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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Lead: Russia's Escalation and Ukraine's Counteroffensive Russia's attempts at escalation via Belarus, where it has delivered more nuclear weapons and held highly publicized joint war games, come as its ground war falters in Ukraine. Ukrainian commander-in-chief Oleksandr Syrskii reports that Ukraine has seized the tactical initiative, with Ukrainian offensive assaults now outnumbering Russian assaults on Ukrainian positions. Russia's Soldier Shortage and Recruitment Crisis Ukraine's forces have gained the upper hand because Russian forces are running out of soldiers to conduct offensive operations. According to Syrskii, "Since the beginning of 2026, the total losses of the enemy have already exceeded 141,500 people, of which more than 83,000 are irreversible." Ukraine's Foreign Intelligence Service believes Russia is unable to replenish these losses of more than 1,000 people a day, and this year is recruiting at a rate of 800-930 a day, suffering a net decrease of battlefield strength. In response, 40 Russian regions have increased sign-up bonuses by between 30 and 100 percent. Putin has also simplified citizenship procedures for Russian speakers in the Transnistrian region of Moldova, which Ukrainian President Volodymyr Zelenskyy described as "Russia looking for new soldiers." Economic Impact: Ukraine's War on Russian Oil Infrastructure Russia's economy is fraying, having run up a $78.4bn deficit in the first four months of 2026 after budgeting for a $50.5bn deficit for the entire year. "Oil dealt the main blow. Revenues from hydrocarbons fell by 38.3 percent," according to Ukraine's Foreign Intelligence Service. Ukraine has scaled up its long-range campaign against Russian refineries and oil export terminals, depriving Moscow of windfall profits from high oil prices. International Energy Agency (IEA) data shows Russia has curtailed production by 460,000 barrels per day (bpd) in April 2026 compared with April 2025. Reuters estimates that Ukrainian drone attacks knocked out about 700,000 bpd of refining capacity between January and May across 16 refineries, accounting for a quarter of Russia's refining capacity. Shift to Asymmetric Warfare: Ukraine's Strategy Evolution "Given our limited resources, to effectively resist a much larger enemy, we are trying to shift from a 'war of attrition' to an asymmetric strategy," Syrskii told the European Union Military Committee. "Our main tasks are to stop the enemy's advance and effectively counterattack, strike at the Russians' rear, including deep within their territory." Ukraine has attacked military-industrial targets in a 100km radius around Moscow, including the Angstrem semiconductor plant, the Solnechnogorsk oil pumping station, and the Moscow Refinery. Ukraine has also targeted refineries in Ryazan, Yaroslavl, Kstovo, and Sizran, as well as military hardware including helicopter gunships, amphibious craft, and anti-aircraft missile systems. Belarus Front: Russia's Nuclear Escalation and Ukraine's Warning Russia has put pressure on Belarus President Alexander Lukashenko to open a new front in the war against Ukraine. Zelenskyy stated that Russia would launch a simultaneous attack from its neighboring region of Bryansk against Chernihiv. "We know that there have been additional contacts between the Russians and Alexander Lukashenko aimed at persuading him to join new Russian aggressive operations," Zelenskyy said. Russia involved Belarus in a joint nuclear exercise with 64,000 personnel, more than 200 missile launchers, 140 aircraft, 73 surface ships and 13 submarines. Russian President Vladimir Putin confirmed that the two countries would launch ballistic and cruise missiles as part of the exercise. Russia has parked its new Oreshnik tactical nuclear missile in Belarus since last year and has threatened to attack European arms manufacturing and military sites with it.

