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In a recent statement, Janet Vance warned that a ceasefire with Iran can only be realized if the parties engage in good‑faith talks. She emphasized that mutual trust and sincere negotiation are essential for any lasting pause in hostilities, highlighting the delicate nature of the diplomatic process.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Cornish film-maker Mark Jenkin has brought his latest film, Rose of Nevada, to his hometown of Newlyn in Cornwall. The film, a ghostly time travel tale, has received excellent early reviews and features Jenkin's signature authentic storytelling.Jenkin, who is from Newlyn, expressed his pride in Cornwall, stating, “This is the greatest town in the world. I see Cornwall as being at the centre of the world.” He emphasized the importance of showcasing Cornwall's culture and community in his films.The film was shot entirely in Cornwall, using a clockwork Bolex camera and featuring a working fishing boat. Jenkin's vision for his homeland is central to the film, rather than using it as a backdrop.Jenkin's success has put a spotlight on Cornwall, with other filmmakers, such as Brett Harvey and Dan Simpkins, highlighting the growing recognition of regional film-making. Laura Giles of Screen Cornwall noted that Jenkin is a “talisman for Cornish film-making” and that there are other emerging filmmakers in the region.The film's producer, Denzil Monk, emphasized the importance of sustainability and inclusivity in the production, stating, “We try to step very lightly” in terms of impact on the environment and community.

Oil markets experienced a dramatic correction on Wednesday, with Brent crude falling 13.9% to $94.10 per barrel and U.S. WTI futures sliding almost 16% to $95, marking the steepest daily percentage drop since the COVID‑19 crash of April 2020. Despite the plunge, prices remain well above pre‑conflict levels, when Brent traded below $73.The price shock followed President Donald Trump's announcement of a two‑week, conditional ceasefire with Iran, contingent on Tehran reopening the strategic Strait of Hormuz for oil tankers. Iran’s foreign minister, Abbas Araghchi, confirmed the strait would be managed by the Iranian military during the grace period, while Iran’s national security council accepted the ceasefire on the condition that U.S. attacks be halted.Equity markets reacted positively. The pan‑European Stoxx 600 surged 4%, its biggest one‑day gain in over four years. In the UK, the FTSE 100 climbed nearly 3% to 10,646 points, its highest level since the early days of the Iran war. Travel and leisure stocks led the rally, with Air France up 14.5%, Lufthansa +11%, IAG +9.5% and TUI +12%.Oil majors were the notable laggards; BP and Shell each lost more than 5% as investors priced in continued supply uncertainty. Asian markets also posted strong gains: Japan’s Nikkei 225 rose over 5%, Australia’s S&P;/ASX 200 jumped 2.55%, South Korea’s Kospi surged 7.5%, Hong Kong’s Hang Seng added 3.1% and China’s CSI300 climbed 3.2%.Bond yields eased on the ceasefire news. The U.S. 10‑year Treasury yield fell to 4.24% from 4.30%, while the UK 10‑year gilt slipped to 4.7% from 4.9%.Safe‑haven assets rallied as well: gold rose more than 2% to $4,812 per ounce, and cryptocurrencies recovered, with Bitcoin up 2.9% to $71,327 and Ether gaining 5.6% to $2,234.Market strategists emphasized the provisional nature of the relief. Jim Reid, Deutsche Bank markets strategist, warned that “investors will be breathing a big sigh of relief, but the durability of the ceasefire remains the key risk.” He noted ongoing Israeli‑Iran strikes and unclear extensions to Lebanon could reignite volatility.Energy analyst Saul Kavonic (MST Financial) described the pause as “an off‑ramp for Trump’s bombastic ultimatum, but not yet an off‑ramp for oil markets or the war.” He expects a limited release of tankers from Hormuz in May, which would ease storage pressure without boosting production.Capital Economics chief economist Neil Shearing highlighted potential transit fees for Hormuz passage, estimating a $1‑2 million charge per tanker—equivalent to roughly $1 per barrel—would have a modest effect on global oil prices but could signal a de‑facto partial nationalisation of the route.TD Securities senior strategist Prashant Newnaha cautioned that “renewed escalation cannot be ruled out, but markets are treating this ceasefire as the real deal, and all parties will sell it as a major win.” He added that oil prices are unlikely to revert to pre‑war levels, keeping inflationary pressures alive.Earlier in the week, U.S. equities swung sharply, with the S&P; 500 dipping 1.2% before rebounding after Pakistan’s prime minister urged Trump to extend the deadline and keep the strait open.The conflict, which began after the U.S. and Israel struck Iranian targets in late February, has choked the Strait of Hormuz—through which about 20% of global oil and LNG supplies flow—fueling a worldwide energy crunch.

