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The conflict in Gaza has resulted in a significant number of amputations, with over 6,000 adults and children undergoing amputations since October 2023, according to the WHO and Palestinian Ministry of Health. Ola Jamal, 36, is one of the many Palestinians who have been forced to flee Gaza due to the conflict. She was breastfeeding her two-month-old son, Zain, when a missile struck al-Nasr hospital in Gaza, causing her to lose her arm. Jamal and her family were forced to separate, with her children being cared for by another family. This traumatic experience has had a lasting impact on Jamal and her children, with her son Zain still experiencing nightmares and trauma two years after the event. Shadi Sharif Ayesh al-Sous, a father of two, lost his leg in a missile strike while collecting firewood. He had his leg amputated above the knee and now waits to return home to Gaza. However, many Palestinians in Egypt face significant challenges, including restricted access to healthcare and prosthetic care due to their uncertain legal status. Yousef El Deeb, a certified prosthetist at Orthomedics in Cairo, says his clinic has treated about 300 Palestinian patients since October 2023, mostly through the support of NGOs. However, the lack of documentation and uncertain legal status of Palestinians in Egypt makes it difficult for them to access long-term prosthetic care without the support of NGOs. The situation for Palestinians in Egypt is further complicated by their lack of formal residency or refugee status. Without valid residency permits, survivors are often restricted to hostels or share a flat with other families, unable to work and living under the constant pressure of temporary status. This lack of documentation makes accessing hi-tech, long-term prosthetic care almost impossible without the support of NGOs.

Matthew Macfadyen headlines the new Sky Atlantic series ‘The Miniature Wife’, playing scientist Les Littlejohn, a brilliant but ethically dubious researcher who accidentally shrinks his wife Lindy (Elizabeth Banks) to six inches tall. The premise promises a darkly comic exploration of marital power dynamics and modern misogyny. However, the show quickly abandons this fertile ground. Showrunners Jennifer Ames and Steve Turner opt for a frenetic, screwball tone that feels forced, leaving the underlying commentary underdeveloped. The central conceit – a miniature wife trapped in a dollhouse – is treated more as a visual gag than a vehicle for satire. The series is littered with side plots that never coalesce. A subplot about a misattributed short story attempts to touch on authorship and truth in the digital age, yet it remains a superficial gesture. Likewise, the ensemble cast—including Zoe Lister‑Jones as a lab overseer, O‑T Fagbenle as a lovelorn colleague, and Sian Clifford as Lindy’s agent—offers colorful moments but fails to achieve narrative momentum. Visually, the production delivers inventive set pieces: Lindy’s daring escapes from towering household objects and explosive laboratory experiments provide occasional laughs. Nevertheless, the novelty wears thin before the series’ nearly ten‑hour runtime concludes. The original short story by Manuel Gonzales required far more expansion than the show supplies, resulting in a stretched‑out narrative that would have benefited from a tighter format. In short, while Macfadyen’s performance is competent, it is largely wasted in a series that promises depth but delivers only scattered comedy. ‘The Miniature Wife’ may satisfy viewers seeking light‑hearted antics, but it falls short of the incisive satire its premise suggests. The series is available on Sky Atlantic, streaming on Now in the UK and on Stan in Australia.

