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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

Weekly Wildlife Roundup: Top Predator StoriesThe latest Guardian wildlife column spotlights three notable predator encounters that illustrate how large and medium‑sized carnivores are adapting to a rapidly changing environment.Leopard Lurks Near Human SettlementsA leopard was observed prowling close to a rural village, prompting both awe and concern among residents.Location: Rural community bordering protected landBehavior: Stealthy movement along forest edges, no direct conflict reportedSignificance: Highlights the thinening buffer between protected habitats and human activityFox's Fortunate Encounter Highlights Urban AdaptationA fox managed to evade a potential roadkill scenario, showcasing its agility and growing comfort in suburban settings.Incident: Narrowly escaped a busy roadway after being spotted by local observersAdaptation: Utilises garden waste and small mammals in urban green spacesImplication: Demonstrates the species' resilience and the need for safe wildlife corridors in citiesCoyote's Clever Behavior Signals Expanding RangeIn a separate observation, a coyote displayed problem‑solving skills while foraging near a suburban park.Behavior: Used a fallen branch to access a bird feederRange: Sightings are moving further north than historic recordsEcological Impact: Potential competition with native mesopredatorsWhat These Predator Movements Mean for Ecosystem ManagementCollectively, the sightings point to a broader trend of predators navigating fragmented landscapes, which raises questions for land‑use planners and conservationists.Increased human‑wildlife interactions demand proactive conflict‑mitigation measuresHabitat corridors become critical for maintaining genetic flowMonitoring programs must adapt to track both apex and mesopredators across mixed‑use zonesLooking Ahead: Conservation Priorities for Apex and MesopredatorsFuture efforts should focus on integrating community education, habitat connectivity, and data‑driven management to ensure coexistence.Promote citizen‑science reporting to fill observation gapsInvest in green infrastructure that accommodates predator movementDevelop region‑specific guidelines that balance agricultural, urban, and wildlife needs

Lead: War Day 84 Marks a Shift Toward DiplomacyThe conflict between Iran and the United States entered its 84th day with renewed diplomatic activity. Both sides are exchanging draft proposals, and US Secretary of State Marco Rubio highlighted "some good signs" while President Donald Trump warned of "very drastic" action if Tehran refuses to relinquish its uranium stockpiles.Mediated Negotiations Gain MomentumPakistani officials are conducting "intense mediation activity" in Tehran, according to Al Jazeera correspondent Almigdad Alruhaid. Senior Iranian sources say negotiators are close to a draft framework, though others caution that a final agreement remains premature.Pakistani mediation is accelerating to prevent further escalation.US‑Iran red‑line shift: Cato Institute senior fellow Doug Bandow stresses the need for both parties to move beyond entrenched nuclear red lines.Key Figures and Financial Stakes7,200 civilians rescued from rubble by the Iranian Red Crescent.More than two dozen MQ‑9 Reaper drones destroyed, losses estimated at $1 bn (≈20% of pre‑war inventory).At least 42 US aircraft damaged or destroyed, total losses near $2.6 bn.US has paused a $14 bn arms sale to Taiwan to preserve munitions for the Iran campaign.Regional and Military ImplicationsCentcom reports the USS Abraham Lincoln strike group remains at "peak readiness" in the Arabian Sea, signaling continued pressure despite diplomatic overtures. Meanwhile, Israeli strikes in southern Lebanon and new US sanctions on Hezbollah allies heighten the risk of a broader regional flare‑up.Outlook for a Potential DealIf the current draft proposals survive scrutiny, a diplomatic settlement could emerge within weeks, easing military pressure and opening pathways for humanitarian aid. However, the dual track of high‑cost equipment losses and political warnings from both Washington and Tehran suggests that any agreement will require substantial concessions on nuclear constraints and future US military commitments in the region.

