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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

The Historical Detective's QuestIn the spring of 2011, author Raf Nicholson embarked on a PhD journey to document the history of women's cricket, only to find a startling lack of resources at the MCC library at Lord's. The women's cricket section contained merely three books, including Rachael Heyhoe Flint's 1978 autobiography. This discovery sparked a decade-long mission to uncover the hidden history of women's cricket, culminating in his book 'The Women in Whites: A History of Women's Cricket in England' published in June 2026.The Lancashire Cowshed TreasureThe breakthrough came when Nicholson was directed to the Women's Cricket Association archive, stored in a former cowshed in a tiny hamlet eight miles east of Blackpool. There, amidst garden furniture and farming equipment, he discovered historical treasures including minute books dating back to 1926 when the WCA was formed, scrapbooks, letters, tour diaries, and newspaper cuttings. Spending two weeks in the summer, Nicholson made daily six-mile round trips from a nearby B&B; to meticulously document these invaluable materials.Pioneers of the Women's GameThrough his research, Nicholson brought to light key figures in women's cricket history. Betty Archdale, captain of the 1934-35 Australian tour, earned the nickname 'Hitler' for her distinctive leadership style. Myrtle Maclagan, daughter of an army officer, demonstrated exceptional cricket prowess with seven for 10 in the first women's Test and the first Test hundred in women's cricket. Marjorie Pollard, the WCA founder, maintained strict dress codes that required women to play international cricket in skirts until 1997, believing 'trousers are beyond the pale'.Overcoming Financial and Social BarriersResearch revealed the constant financial struggles faced by the WCA and women's cricket players. England batter Chris Watmough described writing hundreds of letters begging for financial support for the 1968-69 tour to Australia and New Zealand, which resulted in sponsorship from lingerie brand Berlei. Coach Ruth Prideaux had so little money for the 1993 World Cup that players slept on blow-up mattresses in her living room and trained by running along Eastbourne beach. Norma Izard famously borrowed a wok from MCC kitchens to burn a miniature bat, creating the first Women's Ashes trophy in 1998.Preserving a LegacyMany of the pioneering women Nicholson researched and interviewed have since passed away, but their stories live on through his book. The research journey also led to the MCC acquiring the complete WCA archive in 2017, moving the historical materials from the Lancashire farm to Lord's. This collection now serves as a valuable resource for future researchers, ensuring that the rich history of women's cricket is preserved and accessible for generations to come.

The Legendary Singer's Reflections Barry Manilow, the iconic singer behind hits like 'Copacabana' and 'Can't Smile Without You,' recently opened up about his life, career, and fans in a candid interview. As he approaches his 82nd birthday, Manilow shares his thoughts on love, coming out, and the changing landscape of the music industry. Fans and Adoration Manilow reminisced about his early days as a performer, recalling the enthusiastic fans who would shower him with gifts, including lingerie. 'The knickers that get thrown are bigger now!' he joked, highlighting the evolution of his fanbase over the years. Love and Relationships The singer also spoke about his experiences with love and relationships, including his journey as a gay man in the public eye. Manilow's openness about his personal life has endeared him to fans and helped pave the way for future generations of LGBTQ+ artists. A Life of Music and Love As Barry Manilow celebrates his 82nd birthday, his legacy as a singer, songwriter, and performer continues to inspire new fans. With a career spanning decades, Manilow's music remains a staple of popular culture, and his commitment to living authentically has made him a beloved figure in the entertainment industry.