A British warship together with a Royal Air Force P‑8 maritime patrol aircraft monitored three Russian submarines that were trying to survey key undersea infrastructure in the North Atlantic, the defence secretary John Healey said at a Downing Street briefing.Healey explained that the operation, which lasted **over a month**, took place not within UK territorial waters but in the country's exclusive economic zone – the area extending up to 200 nautical miles from the coastline and bordering neighbouring zones.The Russian vessels comprised an Akula‑class nuclear‑powered submarine and two deep‑sea research submarines from the GUGI directorate, a unit that normally conducts peacetime surveys of underwater infrastructure but possesses the capability to damage it in conflict.According to the minister, the British forces tracked and deterred any malign activity around the submarines 24/7, deploying regular sonar buoys to demonstrate continuous monitoring. The presence of the Royal Navy ship and the P‑8 aircraft, supported by NATO allies, left the Russian crews with “no doubt that they were being watched”.As a result, the Akula submarine “retreated home” and the two GUGI subs subsequently exited the UK’s maritime zone, heading northward. The operation involved **about 500 UK personnel**.Healey stressed that there was **no evidence of damage** to any pipelines or cables, but that UK forces and allies would verify the integrity of the infrastructure. He warned President Putin that any attempt to sabotage the network would “not be tolerated and will have serious consequences”.The defence secretary framed the incident as proof that Moscow is “the primary threat to the UK and to NATO”, underscoring the need for heightened vigilance over undersea assets amid the broader security fallout from the Ukraine war and recent tensions in the Middle East.He also linked the episode to broader defence policy, stating that the successful deterrence demonstrates the UK’s ability to detect, deter and, if necessary, respond to threats against its critical maritime infrastructure, while calling for continued investment in defence capabilities.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

The author's four-decade groundhopping odyssey culminated on a dreary afternoon in December, watching his team lose 3-0 in a modern stadium. This journey, which began in 1982, has seen significant changes in football culture.Traditionally, fans displayed their allegiance by flying scarf outside their homes. Now, this practice has given way to executive car stickers and personalized number plates, reflecting a shift in how fans express their support.Visiting stadiums near town centers has become a rare treat, offering a sense of place and community. However, many pubs near grounds have closed, and clubs now encourage fans to buy beer inside the stadium, altering the pre-match experience.The introduction of safe standing and big flags has enhanced the fan experience. Yet, the author notes that clubs often require prior permission for large flags, suggesting a desire to control these displays of support.The commercialization of football is evident in sponsorship deals and advertising hoardings. The author humorously speculates about obscure sponsors, such as 'Betterwave' and 'D Catchesides Roofing.'Despite changes, some constants remain. The seasonal transition from autumn to winter, marked by a sense of accomplishment after a match day, endures. The author's reflections offer a nostalgic and insightful look at the evolution of football culture.

As rising temperatures push snakes and humans into closer contact, the world faces an estimated 5.5 million snakebites each year, resulting in 138,000 deaths and 400,000 lasting disabilities. In response, a Wisconsin‑based amateur scientist has taken an extreme route to help solve the crisis.For almost 20 years, Tim Friede, a former window cleaner, allowed some of the planet’s most lethal snakes to bite him, accumulating over 200 intentional bites. His goal: to provoke his own immune system into producing antibodies that could be harvested for a near‑universal antivenom.The endeavor has been perilous. Friede survived a coma after being bitten by two cobras within an hour, endured anaphylactic shocks, lost tissue in a finger, and even had to cut necrotic muscle from his leg. Yet he persisted, eventually becoming immune to the inland taipan—the world’s most venomous snake, whose single bite can kill more than 100 people.In 2019, California biotech firm Centivax hired Friede to extract his antibodies. Early laboratory work showed that his serum can neutralise toxins from 19 elapid species, including cobras, mambas, taipans, coral snakes and kraits—roughly half of all venomous snakes worldwide.The next step is a veterinary trial in Australia, slated for later this year, before any human application. If successful, the antivenom could dramatically reduce the burden of snakebite in low‑income regions across Asia and Africa, where most victims live.Climate scientists warn that warming climates will expand snake habitats and increase human exposure, as illustrated by the recent surge of rattlesnake bites in California’s Ventura County. This amplifies the urgency for scalable, affordable antivenoms, especially as international aid budgets face cuts and manufacturing capacity remains insufficient.Friede’s unconventional path underscores a broader lesson: confronting emerging health threats may require bold, unconventional science, but the potential payoff—a life‑saving treatment for millions—could be transformative.