The LeadMajor US social media companies including Meta's Facebook and Instagram platforms have blocked the accounts of Saudi Arabian dissidents so they are no longer visible inside the kingdom, following orders by Saudi authorities. Those affected include Abdullah Alaoudh, a US-based activist and vocal critic of Saudi human rights violations, and Omar Abdulaziz, a Canada and UK-based activist who worked closely with Jamal Khashoggi before the journalist's murder by Saudi agents in 2018.The Platform Response to Government DemandsAt least seven accounts had been blocked by Meta at the end of April, including those of two American citizens and two individuals based in Europe, according to the advocacy group American Committee for Middle East Rights (ACMER). Meta did not respond to the "dirty work" claim, but provided a statement to the Guardian saying that when "something happens" on one of its platforms that is reported as violating local law but not the companies' own community standards, the company may restrict the content's availability in the country where it is alleged to be unlawful.Meta operates a public "transparency center," where it acknowledges that Saudi authorities contacted the company and sought restrictions on a total of 144 Instagram accounts, Facebook pages, and Facebook profiles during April. The site also shows that Meta restricted access to 108 "items".Inconsistent Approaches to Government RequestsInterviews with some of the dissidents targeted suggest the companies approached by Saudi authorities did not all respond in the same way. While Meta did alert users that their content was being blocked due to a "local legal requirement, or a request from a government," Snapchat appears to have slowed or removed accounts in Saudi Arabia – including one used by Abdulaziz – without alerting the account owners of the change. It is not clear how many Snapchat accounts were affected, and its owner, Snap Inc, declined to comment.At least two users of X, which is owned by Elon Musk, received letters informing them that the platform had received a request from the Saudi communications, space and technology commission claiming their accounts violated Saudi laws. X told users including Abdulaziz that it had not taken any action on the reported content yet, writing that the company "strongly believes in defending and respecting the voice of our users". It then urged addressees to seek legal advice if they wished, or to delete the relevant content voluntarily.Human Rights Concerns and ImplicationsAbdulaziz told the Guardian: "I think this is just the introduction to a massive crackdown by the Saudi government to mute opposition. It could go as far as committing atrocities, just like they did with the murder of Jamal Khashoggi." The Saudi government did not respond to a request for comment, sent through the Saudi embassy in Washington.Other accounts targeted include those of individuals linked to the London-based human rights organisation ALQST, including its founder, Yahya Assiri. Dr Maryam Aldossari, an ALQST board member, stated: "These [account holders] are not dangerous actors; they are people documenting abuses, challenging state propaganda and giving voice to Saudis inside the country who cannot speak freely. Blocking these accounts would not protect public safety, it would project authoritarian power from scrutiny."The Future of Digital DissentDr Aldossari further commented: "This is how authoritarian censorship travels: through legal notices, platform pressure and the attempted outsourcing of repression to global technology companies." As social media platforms continue to navigate the complex landscape of international laws and human rights standards, the case of Saudi dissidents highlights the growing challenge of maintaining free expression in an increasingly interconnected digital world where governments increasingly seek to control online discourse beyond their borders.

The Arrest That Sparked International ConcernThe operation began at 9am Moscow time, but took place across all of Russia's 11 time zones. Almost simultaneously, agents of the federal security service (FSB) raided the homes and workplaces of 17 Indigenous rights activists. Officers carried out searches, confiscated laptops and phones, and arrested and interrogated activists about participation in international forums. Most were let go; many have since left the country. Others remain in Russia, but will no longer speak up.Six months later, one remains in jail. Daria Egereva, one of Russia's foremost Indigenous rights activists, is accused of membership of a terror group. No trial date has been set. Her supporters say the charges are fabricated and she has been targeted for speaking out.Egereva was not just any activist. A member of the Selkup indigenous group, from western Siberia, she was a "bright star" of Russia's indigenous rights movement. As a member of the UN's Indigenous Peoples' Coordinating Body, she had international status. Weeks before her arrest, she had played a key role at Cop30 in Brazil as co-chair of the Indigenous People's Forum on Climate Change.Her jailing has shone a spotlight on the plight of Russia's Indigenous people, threatened by authoritarianism, extractivism and climate breakdown.The Climate Crisis in Russia's Arctic"They are really seeing the worst effects of climate change," said Alicia Moncada, director of global advocacy at Cultural Survival, which campaigns for Indigenous rights. "They are on the frontline of the frontline – that's why [Egereva's] advocacy was super important."The polar north is heating faster than any other part of the planet. In recent decades, temperatures in Arctic regions have risen three to four times faster than the global average. Communities based on permafrost are seeing their world collapse around them."The elders are saying that nature has stopped trusting us," said one exiled Indigenous leader, who requested that his name be withheld. "The traditional ways of predicting nature are not working any more."Many settlements sit next to the banks of rivers and lakes. Due to the melting permafrost, those banks are beginning to crumble. "There is a real threat of destruction for a lot of those villages," said the leader, who spoke through an interpreter. And the melting ice has brought a new source of tension: newly accessible critical mineral resources.Resource Extraction and Indigenous Displacement"All these resources of the