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Tyson Fury is set to make a highly anticipated return to the boxing ring on Saturday night, facing off against Arslanbek Makhmudov at Tottenham Hotspur Stadium in London. The Gypsy King, known for his bold claims and unorthodox style, has promised a destructive knockout to mark his comeback. “It’s going to be different because, for the first time in forever, I’m the hunter,” Fury declared at the fight’s final press conference. “I’m not the hunted, and we all know that when I’ve always been the hunter in the past, I’ve always fucked people up.” Fury, who announced his retirement from boxing in January 2025 but quickly reversed his decision, expressed his excitement about returning to the sport. He cited his long-term rival Anthony Joshua’s car crash in Nigeria as a defining moment that made him realize the importance of living in the present. Makhmudov, a formidable Russian opponent standing at 6 feet 7 inches and weighing 18 or 19 stone, seemed unfazed by Fury’s bold claims. “I’m happy and very excited to be here. I can’t wait for Saturday night,” he said. The Russian fighter from Dagestan added, “I don’t have pressure, because God prepared me for this moment all my life. I believe this is my time.” Fury, known for his bombastic delivery, also expressed sympathy for his opponent, stating, “I actually feel sorry for Makhmudov because I’m going to make an example of him. He’s a big lump, but I’ll knock his head right off his shoulders.”

From the world’s smallest footballing nation – a population of just 45,319 – the American Samoa women entered the 2026 World Cup qualifiers ranked 153rd, the lowest spot in the global rankings.Team captain Alma Mana’o describes the squad as a close‑knit family, noting that several sets of sisters play together and that the Mana’o family holds the record for the most relatives to appear at FIFA events.In November, the side faced Tonga, the tournament’s highest‑ranked opponent. 18‑year‑old Cassidy Drago etched her name into Samoan folklore by netting the nation’s first ever goal in women’s World Cup qualifying, followed quickly by a second, sealing a 3‑0 victory. The momentum continued with a win over the Cook Islands, cementing their reputation as genuine upset‑makers.The second round seemed to promise a return to reality when the Solomon Islands – 80 places above them in the rankings and 2025 Pacific Nations Cup champions – thrashed American Samoa 7‑1 in an Olympic qualifier. Yet, just 90 minutes later, the Samoans produced one of the competition’s most astonishing results: a 1‑0 win over the same opponents.That triumph was followed by another narrow victory, 1‑0 against neighbouring Samoa, securing a place in the final OFC qualifying round and completing the team’s evolution “from underdog to dark horse,” as Mana’o puts it.Looking ahead, American Samoa will meet Papua New Guinea in Auckland – the venue of their inaugural women’s international match 28 years ago. The squad now benefits from the guidance of Amanda Cromwell, the 1996 U.S. Olympic gold‑medal‑winning coach, who has overseen four wins in five games. Mana’o credits Cromwell with professionalising the program, from nutrition plans to dedicated training staff, and says the new standards will become the norm.Mana’o herself broke ground as the first “off‑island” player in 2011 at age 15, enduring an 8‑0 debut loss. Today she celebrates a new generation of teenagers, such as Mia Toeaina and Naiyah Ve’e, who are experiencing a vastly different, more positive football environment.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil tanker workers stuck in the Gulf for six weeks are reaching their limit, with mental health concerns escalating due to the prolonged standoff. A crew member, who spoke to the Guardian, revealed that the situation is becoming increasingly unbearable.The worker, one of 20,000 seafarers trapped by Iran's chokehold on the Strait of Hormuz, expressed frustration and despair, stating that any hope of being freed had evaporated. The crew member's tanker is anchored near dozens of loaded tankers, with many feeling unwilling and unable to traverse the strait, even if a ceasefire allowed them to do so.90% of the crew on the tanker want to exercise their right to refuse to sail, citing safety concerns. The situation has taken a toll on the crew's mental health, with one member suffering a 'mental breakdown' and being checked on regularly by colleagues.The International Transport Workers' Federation (ITF) has received about 1,000 inquiries from seafarers on 300 different vessels, with 20% seeking repatriation. The union and other organizations are trying to provide support, but the situation remains dire.The shipping companies are expected to find new crew members willing to work in hazardous areas, offering double pay and promotions. However, the workers stuck on the tankers hope that their vessel will be taken to anchorage to allow new crew to take their places.The situation has reignited calls for shipowners to replace their crews with mariners willing to offer relief, highlighting the human cost of the conflict.

