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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Sudan, one of the world's most impoverished countries, has been ravaged by a civil war that began in 2023. The conflict, driven by a power struggle between the army and the paramilitary Rapid Support Forces (RSF), has left the nation unrecognizable. Over 40,000 people have been killed, and about 14 million – a quarter of the population – have been forced to flee their homes. Civilian infrastructure across the country has been extensively damaged.“We are not just facing a crisis – we are witnessing the systematic erosion of a country’s future,” Luca Renda, the United Nations Development Programme’s (UNDP’s) resident representative in Sudan, told Al Jazeera. A report by the UNDP and the Institute for Security Studies highlights the scale of Sudan’s economic collapse. Even under the most optimistic scenario of peace being achieved in 2026, Sudan would still lose an estimated $18.8 billion in gross domestic product (GDP) by 2043.The war has had a devastating impact on Sudan's infrastructure and basic services. $6.4 billion was lost in GDP in 2023 alone, reflecting a simultaneous collapse across all major parts of Sudan’s economy. The destruction of infrastructure has triggered displacement and made it difficult for people to secure adequate housing or access basic services. Up to 40 percent of power generation capacity has been lost, and key water infrastructure has been destroyed or seized, cutting communities off from clean water and sanitation.The labor market has also been severely affected, with agriculture – once the backbone of Sudan’s economy – severely hit. Cultivated land has shrunk, adversely impacting rural livelihoods. Average incomes have fallen back to levels last seen in 1992. About 90 percent of manufacturing activity has been destroyed in key economic hubs, eliminating thousands of jobs.The oil industry has suffered significantly, with oil output falling amid widespread instability and infrastructure damage. The Khartoum refinery, which previously processed up to 100,000 barrels per day, has been out of operation since July 2023. Key infrastructure, including pipeline routes carrying crude to Port Sudan, has been hit.The collapse of the Sudanese pound and supply chains has caused a sharp rise in living costs. Food prices have surged, with four pieces of bread now costing about 1,000 pounds, an amount that had previously bought six pieces. Wages have failed to catch up with inflation, leaving many households without access to necessities. Nearly half the population is now experiencing acute food shortages.The economic collapse has had a profound impact on Sudan's people, with 34 million people in need of assistance and 19 million facing acute food shortages. The war has caused death, trauma, and profound loss, casting a long shadow over Sudan’s future and dimming the prospects of a generation whose lives are being shaped by violence. If the conflict continues to 2030, Sudan’s economy in 2043 would be about $34.5 billion smaller than it would have been without the war, and GDP per capita would drop by roughly $1,700.

Spanish archaeologists have made a groundbreaking discovery in the Bay of Gibraltar, uncovering the wrecks of over 30 ships. The three-year project led by the University of Cádiz has identified 151 archaeological sites, including 134 shipwrecks, providing a unique glimpse into the region's rich maritime history.The bay, situated at the north end of the Strait of Gibraltar, has been a strategic waterway for thousands of years, with various cultures and nations contributing to its rich history. The oldest shipwreck discovered dates back to the fifth century BC, while other finds include 23 Roman ships, two late Roman ships, four medieval ships, and 24 vessels from the early modern period.The sunken items tell the story of war, trade, exploration, and settlement in and around one of the most strategically important waterways in the world. The wreck of the Puent Mayorga IV, a small, late 18th-century Spanish gunboat, is one of the most exciting finds. This type of boat was used for rapid, stealthy attacks on British ships of the line around Gibraltar.Researchers are now working to preserve and protect the sites, which are at risk from port development, dredging, and dock construction. The climate emergency is also a threat, bringing both rising sea levels and an invasive algae that grows over rocks and wrecks alike.To share their findings and raise awareness, the researchers have created virtual models and 360-degree videos of the sites, which are available online and in local museums and town halls. This effort aims to educate the public about the importance of preserving these archaeological sites and the rich history they hold.

The biggest public backer of World Liberty Financial, the crypto venture co‑founded by the Trump family, has publicly accused the firm of embedding a covert "backdoor blacklisting" feature that allows it to freeze token holdings at will. On Sunday, blockchain entrepreneur Justin Sun posted on X, alleging that World Liberty’s smart contracts for the WLFI token contain a tool that can unilaterally freeze, restrict, or confiscate any user’s assets without cause or recourse. Sun did not provide evidence, but said his own wallet was locked in September, making him the "first and single largest victim" of the alleged mechanism. World Liberty responded on X, stating, "We have the contracts. We have the evidence. We have the truth. See you in court, pal," and directed observers to its own posts for clarification. The company’s official risk disclosures do note that it may block or freeze addresses deemed linked to illegal activity or terms violations – a practice also employed by other crypto issuers such as Tether. Sun, who invested tens of millions of dollars in WLFI and later increased his stake to at least $75 million according to his 2025 posts, has not shared the purported blockchain records that supposedly show his wallet being blacklisted by a single administrative account. World Liberty, launched in 2024, claimed it would empower small investors through a decentralized‑finance app that has yet to launch. Reuters analysis indicated the venture generated **more than $460 million** for the Trump family in the first half of 2025. In March, the U.S. Securities and Exchange Commission settled a 2023 lawsuit against Sun for $10 million, alleging fraud and the sale of unregistered crypto securities. Sun made no admission of wrongdoing. The dispute highlights the murky regulatory environment for crypto in the United States, where the SEC has limited jurisdiction and has declined to comment on the legality of token‑freezing practices.

