.Since their 2024 debut Where We’ve Been, Where We Go From Here, Friko has expanded from a duo (Kapetan and drummer Bailey Minzenberger) to a full four‑piece, adding Robb and touring bassist David Fuller. The new album also benefits from the touch of Grammy‑winning producer John Congleton, known for work with Mannequin Pussy, The Mountain Goats, and St Vincent. His influence shines on the Bowie‑esque chamber‑pop ballad "Seven Degrees", underscoring the group’s evolving sound.In addition to the album news, the Guardian’s weekly Add to Playlist roundup spotlights a curated selection of fresh tracks. Highlights include Wallis’s techno‑laden “Biscuit,” Beth Orton’s intense “The Ground Above,” Toronto pop‑star Chxrry’s catchy “Hall of Fame,” and a collaborative anti‑immigrant‑detention compilation track by Wendy Eisenberg’s trio Darlin’. The list also features Jeff Parker’s hopeful “Like Swimwear (Part One)”, a dubstep‑rap hybrid “Duro” from Skrillex and Young Miko, and Cass McCombs’s garage‑rock anthem “Seeing the Elephant”.Listeners can stream the full playlist on Spotify, Apple Music, Tidal, or other services, ensuring the week’s most inventive indie and electronic releases are just a click away.

Richard Walker, executive chair of the Iceland supermarket chain and Labour’s appointed cost‑of‑living tsar, told BBC Radio 4’s Today programme that the government should extend the 5‑pence fuel duty cut beyond its September expiry to cushion households from soaring petrol prices. The call comes as the Strait of Hormuz—a vital conduit for roughly one‑fifth of the world’s oil—remains blockaded after the United States and Israel launched attacks on Iran at the end of February. The disruption has triggered a sharp rise in global oil prices, intensifying pressure on the UK economy. Under current policy, UK fuel duty is frozen until September, when a review is scheduled. By contrast, Australia recently announced a 14‑pence‑per‑litre cut to its fuel tax, highlighting the disparity with the UK’s modest 5‑pence reduction. Walker emphasized on air: “Given where we are, we need to be thinking about extending or enlarging the existing cut.” He noted that the original 5‑pence reduction was introduced by the Conservative government in March 2022. Chancellor Rachel Reeves had pledged in her November budget to keep the cut in place until August, followed by a gradual increase over five years. Prime Minister Keir Starmer has signalled that the planned September rise will remain “under review” in light of the ongoing conflict. Data from the RAC shows that, since the war began, the average price of a litre of diesel at UK forecourts has jumped 30 % to 185.2 pence, while petrol has risen 16 % to 154.5 pence per litre. Opposition parties are also weighing in: the Conservatives propose scrapping VAT on energy bills for several years, Reform UK calls for a VAT cut on fuel, and the Liberal Democrats advocate a 10‑pence fuel duty reduction.

Labour has challenged Nigel Farage over the cost of his private jet trip to the Maldives, questioning his claim that it cost as little as £25,000. Farage, the leader of Reform UK, initially recorded the two-day trip as costing £12,500, funded by Thailand-based Reform megadonor Christopher Harborne, before later upgrading the cost to £25,000. The Labour Party's chair, Anna Turley, wrote to Farage arguing that chartering a private jet of a similar size would cost many times more than the sum declared. According to publicly available flight logs, the 11,000-mile round trip lasted just over 23 hours, using a model of plane that is currently advertised on multiple private jet websites as costing at least $11,500 (£8,500) per hour to charter. Turley highlighted that the plane's ownership is linked to Harborne, who has given the party more than £12m. She asked Farage to clarify how he valued the cost of the flight, which did not end in him reaching the Chagos Islands, as he did not have permission. Farage has described the visit as a "humanitarian mission", saying he undertook the trip to highlight the plight of the Chagossians, whose families were removed from the islands in the 1960s and are seeking to return. The trip has sparked controversy over the valuation of the private jet donation and Farage's attempts to reach the Chagos Islands, which are subject to a UK government decision to hand sovereignty to Mauritius.