The Guardian’s latest review of Beetlejuice: The Musical notes that the production has turned Tim Burton’s cult‑film into a Halloween‑like, shock‑jock musical extravaganza now playing at the Prince Edward Theatre until 17 April. The show mixes grotesque humor, topical references and high‑octane staging, delivering a wild but uneven theatrical experience.Beetlejuice Musical Reanimates Tim Burton’s Cult Classic on the West EndOriginally staged on Broadway in 2019, the London version abandons the film’s “less‑is‑more” restraint. The titular character, played by David Fynn, bursts onto the stage with a self‑aware ballad, immediately setting a tone of anarchic satire. The production leans heavily into contemporary jokes—hip‑ster vaping, six‑seven slang, and even a jab at Andrew Lloyd Webber—while preserving the film’s macabre spirit.Creative Team’s Off‑kilter Vision Drives the Show’s AestheticDirector Alex Timbers orchestrates a chaotic visual palette: Kenneth Posner’s lighting creates an uncanny glow, Peter Nigrini supplies trippy projections, and set designer David Korins transforms the theatre into a haunted house complete with a sandworm that slithers through the auditorium. Costume designer William Ivey Long delivers “toxic yet sparkly” outfits, from Miss Argentina’s glittering ensemble to Lydia Deetz’s spidery black lace. The special‑effects team—Jeremy Chernick, Michael Weber and puppeteer Michael Curry—adds a layer of tactile wonder, most memorably a roast pig that stands upright during a possession scene set to “Day‑O.”Critical Reception Highlights Strengths and WeaknessesThe review praises standout performances: Hannah Nordberg brings “drop‑dead energy” to Lydia, while David Hunter and Chelsea Halfpenny convincingly portray the newly deceased Maitlands. However, the script’s rapid swing between the Netherworld and the living world can feel “tiresome,” and the musical numbers, though varied, are described as “oddly unmemorable.” The show’s relentless gag‑fest is likened to a “Netflix megastar stand‑up desperate to cause outrage,” suggesting that the novelty may wear thin over a full run.What Lies Ahead for Beetlejuice on the London StageDespite its unevenness, the production’s bold visual identity and strong cast give it a solid footing in the competitive West End market. If the show can harness its cult‑film fanbase and attract audiences seeking a high‑energy, Halloween‑style experience, it may enjoy a sustained run beyond the current booking. Conversely, word‑of‑mouth about the “scattershot dialogue” could limit its appeal to repeat‑viewers, making the next few weeks critical for box‑office momentum.

Early Reading Memories Virginia Evans shares her earliest reading memory, reading either 'The Velveteen Rabbit' by Margery Williams or poems from 'Where the Sidewalk Ends' by Shel Silverstein with her sister. Favorite Books Growing Up Evans loved mysteries and fantasy worlds, reading many Nancy Drew books, 'The Boxcar Children' by Gertrude Chandler Warner, and 'The Wind in the Willows'. She enjoyed books about things that can't exist, calling it escapism. The Book That Changed Her as a Teenager At 15, Evans read John Steinbeck's 'The Grapes of Wrath', which gave her a new understanding of what fiction can do and how words can portray complex living. The Writer Who Changed Her Mind Evans praises Joan Didion, saying every time she reads Didion's work, she is changed in some way, seeing the world, people, and politics differently. The Book That Made Her Want to Be a Writer In college, Evans read Jhumpa Lahiri's 'Interpreter of Maladies', which inspired her to write, making her think: 'I have to do this, I can do this, I will do this'. The Author She Came Back To Evans tried Jane Austen's 'Pride and Prejudice' too young, but when she came back to it in her late 20s, she enjoyed it tremendously. Books She Rereads Daphne du Maurier's 'Rebecca' Steinbeck's 'East of Eden' The Book She Could Never Read Again Evans devoured the Millennium series by Stieg Larsson but was too disturbed to read it again. The Book She Discovered Later in Life Evans didn't read 'Little Women' by Louisa May Alcott until her adult life, relating to the mother character and identifying with Jo's struggles as an author. Current and Comfort Reads Currently reading: 'While I Was Gone' by Sue Miller Comfort reads: 'The Uncommon Reader' by Alan Bennett, 'Beautiful Ruins' by Jess Walter, 'I Capture the Castle' by Dodie Smith