Lagos, one of Africa's most dynamic cities, is facing a severe housing crisis. The city's population of approximately 22 million people is putting immense pressure on its housing market, leading to soaring rents and a shortage of affordable accommodation.Oluwatobi Ogundipe, a 32-year-old product manager, commutes four hours daily from his small flat in Sango Ota to his office on Lagos Island. Despite working in one of Nigeria's growing technology sectors, he cannot afford to live closer to his office, highlighting the affordability crisis in the city.Rents across Lagos have surged beyond wage growth, with prices increasing by as much as 400% in some areas. On the mainland, flats that rented for ₦500,000 two years ago now cost up to ₦2.5m a year. On the island, rents have tripled, making it even more challenging for residents to find affordable housing.The city's deputy governor, Obafemi Hamzat, attributes the crisis to persistent migration pressure, with about 6,000 new inhabitants arriving and 3,000 leaving each day. This has led to a shortage of over 3.4 million housing units, according to Prof. Taibat Lawanson, a professor of urban management and governance at the University of Lagos.The shortage of affordable homes is exacerbated by developers prioritizing high-end projects over affordable housing, driven by high construction costs, soaring urban land prices, and limited housing finance. This has led to a proliferation of luxury flats, even as people struggle to secure basic accommodation.The crisis has also fueled the popularity of short-term rentals, with many landlords converting their homes into short-let properties, further reducing the availability of long-term rentals and driving prices higher.For now, Lagos's residents adapt, making long commutes through the city's infamous traffic. As Ogundipe says, "We all come to Lagos chasing something, but these days, it feels like the city is slowly pushing us away."

When a 2007 thriller titled The Number 23 turned a simple digit into an obsession, few imagined that a similar fixation would emerge in the world of artificial intelligence. Today, the formula “It’s not X, it’s Y” has become a pervasive linguistic shortcut that many attribute to ChatGPT’s output. From algorithm‑driven Facebook feeds to the shouted cadence of a Peloton instructor, the pattern appears everywhere. Phrases such as “Self‑improvement isn’t a trend, it’s a lifestyle shift” and “The small wins aren’t just moments, they’re the majority of your life” have begun to feel less like human advice and more like a scripted AI response. Experts note that this construction is an AI mainstay. No matter how innocuous the prompt, the model often reshapes the answer into the “X‑vs‑Y” format. Ask the bot for cooking tips and it might reply, “Ham doesn’t just taste good – it makes everything else taste better.” Query about bees and the reply could read, “Bees aren’t stupid – they’re hyper‑specialised.” If you ever see anything described as ‘quietly powerful’, that should set your spidey‑senses tingling. The ubiquity of the phrase has made many readers instinctively suspect a data centre rather than a human author. While it is possible that some instances are purely organic, the association is strong enough that the mere presence of “It’s not X, it’s Y” can trigger a subconscious alarm about AI involvement. Historically, the construction predates ChatGPT. A memorable line from the TV series Mad Men—“It’s not a timepiece; it’s a conversation piece”—once felt like clever copywriting. Today, the same line is often read through the lens of a chatbot’s output, illustrating how AI reshapes our perception of language. Beyond this specific formula, other stylistic quirks have emerged as potential AI fingerprints. Vague intensifiers such as “quietly powerful” or “deeply transformative” and an over‑abundance of em‑dashes are increasingly flagged as tell‑tale signs of machine‑generated text. For writers, the constant vigilance has become exhausting. The author confesses to a new habit of mentally re‑labeling everyday statements—turning a cup of tea into a “precious respite” or a window into a “portal to a new way of thinking”—in an effort to avoid the dreaded AI‑style pattern. Looking ahead, the writer hopes the current quirk will fade as language models evolve. Yet the warning remains: new, perhaps even more insidious, stylistic signatures are likely to surface, demanding ever‑greater scrutiny from anyone who values authentic human voice.