The UK's reliance on glyphosate, a widely used herbicide, has come under fire from campaigners who argue that its use has spiralled out of control. Glyphosate, known for its effectiveness in killing weeds, has been linked to various health risks, including cancer, and environmental damage.Originally pioneered by Scottish farmers in the 1980s to dry crops before harvest, the use of glyphosate has expanded globally. In the UK, over 2,200 tonnes of glyphosate were applied in 2024, with more than half used on wheat and other cereals. This represents a 10-fold increase in usage over the past three decades.Despite the World Health Organization classifying glyphosate as 'probably carcinogenic to humans' in 2015, its use has remained high. Bayer, the manufacturer, maintains that its herbicides do not cause cancer, but this stance is contested by many health and environmental organizations.Campaigners, including Nick Mole of Pesticide Action Network UK, are urging the government to phase out and ultimately ban glyphosate, citing its links to a range of cancers and other life-threatening diseases, as well as its impact on the environment. They argue that safer, more sustainable alternatives are available and should be adopted by farmers and local councils.However, some agricultural experts, like Helen Metcalfe of Rothamsted Research, suggest that glyphosate is used differently in the UK compared to the US, where genetically modified crops are involved. The shift towards 'regenerative' farming practices has contributed to the increased use of glyphosate, as it helps protect soil health and prevent erosion.The debate over glyphosate's safety and environmental impact continues, with the EU banning its use in pre-harvest desiccation in 2023 due to concerns about food accumulation. In the US, Bayer has offered $7.25bn to settle lawsuits alleging that Roundup, which contains glyphosate, can cause cancer. The UK government maintains that pesticide use is strictly regulated and only approved if it does not harm human or animal health or the environment.

The Strategic Duality of Amazon's AI PortfolioAWS CEO Matt Garman has officially validated a strategy that seemed contradictory on the surface: investing billions in both OpenAI and Anthropic. Speaking at the HumanX conference in San Francisco, Garman addressed the inevitable questions regarding the $50 billion investment in OpenAI following the long-standing $8 billion investment in Anthropic.Garman, a veteran of Amazon since 2005, argued that this is not a conflict of interest, but a standard operating procedure for the cloud giant. He explained that AWS has long accepted the reality that it must compete with the very partners that help it succeed.Analyzing the $50 Billion Dual-Track StrategyThe core of Garman's argument lies in the interconnected nature of technology. He noted that in AWS's earliest years, the company realized it could not build every cloud offering itself. Instead, they built a "muscle" for navigating the complex market where partners often become competitors.Historical Context: In 2006, it was radical for partners to compete with those who helped them succeed.Current Reality: Today, even Oracle sells its database services directly on AWS, a direct competitor to Amazon's own database offerings.Competitive Promise: AWS has promised partners they will not grant themselves an unfair competitive advantage.Redefining the Cloud Partner EcosystemThe AI landscape is mirroring this historical shift. When Anthropic raised its latest $30 billion round in February, it included investors who were also backing OpenAI, such as Microsoft. Garman pointed out that this is the new normal in the "wild, money-grabbing world of AI."For AWS, the OpenAI investment was a strategic imperative. Both OpenAI and Anthropic models were already available on Microsoft's cloud, AWS's biggest rival. By investing in OpenAI, Amazon ensured it remained a technology development partner rather than being locked out of the loop.The Future of Model Routing and Homegrown IntegrationGarman predicts that the industry will move toward AI model-routing services. These services will allow customers to automatically switch between different models based on task requirements—such as using a cheaper model for code completion and a powerful model for complex reasoning.This routing capability is the key to how Amazon and Microsoft will slip their own homegrown models into usage, effectively recreating the "competing with your partners" dynamic that defines the modern cloud era.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

