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The Earliest Known Dental TreatmentNeanderthals used stone drills to treat cavities almost 60,000 years ago in what is the earliest known evidence of dental treatment. This groundbreaking discovery challenges previous assumptions about Neanderthal capabilities and reveals their sophisticated approach to medical care.The Discovery in SiberiaThe single molar, unearthed in a cave in southern Siberia's Chagyrskaya site, features a deep hole that appears to have been created using a sharp, thin stone tool during the lifetime of the tooth's owner. The tooth, dated to be 59,000 years old, was found alongside the remains of Neanderthals and thousands of stone tools that have been excavated at the site.Scientific Evidence of Ancient DentistryThe lower molar features a deep hole in the centre of the tooth extending into the pulp cavity. Microscopic X-ray imaging revealed changes in mineralization that indicated severe tooth decay. Researchers conducted experiments on three modern human teeth to demonstrate that a hole of the same shape and patterns of microscopic grooves could be created by manually rotating a narrow, elongated tool made from local jasper between two fingers. Penetrating the dentin using this approach took between 35 and 50 minutes of continuous work.Expert Analysis of the ProcedureDr. Kseniya Kolobova, an archaeologist at the Siberian branch of the Russian Academy of Sciences, noted that this discovery "powerfully reinforces the now well-supported view that Neanderthals were not the brutish, inferior cousins of outdated stereotypes but a sophisticated human population with complex cognitive and cultural capacities."A dental professor who reviewed images of the tooth rated the Neanderthal's work as "a decent job." Justin Durham, a professor of orofacial pain at Newcastle University and the British Dental Association's chief scientific adviser, stated: "If I was marking this for a dental student, I wouldn't give it an A, but given the circumstances it's pretty impressive."Implications for Understanding Neanderthal CapabilitiesThis discovery represents the first time dental drilling has been demonstrated outside of Homo sapiens, and it is the oldest example of such behavior by more than 40,000 years. The smoothed edges of the drilled cavity and wear patterns inside it suggest the individual survived and continued to chew with the tooth for some time after the procedure.Dr. Lydia Zotkina, an archaeologist at the Russian Academy of Sciences and co-author, emphasized the remarkable strength of will required: "What struck me, and continues to strike me, is what an incredibly strong-willed person this Neanderthal must have been. They must have surely understood that although the pain of the procedure was greater than the pain of the inflammation, it was only temporary and had to be endured."This finding adds to previous evidence of Neanderthals caring for the sick and vulnerable group members, including an adult man with a withered arm and deformities in both legs, and a child with Down's syndrome who survived until at least the age of six. The latest discovery reveals not only compassion, but an impressive level of self-control by the patient and advanced technical skills by the practitioner.

The Lead: Middlesbrough's Unexpected Playoff PathMiddlesbrough are scheduled to return to training on Friday in preparation for a potential playoff final against Hull at Wembley on Saturday week, despite having lost their semi-final to Southampton. This unusual situation arises from a "spygate" scandal that has seen the south-coast club charged with misconduct after one of their analysts was allegedly caught spying on Middlesbrough's training.The Spygate Incident: Details of the Alleged EspionageThe controversy erupted when William Salt, one of Tonda Eckert's analysts for Southampton, was allegedly caught spying on Kim Hellberg's Middlesbrough team at their Rockliffe Park base near Darlington last Thursday. This led to Southampton being charged with misconduct by the English Football League, with Boro and the EFL hoping that an independent disciplinary commission will reach a verdict in the coming days.The disciplinary panel possesses the power to impose a wide range of punishments if Southampton is found guilty, ranging from fines to the deduction of points and expulsion from the playoffs. This follows a precedent set in 2024 when Canada Women's team was deducted six Olympic points and their head coach received a 12-month FIFA ban after using a drone to spy on New Zealand at the Paris Olympics.Punishment Precedents: Analyzing Potential SanctionsThe EFL has reminded the disciplinary commission that the Priestman case was resolved within seven days and a similarly swift outcome is hoped for. However, there is a right of appeal, and it remains to be seen whether other Championship clubs will support suspicions that they were also spied on by Southampton by presenting the commission with hard evidence of training-ground espionage.Historically, Leeds were fined £200,000 after their then manager, Marcelo Bielsa, admitted sending a staff member to spy on Derby's training in 2019. However, a tougher EFL rule designed to deal with the problem has since been introduced, suggesting potential harsher consequences for Southampton.Championship Implications: Wider Effects of the ScandalThe incident has sent shockwaves through the Championship, with clubs potentially reviewing their security protocols at training facilities. The case also highlights the increasing importance of sports integrity in an era where technological advancements make espionage easier to conduct.Meanwhile, Middlesbrough's players and coaching staff are maintaining their focus on football matters. Hellberg and his players stayed in Hampshire on Tuesday night before flying back to Teesside, with a squad meeting scheduled for Thursday before returning to full training on Friday.Prediction: Likely Outcomes and Next StepsShould Southampton be found guilty, a sporting sanction rather than a fine seems increasingly likely. The Priestman precedent suggests that a points deduction, which could be applied in the Premier League or EFL next season, could prove a feasible alternative to expelling Southampton from the playoffs and reinstating Boro.The timeline for resolution remains uncertain, but with the EFL pushing for a swift verdict similar to the Priestman case, a decision could come within days. Regardless of the outcome, this incident has already cast a shadow over the Championship playoffs and raised important questions about sportsmanship and integrity in professional football.