At 75, Suzi Quatro is still rocking with the same energy and passion that defined her glam era. Her signature scream, which has been thrilling audiences since she was a kid playing dance halls around Detroit, was on full display during her recent concert at Glasgow. The Suzi Q scream is a defining sound of the glam era, a holler of swallow-the-world desire that leaves the audience galvanized.While the opening hour of the concert was entertaining and well-paced, the second set was a bit of a mess, with tedious solos and drawn-out introductions of her eight-piece band. The highlight of the evening came when Quatro played Can the Can and Devil Gate Drive back to back, delivering a pure pop rush. However, the concert could have benefited from a few cuts, as Quatro seemed to struggle with pacing.Despite some minor issues, Quatro's performance was still thrilling, and her infectious energy was palpable throughout the evening. As she told the Glasgow crowd, 'I can still scream just as loud,' and she proved it with her powerful vocals.

Arthur Rosenfeld, 73, and Meryl Tankard, 70, open the performance by introducing themselves as “sprightly old geezers,” setting a tone of candid humor that runs through the evening. The production, ‘Kontakthof – Echoes of 78,’ is a fresh staging of Pina Bausch’s iconic 1978 work, now re‑imagined by Australian choreographer Meryl Tankard. Unlike the 2010 London run that split the piece between teenagers and senior amateurs, this rendition features the eight surviving members of the original cast—all now in their late sixties to early eighties—performing the very roles they created half a century ago. A ninth dancer was absent due to illness. Their live movements are mirrored on a large screen by the black‑and‑white film of the 1978 performance, creating a visual palimpsest where past and present dance together. The choreography, set to 1930s dance‑hall songs, remains a wry commentary on courtship, power dynamics and consent. Tankard’s direction emphasizes the passage of time, allowing audiences to witness the same steps executed by bodies that have aged, yet retain a striking vitality. Dancers such as Josephine Ann Endicott, now in her seventies, glide across the stage in silk dresses, their frames more fragile but their confidence undiminished. Moments of poignancy arise when the film shows cast members who have since passed away. Onstage, John Giffin reaches for his late partner’s face, only to grasp empty air—a visual metaphor for loss that resonated deeply with the audience. Personal revelations punctuate the performance: Beatrice Libonati, 71, describes herself as “paranoid and a misanthrope,” while Tankard admits, “I wish I’d had children; I miss my mother every day,” underscoring the undercurrent of longing that runs through the piece. Beyond its narrative, the production offers a meditation on continuity. Bausch’s signature walking patterns—slow circles and linear traverses—are repeated, suggesting that despite changing bodies, the human species continues to tread familiar social routes. The music, unchanged from the original, carries on until the final dancer pauses, symbolising the inevitable end of the dance of life. The show runs at Sadler’s Wells, London through 11 April, offering a rare glimpse into how art can bridge generations and celebrate the endurance of the human spirit.