Russian Federation, a majority of them are located under the lands of Indigenous people: gold, diamonds, oil, gas, coal," the leader said. "For some people it is a treasure, but for us it is a curse."Because the companies are coming to our land for those resources and they are pushing us out. Even if they don't push us out, the environmental situation in those places will become so bad that we are unable to hunt or fish."One of the elders said that we can adapt to anything, but we will not be able to survive without our land."The Government Crackdown on Indigenous ActivismAlthough Indigenous groups maintained their identities, by the end of the Soviet era they lacked independent organisation and relied on the state. Egereva had been part of a new generation of leaders who had encouraged community self-empowerment.But this assertiveness brought them into conflict with the authorities. Even before the war in Ukraine, the Russian state claimed that its enemies were exploiting environmental and indigenous issues. Now, with the war a pretext for a crackdown on civil society, Indigenous people are among those at the sharp end.To date, 830 organisations and 20,813 individuals have been put on the "list of terrorists and extremists", according to the UN. Among them was Aborigen Forum, a network of Indigenous defenders designated an "extremist organisation" in July 2024.Russian authorities have based their charges against Egereva and her co-defendant, Natalia Leongardt, a civil rights activist, on their involvement with Aborigen. Authorities claim it is part of an anti-state "post-Russia free nations forum".International Response and Russian DefenseIn a bail hearing on 29 April, Egereva and Leongardt denied being part of any anti-state conspiracy. "I am not familiar with and do not know this organisation," Egereva told the court. "What we are being accused of is completely untrue ... I ask to be allowed to return home and embrace my children."The court refused to grant them bail, remanding them in custody until at least mid-June. The following day, Russia celebrated a new federal holiday: the "Day of Indigenous Small-Numbered Peoples".The Russian embassy told the Guardian: "The investigation concerning Daria Egereva is an internal Russian legal matter, conducted in full accordance with Russian law. As proceedings are ongoing, we are not in a position to comment on the specifics of the case."Russia firmly rejects any allegations of violations of Indigenous people's rights. Unlike a number of western states – including Britain in its former colonies – Russia has no history of forced assimilation of Indigenous communities. Russian law affords Indigenous peoples special legal protections, guaranteeing their collective and individual rights, cultural identity, and linguistic heritage under the constitution and in line with international norms."Russia is actively engaged in the international climate agenda, taking account of both the challenges and the economic opportunities emerging in its northern regions – including expanded access to the northern sea route and mineral resources in permafrost zones. All such projects are carried out with the aim of supporting regional development, creating jobs and attracting investment, including for the benefit of Indigenous communities in these areas."

Lead: On May 14, 2026 a Madhya Pradesh high court declared the historic Kamal Maula mosque in Dhar a Hindu temple, prompting saffron‑flag displays by far‑right groups and reviving scrutiny of Hindutva—the nationalist ideology driving Prime Minister Narendra Modi and the Bharatiya Janata Party (BJP). The episode underscores how a century‑old movement has moved from pamphlets to courtroom battles and national policy. The Madhya Pradesh Verdict and Its Immediate Symbolic Fallout The court’s decision sparked a rapid on‑ground response: supporters unfurled saffron flags, filmed rituals, and celebrated the reclassification as a triumph of Hindu heritage over perceived Islamic encroachment. This mirrors a pattern where legal rulings become flashpoints for Hindutva activism. Chronology of Hindutva’s Evolution and Electoral Milestones 1923: Vinayak Savarkar publishes *Essentials of Hindutva*, defining a Hindu cultural nation. 1925: Keshav Baliram Hedgewar founds the Rashtriya Swayamsevak Sangh (RSS), the movement’s organisational hub. 1948: Assassination of Mahatma Gandhi by a former RSS member intensifies scrutiny of the ideology. 1951: RSS‑linked political party formed, later becoming the BJP in 1980. 1992: Demolition of the Babri Mosque triggers nationwide sectarian violence. 1996‑2004: BJP cycles through short‑lived governments before losing to the Congress. 2014: Modi leads BJP to a historic mandate, the largest since 1984. 2019: Abrogation of Article 370 and passage of the Citizenship Amendment Act (CAA) reflect Hindutva‑inspired policy shifts. 2024: CAA implementation accompanied by the National Register of Citizens (NRC). 2026: Court ruling in Madhya Pradesh reignites public debate. Policy Shifts Attributed to Hindutva Governance Since 2014, Hindutva‑aligned legislation has targeted three main areas: Territorial sovereignty: Removal of Jammu & Kashmir’s special status (Article 370, 2019). Citizenship criteria: CAA granting fast‑track citizenship to non‑Muslim migrants, followed by the NRC framework. Cultural protectionism: State‑level bans on cow slaughter, anti‑conversion laws, and pushes for a Uniform Civil Code. Societal and Communal Repercussions Across India The legal and policy agenda has deepened communal fault lines. High‑profile incidents—such as the 1999 burning of missionary Graham Staines and the 2002 Gujarat riots—remain cited by critics as evidence of Hindutva‑fuelled violence. Recent lynchings of alleged cow‑carriers since 2014 illustrate ongoing tensions, with few convictions recorded. Outlook: Hindutva’s Trajectory Ahead of the 2026 Elections Looking forward, analysts anticipate that the BJP will leverage the court ruling to reinforce its narrative of reclaiming Hindu heritage, potentially mobilising voters in upcoming state elections. However, heightened legal challenges and growing domestic and international criticism could force the party to balance hard‑line rhetoric with broader electoral appeal. The evolution of Hindutva will likely hinge on how effectively it can translate cultural symbolism into sustainable policy without alienating India’s pluralistic electorate.