Michael Carrick has guided Manchester United to a third‑place finish and Champions League qualification with three matches left, yet the board still debates whether his understated style merits a full‑time appointment.The Calm Blueprint Carrick Brings to Manchester UnitedSince taking over after Ruben Amorim’s brief spell, Carrick has imposed a low‑key, possession‑oriented philosophy that mirrors the composure he displayed as a player. He favours patient buildup, tight midfield triangles and a disciplined 4‑4‑2 shape, contrasting sharply with the more adventurous tactics of his predecessor.Emphasis on “tiny details” – first touch, body position – as noted by former Middlesbrough midfielder Hayden Hackney.Maintains a narrow buildup, often resorting to a “doughnut” shape when full‑backs are unavailable.Relies on senior players such as Kobbie Mainoo and Bruno Fernandes to execute the plan.Numbers Behind United’s Late‑Season SurgeKey metrics from the final stretch illustrate both progress and lingering concerns:United secured Champions League football with three games remaining, sitting third in the league.Expected goals (xG) have dipped slightly compared with the Amorim era, while possession percentages remain above 55%.High‑turnover incidents have risen, indicating occasional loss of shape under pressure.Strategic Implications for United’s Squad and the Premier LeagueThe board’s indecision on a permanent manager sends mixed signals to the transfer market. A Carrick‑led United may prioritize:Midfield reinforcement to add “hard legs” and balance the 4‑4‑2 system.Full‑back upgrades to widen the narrow buildup.Retention of emerging talents like Mainoo to preserve the club’s cultural continuity.For the Premier League, a stable United under Carrick could re‑establish the traditional “big‑six” hierarchy, challenging the recent rise of clubs such as Liverpool and Chelsea.What the Next Season Could Hold for Carrick and UnitedIf United appoint Carrick permanently, the club will need to:Invest in a clear recruitment plan during the summer window to address squad gaps.Develop a more dynamic attacking philosophy to complement his possession base.Navigate heightened fan expectations that demand both results and an identifiable playing style.Failure to do so may see the “confidence trick” narrative resurface, risking a rapid decline once opposition teams adapt to United’s calm but predictable approach.

Lead: A Coordinated Drone Wave Rocks Multiple Ukrainian CitiesAt least six people were killed and dozens injured as a "one of the longest, massive Russian attacks" swept through Ukraine on Wednesday morning, according to President Volodymyr Zelenskyy. The barrage hit Kyiv, Lviv, Odesa and several other locations, challenging recent statements that the war may be winding down.Massive Multi-Region Drone Assault Across UkraineZelenskyy described the attack as lasting for hours, employing both cruise and ballistic missiles alongside swarms of drones. Key incidents included:Kyiv: air defenses strained by sustained strikes.Lviv (near the Polish border): civilian areas targeted.Odesa (Black Sea port): strategic maritime hub hit.Kherson region (Bilozerka): a woman killed when a drone struck a bus.Rivne region: three killed, four injured.Kharkiv region (near Zolochiv): a 60‑year‑old man killed, homes damaged.Zaporizhia region: a 76‑year‑old man killed at an agricultural enterprise.Casualties and Material Damage Across Six RegionsThe confirmed human toll stands at six dead and "dozens" wounded, with additional civilian infrastructure harmed:Two homes and a civilian car damaged in Russia’s Bryansk region after Ukrainian drones.Four injured in Belgorod’s village of Bessonovka.Russian Ministry of Defence reported destroying 286 Ukrainian drones overnight across multiple border regions.Strategic Implications Amid Claims of War’s EndThe offensive coincided with remarks from U.S. President Donald Trump and Russian President Vladimir Putin suggesting the four‑year conflict could be nearing a resolution. Zelenskyy warned that Russia aims to "overload air defences," hinting at a possible escalation with cruise and ballistic missile strikes following the drone wave. The juxtaposition of diplomatic optimism and on‑ground violence highlights the fragility of any cease‑fire prospects.What the Next Weeks May Hold for Ukrainian Defense and Diplomatic EffortsAnalysts anticipate that Ukraine will reinforce its air‑defence network, especially around major urban centers, while seeking accelerated diplomatic engagement from Western allies. Continued drone activity on both sides suggests that any negotiated settlement will need to address the persistent threat of unmanned aerial attacks and the capacity of Russian forces to launch prolonged barrages.