The US seafood industry is tackling a significant challenge: Americans' low fish consumption. With an average annual intake of about 19lb per person, the US lags far behind the global average of 45lb. In contrast, Iceland leads the world with an impressive 200lb of seafood per person per year.To crack the US market, the seafood industry has devised a strategy to make fish more appealing by making it look like meat. This approach involves creating products such as tuna that resembles chicken nuggets and salmon sticks that look like beef jerky. This tactic is similar to hiding vegetables in recipes for picky toddlers, but with a twist: it's about presentation rather than altering the product's nature.This isn't a new concept, as plant-based meat gained popularity when placed in the meat department rather than the vegetarian aisle. Similarly, fish-as-meat marketing has been around with products like tuna steaks and salmon burgers. However, the trend seems to be gaining momentum, with recent reports from the Seafood Expo circuit indicating a surge in interest.While this strategy may be effective, its environmental implications are questionable. With 348 million people in the US potentially increasing their seafood consumption, concerns about overfishing and the collapse of marine life arise. Guardian columnist George Monbiot has argued that there are almost no fish or shellfish that can be safely eaten if the goal is to save the oceans, suggesting that stopping fish consumption is a more impactful action.The success of this strategy may also be influenced by economic factors, such as food inflation and tariffs. If supply chains collapse due to global conflicts, the demand for Fishy Meat may become irrelevant as Americans struggle to afford basic food items.

Thirty years after the passionate road protests against the Newbury bypass, the elevated road now looms large, a constant reminder of the environmental costs of progress. For the author, who was part of the campaign, the Newbury bypass remains a sore point, even today.On a walk in The Chase, a nature reserve adjacent to the bypass, the author is accompanied by their friend Sarah, a 'cow watcher' for the National Trust. Their mission is to check on the wellbeing of conservation grazers – Shetland cows with upswept horns – which play a crucial role in maintaining biodiversity and plant life.The reserve, once common land with a rich history dating back to 1819, has been a playground for the author and Sarah. They recall devastating sewage spills that killed local wildlife and the great storms of 1987 and 1990 that left trees like 'spilled pencils.'As they wade across a stream to find the cows grazing among wild daffodils and golden saxifrages, memories of their children come flooding back – 'welly walks' with grandparents, watching great spotted woodpecker chicks fledge, and following silver-washed fritillary butterflies.Their walk complete, they meet at a garden centre cafe, where the author, aided by 'brain fog,' mistakenly heads to the pub first. The zigzag patterns of peaty-black mud from Sarah's boots across the polished floor serve as a humorous reminder of their conservation work and shared experiences.

Uber confirmed on April 7, 2026 that it is broadening its AWS cloud contract to run additional ride‑sharing features on Amazon’s in‑house silicon. The company will increase usage of the ARM‑based Graviton server CPUs and begin a pilot of the Trainium3 AI chip, Amazon’s answer to Nvidia’s accelerators. Uber Expands AWS Contract to Include Graviton CPUs and Trainium3 AI Chip Expanded workload migration from Uber’s legacy data centers to AWS. Increased deployment of low‑power Graviton instances for core ride‑matching services. Launch of a controlled trial of the next‑gen Trainium3 AI accelerator for demand‑forecasting and routing algorithms. Financial Stakes and Chip Market Shifts Amazon’s AI chip business was described by CEO Andy Jassy as a "multibillion‑dollar" operation. Oracle’s earlier exit from Ampere yielded a $2.7 billion pre‑tax gain, underscoring the high‑value nature of ARM‑based silicon. Uber’s renewed spend with AWS is expected to offset portions of its prior multi‑year contracts with Google Cloud and Oracle Cloud Infrastructure. Strategic Blow to Google, Oracle and Nvidia The deal is less about a direct threat to Nvidia and more about Amazon flexing its silicon advantage against cloud rivals. By pulling a former Oracle‑backed ARM player (Ampere) into its ecosystem, AWS positions itself as the preferred partner for AI‑intensive workloads, challenging both Google and Oracle which have historically leaned on Nvidia GPUs. Future Outlook: Cloud Competition and AI Chip Landscape Expect more enterprise customers to evaluate ARM‑based CPUs and Amazon‑designed AI chips for cost‑efficiency. Google and Oracle may accelerate their own silicon roadmaps or deepen Nvidia ties to retain market share. Uber’s trial of Trainium3 could set a benchmark for AI‑driven ride‑hailing optimization, potentially prompting broader industry adoption.