Translated Fiction Review Roundup A collection of recent translated fiction has been reviewed, showcasing the diversity and complexity of global literature. The reviews include: 'Sisters in Yellow' by Mieko Kawakami Sisters in Yellow by Mieko Kawakami, translated by Laurel Taylor and Hitomi Yoshio (Picador, £16.99) Kawakami’s latest opens with a bang, as narrator Hana learns that her old friend Kimiko has been charged with abduction. This MacGuffin takes us to their friendship in late-1990s Tokyo, when teen Hana and the older woman open a bar called Lemon: “Yellow attracts money.” But it’s a turbulent ride and soon Hana is in a world of organised crime. “The world is crazy. I feel like I’m living in a manga.” She’s not the only one, and you need an appetite for Kawakami’s style, which prefers to explore rather than explain – people come and go, buildings burn down, cancer is diagnosed, almost at random – but the relentless rush means there’s no time to get bored. At its best – as in a scene where Hana’s unreliable mother wants to borrow 2m yen for investment in lingerie that helps “your spine and organs move back to where they’re supposed to be” – this is a story both absurd and horrifying. 'All Flesh' by Ananda Devi All Flesh by Ananda Devi, translated by Jeffrey Zuckerman (Pushkin, £12.99) “Forgive me for starting this story with bodily, unpalatable origins.” You may as well – it’s all like that. In an unnamed European country, a schoolgirl “born with no urge but to consume” is getting bigger and bigger. “My gut, my ass, my thighs – they were all set on reaching the farthest corners of the world.” She blames her gluttony on the need to silence the voice of her dead twin sister, who was “absorbed into my tissues” in the womb. She hates school, where other kids mock her, as though her own self-disgust weren’t enough. After a blackly comic scene where she gets stuck in her bedroom doorframe like “an uncooperative cork”, she falls in love with the lonely carpenter who arrives to widen the door – but there are more twists to come. This powerful story is deeply physical, but driven by a compelling voice describing the torment of a girl who is “the psychical mirror of our time … immoderation made manifest”. 'The White Desert' by Luis López Carrasco The White Desert by Luis López Carrasco, translated by Rosalind Harvey (Granta, £14.99) This unpredictable book, comprising five linked stories about a Spanish couple, opens with the end of the world and gets weirder from there. A balloon debate about a post-apocalyptic scenario turns nasty when one participant pulls a knife, or thinks he does. A plane crash-lands on an island. “Can [we] go and get our luggage … Lots of people have, you know, soiled themselves.” What links the scenes is a sense of disconnection in our connected world, but the book subverts expectations: when a group of people celebrating New Year’s Eve go missing, it turns out to be a game of hide and seek. Footnotes peppered throughout suggest we’re viewing all this from the future (“Emirates was a well-known passenger airline …”), and discovering what the white desert is turns everything on its head. For readers who like to do their own joining up, and who want a playful, original take on our precarious lives, this is a thought-provoking treat. 'The Home of the Drowned' by Elin Anna Labba The Home of the Drowned by Elin Anna Labba, translated by Elizabeth Clark Wessel (Harvill, £16.99) “You could have waited, you bastards.” In 1942 Lapland, a village occupied by the semi-nomadic Sámi people is flooded by a new hydroelectric plant’s dam. One family watch as their goahti (peat-covered hut) disappears under the water. “It wasn’t the nicest goahti,” says Ánne. “No, but it was mine,” says her sister Rávdná. When Rávdná wants to build a house to replace it, the authorities refuse permission: the Sámi way of life has been rejected but alternatives are not permitted. A local newspaper half-heartedly offers to publicise their case, but “we receive a lot of angry letters if we use any foreign words”. When the government tells local people the new dam “will lift us out of poverty and injustice”, the words reek with irony. This intimate story of infuriating discrimination is, Labba says, based on real events in Sweden.

The Dark Side of the Space Race 'Star City' is a gripping space race thriller that serves as a counterpoint to 'For All Mankind', exploring what if the Russians had been the first to land on the moon. The series, created by Ronald D Moore, Ben Nedivi, and Matt Wolpert, shifts its focus to the USSR, delving into the lives of characters behind the iron curtain. Alternate History and Character Development The show is set in 'Star City', a Soviet equivalent of Cape Canaveral, where the characters celebrate the success of Alexei Leonov walking on the moon. The story follows Lyudmilla, a terrifying colonel in the Great Patriotic War and head of KGB surveillance, played by Anna Maxwell Martin. The series weaves together the daily compromises, doubts, stresses, and accidental indiscretions of characters living under a strict regime. The Impact of a Strict Regime The show masterfully layers the tension and fear of living in a regime where every word must be considered, and every decision is carefully calibrated to minimize risk. The characters' lives are marked by the constant threat of repercussions, making even the smallest actions potentially fatal missteps. A Deep Dive into Human Nature 'Star City' offers space history fans a deep dive into the 'what if?' possibilities surrounding the space race, while also exploring broader themes of human nature. The show examines how people survive intolerable stress, and what they will do to be free, making it a fascinating watch for a broad audience. Conclusion and Availability 'Star City' is now available on Apple TV, offering a unique perspective on the space race and the human experience. With its gripping storyline and exceptional performances, including Anna Maxwell Martin's portrayal of Lyudmilla, this series is a must-watch for fans of historical dramas and space thrillers.