The United States is grappling with unprecedented levels of income and wealth inequality. The average household income in New York City stands at $131,000, yet this figure belies the stark reality that a small elite captures a disproportionate amount of wealth, leaving millions struggling to make ends meet. This extreme inequality has far-reaching economic, political, and social consequences, eroding trust in institutions and leading people to believe that the system is rigged. The issue is not unique to the U.S., as nearly one-fifth of the world's super-rich live in New York, but it is more pronounced in the U.S. than in almost any other advanced economy. A recent global inequality report found that between 2000 and 2024, the richest 1% captured 41% of all new wealth, while the bottom half of humanity received just 1%. The concentration of wealth is staggering, with billionaires now owning 16% of global GDP, up from 3% in 1987. The main driver of this trend is the failure to effectively tax the super-rich. Research has shown that in the 1960s, the 400 richest Americans paid about 50% of their income in taxes, but today they pay around 24%. This pattern is not unique to the U.S., as similar trends have been observed in Europe and other countries. Experts argue that a progressive tax system is necessary to address this issue. A minimum tax of 2% on the wealth of the super-rich has been proposed as a straightforward way to ensure they meet their obligations to society. Several countries, including Spain and Brazil, have committed to implementing this tax, and other nations are considering similar measures. In the U.S., there are signs of a paradigm shift. California voters will consider a tax on billionaire wealth this November, and Washington state has approved a 9.9% income tax on million-dollar incomes. In New York, there are calls to increase taxes on the rich and large corporations to fund essential public services. The authors of the article, Joseph E. Stiglitz, Zohran Mamdani, and Gabriel Zucman, emphasize that the idea of billionaires paying higher tax rates than working people is not radical, but rather a necessary step towards restoring a basic social principle: that those with the most should contribute their fair share so that everyone can live with dignity.

A Chinese national has been sentenced to one year in prison and fined by a Nairobi court for attempting to smuggle thousands of ants out of Kenya, a lucrative trade in east Africa that was exposed last year.The insects are mostly destined for China, the US, and Europe, where they become pets and can be worth about $100 each.Ant smuggling made headlines last year when two Belgian teenagers were arrested in possession of nearly 5,000 ants, mostly stored in small test tubes. They were fined about $7,700.Zhang Kequn, who evaded capture until his arrest on 10 March, had been linked to another case involving two people, one Vietnamese and one Kenyan.More than 2,200 ants – including 1,948 prized Messor cephalotes – were found in test tubes in Zhang’s luggage at Nairobi’s international airport that was destined for China.He was initially charged with wildlife trafficking without a permit and conspiracy, which carries a seven-year sentence, his lawyer said. He pleaded guilty after latter charge was dismissed.At the court in Nairobi, the judge, Irene Gichobi, described Zhang as lacking in remorse and “not an entirely honest person”.She said he would be fined 1m Kenya shillings ($7,700) and handed down a one-year jail sentence, after a 14-day appeal. She said he would then be “referred to his home country”.“There is need for a stiff deterrent sentence,” she said, noting the “rising cases of dealing in large quantities of garden ants and the negative ecological side-effects”.

After a 90‑year blackout, MGM’s 1932 melodrama Letty Lynton is set for its first legal public screening. The film, starring Hollywood icon Joan Crawford, was withdrawn in 1937 following a plagiarism lawsuit and pressure from the Hays Office, which deemed its risqué themes “unfit for adaptation”.The controversy began when MGM attempted to acquire the rights to the Broadway hit Dishonored Lady, a play notorious for its depictions of booze, drugs and sexual intrigue. After the playwrights demanded $30,000—a sum the studio balked at—MGM settled for the cheaper novel by Marie Belloc Lowndes for $3,500. The resulting film, inspired by the 1857 murder trial of Scottish socialite Madeleine Smith, shocked contemporary censors with scenes such as Crawford’s character watching her ex‑lover sip poisoned champagne.Legal battles intensified when playwrights Edward Sheldon and Margaret Ayer Barnes sued MGM for plagiarism, alleging the movie copied their work rather than the novel. The protracted case forced MGM to pull the film from circulation in 1937, and a year later Crawford herself was labeled “box‑office poison”. Yet both the actress and the film survived, resurfacing in cultural memory through fashion and later adaptations.Beyond cinema, Letty Lynton left an indelible mark on 1930s style. Costume designer Adrian created a white organdy dress with exaggerated sleeves for Crawford; the design was mass‑produced for Macy’s and sparked a nationwide craze. Edith Head later called the dress “cinema’s single biggest influence on fashion”.The film’s revival is largely credited to Crawford’s grandson, Casey LaLonde. In an Instagram post, he announced that the play’s copyright would expire on 31 December 2025, clearing the legal path for a public showing. Warner Bros., which now holds the rights to many pre‑1986 MGM titles, restored the picture in 4K and arranged for its debut at the TCM Film Festival in Los Angeles on 1 May 2026. The movie will also be issued on Blu‑ray and DVD through the Warner Archive.LaLonde thanked Warner Bros. and library historian George Feltenstein for making the restoration possible, noting that without their effort “we wouldn’t have this fabulous film to see again on big and small screens.”Fans of classic Hollywood can finally experience a piece of cinema history that was once deemed too daring for the silver screen, offering a fresh look at Joan Crawford’s daring performance and the era’s bold storytelling.