Korean fried chicken, also known as yangnyeom chicken, has become a global phenomenon, with a presence in over 60 countries and more than 1,800 stores worldwide.The dish, which originated in South Korea, was introduced by American soldiers after the Korean War. However, it wasn't until the 1980s that a Korean chicken shop owner, Yoon Jong-gye, developed a sweet and spicy recipe that made it distinctly Korean.The cultural breakthrough for Korean fried chicken came in 2014 with the Korean drama My Love from the Star, which became a sensation in China and triggered a surge in popularity for Korean chicken restaurants.Today, Korean fried chicken is the most popular Korean food among international consumers, according to a South Korean government survey. The dish has become a staple in many countries, with chimaek, the portmanteau meaning 'fried chicken and beer,' entering the Oxford English Dictionary.The success of Korean fried chicken can be attributed to its simplicity, technique, and adaptability. Korean chicken brands have expanded internationally, with many offering a range of recipes tailored to local tastes.At the heart of Korean fried chicken's success is its unique cooking technique, which involves double-frying the chicken to achieve extra crispiness. The batter, typically made with potato or corn starch, holds up well under the sauce, allowing it to stay crisp even after being boxed up for delivery.Prof Joo Young-ha, a cultural anthropologist, argues that Korean chicken's global success stems from its simplicity and universal appeal. 'Unlike pork, chicken crosses religious prohibition boundaries,' he says. 'And unlike kimchi, which is treated like a side dish, or bibimbap, which isn't immediately obvious as a dish, fried chicken is immediately recognizable as a meal.'

The UK government announced legislation that will protect disabled claimants from an automatic reassessment of benefits when they begin paid employment or volunteering. The measure, dubbed the “right to try”, is slated to take effect at the end of April and aims to remove the fear of losing financial support that many say discourages job‑seeking. Minister for Social Security and Disability Sir Stephen Timms framed the policy as a reassurance for people “stranded in the benefits system”. He emphasized that the change also extends to volunteering, which he described as a vital stepping‑stone toward sustainable employment. The new rules will apply to recipients of Employment and Support Allowance (ESA), Personal Independence Payment (PIP) and the health element of Universal Credit. Under the current system, taking up work can trigger a reassessment that often leads to reduced or withdrawn support, a risk that has deterred many disabled individuals from seeking employment. Disability advocates welcomed the development but cautioned that it does not tackle the deeper obstacles faced by disabled job‑seekers. James Taylor, a director at the charity Scope, called the policy “a step in the right direction” but warned that “the odds are stacked against disabled people when it comes to finding suitable work”. He urged the government to fund personalised employment support and to halt further benefit cuts. Research from the flexible‑working nonprofit Timewise underscores the challenge: only 2.5% of long‑term sick or disabled individuals who are economically inactive manage to return to work each year, and more than half of those jobs last fewer than four months. Mikey Erhardt of Disability Rights UK highlighted that a secure “right to try” is essential to ensure that anyone who tries work can retain the same level of support if the venture fails. Critics also noted that the announcement coincides with a controversial reduction to the health element of Universal Credit, which will be halved for new claimants and frozen unless stricter eligibility criteria are met. Timms acknowledged the pressure this creates, saying the previous system forced people to prove they were “too unwell to work”. Campaigners fear the simultaneous cuts will exacerbate financial strain for disabled claimants already navigating an uncertain labour market. Erhardt warned that “hundreds of thousands of disabled people will experience yet another cut in living standards”, arguing that successive governments have treated social security more as a coercive tool than a safety net.

The United States' newly disclosed arrangement to transfer certain detainees to third‑country destinations has triggered a wave of criticism across the Democratic Republic of Congo (DRC). Local authorities and human‑rights groups argue that the deal undermines the DRC's sovereignty and raises serious concerns about the treatment of deportees. While details of the agreement remain limited, the backlash underscores growing tensions over migration policies that involve multiple nations. Critics in the DRC are calling for greater transparency and for the United States to reassess the humanitarian implications of the deportation scheme. Stakeholders emphasize that any such arrangement must comply with international law and respect the rights of individuals facing removal, warning that failure to do so could damage diplomatic relations between the two countries.