The Family's Mission to Save the Glutinous Snail Ian Hughes and his son, Ben, are driving through the hills of north Wales with an array of homemade animal artefacts. They finally reach Llyn Tegid – Bala Lake, where, knee-deep in the water, Ian brandishes two glutinous snails. The snails have been driven to extinction in England by poor water quality. Pollutants from agriculture and industry have ruined their habitats in ponds, ditches, lakes, and streams. The lake in Gwynedd hosts the last remaining wild population of glutinous snails in Britain. The Conservation Efforts Hughes has dedicated more than a decade to conserving the tiny mollusc and other rare species. This year, the Department for Environment, Food and Rural Affairs (Defra) has listed the snail as one of the threatened species that will benefit from a £60m government funding boost. With the funding, the British and Irish Association of Zoos and Aquariums will receive support to build ark populations of the glutinous snail, while the Freshwater Habitats Trust hopes to use new resources to find locations suited to wild reintroductions. The Impact of Conservation Hughes's passion for invertebrates extends to convincing other people to care about them. He writes children's books, which Ben illustrates, about the species he has studied, and the pair sell T-shirts showcasing their wildlife drawings. Ben says, 'Well, why do we matter? We're part of a huge living system. If you take a cog out of a machine, it doesn't work any more.' The Future of the Glutinous Snail Now, Hughes hopes the Defra funding will help the conservation efforts he has long championed. The goal is to keep the snails moving and preserve their population. By continually moving snails from one container to another, Hughes and his family aim to prevent the water from becoming polluted and ensure the survival of the species.

The Appeal of Period Homes with Modern ExtensionsPeriod properties in England continue to capture the imagination of homebuyers seeking a blend of historical character and contemporary living. The trend of adding stylish extensions to these heritage homes has created a unique niche in the property market, offering the best of both worlds – original features with modern functionality.Architectural Harmony: Blending Old with NewSuccessful period home extensions require careful consideration of architectural harmony. Leading architects specializing in heritage properties emphasize the importance of respecting the original building's character while introducing modern elements that complement rather than compete with the existing structure. This approach has resulted in some stunning transformations across England's historic towns and cities.Market Value and Premium PricingProperties that successfully blend period charm with contemporary living spaces command premium prices in England's real estate market. Recent sales data indicates that well-designed extensions can increase a property's value by 15-25%, with some exceptional cases achieving even higher returns. This financial incentive has driven many homeowners to invest in thoughtful extensions that enhance both lifestyle and investment potential.Popular Extension Styles and FeaturesThe most sought-after extensions include open-plan kitchen-dining areas that flow seamlessly from original reception rooms, glass-walled extensions that flood interiors with natural light while preserving sightlines of period features, and orangery-style spaces that bridge the gap between traditional and contemporary design. Modern amenities under these historic roofs often include underfloor heating, energy-efficient glazing, and smart home technologies discreetly integrated into the original fabric.Regional Hotspots for Period Home ExtensionsCertain areas of England have become particularly known for their innovative period home extensions. London boroughs like Camden and Richmond see frequent transformations of Victorian and Georgian properties, while cities such as Bath, York, and Cambridge showcase remarkable blends of architectural heritage with contemporary design. The Cotswolds and other rural areas also feature prominently, with barn conversions and farmhouses receiving sensitive yet modern updates.Future Trends in Period Property RenovationAs sustainability becomes increasingly important in the property sector, period home extensions are evolving to incorporate eco-friendly features. From solar panels integrated into roofs sympathetic to the original style to heat pumps disguised within period-appropriate outbuildings, the future of period home renovation lies in sustainable modernization. Additionally, there's growing interest in multi-generational living solutions, with extensions designed to accommodate extended families while maintaining the property's historical integrity.