President Donald Trump and Supreme Leader Ayatollah Mojtaba Khamenei have issued opposing statements on Iran’s 60‑percent enriched uranium stockpile, intensifying a diplomatic deadlock that could shape the future of the nuclear talks between Washington and Tehran. Trump’s Stance and Khamenei’s Countermand on Iran’s Uranium Stockpile During a Thursday press briefing, Trump declared, “We will get it. We don’t need it, we don’t want it. We’ll probably destroy it after we get it, but we’re not going to let them have it.” The same day, Reuters reported that Khamenei issued a directive forbidding the removal of the uranium, emphasizing a consensus within Iran’s establishment that the material must stay inside the country. Quantifying the 60‑Percent Enriched Uranium Stockpile 440 kg (approximately 970 lb) of uranium enriched to 60 percent is believed to be held by Iran. Enrichment to 90 percent is required for weapons‑grade material; the current level shortens the time needed to reach that threshold. International Atomic Energy Agency chief Rafael Grossi warned that, if further enriched, the stockpile could produce more than 10 nuclear warheads. The material is stored primarily as uranium hexafluoride gas in small canisters, each comparable in size to a scuba tank. Geopolitical Stakes of the Uranium Dispute The stockpile sits at the heart of US‑Iran negotiations. The United States seeks its removal—potentially handing it over to the US or a third party—while Iran, backed by its supreme leader, resists any export. Israeli Prime Minister Benjamin Netanyahu has linked the end of the regional conflict to the removal of the uranium, the cessation of Iran’s proxy support, and the dismantling of its ballistic missile capabilities. Scenarios for the Future of Iran’s Enriched Uranium Recent diplomatic exchanges suggest several possible pathways: Deadlock: Iran’s top diplomat Abbas Araghchi described the issue as postponed, indicating a stalemate in current talks. Down‑blending: Unconfirmed reports claim Iran offered to irreversibly reduce the enrichment level from 60 percent to the 3.67 percent limit of the 2015 JCPOA. Third‑party custodianship: The United States has hinted at a clause ensuring the stockpile’s removal, while Iran has reportedly considered handing it only to a neutral third party. Safe transport protocols: The IAEA outlines the use of type 30B steel cylinders to move uranium hexafluoride, mitigating criticality and toxic‑chemical risks. Historical precedents include the US‑Canada medical‑isotope shipments of highly enriched uranium (mid‑1980s to 2021) and the 1994 “Project Sapphire” operation that safely relocated 600 kg of weapons‑grade uranium from Kazakhstan to the United States. Outlook: What Lies Ahead for the Negotiations? Given the entrenched positions of both Washington and Tehran, the uranium issue is likely to remain a bargaining chip in any future agreement. If Iran proceeds with down‑blending or agrees to third‑party oversight, the immediate proliferation risk could diminish, potentially unlocking broader diplomatic concessions. Conversely, a refusal to move the material may prolong sanctions and heighten regional tensions, especially with Israel emphasizing its removal as a precondition for peace.

The Stumbling Blocks in US-Iran War Talks Future control over the Strait of Hormuz and a demand from Washington that Tehran export its stockpile of highly enriched uranium remain key stumbling blocks, as Pakistani mediators continued to seek a permanent ceasefire they believe is still within reach between the US and Iran. Escalating Tensions and Fear of Surprise Attacks Meanwhile, Israel and Iran each fear the other is about to launch a surprise attack on its territory while the US president, Donald Trump, continues to insist a fresh assault on Iran is an option available to him. Pakistani Mediation Efforts The Pakistani interior minister, Mohsen Naqvi, met the Iranian foreign minister, Abbas Araghchi, for the second time in two days in a bid to secure a breakthrough in talks, and it is still possible that a delayed visit to Tehran by Field Marshal Asim Munir, the commander of the Pakistani army, will signal progress is being made. Iran's Conditions for a Ceasefire Iran has emphasised it is seeking to postpone all talks on its nuclear program and focus instead on a permanent cessation of hostilities that it hopes will include a phased lifting of US sanctions, unfreezing of frozen Iranian assets, compensation for US-Israeli war damage, and commitments not to resort to force in future. The Strait of Hormuz Dispute The future management of the strategic Strait of Hormuz is a key point of dispute, with Pakistan floating plans for joint control under UN auspices. Tehran has also proposed that its recently created Persian Gulf Strait Authority take responsibility for the channel, in which fees would be charged and ships would have to follow instructions from over selected transit routes. International Response and Concerns Five Gulf states have written a letter to the International Maritime Authority, a global shipping watchdog, urging merchant and commercial ships not to engage with the PGSA. The list of signatories are Bahrain, Kuwait, Qatar, Saudi Arabia and the United Arab Emirates.