The LeadA friend of mine was recently left in tears after filling up the car she relies on to drive to work. Thanks to the US-Israeli attacks on Iran, prices at the pumps have soared. She wasn't sure how her family was going to make it to the next paycheck.It is a personal story and a distressing one, but the big picture is truly obscene. Fossil fuel companies are raking in monstrous, unearned war profits taken from the pockets of people like you, me, my friend, and any of us who fills up a vehicle or pays an energy bill.The War-Profits Bonanza$30m an hour: that's the pure, unearned profits banked by the world's top 100 oil and gas companies in the first month of the conflict in Iran, purely due to the spike in the oil price. Now the first numbers are in, and that $30m may have been a major underestimate.Shell's profit for the first three months of 2026 more than doubled to $6.9bn, as did BP's, to $3.2bn. TotalEnergies profits also surged by more than 50%, up to $5.8bn. Even in the Gulf itself, where the flow of oil through the strait of Hormuz has been heavily restricted, some companies have still flourished. Aramco, the state oil company of Saudi Arabia, saw its profits soar by 26% to $33.6bn in the first quarter.The Financial Impact on ConsumersThose four companies alone, benefiting not just from the oil price hike but also bumper oil-trading profits, made $23m an hour for the whole of January, February and March. And the Iran conflict only started on 28 February.To get some idea of the scale of this, imagine I gave you $6,200. What would you do? Pay off a loan? Book a fancy holiday? A second later, I give you another $6,200; then again, for hours, weeks and months. That is the rate of profit of just those four companies.There is plenty more to come for the industry. Oil and gas supplies will take months to return to prewar levels, and reserves are getting dangerously low. Even if the oil price remains at today's level of about $100 a barrel, those 100 companies will make $234bn by the end of the year. Remember, the companies, and petrostates such as Russia, have done no extra work for this, just ridden a soaring oil price. Also remember, you are paying for this. Where I live in the UK, household energy bills are about to jump by £209 ($280) a year for the average home.The Industry's Climate ObstructionThe profits are extreme, but not new: big oil and gas has been wildly profitable for decades. It has made an average $1tn a year in pure profit for about 50 years. The fossil fuel sector also benefits from explicit subsidies that totalled $1.3tn in 2022, according to the International Monetary Fund.These riches have funded the lobbying and campaigns that block climate action and have done so for years, long after the science became crystal clear. As an example of the consequences, the UK's official climate advisers said on Tuesday that all care homes and hospitals will need air conditioning within the coming 10 years, to stop the heat killing people.The Green Transition AccelerationBut here's that silver lining I promised: these peak profits contain the seeds of their own downfall. Sky-high fossil fuel prices are pushing people, companies and nations to supercharge their rush towards green power for the simple reason that it is now cheaper and more reliable. Solar power does not need to transit through the strait of Hormuz, as Bill McKibben has observed.The numbers on the surge in renewable energy deployment, already exponential, are not yet in, but they will almost certainly be huge. Green funds are already attracting billions of dollars in new investments and one consultancy estimates that an oil price of $100 a barrel will drive $4tn of extra green investment by 2030.Big oil remains a formidable political force but, on the ground, people are already voting with their feet. Sales of new electric cars in the UK leapt by 59% in April, for example. The pain and anger of today's energy crisis may yet become a critical turning point in confronting the climate crisis.

Meta has reached a confidential settlement with Breathitt County Schools in Kentucky, ending a lawsuit that alleged the company’s social networks are engineered to be addictive and cause mental‑health harm to students.Meta Settles Kentucky School District Lawsuit Over Alleged Addiction DesignThe settlement was announced less than three weeks before the case was set to go to trial in federal court in California. While the exact terms were not disclosed, Meta emphasized its ongoing work on safety tools such as Teen Accounts and parental controls.Financial Stakes and Settlement LandscapeThe Kentucky district originally sought more than $60 million to cover mental‑health services and a 15‑year remediation program.Meta’s settlement follows similar agreements by TikTok and Snap with the same group of roughly 1,200 school districts.Recent jury verdicts ordered Meta and YouTube to pay $6 million in damages and Meta to pay $375 million in civil penalties for related claims.Implications for Social Media Regulation and Child SafetyThe case adds pressure on the industry to redesign features such as infinite scrolling and autoplay video, which plaintiffs argue are deliberately addictive. Lawmakers and advocacy groups are citing these lawsuits as evidence that existing self‑regulation is insufficient, potentially accelerating federal or state legislation aimed at protecting minors online.Future Legal Battles and Industry OutlookAttorneys for the remaining school districts say they will continue pursuing justice, with another 1,200 districts still in litigation. Upcoming trials include an individual case in California and a Tennessee attorney‑general suit slated for July, while a federal case by the Tucson Unified School District is scheduled for January 2027. The outcomes of these cases will likely shape the next wave of social‑media liability and could force broader industry changes.

The LeadThe Guardian's Politics Weekly podcast has brought attention to allegations of a new financial arrangement involving former President Donald Trump, which critics are calling a "slush fund" designed to benefit his associates and allies.The Financial Arrangement DetailsThe podcast examines the structure and purpose of this fund, which has emerged as a subject of political controversy. While specific details about the fund's operations remain limited, the discussion centers on how such arrangements might influence political processes and donor relationships.The Political Impact AnalysisThis development comes at a time when political financing and ethics are under increased scrutiny. The alleged slush fund could potentially reshape perceptions of Trump's political operation and influence fundraising strategies for upcoming elections.The Future OutlookPolitical observers are watching closely to see how this story develops and whether it will have any lasting impact on Trump's political standing or the broader conversation about campaign finance reform in the United States.Listen to the full episode on Politics Weekly YouTube channelCheck out The Guardian's US podcast: Stateside with Kai and CarterSend questions and feedback to [email protected] The Guardian at theguardian.com/politicspodus