The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

The Lead: Preserving Environmental HistoryOver four years in the 1820s, Charles Waterton built a 9ft-high, 3-mile-long wall around the parkland and lake of Walton Hall in Yorkshire, creating what could be the world's first nature reserve. Now, the overlooked achievements of this innovative reserve and the crumbling wall that still surrounds Waterton's former home are being remembered through WallFest, a programme of 60 community events organised by a charity dedicated to protecting the wall and preserving its legacy.The Historic Wall: Engineering Environmental ProtectionThe wall, built between 1820-1824, was designed to be fox- and poacher-proof, enclosing Waterton's estate and creating a sanctuary for wildlife. After completing the wall and banning hunting and shooting, Waterton recorded 5,000 wildfowl on his lake and 123 species of birds, including those widely persecuted at the time, such as herons and kestrels. The boundary allowed hedgehogs and so-called vermin, like weasels, to roam freely through his reserve.Waterton's Environmental Legacy: A Pioneer Ahead of His TimeWaterton, an eccentric, controversial and pioneering environmentalist, implemented innovative conservation practices long before they became mainstream. He built nest boxes, special banks for sand martins and innovative bird hides, and offered local people sixpence for every hedgehog they brought into his reserve. Unlike sportsman-naturalists of the day, Waterton abhorred shooting and got into fistfights with armed poachers, thwarting their attempts to kill birds by placing dummy birds made from metal and wood in the trees.Waterton's environmentalism began after experiencing the natural wonders of the rainforests of Guyana, where he managed his father's sugar plantations. Upon returning to his family home in rapidly industrializing West Yorkshire, he was dismayed at the polluted state of waterways, woodlands stripped of birdlife and workers looking ill.The Conservation Challenge: A Wall in PerilToday, the historic wall has collapsed in places and is in urgent need of repair. Some sections have completely deteriorated, threatening the physical boundary that Waterton created and the historical significance it represents. The Friends of Waterton's Wall charity was created after Covid when local residents realized the wall they walked beside daily might not last another century.Waterton also launched one of the first known environmental legal actions, against a nearby soap works for releasing pollutants that killed trees and damaged his lake. Despite his visionary environmentalism, Waterton is mostly remembered for his eccentricity rather than his groundbreaking conservation efforts.WallFest: Community Action for HeritageThe WallFest events, taking place during May around the village of Walton, West Yorkshire, and in Waterton's former home (now a hotel), will help raise funds to repair the crumbling wall. The festival includes a short film supported by David Attenborough and various community activities designed to raise awareness of both the wall's condition and Waterton's environmental legacy."We're keen to raise the profile of the first nature reserve in the world," said John Smith, the chair of trustees of Friends of Waterton's Wall. "Waterton was a pioneering environmentalist, probably the first in this country. We also want to raise the profile of the wall itself and the need to preserve our heritage for future generations."The Future Outlook: Rediscovering an Environmental PioneerAccording to Barbara Phipps, a local resident and author of a biography of Waterton, his historical portrayal as "an amusing and strange fellow," in the words of Charles Darwin, was partly because he was a Catholic and was discriminated against, being excluded from mainstream careers in politics, law and the military.John Whitaker, a curator at Wakefield council's museums and castles and a trustee of the charity, also attributed the lack of acclaim for Waterton to his Catholicism. "He was a marginalised aristocrat, which is a weird situation to be in. He was never in the establishment. He was massively affectionate and incredibly progressive in many ways but also hugely contradictory."As WallFest aims to raise both funds and awareness, there's hope that Waterton's true legacy as an environmental pioneer will be properly recognized and that the historic wall will be preserved for future generations to appreciate.