Manchester United confirmed on Friday that Michael Carrick has been appointed permanent manager, ending his interim spell that sparked a dramatic turnaround in the club’s fortunes.From Interim to Permanent: Carrick’s Rapid AscensionAfter Ruben Amorim was dismissed in January, Carrick stepped in as caretaker. Within weeks the team shifted from uncertainty to conviction, climbing the league table and re‑establishing a competitive edge.Interim appointment: January 2026Permanent contract signed: 22 May 2026Key tactical change: reverted to a traditional back‑fourStatistical Turnaround Under Carrick’s TenureResults under the former midfielder have been striking:11 wins from 16 Premier League matchesOnly 2 defeatsUnited accumulated more league points than any other side during the same periodVictories over Manchester City, Arsenal, Liverpool and ChelseaThe resurgence lifted United from a 15th‑place finish the previous season to the brink of a third‑place finish and secured Champions League qualification with games to spare.Reviving Club Culture and On‑field PerformanceBeyond the numbers, Carrick has reset the dressing‑room atmosphere. Players cite clarity, communication and a calm leadership style.Harry Maguire highlighted the confidence gained after early wins against Arsenal and City.Kobbie Mainoo praised Carrick’s trust, noting his own rise to a Premier League Young Player of the Season finalist.Bruno Fernandes returned to an advanced role, matching the league record for assists with one game remaining.The shift has also quietened external noise, replacing it with a renewed sense of excellence.What Lies Ahead for United Under CarrickCarrick does not promise a revolution, but his focus on stability provides a platform for sustainable growth. The club now looks to:Consolidate a top‑three league finish and deepen the Champions League run.Continue developing young talent such as Mainoo.Maintain the cultural reset that has restored player confidence.If the current trajectory holds, United could re‑establish themselves as a perennial title contender while preserving the calm, intelligent ethos that defines Carrick’s leadership.

The Lead: Indigenous Voices Warn of a New Extraction EraIn the arid dry‑tropical forest of La Guajira, Maria Elena Aguilar Uriana points to a dried‑up watering hole and describes how mining has already devastated her community. Now she and other Wayúu leaders fear that the country’s push for wind‑energy is creating a second wave of exploitation.Coal Mining Legacy and Emerging Renewable Projects in La GuajiraFor decades the region has been dominated by Cerrejón, one of the world’s largest open‑pit coal mines, operated by UK‑listed Glencore. The mine has polluted water, spread coal dust over pastures and forced families to relocate. Today, national and corporate plans aim to replace that extractive model with large‑scale wind farms, but Wayúu representatives say the same top‑down approach is being repeated.Scale of the Cerrejón Mine and Planned Wind InfrastructureCerrejón is among the biggest open‑pit coal mines globally, covering thousands of hectares.Renewable‑energy developers are proposing dozens of wind turbines across Wayúu territory, though exact capacity figures have not been disclosed publicly.The projects are promoted as “green” solutions for Colombia’s energy transition, yet community consent processes remain limited.Health, Water Scarcity and Displacement Impacts on Wayúu CommunitiesWayúu testimonies describe chronic respiratory illness, malnutrition and the loss of livestock due to coal dust and dwindling water supplies. José Silva Duarte, president of Nación Wayúu, notes that water is already scarce, and mining consumes vast quantities, forcing families to rely on state‑provided water deliveries or travel long distances to unsafe wells. The combined stress of past mining and looming wind projects has spurred migration to urban centres and across borders, eroding cultural practices built over centuries.Outlook: Negotiating Consent and Sustainable DevelopmentWhile Glencore asserts it monitors air quality and follows Colombian law in land purchases, Wayúu leaders demand genuine participation, protection of water resources and health safeguards before any renewable infrastructure proceeds. The coming months will test whether Colombia can balance its climate ambitions with the rights and wellbeing of its largest Indigenous group.