In the spring of 2002, the modest Free Butt pub on Brighton’s seafront buzzed with a restless energy. Future stars such as Natasha Khan, then a university art student, danced atop the bar while the Yeah Yeah Yeahs thundered through their first UK dates. Behind the scenes, band frontmen like Guy McKnight of Eighties Matchbox B‑Line Disaster served pints, and budding engineers like Steve Ansell of Cat on Form fine‑tuned the sound. The atmosphere felt like a rite of passage, where any performer could slip from a cramped stage to national attention.Unlike the neatly branded scenes of New York’s garage‑rock revival or London’s Libertines‑driven hype, Brighton’s early‑2000s scene resisted a single aesthetic. Rock groups emerged from rehearsal rooms and tiny clubs with wildly different looks and sounds, creating a cultural mosaic rather than a monolithic movement.Electrelane’s guitarist recalls recording their debut Rock It to the Moon in a studio once owned by the Levellers, and crafting their sophomore effort inside a former public toilet. These unconventional spaces proved surprisingly fertile, underscoring the city’s DIY spirit.By the turn of the millennium, the big‑beat dominance of Fatboy Slim and Skint Records had faded, making way for a grassroots rock surge. Sea Power relocated from Reading to Brighton, drawn by the city’s “dilapidated charm and fresh sea air”. Their self‑organized Club Sea Power nights at the Lift offered a chaotic yet liberating platform that eventually caught Rough Trade’s attention.Women played a pivotal role in shaping the scene’s infrastructure. Promoters Lisa Lout and Anna Moulson, both still active, booked seminal shows—including the Strokes’ first UK gig at the Lift in 2001—and helped launch the Great Escape festival. Their efforts ensured that bands such as the Pipettes, Electrelane and Bat for Lashes could share stages and media coverage.Artists recall the city’s palpable sense of belonging. Rose Dougall of the Pipettes describes a landscape where “alternative culture was on every street, from vintage shops to the colour of the houses,” and where “small venues made it feel attainable to launch a project.” Similarly, Brakes frontman Eamon Hamilton contrasts Brighton’s walk‑able, collaborative vibe with London’s darker, more competitive energy.Music journalism mirrored the scene’s intensity. Everett True and photographer Steve Gullick launched Careless Talk Costs Lives in 2002, a deliberately short‑run magazine that championed female writers and bands at a time when the industry was still heavily male‑dominated.As rents surged through the 2010s, many of the cheap flats, rehearsal rooms and iconic venues that underpinned the scene vanished. The Free Butt closed, independent record stores shuttered, and the once‑abundant low‑cost infrastructure dwindled, prompting a migration of creative energy down the coast to places like Margate, Ramsgate, Folkestone and Shoreham.Nevertheless, the remnants of Brighton’s network continue to nurture new talent, from the Kooks to Dream Wife and Gazelle Twin. The city’s strength lies not in a singular sound but in its capacity to host a “constant collision of wildly dissimilar bands,” allowing artists to develop authentically and fearlessly.

Ballon d’Or prospects are wider than ever after more than a decade dominated by Lionel Messi and Cristiano Ronaldo. This season’s Champions League quarter‑finals could tip the balance as the 103‑day run‑in to the World Cup final approaches. Harry Kane leads the conversation, having netted 54 goals across club and country – a tally that includes Bayern Munich’s recent 2‑1 win over Real Madrid. A Champions League triumph with Bayern and a World Cup victory with England would make him the first English Ballon d’Or winner since Michael Owen in 2001. Other candidates include Kylian Mbappé, currently the top scorer in both the Champions League and La Liga, and teenage sensation Lamine Yamal, whose creativity for Barcelona and Spain adds a different flavour to the race. The field remains open enough that a surprise performer – perhaps an Arsenal double‑winner or a PSG‑Portugal combo – could leapfrog the traditional favourites. Folarin Balogun’s USMNT future is under scrutiny. The 24‑year‑old Monaco striker has scored in five consecutive Ligue 1 matches, highlighted by a spectacular chip against Marseille that showcased his peak form. Yet head coach Mauricio Pochettino opted to start Christian Pulisic at centre‑forward in the final warm‑up against Portugal, limiting Balogun’s chance to cement his role. While Pulisic displayed moments of flair, his hold‑up play was described as “more like a winger than a No 9”, underscoring the coach’s dilemma. Balogun’s club form, however, argues that the United States already possess a striker capable of leading the line. Roberto De Zerbi faces a seven‑game deadline at Tottenham Hotspur. Signed on a five‑year deal, the Italian tactician inherits a side that struggled to adapt to his possession‑based philosophy under previous managers. Tottenham rank 12th for touches inside the opposition box and 14th for big chances created (Opta), indicating a lack of the creative outlets De Zerbi favours. He achieved his first win at Brighton after six games and impressed at Marseille with four wins in five, but both successes came after a full pre‑season and targeted transfers – luxuries Tottenham lack at the moment. The upcoming Sunderland clash will be his first real test of whether his style can be implemented quickly enough to steer the club away from relegation danger. In summary, the next three months will decide not only who lifts the 2026 Ballon d’Or, but also whether Balogun can secure a starring role for the USMNT and if De Zerbi can reverse Tottenham’s fortunes before his contract’s short‑term clause expires.