Smithsonian's Monumental Celebration of America's 250 Years To paraphrase the musical Rent, 131,487,300 minutes – how do you measure, measure 250 years? Especially in a country navigating an election year fraught with divisions and disagreements over basic facts? That is the challenge facing the Smithsonian National Museum of American History in Washington DC as it marks the semiquincentennial of US independence. The museum's answer is with 250 objects that tell the American story, ranging from a revolutionary war-era gunboat to gloves worn by a "Miracle on Ice" hockey player, from Thomas Jefferson's desk to a Donald Trump fan's "Make America great again" hat. A Museum-Wide Journey Through American History Opening on 14 May, "In Pursuit of Life, Liberty & Happiness" will display 250 objects encompassing 250,000 sq ft across all three floors of the museum. They range from old to new, from big to small and from sublime to mundane. Seventy-six of them – many rarely or never seen by the public – will be concentrated in cases lining the entry halls, while the remainder will be embedded throughout the museum's existing galleries, connected by a "ribbon" design to guide visitors on a historical treasure hunt. Each is paired with an action verb to underscore the view of democracy as a "highly participatory sport." Among the star attractions is the Philadelphia, a 53ft, flat-bottomed wooden gunboat constructed in the chaotic, sweltering summer of 1776. On a recent preview tour, visitors stepped into a climate-controlled enclosure at the museum where the air was thick with the scent of 100% acetone. Behind viewing windows that allow the public to see the work in progress, two conservators clad in headlamps and respirators were meticulously wielding soft and stiff bristle brushes, dental picks and wooden dowel rods to strip away decades of accumulated lacquer from a rusted iron cannon and its surrounding timber. By the Numbers: The Scale of the Exhibition The exhibition features 250 objects spread across 250,000 square feet of museum space. Seventy-six of these objects – many rarely or never seen by the public – will be concentrated in cases lining the entry halls. The Philadelphia gunboat itself weighs 16,000 pounds and was constructed in 1776. The wreck languished underwater for 159 years before being salvaged in 1935, fully intact with its armament and hundreds of artifacts scattered across its deck. When raised, the boat revealed about 600 to 800 items, including cannons, carriages, wheels, a stew pot, a melting pot for pitch, shoe leather, buttons from regimental coats, and even a leather button that was probably from someone's breeches. Reframing America's Complex Narrative "How do you structure a commemoration, celebration and time for reflection?" asks Anthea Hartig, the museum's director. "What we landed on were those moments where individuals or communities had fought for recognition and advocated for their own sense of identity and self in their role in creating and becoming a part of the United States. But we also wanted to do the playful." Hartig describes the US as "amazing, beautiful, complicated", and cites the African American writer James Baldwin's celebrated observation: "American history is longer, larger, more various, more beautiful, and more terrible than anything anyone has ever said about it." The exhibition captures both the monumental and the intimate aspects of American history. Alongside iconic items like Thomas Jefferson's portable desk on which he drafted the Declaration of Independence, the Star-Spangled Banner that inspired the national anthem, and George Washington's military uniform, are personal artifacts like a faux-pearl necklace worn by Abigail Adams in the mid-18th century. The Future of Historical Commemoration Hartig adds: "We believe that this anniversary is so important not only to the nation but the world, and that our past 250 years are filled with so much history that it takes an entire museum to do it justice." The exhibition also incorporates modern technology to enhance the visitor experience, including a virtual reality experience that transports visitors back to the Philadelphia's construction 250 years ago. As the museum continues to preserve and interpret America's complex past, the exhibition represents a new approach to historical commemoration – one that embraces the full spectrum of American experiences, from the revolutionary to the contemporary, and from the sublime to the mundane.