The US-Taiwan Arms Sale Pause A top official in the United States military has said Washington is pausing a $14bn arms sale to Taiwan to conserve munitions for its war on Iran. Details of the Pause Acting Navy Secretary Hung Cao provided the update to lawmakers during a Senate hearing on Thursday, a week after the weapons sale took centre stage in talks between US President Donald Trump and Chinese leader Xi Jinping in Beijing. Cao told the Senate Appropriations Subcommittee on Defense that the US is pausing the sale to ensure it has enough munitions for its potential conflict with Iran. The decision to move forward with the sale would be made by Secretary of Defense Pete Hegseth and Secretary of State Marco Rubio. Impact on Taiwan's Defense Taiwanese Premier Cho Jung-tai told reporters on Friday that Taiwan would continue to pursue arms purchases, according to Taiwanese news outlet FTV News. William Yang, senior analyst for northeast Asia at the Crisis Group, said in a social media post that the pause will “exacerbate anxiety and scepticism about US support in Taiwan and make it difficult for the Taiwanese government to request additional defence budget for the foreseeable future”. The Iran Conflict and US Military Preparedness The war has been paused since the US and Iran agreed to a ceasefire on April 8, but the sides have yet to reach a permanent peace deal. “Right now, we’re doing a pause in order to make sure we have the munitions we need for Epic Fury – which we have plenty,” Cao said. Future Outlook Trump, who has confirmed that he discussed the arms sale with Xi, said last week in an interview with Fox News that he “may” or “may not” approve the package. Trump has also suggested that the package could be used as a “negotiating chip” – despite a decades-old precedent against consulting with Beijing on arms sales.

Senate Delays Immigration Enforcement Vote Amid Internal GOP PushbackThe Republican‑led Senate put off a vote on a $72 bn immigration enforcement package ahead of a long holiday weekend, marking a rare public rebuke of President Donald Trump from within his own party.Trump’s $1.776 bn “Anti‑Weaponisation” Settlement Sparks Senate ScrutinyOn Monday the administration announced a settlement that earmarked nearly $1.776 bn for an “anti‑weaponisation” fund intended to compensate parties the government allegedly treated unfairly. The settlement arose from Trump’s lawsuit against the Internal Revenue Service over a 2019 tax‑refund leak. Senate Republicans summoned acting Attorney General Todd Blanche to question the use of Justice Department money that normally bypasses congressional approval.Senators voiced concern:Don Bacon (Nebraska) warned that the move “smells” of conflict of interest and has eroded Trump’s Senate backing.Thom Tillis (North Carolina) called the fund “stupid on stilts” and predicted public rejection.Fiscal Numbers: $72 bn Immigration Bill vs. $1.8 bn Settlement and $1 bn Ballroom Request$72 bn – total amount of the immigration enforcement bill slated for vote.$1.776 bn – allocated to the anti‑weaponisation fund.$1 bn – Trump’s proposed addition for a White House ballroom, later removed from the bill.The ballroom addition would have blocked the use of budget reconciliation, a streamlined voting process that requires only a simple majority.Political Ramifications for Trump and the Republican CaucusThe internal dissent highlights a fracture in GOP loyalty. Senate Majority Leader John Thune described the bill’s evolution as “more complicated than it should be,” noting that the ballroom request forced leaders to reconsider the legislative strategy.House Republicans also delayed a war‑powers resolution on the US‑Israeli conflict with Iran, further illustrating coordinated maneuvering ahead of the Memorial Day recess.What’s Next: Legislative Outlook After the Memorial Day RecessThe Senate reconvenes in June. Thune signaled that Republicans will “pick up where we left off,” suggesting the immigration bill may return without the ballroom provision, preserving the reconciliation pathway.Key questions moving forward:Will the anti‑weaponisation fund be re‑approved or redirected?Can Trump secure alternative funding for the ballroom without jeopardising the immigration package?How will the Senate’s internal pushback affect Trump’s broader legislative agenda ahead of the 2026 midterms?

The San Diego Mosque Attack Funeral More than 2,000 people have gathered in a park in San Diego, California, to mourn a security guard and two other men murdered as they tried to stop this week’s attack on the city’s largest mosque. Details of the Funeral Service Mourners, including police officers in uniform, stood in rows for the Islamic funeral prayer, or Janazah, on Thursday. The bodies of the three men — 51-year-old Amin Abdullah, 78-year-old Mansour Kaziha, and 57-year-old Nadir Awad — lay beneath cloth, underneath a white canopy. The Impact of the Attack “God is the greatest,” the attendees chanted in Arabic, raising their hands. Many remembered the three men as heroes for delaying and distracting the two teenage suspects who opened fire at the Islamic Center of San Diego on Monday, during school hours. The Victims' Actions During the Attack Police have indicated that the three victims’ actions likely prevented further bloodshed. Amin Abdullah, the centre’s security guard, engaged in a gun battle with the teenage assailants and used his radio to order a lockdown at the mosque, which houses a primary school with 140 students. The Future Outlook “Today is a message to everyone: Our community got hurt, but our community is standing strong and firm,” said the centre’s imam, Taha Hassane. The victims are set to be buried alongside one another later in the day at a nearby cemetery.