The Current Champions Argentina head into the FIFA World Cup 2026 as the reigning champions after dethroning France at the Qatar World Cup 2022 to win their third title. Historical World Cup Winners Brazil is the most successful team in the tournament’s history, having won the title five times. Here is a list of all the previous World Cup winners: 1930 – Uruguay – Uruguay hosted and won the inaugural World Cup, defeating Argentina in the final. 1934 – Italy – Italy won the first of their four World Cups in this edition. 1938 – Italy – Italy won the last World Cup before World War II put the tournament on hold for 12 years. 1950 – Uruguay – La Celeste famously defeated Brazil in the final at the Maracana to win their second World Cup. 1954 – West Germany – West Germany won the World Cup hosted by Switzerland. 1958 – Brazil – A 17-year-old Pele scored six goals as Brazil lifted their first World Cup. 1962 – Brazil – Brazil became the second team after Italy to successfully defend a World Cup crown. 1966 – England – Football “came home” for the first and only time so far in 1966 when England won the World Cup at Wembley. 1970 – Brazil – Pele got his hands on the trophy for the third time in 1970. No player in history has won as many World Cups as him. 1974 – West Germany – Led by Gerd Mueller, West Germany won their second World Cup. 1978 – Argentina – Argentina won their first World Cup in 1978, defeating the Netherlands in the final. 1982 – Italy – A Paolo Rossi-inspired Italy won the 1982 tournament in Spain. 1986 – Argentina – The legend of Diego Maradona was written at the 1986 World Cup in Mexico, where the mercurial genius almost single-handedly led Argentina to glory. 1990 – West Germany – Maradona’s Argentina reached the final in 1990 as well but were thwarted by West Germany, which won eight months after the Berlin Wall fell and three months before Germany’s unification. 1994 – Brazil – The first World Cup in North America was won by Brazil, which claimed their fourth title in the United States. 1998 – France – France won the tournament at home with players like Zinedine Zidane, Thierry Henry and Patrick Vieira ushering in a new era of success for Les Bleus. 2002 – Brazil – Brazil won a record fifth World Cup, overcoming Germany in the final. 2006 – Italy – Despite Serie A being rocked by match-fixing allegations, Italy showed great resolve to win the 2006 edition. 2010 – Spain – Spain’s possession style of football saw them win their first World Cup in South Africa in 2010. 2014 – Germany – After making the semifinals in each of the previous two editions, Germany finally got their hands on the trophy again in 2014. 2018 – France – Didier Deschamps, who captained France to their 1998 triumph, won the World Cup for a second time in 2018 as coach. 2022 – Argentina – Lionel Messi, one of the greatest footballers the world has ever seen, won the one title that had eluded him in one of the greatest finals the World Cup has ever seen. After battling France to a 2-2 draw after 90 minutes and a 3-3 draw after extra time, Argentina won 4-2 on penalties. The Legacy of the World Cup Eight countries have won the World Cup in its 92-year history. The tournament continues to be a pinnacle of achievement in international football.

As the US‑Israel war on Iran reaches its 12th week, the city of Tucson, Arizona, is quietly transforming its sports complex into the home base for Team Melli ahead of the 2026 FIFA World Cup, underscoring a stark contrast between battlefield headlines and the unifying promise of football. Training Camp Set Up at Kino Sports Complex The Kino Sports Complex, overseen by Sarah Hanna, director of the facility, is being pre‑pared to FIFA‑regulation standards. Grass is being watered and cut to exact height, weight rooms, ice‑baths and massage tables are readied, and meeting spaces have been booked for the team’s staff. Location: Tucson, Arizona – a desert oasis of ~540,000 residents. Facility: Kino Sports Complex, equipped with FIFA‑approved pitch. Key personnel: Sarah Hanna (facility director), Jon Pearlman (FC Tucson president). Logistics and Security Amid Geopolitical Tension Preparation intensity is high: Hanna reports averaging 12 to 20 meetings each week, ranging from food‑service contracts to FIFA inspections. Security measures have been tightened, and hotel rooms for the squad are locked in. Travel timeline: Arrival expected two weeks before opening match on June 15, 2026 in Los Angeles. Group‑stage venues: Los Angeles (vs New Zealand), Seattle (vs Egypt), and a match against Belgium six days after the opener. Political backdrop: Ongoing naval blockade of Iranian ports and a de‑facto closure of the Strait of Hormuz. Sport as a Diplomatic Bridge in a Conflict Zone Local leaders stress that football can transcend politics. Jon Pearlman said, “We welcome them with open arms… the game brings nations together, not drives them apart.” Residents echo this sentiment, despite President Donald Trump’s earlier social‑media doubts about the team’s safety. Community response: Positive, with local clubs and fans offering support. FIFA stance: The tournament will proceed with Iran’s participation as planned. Outlook for Iran’s World Cup Participation While visa and staff‑treatment demands remain under negotiation, the logistical groundwork in Tucson suggests a high probability that Iran will compete as scheduled. Should diplomatic friction intensify, contingency plans could involve neutral venues, but current momentum points to a full tournament presence. Potential risk: Escalation of hostilities could trigger travel restrictions. Best‑case scenario: Iran plays all group matches, using Tucson as a stable training hub.